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Cited by 214Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Treatment and AccessHealth Systems, Economic Evaluations, Quality of Life

Health-Related Quality of Life Across the Anxiety Disorders: Results From the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)

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Comer, Jonathan S., Blanco, Carlos, Hasin, Deborah S., Liu, Shang-Min, Grant, Bridget F., Turner, J. Blake, Olfson, Mark·2011·The Journal of Clinical Psychiatry
DOI 10.4088/jcp.09m05094bluPMC PMC3000882
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Abstract

OBJECTIVE: Although clinical studies have documented that specific anxiety disorders are associated with impaired psychosocial functioning, little is known regarding their comparative effects on health-related quality of life within a general population. The current analysis compares health-related quality of life in a US community-dwelling sample of adults with DSM-IV social anxiety disorder, generalized anxiety disorders (GAD), panic disorder, and specific phobia. METHOD: A face-to-face survey of a US nationally representative sample of over 43,000 adults aged 18 years and older residing in households and group quarters was conducted. Prevalence of DSM-IV anxiety disorders and relative associations with health-related quality of life indicators were examined. The survey was conducted from 2001 to 2002. RESULTS: Roughly 9.8% of respondents met diagnostic criteria for at least 1 of 4 twelve-month DSM-IV anxiety disorders which, relative to the non-anxiety-disordered general population, were each associated with lower personal income, increased rates of 12-month physical conditions, and greater numbers of Axis I and Axis II DSM-IV psychiatric conditions. After adjusting for sociodemographic and clinical correlates, including other anxiety disorders, GAD was associated with significant decrements in the SF-12 mental component summary score. In similar models, GAD and, to a lesser extent, panic disorder were significantly associated with impairment in social functioning, role emotional, and mental health SF subscales. CONCLUSIONS: GAD, followed by panic disorder, appears to exact significant and independent tolls on health-related quality of life. Results underscore the importance of prompt and accurate clinical identification and improving access to effective interventions for these disorders.

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Crossref · 10.4088/jcp.09m05094blu

Cites

77 of 77 references verified0 citation errors · 0 not checkable

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  • Anxiety disorders are associated with high socioeconomic costs and often a chronic, debilitating course for the affected person.

    “Anxiety disorders are associated with high socioeconomic costs and often a chronic, debilitating course for the affected person [5–7].”

    From Results of a randomized controlled superiority trial of the effect of modified collaborative assessment vs. standard assessment on patients’ readiness for psychotherapy (CO-ASSM-RCT) (2024) · cites this paper as [5]

    The introductory passage under Abstract > Conclusion reports high health care costs and lost worker productivity, and the Conclusions describe substantial impairment in functioning and well-being. The paper does not establish that anxiety disorders often follow a chronic course; its analysis concerns 12-month diagnoses rather than their course over time. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Patients with anxiety disorders have a higher prevalence of hypertension and other cardiovascular conditions, gastrointestinal disease, arthritis, thyroid disease, respiratory disease, migraine headaches, and allergic conditions compared to those without anxiety disorders.

    “Patients with anxiety disorders have a higher prevalence of hypertension and other cardiovascular conditions, gastrointestinal disease, arthritis, thyroid disease, respiratory disease, migraine headaches, and allergic conditions compared to those without anxiety disorders [16,52].”

    From Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders (2014) · cites this paper as [16]

    The Results (Clinical correlates; page not available in our copy) report higher proportions of respondents with each studied anxiety disorder reporting hypertension, angina, tachycardia, stomach ulcer, gastritis, and arthritis than respondents without anxiety disorders. This supports the cardiovascular, gastrointestinal, and arthritis portions of the claim, but the passage does not report higher prevalence of thyroid or respiratory disease, migraine headaches, or allergic conditions. (LLM, conf=0.89)

    Experimental — accuracy not yet measured

  • Medical conditions frequently reported in patients with anxiety and related disorders include cardiovascular disease, gastrointestinal disease, arthritis, respiratory disease, thyroid disease, migraine, and allergic conditions.

    “Medical conditions frequently reported in patients with anxiety and related disorders include cardiovascular disease, gastrointestinal disease, arthritis, respiratory disease, thyroid disease, migraine, and allergic conditions [16,52].”

    From Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders (2014) · cites this paper as [16]

    The Results (Clinical correlates; page unavailable) report higher proportions of respondents with anxiety disorders diagnosed with cardiovascular conditions, stomach ulcer or gastritis, and arthritis. The Methods (Measures; page unavailable) list the conditions surveyed but do not include respiratory or thyroid disease, migraine, or allergic conditions, so this source does not support those parts of the list. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • Medical conditions are reported in over 60% of patients with anxiety and related disorders.

    “Medical conditions are reported in over 60% of patients with anxiety and related disorders including cardiovascular diseases, gastrointestinal diseases, arthritis, respiratory diseases such as asthma, thyroid disease, migraine headaches, back pain, and allergic conditions [16,52,1430-1432].”

    From Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders (2014) · cites this paper as [16]

    The Results (Clinical correlates; page unavailable) report higher proportions of several self-reported medical conditions among adults with anxiety disorders, including hypertension, stomach ulcer, gastritis, and arthritis. The paper does not report that over 60% had medical conditions, and its listed conditions do not include several examples in the citing sentence, such as asthma, thyroid disease, and migraine. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Comorbidities are particularly common among patients with GAD, panic disorder, and PTSD.

    “Comorbidities are particularly common among patients with GAD, panic disorder, and PTSD [16,140,515, 517,1390,1433].”

    From Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders (2014) · cites this paper as [16]

    The Conclusions report particularly high medical comorbidity among people with GAD and panic disorder. The Results also report more psychiatric diagnoses among respondents with the anxiety disorders studied. PTSD was not among those disorders, so this paper does not support the PTSD portion of the claim. (LLM, conf=0.88)

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Cites

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Research works printed but not linked: 4

  1. [3]Kessler RC Greenberg PE Davis K The economic burden of anxiety and stress disorders Neuropsychopharmacology: The fifth generation of progress 2002 The American College of Neuropsychopharmacology and Lippincott Williams & Wilkins Baltimore, MD
  2. [21]Ware JE Kosinski M Keller SK How to Score the SF-12 Physical and Mental Health Summary Scales 1995 The Health Institute, New England Medical Center Boston, MA Second edition
  3. [22]Turner-Bowker DM Bartley PJ Ware JE SF-36 Health Survey & SF Bibliography: Third Edition (1988–2000) 2002 QualityMetric Inc Lincoln, RI
  4. [54]Manocchia M Bayliss MS Connor J Keller SD Shiely J-C Tasai C SF-36 Health Survey Annotated Bibliography: Second Edition (1988–1996) 1998 The Health Assessment Lab Boston, MA

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Authors
Comer, J. S., Blanco, C., Hasin, D. S., Liu, S.-M., Grant, B. F., Turner, J. B., & Olfson, M.
Affiliations
  • New York State Psychiatric Institute (US)
  • National Institute on Alcohol Abuse and Alcoholism (US)
Corresponding author
Olfson, Mark
ORCID
Venue
The Journal of Clinical Psychiatry
Publisher
Physicians Postgraduate Press, Inc
Published
2010-08-24
Volume
72
Issue
01
Pages
43-50
ISSN
0160-6689 (ISSN-L)
DOI
10.4088/jcp.09m05094blu
PMC
PMC3000882
OpenAlex
W2011237439
Cited by
214
References
77
Citations by year
2026: 10 · 2025: 11 · 2024: 17 · 2023: 14 · 2022: 17 · 2021: 21 · 2020: 10 · 2019: 17 · 2018: 16 · 2017: 15 · 2016: 12 · 2015: 13 · 2014: 18 · 2013: 15 · 2012: 3
FWCI
9.57
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • American Foundation for Suicide Prevention
  • Eli Lilly and Company
  • Pfizer
  • AstraZeneca
  • GlaxoSmithKline
  • National Institutes of Health (Z99‐AA999999)
  • Agency for Healthcare Research and Quality (U18HS016097)
  • National Institute on Alcohol Abuse and Alcoholism (Z01AA000449, AA-014223, K05AA014223)
  • National Institute of Mental Health (T32MH016434, MH076051, R01MH076051)
  • National Institute on Drug Abuse (R01DA020783, DA019606, DA020783, DA023200, R01DA019606, K02DA023200)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Keywords
health-related quality of life, anxiety disorders, generalized anxiety disorder, panic disorder, social anxiety disorder, specific phobia, social functioning, mental health, physical health, psychiatric comorbidity, income, community-dwelling adults
MeSH terms
Adolescent, Adult, Alcoholism, Anxiety Disorders, Data Collection, Female, Health Status, Health Surveys, Humans, Male, Psychiatric Status Rating Scales, Quality of Life, Surveys and Questionnaires, United States, Prevalence, Diagnostic and Statistical Manual of Mental Disorders

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