Estrogen effects in allergy and asthma
Open accessAbstract
PURPOSE OF REVIEW: Asthma prevalence and severity are greater in women than in men, and mounting evidence suggests this is in part related to female steroid sex hormones. Of these, estrogen has been the subject of much study. This review highlights recent research exploring the effects of estrogen in allergic disease. RECENT FINDINGS: Estrogen receptors are found on numerous immunoregulatory cells and estrogen's actions skew immune responses toward allergy. It may act directly to create deleterious effects in asthma, or indirectly via modulation of various pathways including secretory leukoprotease inhibitor, transient receptor potential vanilloid type 1 ion channel and nitric oxide production to exert effects on lung mechanics and inflammation. Not only do endogenous estrogens appear to play a role, but environmental estrogens have also been implicated. Environmental estrogens (xenoestrogens) including bisphenol A and phthalates enhance allergic sensitization in animal models and may enhance development of atopic disorders like asthma in humans. SUMMARY: Estrogen's role in allergic disease remains complex. As allergic diseases continue to increase in prevalence and affect women disproportionately, gaining a fuller understanding of its effects in these disorders will be essential. Of particular importance may be effects of xenoestrogens on allergic disease.
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Sex hormones have crucial effects on mast cell behavior in physiological and several pathological situations.
“Strong data in the last years reinforced the idea that sex hormones have crucial effects on MCs behavior, not only in physiological conditions, but also in several pathological situations [15–18].”
From Gender-Related Effects of Sex Steroids on Histamine Release and Fc<i>ε</i>RI Expression in Rat Peritoneal Mast Cells (2015) · cites this paper as [15]
The section “Estrogens promote the degranulation of mast cell/basophils” reports that estradiol induces mast-cell mediator release and that mast-cell numbers vary with the estrous stage in rats. The Conclusion links estrogen-driven mast-cell degranulation to allergic disease. This supports effects in physiological and allergic contexts, but not the broader claim about sex hormones generally or several pathological situations. (LLM, conf=0.84)
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- Authors
- Bonds, R. S., & Midoro-Horiuti, T.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- Corresponding author
- Bonds, Rana S.
- Venue
- Current Opinion in Allergy & Clinical Immunology
- Published
- 2013-02
- Volume
- 13
- Issue
- 1
- Pages
- 92-99
- ISSN
- 1473-6322 (ISSN-L)
- 1528-4050
- PMC
- PMC3537328
- OpenAlex
- W1998158718
- Cited by
- 208
- References
- 59
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 12 · 2023: 15 · 2022: 18 · 2021: 17 · 2020: 18 · 2019: 17 · 2018: 18 · 2017: 18 · 2016: 12 · 2015: 16 · 2014: 13 · 2013: 10
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Current Opinion in Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000071)
- National Institute of Environmental Health Sciences (R21ES016428, P30ES006676, ES016428)
- National Center for Research Resources (UL1RR029876)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- estrogen, asthma, allergy, sex hormones, estrogen receptor, immune regulation, secretory leukocyte protease inhibitor, TRPV1, nitric oxide, lung mechanics, lung inflammation, xenoestrogens, bisphenol A, phthalates, allergen sensitization, atopic diseases, sex differences
- MeSH terms
- Antigen-Presenting Cells, Asthma, Environmental Pollutants, Estrogens, Humans, Hypersensitivity, Mast Cells, Receptors, Estrogen, Cell Polarity, Immunoglobulin Class Switching, Th2 Cells
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