The DOI matches its Crossref record; 58 of the 59 references it cites were found in a registry or an index.
Estrogen effects in allergy and asthma
Open accessAbstract
PURPOSE OF REVIEW: Asthma prevalence and severity are greater in women than in men, and mounting evidence suggests this is in part related to female steroid sex hormones. Of these, estrogen has been the subject of much study. This review highlights recent research exploring the effects of estrogen in allergic disease. RECENT FINDINGS: Estrogen receptors are found on numerous immunoregulatory cells and estrogen's actions skew immune responses toward allergy. It may act directly to create deleterious effects in asthma, or indirectly via modulation of various pathways including secretory leukoprotease inhibitor, transient receptor potential vanilloid type 1 ion channel and nitric oxide production to exert effects on lung mechanics and inflammation. Not only do endogenous estrogens appear to play a role, but environmental estrogens have also been implicated. Environmental estrogens (xenoestrogens) including bisphenol A and phthalates enhance allergic sensitization in animal models and may enhance development of atopic disorders like asthma in humans. SUMMARY: Estrogen's role in allergic disease remains complex. As allergic diseases continue to increase in prevalence and affect women disproportionately, gaining a fuller understanding of its effects in these disorders will be essential. Of particular importance may be effects of xenoestrogens on allergic disease.
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“Strong data in the last years reinforced the idea that sex hormones have crucial effects on MCs behavior, not only in physiological conditions, but also in several pathological situations [15–18].”
From Gender-Related Effects of Sex Steroids on Histamine Release and Fc ε RI Expression in Rat Peritoneal Mast Cells (2015) · cites this paper as [15]
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Cites
Asthma prevalence, health care use, and mortality: United States, 2005-2009.
Akinbami, L. J., Moorman, J. E., & Liu, X. (2011) · PubMed · Cited by 951
Parent bisphenol A accumulation in the human maternal-fetal-placental unit.
Schönfelder, G., Wittfoht, W., Hopp, H., Talsness, C. E., Paul, M., & Chahoud, I. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.021100703 · Cited by 668
Impact of gender on asthma in childhood and adolescence: a GA 2 LEN review
Almqvist, C., Worm, M., Leynaert, B., & for the working group of GALEN WP 2.5 ‘Gender’ (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01524.x · Cited by 563
Seillet, C., Laffont, S., Trémollières, F., Rouquié, N., Ribot, C. A., Arnal, J., Douin‐Echinard, V., Gourdy, P., & Guéry, J. (2011) · Blood · doi:10.1182/blood-2011-08-371831 · Cited by 346
Leynaert, B., Sunyer, J., García‐Esteban, R., Svanes, C., Jarvis, D., Cerveri, I., Dratva, J., Gíslason, Þ., Heinrich, J., Janson, C., et al. (2012) · Thorax · doi:10.1136/thoraxjnl-2011-201249 · Cited by 268
Estradiol activates mast cells via a non-genomic estrogen receptor-α and calcium influx
Zaitsu, M., Narita, S.-I., Lambert, K. C., Grady, J. J., Estes, D. M., Curran, E. M., Brooks, E. G., Watson, C. S., Goldblum, R. M., & Midoro-Horiuti, T. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2006.09.030 · Cited by 262 · cited 3×
“ce partial release ts release induced [13,27] About 40% of women have perimenstrual worsening of their asthma symptoms”
BackgroundSelf-citationYoshimura, S., Bondeson, J., Foxwell, B. M. J., Brennan, F. M., & Feldmann, M. (2001) · International Immunology · doi:10.1093/intimm/13.5.675 · Cited by 241
Vink, N. M., Postma, D. S., Schouten, J. P., Rosmalen, J. G. M., & Boezen, H. M. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.06.018 · Cited by 228
Hsu, N., Lee, C., Wang, J., Li, Y.-C., Chang, H.-W., Chen, C., Bornehag, C., Wu, P., Sundell, J., & Su, H.-J. J. (2011) · Indoor Air · doi:10.1111/j.1600-0668.2011.00753.x · Cited by 207
The role of female hormones on lung function in chronic lung diseases
Tam, A., Morrish, D., Wadsworth, S. J., Dorscheid, D. R., Man, S. P., & Sin, D. D. (2011) · BMC Women s Health · doi:10.1186/1472-6874-11-24 · Cited by 205
Estrogen receptor profiles in human peripheral blood lymphocytes
Pierdominici, M., Maselli, A., Colasanti, T., Giammarioli, A. M., Delunardo, F., Vacirca, D., Sanchez, M., Giovannetti, A., Malorni, W., & Ortona, E. (2010) · Immunology Letters · doi:10.1016/j.imlet.2010.06.003 · Cited by 188
Narita, S.-I., Goldblum, R. M., Watson, C. S., Brooks, E. G., Estes, D. M., Curran, E. M., & Midoro-Horiuti, T. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9378 · Cited by 186
Self-citationBeneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis
Blasko, E., Haskell, C. A., Leung, S., Gualtieri, G., Halks‐Miller, M., Mahmoudi, M., Dennis, M. K., Prossnitz, E. R., Karpus, W. J., & Horuk, R. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.06.023 · Cited by 183
The Cough Hypersensitivity Syndrome: A Novel Paradigm for Understanding Cough
Morice, A. H. (2009) · Lung · doi:10.1007/s00408-009-9185-z · Cited by 162
Maternal Bisphenol A Exposure Promotes the Development of Experimental Asthma in Mouse Pups
Midoro‐Horiuti, T., Tiwari, R., Watson, C. S., & Goldblum, R. M. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0901259 · Cited by 159
Self-citationEndogenous and exogenous sex steroid hormones and asthma and wheeze in young women
Salam, M. T., Wenten, M., & Gilliland, F. D. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.02.004 · Cited by 154
Prenatal Exposure to Bisphenol A and Child Wheeze from Birth to 3 Years of Age
Spanier, A. J., Kahn, R. S., Kunselman, A. R., Hornung, R., Xu, Y. Y., Calafat, A. M., & Lanphear, B. P. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104175 · Cited by 151
Bisphenol A and children's health
Braun, J. M., & Hauser, R. B. (2011) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e3283445675 · Cited by 146
Lambert, K. C., Curran, E. M., Judy, B. M., Milligan, G. N., Lubahn, D. B., & Estes, D. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.9.5716 · Cited by 142
Kovats, S. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.04.011 · Cited by 138
Giannoni, É., Guignard, L., Reymond, M. K., Perreau, M., Roth‐Kleiner, M., Calandra, T., & Roger, T. (2011) · Infection and Immunity · doi:10.1128/iai.00076-11 · Cited by 135
Early Age at Menarche, Lung Function, and Adult Asthma
Macsali, F., Real, F. G., Plana, E., Sunyer, J., Antó, J. M., Dratva, J., Janson, C., Jarvis, D., Omenaas, E. R., Zemp, E., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200912-1886oc · Cited by 130
Country of Birth as a Risk Factor for Asthma among Mexican Americans
Holguín, F., Mannino, D. M., Antó, J. M., Mott, J. A., Ford, E. S., Teague, W. G., Redd, S. C., & Romieu, I. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200402-143oc · Cited by 128
Effects of the Menstrual Cycle on Lung Function Variables in Women with Asthma
Farha, S., Asosingh, K., Laskowski, D. M., Hammel, J., Dweik, R. A., Wiedemann, H. P., & ERZURUM, S. C. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200904-0497oc · Cited by 124
Gender-specific presentations for asthma, allergic rhinitis and eczema in primary care
Osman, M., Hansell, A., Simpson, C. R., Hollowell, J., & Helms, P. J. B. (2007) · Primary Care Respiratory Journal · doi:10.3132/pcrj.2007.00006 · Cited by 123
Nakajima, Y., Goldblum, R. M., & Midoro‐Horiuti, T. (2012) · Environmental Health · doi:10.1186/1476-069x-11-8 · Cited by 116
Self-citationSex hormone-dependent regulation of cilia beat frequency in airway epithelium.
Jain, R., Ray, J., Pan, J.-H., & Brody, S. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0107oc · Cited by 109
Endogenous and exogenous sex steroid hormones and asthma and wheeze in young women
Willsie, S. K. (2007) · Yearbook of Pulmonary Disease · doi:10.1016/s8756-3452(08)70312-8 · Cited by 104
Prevalence and risk factors of atopic diseases in German children and adolescents
Schmitz, R., Atzpodien, K., & Schlaud, M. (2012) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2012.01342.x · Cited by 102
Yu, X., Ma, H., Barman, S. A., Liu, A. T., Sellers, M., Stallone, J. N., Prossnitz, E. R., White, R. E., & Han, G. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00037.2011 · Cited by 102
The Effects of Maternal Exposure to Bisphenol A on Allergic Lung Inflammation into Adulthood
Bauer, S. M., Roy, A., Emo, J. A., Chapman, T. J., Georas, S. N., & Lawrence, B. P. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs227 · Cited by 102
Rapid effects of estrogen on intracellular Ca2+ regulation in human airway smooth muscle
Townsend, E. A., Thompson, M. A., Pabelick, C. M., & Prakash, Y. S. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00287.2009 · Cited by 101
Guo, J., Han, B., Qin, L., Li, B. J., You, H., Yang, J., Liu, D., Wei, C., Nånberg, E., Bornehag, C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039008 · Cited by 91
Infant exposure to dioxin-like compounds in breast milk.
Lorber, M., & Phillips, L. J. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.021100325 · Cited by 89
Cai, Y., Zhou, J., & Webb, D. C. (2012) · International Archives of Allergy and Immunology · doi:10.1159/000331437 · Cited by 82
Lee, S. Y., Kwon, J., Seo, J., Song, Y. H., Kim, B., Yu, J., Park, K. S., Kim, H., Kim, E.-K., Lee, J. S., et al. (2012) · International Archives of Allergy and Immunology · doi:10.1159/000330820 · Cited by 61
Estrogen Increases Nitric-Oxide Production in Human Bronchial Epithelium
Townsend, E., Meuchel, L. W., Thompson, M. A., Pabelick, C. M., & Prakash, Y. S. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.184416 · Cited by 59
Gender-Specific Asthma Treatment
Choi, I. S. (2011) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2011.3.2.74 · Cited by 56
Guo, H., Liu, T., Uemura, Y., Jiao, S., Wang, D., Lin, Z., Narita, Y., Suzuki, M., Hirosawa, N., Ichihara, Y., et al. (2010) · Cellular and Molecular Immunology · doi:10.1038/cmi.2010.14 · Cited by 56
Dratva, J., Schindler, C., Curjuric, I., Stolz, D., Macsali, F., Real, F. G., & Zemp, E. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.12.938 · Cited by 54
Vaidya, S. V., & Kulkarni, H. R. (2012) · Journal of Asthma · doi:10.3109/02770903.2012.721041 · Cited by 54
Suzuki, T., Shimizu, T., Yu, H.-P., Hsieh, Y.-C., Choudhry, M. A., Schwacha, M. G., & Chaudry, I. H. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00964.2006 · Cited by 48
Uemura, Y., Liu, T., Narita, Y., Suzuki, M., & Matsushita, S. (2008) · Human Immunology · doi:10.1016/j.humimm.2008.01.017 · Cited by 47
Cough Hypersensitivity Syndrome Is an Important Clinical Concept: A Pro/Con Debate
Morice, A. H., McGarvey, L. P., & Dicpinigaitis, P. V. (2011) · Lung · doi:10.1007/s00408-011-9351-y · Cited by 41
Du, S., Sandoval, F., Trinh, P., Umeda, E. A., & Voskuhl, R. R. (2010) · European Journal of Immunology · doi:10.1002/eji.201040796 · Cited by 36
Effect of Oestradiol on Mast Cell Number and Histamine Level in the Mammary Glands of Rat
Jing, H., Wang, Z., & Chen, Y. (2011) · Anatomia Histologia Embryologia · doi:10.1111/j.1439-0264.2011.01120.x · Cited by 34
Douin‐Echinard, V., Calippe, B., Billon-Galés, A., Fontaine, C., Lenfant, F., Trémollières, F., Bayard, F., Guéry, J., Arnal, J., & Gourdy, P. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0210073 · Cited by 33
Clinical characteristics of women with menstrual-linked asthma
Thornton, J. S., Lewis, J. F., Lebrun, C. M., & Licskai, C. J. (2012) · Respiratory Medicine · doi:10.1016/j.rmed.2012.05.003 · Cited by 31
SLPI and inflammatory lung disease in females
McKiernan, P. J., McElvaney, N. G., & Greene, C. M. (2011) · Biochemical Society Transactions · doi:10.1042/bst0391421 · Cited by 30
Estrogen Receptor β: Expression Profile and Possible Anti-Inflammatory Role in Disease
Catley, M. C., Birrell, M. A., Hardaker, E. L., Alba, J. D., Farrow, S. N., Haj‐Yahia, S., & Belvisi, M. G. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.136275 · Cited by 28
Doucet, D. R., Bonitz, R. P., Feinman, R., Colorado, I., Ramanathan, M., Feketeova, E., Condon, M. R., Machiedo, G. W., Hauser, C. J., Xu, D.-Z., et al. (2010) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3181bbbddb · Cited by 24
The Soy Isoflavone Equol Enhances Antigen-Specific IgE Production in Ovalbumin-Immunized BALB/c Mice
Sakai, T., FUROKU, S., Nakamoto, M., Shuto, E., Hosaka, T., Nishioka, Y., & Sone, S. (2010) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.56.72 · Cited by 23
Patberg, K. W. (2011) · Lung · doi:10.1007/s00408-011-9295-2 · Cited by 21
Role of tachykinins in airway responses to ozone in rats
Takebayashi, T., Abraham, J., Murthy, G. G. K., Lilly, C. M., Rodger, I. W., & Shore, S. A. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.2.442 · Cited by 20
Sabry, E. Y. (2010) · Allergologia et Immunopathologia · doi:10.1016/j.aller.2010.02.011 · Cited by 13
Dratva, J. (2010) · BMJ Evidence-Based Medicine · doi:10.1136/ebm1135 · Cited by 11
Mancuso, C. A., Peterson, M. G. E., Gaeta, T. J., Fernández, J., Birkhahn, R., Matozo, T. M., & On behalf of the QUALITX Study Investigators (2012) · Journal of Asthma · doi:10.3109/02770903.2012.661011 · Cited by 8
Wegienka, G., Hasiec, E., Boushey, H. A., Johnson, C. C., Strickler, R. C., Zoratti, E. M., & Havstad, S. L. (2012) · BMC Research Notes · doi:10.1186/1756-0500-5-261 · Cited by 8
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Metadata
- Authors
- Bonds, R. S., & Midoro-Horiuti, T.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- Corresponding author
- Bonds, Rana S.
- Venue
- Current Opinion in Allergy & Clinical Immunology
- Published
- 2013-02
- Volume
- 13
- Issue
- 1
- Pages
- 92-99
- ISSN
- 1473-6322 (ISSN-L)
- 1528-4050
- PMC
- PMC3537328
- OpenAlex
- W1998158718
- Cited by
- 208
- References
- 59
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 12 · 2023: 15 · 2022: 18 · 2021: 17 · 2020: 18 · 2019: 17 · 2018: 18 · 2017: 18 · 2016: 12 · 2015: 16 · 2014: 13 · 2013: 10
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Current Opinion in Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000071)
- National Institute of Environmental Health Sciences (R21ES016428, P30ES006676, ES016428)
- National Center for Research Resources (UL1RR029876)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- estrogen, asthma, allergy, sex hormones, estrogen receptor, immune regulation, secretory leukocyte protease inhibitor, TRPV1, nitric oxide, lung mechanics, lung inflammation, xenoestrogens, bisphenol A, phthalates, allergen sensitization, atopic diseases, sex differences
- MeSH terms
- Antigen-Presenting Cells, Asthma, Environmental Pollutants, Estrogens, Humans, Hypersensitivity, Mast Cells, Receptors, Estrogen, Cell Polarity, Immunoglobulin Class Switching, Th2 Cells
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