The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Oligodendrocytes and Ischemic Brain Injury
Open accessAbstract
Oligodendrocytes, myelin-forming glial cells of the central nervous system, are vulnerable to damage in a variety of neurologic diseases. Much is known of primary myelin injury, which occurs in settings of genetic dysmyelination or demyelinating disease. There is growing awareness that oligodendrocytes are also targets of injury in acute ischemia. Recognition of oligodendrocyte damage in animal models of ischemia requires attention to their distinct histologic features or use of specific immunocytochemical markers. Like neurons, oligodendrocytes are highly sensitive to injury by oxidative stress, excitatory amino acids, trophic factor deprivation, and activation of apoptotic pathways. Understanding mechanisms of oligodendrocyte death may suggest new therapeutic strategies to preserve or restore white matter function and structure after ischemic insults.
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“Moreover, oligodendrocytes express AMPA and kainate type glutamate receptors, and are sensitive to excitotoxic damage from excess glutamate (Dewar et al, 2003;Matute et al, 1997;McDonald et al, 1998).”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as Dewar et al, 2003
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“Moreover, oligodendrocytes express AMPA and kainate type glutamate receptors, and are sensitive to excitotoxic damage from excess glutamate (Dewar et al, 2003;Matute et al, 1997;McDonald et al, 1998).”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as Dewar et al, 2003
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“oligodendrocytes express AMPA and kainate type glutamate receptors, and are sensitive to excitotoxic damage from excess glutamate (Dewar et al. 2003; Matute et al. 1997; McDonald et al. 1998).”
From Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008) · cites this paper as Dewar et al. 2003
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Cites
Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.
McCarthy, K. D., & de Vellis, J. (1980) · The Journal of Cell Biology · doi:10.1083/jcb.85.3.890 · Cited by 3,825
Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP
Feng, G., Mellor, R. H., Bernstein, M., Keller-Peck, C., Nguyen, Q. T., Wallace, M., Nerbonne, J. M., Lichtman, J. W., & Sanes, J. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00084-2 · Cited by 3,042
RAFF, M. C., Miller, R. H., & Noble, M. (1983) · Nature · doi:10.1038/303390a0 · Cited by 2,030
Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
Baumann, N., & Pham-Dinh, D. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.871 · Cited by 1,828
Asahi, M., Wang, X., Mori, T., Sumii, T., Jung, J.-C., Moskowitz, M. A., Fini, M. E., & Lo, E. H. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07724.2001 · Cited by 1,004
Neurobiology of Periventricular Leukomalacia in the Premature Infant
Volpe, J. J. (2001) · Pediatric Research · doi:10.1203/00006450-200111000-00003 · Cited by 945
Back, S. A., Luo, N. L., Borenstein, N. S., Levine, J. M., Volpe, J. J., & Kinney, H. C. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01302.2001 · Cited by 936
Inflammatory Mediators and Stroke: New Opportunities for Novel Therapeutics
Barone, F. C., & Feuerstein, G. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199908000-00001 · Cited by 924
Galactocerebroside is a specific cell-surface antigenic marker for oligodendrocytes in culture
RAFF, M. C., Mirsky, R., Fields, K. L., Lisak, R. P., Dorfman, S. H., Silberberg, D. H., Gregson, N. A., Leibowitz, S., & KENNEDY, M. C. (1978) · Nature · doi:10.1038/274813a0 · Cited by 808
Glutamate excitotoxicity in a model of multiple sclerosis
Pitt, D., Werner, P., & Raine, C. S. (2000) · Nature Medicine · doi:10.1038/71555 · Cited by 744
Flagged first, then by citations
Research works printed but not linked: 7
- 10.1002/(SICI)1098-1136(20000115)29:2<124::AID-GLIA5>3.0.CO;2-O · DOI
- Levine JM, 1996, Perspect Dev Neurobiol, 3, 245
- Leviton A, 1971, Am J Pathol, 65, 303
- Shin R-W, 1991, Lab Invest, 64, 693
- Szuchet S, 1995, Neuroglia, 23
- Tekkök SB, 2002, Glia, S66
- Underhill SM, 2002, Glia, S66
Cited by
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Danton, G. H., & Dietrich, W. (2005) · Elsevier eBooks · doi:10.1016/b978-012738903-5/50015-1
Hatayama, K., Kim, B., Chen, X. F., Lim, Y., Davidson, J. O., Bennet, L., Gunn, A. J., & Stonestreet, B. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910751 · Cited by 1
Tewarie, P. K. B., Tjepkema‐Cloostermans, M. C., Abeysuriya, R., Hofmeijer, J., & van Putten, M. J. A. M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.02.514844 · Cited by 1
Guo, Y., Ma, J., Ma, X., Ye, K., Jiang, C., Xu, J., Huang, Y., Yang, X., Ge, Q., Zhang, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.30.630832 · Cited by 1
Molecular Mechanisms of Calcium Influx in Axonal Degeneration
Stys, P. K., & Waxman, S. G. (2005) · Elsevier eBooks · doi:10.1016/b978-012738761-1/50020-1 · Cited by 1
Walker, E. J. (2009) · UNM’s Digital Repository (University of New Mexico)
Shah, S. K., Jimenez, F., & Walker, P. A. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-965-9_4 · Cited by 1
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Seo, J. H., Hayakawa, K., Miyamoto, N., Maki, T., Pham, L. D., Lo, E. H., & Arai, K. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9123-1_10
Liao, H., & Mani, D. S. (2011) · Neuroscience & Medicine · doi:10.4236/nm.2011.22014
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Nunes, R. R., Nora, F. S., Dumaresq, D. M. H., Cavalcante, R. M. A., Costa, A. A., Carneiro, L. M. M., de Alencar, J. C. G., & Cardoso, F. P. F. (2012) · Brazilian Journal of Anesthesiology · doi:10.1590/s0034-70942012000400002
Histone deacetylase inhibition-mediated cytotoxicity of oligodendrocytes.
Dincman, T. A. (2011) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/351
Arnab, D. (2012) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/60746
Neuroimaging of White Matter Injury: A Multimodal Approach to Vascular Disease
Rosenberg, G. A., Huisa, B. N., Jalal, F. Y., & Yang, Y. R. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9123-1_4
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Zhang, Z. G., & Chopp, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-29544-4.00011-6
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Silverman, W. F. (2004) · CRC Press eBooks · doi:10.1201/9781420039740.ch22
Sources of extracellular glutamate in developing white matter
Fern, R. F. (2011) · OAR@UM (University of Malta)
Szalárdy, L. (2016) · SZTE Repository of Dissertations (University of Szeged) · doi:10.14232/phd.3120 · Cited by 1
Wang, Y. (2014) · TSpace (University of Toronto)
Dynamics of myelin content decrease in the rat stroke model
Kisel, A. A., Khodanovich, M. Y., Atochin, D. N., Mustafina, L. R., & Yarnykh, V. L. (2017) · Journal of Physics Conference Series · doi:10.1088/1742-6596/886/1/012008
Eftevaag, M. (2019) · NORA - Norwegian Open Research Archives
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Yoshioka, H., Wakai, T., Kinouchi, H., & Chan, P. H. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9123-1_20
Ransom, B. R., Goldberg, M. P., Arai, K., & Baltan, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-69424-7.00009-0
Self-citationNeuroprotective effect of betanin in mice with cerebral ischemia reperfusion injuryPreprint
Thong-asa, W., Puenpha, K., Lairaksa, T., & Saengjinda, S. (2022) · Research Square · doi:10.21203/rs.3.rs-1603157/v1
Laporte, J. P., Faulkner, M. E., Gong, Z., Akhonda, M. A. B. S., Ferrucci, L., Egan, J. M., & Bouhrara, M. (2023) · medRxiv · doi:10.1101/2023.02.21.23286279
Verkhratsky, A., & Butt, A. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821565-4.00005-5
Gholami, M., Morris, K., Torres, A. M., Kamal, T. T., Jahromi, B. R., Haridas, A., & Kateb, B. (2024) · Springer eBooks · doi:10.1007/978-3-030-80662-0_19
Wang, Y., Zhu, M., Park, J., Kim, H. K., Ge, X., Chen, X., Chen, B., Ding, S., Lin, W., & Guo, F. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.29.702669
Liu, Y., Wang, S., Liu, H., Liang, G., Xu, Z. S., & Meng, Q. (2026) · Research Square · doi:10.21203/rs.3.rs-9885354/v1
Pathophysiology and Repair Potential in Degenerative Cervical Myelopathy
Lares, S. A., Hejrati, N., & Guest, J. D. (2026) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2026.05.012
Zhiping, M., Zeh, D. J., Ma, J., Weng, Z., Bozenko, M. G. M., Foley, L. M., Rose, M. E., Hitchens, T. K., Cao, G., & Graham, S. H. (2026) · Scientific Reports · doi:10.1038/s41598-026-74470-y
Electrical responses of oligodendrocytes to pathological stimuli
Kołodziejczyk, K. (2011) · UCL Discovery (University College London)
Metadata
- Authors
- Dewar, D., Underhill, S. M., & Goldberg, M. P.
- Affiliations
- University of Glasgow (GB)
- Washington University in St. Louis (US)
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2003-03
- Volume
- 23
- Issue
- 3
- Pages
- 263-274
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2077440654
- Cited by
- 335
- References
- 123
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 17 · 2023: 17 · 2022: 14 · 2021: 18 · 2020: 19 · 2019: 20 · 2018: 12 · 2017: 9 · 2016: 24 · 2015: 25 · 2014: 10 · 2013: 23 · 2012: 15
- FWCI
- 6.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Funders
- National Institutes of Health (5r01ns032626-04)
- Medical Research Council
- National Institute of Neurological Disorders and Stroke (NS 32626, NS36265, R01NS036265)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Keywords
- oligodendrocytes, ischemic brain injury, myelin damage, demyelinating disease, acute cerebral ischemia, oxidative stress, excitatory amino acids, trophic factor deprivation, apoptosis, white matter preservation, immunocytochemical markers
- MeSH terms
- Animals, Brain Ischemia, Humans, Necrosis, Neurotoxins, Oligodendroglia, Apoptosis, Oxidative Stress, Neuroprotective Agents
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