Long-term safety and effectiveness of growth hormone therapy in Korean children with growth disorders: 5-year results of LG growth study
Open accessAbstract
PURPOSE: The aim of this registry study was to analyze the long-term safety and effectiveness of recombinant human growth hormone (rhGH) in South Korean pediatric patients (≥2 years of age) with growth hormone deficiency GHD) of idiopathic or organic etiology, idiopathic short stature, Turner syndrome, small for gestational age and chronic renal failure. METHODS: The study patients were followed-up till two years after the epiphyseal closure, with visits scheduled every six months. The outcome measures included the incidence of adverse events (AEs, in particular, neoplasia, glucose intolerance and hypothyroidism), as well as height standard deviation score (Ht SDS) and annual height velocity. The results of the interim analysis of a 5-year accumulated data for 2,024 patients (7,342 patient-years, PY) are presented. RESULTS: A total of 14 neoplasms were diagnosed (191/100,000 PY); 7 out of 9 malignancies were recurrent craniopharyngioma found in patients with organic GHD. Seven cases of glucose intolerance (95/100,000 PY) and 22 cases of hypothyroidism (300/100,000 PY) were detected; about half of the cases (4 and 10 cases each) were considered to be related with rhGH treatment. Most of the growth-retarded patients showed continuous improvement in Ht SDS, with the most prominent effect observed within a year of treatment initiation. The beneficial effect of rhGH on Ht SDS gain was maintained for 2-4 years. CONCLUSIONS: The incidence of AEs of interest in rhGH-treated patients was low, and most of the neoplasms were benign and/or non-related to rhGH. Most patients benefited from the therapy in terms of height increment.
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IGF-I values more than 2 SD above the mean for age and sex are common during GH treatment.
“IGF-I values more than 2 SD above the mean for age and sex are common during GH treatment199”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [199]
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- Authors
- Rhie, Y.-J., Yoo, J.-H., Choi, J.-H., Chae, H.-W., Kim, J. H., Chung, S., Hwang, I. T., Shin, C. H., Kim, E. Y., & Kim, H.-S.
- Affiliations
- Korea University (KR)
- Dong-A University (KR)
- Asan Medical Center (KR)
- Yonsei University (KR)
- Seoul National University (KR)
- Konkuk University (KR)
- Hallym University (KR)
- LG Chem (South Korea) (KR)
- Corresponding author
- Kim, Ho-Seong
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2019-05-16
- Volume
- 14
- Issue
- 5
- Pages
- e0216927
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6522217
- OpenAlex
- W2946348977
- Cited by
- 49
- References
- 32
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 6 · 2023: 3 · 2022: 12 · 2021: 11 · 2020: 1 · 2019: 2
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- Chonbuk National University
- Chonnam National University
- Chosun University
- Chungbuk National University
- Chungnam National University
- Kangwon National University
- Keimyung University
- Konyang University
- Kyungpook National University
- Soonchunhyang University
- Ewha Womans University
- Hallym University
- Sungkyunkwan University
- Catholic University of Korea
- Catholic Kwandong University
- CHA University
- LG Chem
- Samsung
- Seoul St. Mary's Hospital, Catholic University of Korea
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- recombinant human growth hormone, growth hormone therapy, growth hormone deficiency, idiopathic short stature, Turner syndrome, small for gestational age, chronic kidney disease, long-term safety, adverse events, neoplasms, impaired glucose tolerance, hypothyroidism, height standard deviation score, height velocity, Korean children
- MeSH terms
- Adolescent, Blood Glucose, Body Height, Child, Child, Preschool, Female, Follow-Up Studies, Growth Disorders, Glycated Hemoglobin, Humans, Infant, Small for Gestational Age, Insulin-Like Growth Factor I, Kidney Failure, Chronic, Male, Neoplasms, Recombinant Proteins, Registries, Thyrotropin, Thyroxine, Turner Syndrome, Insulin-Like Growth Factor Binding Protein 3, Human Growth Hormone, Young Adult, Republic of Korea, Patient Safety
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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