The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
The Potential of Minocycline for Neuroprotection in Human Neurologic Disease
Abstract
Minocycline is a member of the tetracycline class of molecules with broad-spectrum antibiotic activity. The unique properties of minocycline result in increased tissue distribution when compared with the other tetracyclines. Of particular interest is the ability of minocycline to diffuse into the central nervous system at clinically effective levels. Aside from its antimicrobial properties, minocycline has been found to have beneficial effects on inflammation, microglial activation, matrix metalloproteinases, nitric oxide production, and apoptotic cell death. Concordantly, minocycline has been found to have neuroprotective effects in animal models of a number of diseases including stroke, multiple sclerosis, and Parkinson disease. The proven safety of minocycline over decades of use as an antibiotic suggests that it may have potential for development into an effective treatment of multiple neurologic conditions in humans.
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“Thanks to the ability to efficiently cross the BBB, minocycline is considered neuroprotective for a variety of neurological conditions, including PD [251,252,253,254,255,256,257].”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [257]
In the citing paper
“Thanks to the ability to efficiently cross the BBB, minocycline is considered neuroprotective for a variety of neurological conditions, including PD [251,252,253,254,255,256,257].”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [257]
Citations
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Metadata
- Authors
- Zemke, D., & Majid, A.
- Affiliations
- Michigan State University (US)
- ORCID
- Majid, Arshad
- Venue
- Clinical Neuropharmacology
- Published
- 2004-11
- Volume
- 27
- Issue
- 6
- Pages
- 293-298
- ISSN
- 0362-5664 (ISSN-L)
- OpenAlex
- W2047780499
- Cited by
- 125
- References
- 64
- Citations by year
- 2026: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 8 · 2013: 9 · 2012: 10
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- minocycline, neuroprotection, tetracycline, CNS penetration, neuroinflammation, microglial activation, matrix metalloproteinases, nitric oxide, apoptosis, stroke, multiple sclerosis, Parkinson's disease, neurological disorders
- MeSH terms
- Animals, Humans, Minocycline, Nervous System Diseases, Cell Death, Microglia, Neuroprotective Agents, Matrix Metalloproteinases
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