Cited by 335Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and TreatmentsNeuroprotection in Cerebral Ischemia

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Oligodendrocytes and Ischemic Brain Injury

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Dewar, Deborah, Underhill, Suzanne M., Goldberg, Mark P.·2003·Journal of Cerebral Blood Flow & Metabolism

DOI 10.1097/01.wcb.0000053472.41007.f9

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Abstract

Oligodendrocytes, myelin-forming glial cells of the central nervous system, are vulnerable to damage in a variety of neurologic diseases. Much is known of primary myelin injury, which occurs in settings of genetic dysmyelination or demyelinating disease. There is growing awareness that oligodendrocytes are also targets of injury in acute ischemia. Recognition of oligodendrocyte damage in animal models of ischemia requires attention to their distinct histologic features or use of specific immunocytochemical markers. Like neurons, oligodendrocytes are highly sensitive to injury by oxidative stress, excitatory amino acids, trophic factor deprivation, and activation of apoptotic pathways. Understanding mechanisms of oligodendrocyte death may suggest new therapeutic strategies to preserve or restore white matter function and structure after ischemic insults.

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Authors: Dewar, D., Underhill, S. M., & Goldberg, M. P.
Affiliations: University of Glasgow (GB)
Washington University in St. Louis (US)
ORCID: Dewar, Deborah
Underhill, Suzanne M.
Goldberg, Mark P.
Venue: Journal of Cerebral Blood Flow & Metabolism
Publisher: SAGE Publications
Published: 2003-03
Volume: 23
Issue: 3
Pages: 263-274
ISSN: 0271-678X (ISSN-L)
1559-7016
DOI: 10.1097/01.wcb.0000053472.41007.f9
OpenAlex: W2077440654
Cited by: 335
References: 123
Citations by year: 2026: 11 · 2025: 11 · 2024: 17 · 2023: 17 · 2022: 14 · 2021: 18 · 2020: 19 · 2019: 20 · 2018: 12 · 2017: 9 · 2016: 24 · 2015: 25 · 2014: 10 · 2013: 23 · 2012: 15
FWCI: 6.35
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Funders: National Institutes of Health (5r01ns032626-04)
Medical Research Council
National Institute of Neurological Disorders and Stroke (NS 32626, NS36265, R01NS036265)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords: oligodendrocytes, ischemic brain injury, myelin damage, demyelinating disease, acute cerebral ischemia, oxidative stress, excitatory amino acids, trophic factor deprivation, apoptosis, white matter preservation, immunocytochemical markers
MeSH terms: Animals, Brain Ischemia, Humans, Necrosis, Neurotoxins, Oligodendroglia, Apoptosis, Oxidative Stress, Neuroprotective Agents

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