Association of Comorbid Generalized Anxiety Disorder and Alcohol Use Disorder Symptoms with Health-Related Quality of Life: Results From the National Epidemiological Survey on Alcohol and Related Conditions
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BACKGROUND: Although prior studies have documented the co-occurrence of generalized anxiety disorder (GAD) and alcohol use disorder (AUD) disorder, there is a paucity of research assessing the patterns of alcohol involvement among individuals with GAD symptoms. This study investigated subtypes, or classes, of comorbid AUD and GAD symptoms, and assessed the association of class membership with health-related quality of life. METHODS: Using data from the Wave 1 of the National Epidemiologic Survey on Alcohol and Related Conditions, a latent class analysis was performed on the subset of individuals who were current drinkers and had reported ever experiencing a 6-month episode of feeling tense, nervous, or worried most of the time. We examined the association of these latent classes with physical and mental health-related quality of life measured by the Short Form-12, version 2. RESULTS: Latent class analysis identified a 5-class model of AUD and GAD symptoms. A significant graded relationship was observed between the ordered classes and severity of impairment on the mental health scale of the Short Form-12, version 2, but no significant relationship was found with the physical health scale. CONCLUSIONS: Mental, but not physical, health-related quality of life in this population is associated with both the number and pattern of comorbid GAD and AUD symptoms.
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Individuals with anxiety who regularly use or abuse substances report lower quality of life than those who do not use substances.
“prior research has shown that individuals with anxiety who regularly use or abuse substances (e.g., alcohol and/or drugs) report lower QOL than those who do not use substances [44, 45].”
From Correlates of Quality of Life in Anxiety Disorders: Review of Recent Research (2021) · cites this paper as [44]
The Results (Mental and Physical Health Functioning Outcomes; page unavailable) associate more severe combined anxiety and alcohol symptoms with poorer mental-health quality of life. But the study included only current drinkers, and its reference class had fewer anxiety as well as fewer alcohol symptoms. It does not establish the claimed comparison with people who do not use substances, or address drug use. (LLM, conf=0.84)
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WARE, J. E., KOSINSKI, M., & KELLER, S. D. (1996) · Medical Care · doi:10.1097/00005650-199603000-00003 · Cited by 17,392 · see citing works
Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.617 · Cited by 12,052 · see citing works
Nylund, K. L., Asparouhov, T., & Muthén, B. O. (2007) · Structural Equation Modeling: A Multidisciplinary Journal · doi:10.1080/10705510701575396 · Cited by 11,415 · see citing works
Hasin, D. S., Stinson, F. S., Ogburn, E., & Grant, B. F. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.7.830 · Cited by 2,908 · see citing works
Grant, B. F., Stinson, F. S., Dawson, D. A., Chou, S. P., Dufour, M. C., Compton, W., Pickering, R. P., & Kaplan, K. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.807 · Cited by 2,889 · see citing works
Kessler, R. C., Nelson, C. B., McGonagle, K. A., Edlund, M. J., Frank, R. G., & Leaf, P. J. (1996) · American Journal of Orthopsychiatry · doi:10.1037/h0080151 · Cited by 1,378 · cited 2× · see citing works
“6% for those with GAD and alcohol dependence (Kessler et al., 1996).”
BackgroundInfluentialGrant, B. F., Dawson, D. A., Stinson, F. S., Chou, P. S., Kay, W., & Pickering, R. (2003) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(03)00070-x · Cited by 1,110 · see citing works
Bruce, S. E., Yonkers, K. A., Otto, M. W., Eisen, J. L., Weisberg, R. B., Pagano, M., Shea, M. T., & Keller, M. B. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.6.1179 · Cited by 963 · see citing works
Conway, K. P., Compton, W., Stinson, F. S., & Grant, B. F. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0211 · Cited by 934 · cited 2× · see citing works
“Furthermore, the link between these 2 disorders has been well established (Grant et al., 2004; Kessler et al., 2005; Conway et al., 2006), and prior analyses of population-based samples such as the National Co-morbidity Survey have found annual comorbid prevalence estimates of 11.”
BackgroundInfluentialGeneralized anxiety disorder: prevalence, burden, and cost to society
Wittchen, H.-U. (2002) · Depression and Anxiety · doi:10.1002/da.10065 · Cited by 733 · see citing works
Goetzel, R. Z., Hawkins, K., Ozminkowski, R. J., & Wang, S. S. (2003) · Journal of Occupational and Environmental Medicine · doi:10.1097/00043764-200301000-00007 · Cited by 694 · see citing works
Grant, B., Hasin, D., Stinson, F., Dawson, D., Ruan, W., Goldstein, R., Smith, S. M., Saha, T., & Huang, B.-J. (2005) · Psychological Medicine · doi:10.1017/s0033291705006069 · Cited by 437 · see citing works
The epidemiology of generalized anxiety disorder
Kessler, R. C., Keller, M. B., & Wittchen, H.-U. (2001) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70204-5 · Cited by 337 · see citing works
Phenomenology and Course of Generalised Anxiety Disorder
Yonkers, K. A., Warshaw, M. G., Massion, A. O., & Keller, M. B. (1996) · British Journal of Psychiatry · doi:10.1192/bjp.168.3.308 · Cited by 242 · cited 1× · see citing works
“Yet, it should be kept in mind that it is common for GAD symptoms to be chronic (Yonkers et al., 1996; Bruce et al., 2005), and in this sample, a large proportion of those with lifetime GAD symptoms also had current symptoms.”
BackgroundComer, J. S., Blanco, C., Hasin, D. S., Liu, S.-M., Grant, B. F., Turner, J. B., & Olfson, M. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05094blu · Cited by 214 · see citing works
Smith, J. P., & Book, S. W. (2009) · Addictive Behaviors · doi:10.1016/j.addbeh.2009.07.002 · Cited by 114 · see citing works
Flair, L. N. L., Bradshaw, C. P., Storr, C. L., Green, K. M., Alvanzo, A. A. H., & Crum, R. M. (2012) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2012.73.351 · Cited by 94 · see citing works
Self-citationMagidson, J. F., Liu, S.-M., Lejuez, C. W., & Blanco, C. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.02.011 · Cited by 62 · see citing works
Jones, G. N., Ames, S. C., Jeffries, S. K., Scarinci, I. C., & Brantley, P. J. (2001) · The International Journal of Psychiatry in Medicine · doi:10.2190/2x44-cr14-yhjc-9eq3 · Cited by 52 · see citing works
Bobes, J., Caballero, L., Vilardaga, I., & Rejas, J. (2011) · Annals of General Psychiatry · doi:10.1186/1744-859x-10-7 · Cited by 12 · see citing works
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Research works printed but not linked: 1
- McCutcheon AL Latent Class Analysis Quantitative Applications in the Social Sciences Newbury Park, CA Sage Publications 1987
Cited by
Sorted by citations
Network analysis of substance abuse and dependence symptoms
Rhemtulla, M., Fried, E. I., Aggen, S. H., Tuerlinckx, F., Kendler, K. S., & Borsboom, D. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.02.005 · Cited by 219 · see citing works
Correlates of Quality of Life in Anxiety Disorders: Review of Recent Research
Wilmer, M. T., Anderson, K., & Reynolds, M. (2021) · Current Psychiatry Reports · doi:10.1007/s11920-021-01290-4 · Cited by 150 · see citing works
Subtypes of alcohol use disorder in the general population: A latent class analysis
Müller, M., Ajdacic‐Gross, V., Vetrella, A. B., Preisig, M., Castelao, E., Lasserre, A. M., Rodgers, S., Wulf Rössler, A., Vetter, S., Seifritz, E., et al. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.112712 · Cited by 20 · see citing works
Logan, R. W., Wynne, O., Maglakelidze, G., Zhang, C., O’Connell, S., Boyadjieva, N. I., & Sarkar, D. K. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12611 · Cited by 18 · see citing works
Keen‐Rhinehart, E., Nentwig, T. B., Wilson, D. E., Leonard, K. T., Chaney, B. N., & Grisel, J. E. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00567 · Cited by 10 · see citing works
Bimstein, J. G., O’Bryan, E. M., Jean, A., & McLeish, A. C. (2023) · Substance Use & Misuse · doi:10.1080/10826084.2023.2215318 · Cited by 5 · see citing works
Pacek, L. R., Reboussin, B. A., Green, K. M., Flair, L. L., Storr, C. L., Alvanzo, A. A. H., Mojtabai, R., Cullen, B., Young, A. S., Tormohen, K., et al. (2019) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.1789 · Cited by 5 · see citing works
Self-citation
- Authors
- Cullen, B. A., La Flair, L. N., Storr, C. L., Green, K. M., Alvanzo, A. A. H., Mojtabai, R., Pacek, L. R., & Crum, R. M.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Cullen, Bernadette A.
- ORCID
- Venue
- Journal of Addiction Medicine
- Published
- 2013-11
- Volume
- 7
- Issue
- 6
- Pages
- 394-400
- ISSN
- 1932-0620 (ISSN-L)
- PMC
- PMC3839307
- OpenAlex
- W2331007542
- Cited by
- 7
- References
- 20
- Citations by year
- 2023: 1 · 2021: 1 · 2019: 2 · 2018: 1 · 2016: 1 · 2015: 1
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Addiction Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA016346, AA016346, K23AA020316)
- National Institute on Drug Abuse (DA030460, R01DA030460)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- generalized anxiety disorder, alcoholism, comorbidities, health-related quality of life, mental health, physical health, latent class analysis, current drinkers, anxiety symptoms, impairment severity
- MeSH terms
- Adult, Alcoholism, Anxiety Disorders, Behavioral Symptoms, Female, Health Surveys, Humans, Male, Mental Health, Middle Aged, Psychiatric Status Rating Scales, Quality of Life, Statistics as Topic, United States, Comorbidity, Diagnostic and Statistical Manual of Mental Disorders, Health Status Disparities
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