Cited by 236Cannabis and Cannabinoid ResearchPain Management and Opioid UseMusculoskeletal pain and rehabilitation

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The Effect of Medicinal Cannabis on Pain and Quality-of-Life Outcomes in Chronic Pain: A Prospective Open-label Study

Haroutounian, Simon, Ratz, Yael, Ginosar, Yehuda, Furmanov, Karina, Saifi, Fayez, Meidan, Ronit, Davidson, Elyad·2016·The Clinical Journal of Pain

DOI 10.1097/ajp.0000000000000364

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Abstract

Objectives: The objective of this prospective, open-label study was to determine the long-term effect of medicinal cannabis treatment on pain and functional outcomes in participants with treatment-resistant chronic pain. Patients and Methods: The primary outcome was the change in the pain symptom score on the S-TOPS (Treatment Outcomes in Pain Survey—Short Form) questionnaire at the 6-month follow-up in an intent-to-treat population. Secondary outcomes included the change in S-TOPS physical, social, and emotional disability scales, the pain severity, and pain interference on the Brief Pain Inventory, sleep problems, and the change in opioid consumption. Results: A total of 274 participants were approved for treatment; complete baseline data were available for 206 (intent-to-treat), and complete follow-up data for 176 participants. At follow-up, the pain symptom score improved from median 83.3 (95% confidence interval [CI], 79.2-87.5) to 75.0 (95% CI, 70.8-79.2) ( P <0.001). The pain severity score (7.50 [95% CI, 6.75-7.75] to 6.25 [95% CI, 5.75-6.75]) and the pain interference score (8.14 [95% CI, 7.28-8.43] to 6.71 [95% CI, 6.14-7.14]) improved (both P <0.001), together with most social and emotional disability scores. Opioid consumption at follow-up decreased by 44% ( P <0.001). Serious adverse effects led to treatment discontinuation in 2 participants. Discussion: The treatment of chronic pain with medicinal cannabis in this open-label, prospective cohort resulted in improved pain and functional outcomes, and a significant reduction in opioid use. Results suggest long-term benefit of cannabis treatment in this group of patients, but the study’s noncontrolled nature should be considered when extrapolating the results.

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Authors: Haroutounian, S., Ratz, Y., Ginosar, Y., Furmanov, K., Saifi, F., Meidan, R., & Davidson, E.
Affiliations: Washington University in St. Louis (US)
Pain Relief Unit
Hadassah Medical Center (IL)
Hebrew University of Jerusalem (IL)
Corresponding author: Haroutounian, Simon
Ratz, Yael
Saifi, Fayez
Meidan, Ronit
Davidson, Elyad
ORCID: Haroutounian, Simon
Ginosar, Yehuda
Venue: The Clinical Journal of Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2016-12
Volume: 32
Issue: 12
Pages: 1036-1043
ISSN: 0749-8047 (ISSN-L)
DOI: 10.1097/ajp.0000000000000364
OpenAlex: W2281864230
Cited by: 234
References: 69
Citations by year: 2026: 6 · 2025: 16 · 2024: 21 · 2023: 20 · 2022: 29 · 2021: 34 · 2020: 36 · 2019: 22 · 2018: 29 · 2017: 19 · 2016: 2
FWCI: 19.40
Type: journal article
Language: en
Open access: closed
Locations: Clinical Journal of Pain (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Keywords: medical cannabis, chronic pain, treatment-resistant pain, quality of life, disability, pain intensity, pain interference, opioid consumption, sleep disorders, long-term outcomes, adverse effects
MeSH terms: Analgesics, Disability Evaluation, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Pain Measurement, Prospective Studies, Surveys and Questionnaires, Sleep, Treatment Outcome, Chronic Pain, Pain Management, Medical Marijuana

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The Effect of Medicinal Cannabis on Pain and Quality-of-Life Outcomes in Chronic Pain: A Prospective Open-label Study

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