Increased prevalence of scoliosis in Turner syndrome
Abstract
Turner syndrome (TS) is associated with multiple skeletal abnormalities. However, the prevalence of scoliosis in children with TS has not been reported in the orthopaedic literature. The purpose of this study was to determine the prevalence and characteristics of scoliosis in these patients. The authors performed a retrospective study of 43 patients with TS and found 5 children with a curve >10 degrees. The prevalence of scoliosis in this TS population, 11.6%, was significantly greater than the reported prevalence of idiopathic scoliosis in normal girls, 2.4%. The mean age of onset was 9 years 11 months. All curves were >34 degrees, with curves consisting of a right thoracic or S-shaped (larger lumbar segment) pattern. At the time of scoliosis presentation, two patients were not receiving growth hormone therapy. The results of this study suggest that children with TS need to be examined and closely monitored for progression of scoliosis by orthopaedists. Although curve progression can occur during growth acceleration, a direct causal association with growth hormone has not been established.
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TS is associated with increased prevalence of skeletal anomalies including scoliosis, kyphosis, cubitus valgus, genu valgum, Madelung deformity, and short fourth and fifth metacarpals and metatarsals.
“TS is also associated with increased prevalence of skeletal anomalies, including scoliosis, kyphosis, cubitus valgus, genu valgum, Madelung deformity of the wrist and short fourth and fifth metacarpals and metatarsals.154,155”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [155]
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Clinical practice guidelines for the care of girls and women with Turner syndrome.
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Rhie, Y.-J., Yoo, J.-H., Choi, J.-H., Chae, H.-W., Kim, J. H., Chung, S., Hwang, I. T., Shin, C. H., Kim, E. Y., & Kim, H.-S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216927 · Cited by 49 · see citing works
Self-citationMarx, J. S., Pagadala, M., Carney, J., Gerlach, E., Swiatek, P., Zabinsky, J. A., Sarwark, J., Brickman, W. J., & Habiby, R. L. (2023) · Journal of Pediatric Orthopaedics · doi:10.1097/bpo.0000000000002367 · Cited by 7 · see citing works
Angle of trunk rotation in children suffering from growth hormone deficiency
Kobylińska, M., Malak, R., Majewska, K. A., Fechner, B., Samborski, W., & Kędzia, A. (2023) · Pediatria Polska · doi:10.5114/polp.2023.126246 · Cited by 1 · see citing works
- Authors
- Kim, J. Y., Rosenfeld, S. R., & Keyak, J. H.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Kim, Joanne Y.
- Rosenfeld, Samuel R.
- Keyak, Joyce H.
- Venue
- Journal of Pediatric Orthopaedics
- Published
- 2001-11
- Volume
- 21
- Issue
- 6
- Pages
- 765-766
- ISSN
- 0271-6798 (ISSN-L)
- OpenAlex
- W2072348641
- Cited by
- 49
- References
- 6
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 3 · 2013: 1 · 2012: 4
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pediatric Orthopaedics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Scoliosis diagnosis and treatment
- Health Sciences › Medicine › Surgery › Pectus Deformity Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Keywords
- Turner syndrome, scoliosis, prevalence, spinal curvature, growth hormone therapy, curve progression, skeletal abnormalities, children
- MeSH terms
- Adolescent, Child, Child, Preschool, Female, Humans, Male, Retrospective Studies, Scoliosis, Turner Syndrome, Prevalence
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