Cited by 125Neuroinflammation and Neurodegeneration MechanismsNeuroprotection in Cerebral IschemiaNeurological Disease Mechanisms and Treatments

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The Potential of Minocycline for Neuroprotection in Human Neurologic Disease

Zemke, Daniel, Majid, Arshad·2004·Clinical Neuropharmacology

DOI 10.1097/01.wnf.0000150867.98887.3e

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Abstract

Minocycline is a member of the tetracycline class of molecules with broad-spectrum antibiotic activity. The unique properties of minocycline result in increased tissue distribution when compared with the other tetracyclines. Of particular interest is the ability of minocycline to diffuse into the central nervous system at clinically effective levels. Aside from its antimicrobial properties, minocycline has been found to have beneficial effects on inflammation, microglial activation, matrix metalloproteinases, nitric oxide production, and apoptotic cell death. Concordantly, minocycline has been found to have neuroprotective effects in animal models of a number of diseases including stroke, multiple sclerosis, and Parkinson disease. The proven safety of minocycline over decades of use as an antibiotic suggests that it may have potential for development into an effective treatment of multiple neurologic conditions in humans.

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Morgan, J. C., & Sethi, K. D. (2006) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.11.3.403 · Cited by 19
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Zhang, Z., Zhang, Z., Fauser, U., & Schluesener, H. J. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00172.x · Cited by 18
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Du, B., Zhang, Y., Tang, Y., & Wang, P. (2011) · Otolaryngology · doi:10.1177/0194599810395090 · Cited by 14
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Wu, W. E., Tal, A., Kirov, I. I., Rusinek, H., Charytonowicz, D., Babb, J. S., Ratai, E., González, R., & Gonen, O. (2013) · NMR in Biomedicine · doi:10.1002/nbm.2889 · Cited by 8
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Authors: Zemke, D., & Majid, A.
Affiliations: Michigan State University (US)
ORCID: Majid, Arshad
Venue: Clinical Neuropharmacology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-11
Volume: 27
Issue: 6
Pages: 293-298
ISSN: 0362-5664 (ISSN-L)
DOI: 10.1097/01.wnf.0000150867.98887.3e
OpenAlex: W2047780499
Cited by: 125
References: 64
Citations by year: 2026: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 8 · 2013: 9 · 2012: 10
FWCI: 0.96
Type: journal article
Language: en
Open access: closed
Locations: Clinical Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: minocycline, neuroprotection, tetracycline, CNS penetration, neuroinflammation, microglial activation, matrix metalloproteinases, nitric oxide, apoptosis, stroke, multiple sclerosis, Parkinson's disease, neurological disorders
MeSH terms: Animals, Humans, Minocycline, Nervous System Diseases, Cell Death, Microglia, Neuroprotective Agents, Matrix Metalloproteinases

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The Potential of Minocycline for Neuroprotection in Human Neurologic Disease

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