Cited by 313Blood transfusion and managementCraniofacial Disorders and TreatmentsHemostasis and retained surgical items

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Efficacy of Tranexamic Acid in Pediatric Craniosynostosis Surgery: A Double-blind, Placebo-controlled Trial

Goobie, Susan M., Meier, Petra M., Pereira, Luis M., McGowan, Francis X., Prescilla, Randy P., Scharp, Laurie A., Rogers, Gary F., Proctor, Mark R., Meara, John G., Soriano, Sulpicio G., Zurakowski, David, Sethna, Navil F.·2011·Anesthesiology

DOI 10.1097/aln.0b013e318210fd8f

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Abstract

BACKGROUND: Extensive blood loss is common in pediatric craniosynostosis reconstruction surgery. Tranexamic acid (TXA) is increasingly used to reduce perioperative blood loss in various settings, but data on its efficacy are limited in children. The purpose of this randomized, double-blind, placebo-controlled, parallel trial was to evaluate the efficacy of TXA in pediatric craniosynostosis correction surgery. The primary and secondary outcome variables were reduction in perioperative blood loss and reduction in blood transfusion, respectively. METHODS: Forty-three children, ages 2 months to 6 yr, received either placebo or TXA in a loading dose of 50 mg·kg(-1), followed by an infusion of 5 mg·kg·h(-1) during surgery. TXA plasma concentrations were measured. RESULTS: The TXA group had significantly lower perioperative mean blood loss (65 vs. 119 ml·kg(-1), P < 0.001) and lower perioperative mean blood transfusion (33 vs. 56 ml· kg(-1), P = 0.006) compared to the placebo group. The mean difference between the TXA and placebo groups for total blood loss was 54 ml·kg(-1) (95% CI for the difference, 23-84 ml·kg(-1)) and for packed erythrocytes transfused was 23 ml·kg(-1) (95% CI for the difference, 7-39 ml·kg(-1)). TXA administration also significantly diminished (by two thirds) the perioperative exposure of patients to transfused blood (median, 1 unit vs. 3 units; P < 0.001). TXA plasma concentrations were maintained above the in vitro thresholds reported for inhibition of fibrinolysis (10 μg·ml(-1)) and plasmin-induced platelet activation (16 μg·ml(-1)) throughout the infusion. CONCLUSIONS: TXA is effective in reducing perioperative blood loss and transfusion requirement in children undergoing craniosynostosis reconstruction surgery.

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On the Kolmogorov-Smirnov Test for Normality with Mean and Variance Unknown
Lilliefors, H. W. (1967) · Journal of the American Statistical Association · doi:10.2307/2283970 · Cited by 4,530
Tranexamic Acid
Dunn, C. J., & Goa, K. L. (1999) · Drugs · doi:10.2165/00003495-199957060-00017 · Cited by 1,020
Practice Guidelines for blood component therapy: A report by the American Society of Anesthesiologists Task Force on Blood Component Therapy.
Stehling, L. C., Doherty, D. C., Faust, R. J., Greenburg, A. G., Harrison, C. R., Landers, D. F., Laros, R. K., Pierce, E. C., Prust, R. S., Rosenberg, A. D., et al. (1996) · PubMed · Cited by 894
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Wong, J., Abrishami, A., Beheiry, H. E., Mahomed, N. N., Davey, J. R., Gandhi, R. A., Syed, K., Hasan, S. M. O., Silva, Y. D., & Chung, F. F. (2010) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.i.01518 · Cited by 491
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Murkin, J. M., Falter, F., Granton, J. T., Young, G. B., Burt, C. C., & Chu, M. W. A. (2010) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181c92b23 · Cited by 369
Tranexamic Acid Reduces Intraoperative Blood Loss in Pediatric Patients Undergoing Scoliosis Surgery
Sethna, N. F., Zurakowski, D., Brustowicz, R. M., Bacsik, J., Sullivan, L. J., & Shapiro, F. (2005) · Anesthesiology · doi:10.1097/00000542-200504000-00006 · Cited by 302
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ROLE OF UROKINASE AND TISSUE ACTIVATOR IN SUSTAINING BLEEDING AND THE MANAGEMENT THEREOF WITH EACA AND AMCA
Andersson, L. I., Nilsoon, I. M., COLLEEN, S., Granstrand, J. B., & Melander, B. (1968) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1968.tb20322.x · Cited by 247
Pharmacokinetics of Tranexamic Acid during Cardiopulmonary Bypass
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Evaluation and Management of Nonsyndromic Craniosynostosis
Marbate, T., Kedia, S., & Gupta, D. K. (2022) · Journal of Pediatric Neurosciences · doi:10.4103/jpn.jpn_17_22 · Cited by 20
Whole Blood in Pediatric Craniofacial Reconstruction Surgery
Thottathil, P., Sesok‐Pizzini, D. A., Taylor, J. A., Fiadjoe, J. E., Vincent, A., & Stricker, P. A. (2017) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000003594 · Cited by 20
Minimizing transfusion in sagittal craniosynostosis surgery: the Children’s Hospital of Minnesota Protocol
Escher, P. J., Tu, A., Kearney, S. L., Wheelwright, M., Petronio, J. A., Kebriaei, M. A., Chinnadurai, S., & Tibesar, R. J. (2019) · Child s Nervous System · doi:10.1007/s00381-019-04157-5 · Cited by 20
Intraoperative blood loss during decompressive craniectomy for intractable intracranial hypertension after severe traumatic brain injury in children
Desgranges, F., Javouhey, É., Mottolèse, C., Migeon, A., Szathmári, A., Baudin, F., Queiroz, M. D., Cogniat, B., & CHASSARD, D. (2014) · Child s Nervous System · doi:10.1007/s00381-014-2417-4 · Cited by 19
Prophylactic versus reactive transfusion of thawed plasma in patients undergoing surgical repair of craniosynostosis: a randomized clinical trial
Pieters, B. J., Conley, L., Weiford, J., Hamilton, M. S., Wicklund, B. M., Booser, A., Striker, A., Whitney, S. L., & Singhal, V. K. (2014) · Pediatric Anesthesia · doi:10.1111/pan.12571 · Cited by 19
Reducing blood loss in pediatric craniosynostosis surgery by use of tranexamic acid
Eustache, G., & Riffaud, L. (2019) · Neurochirurgie · doi:10.1016/j.neuchi.2019.09.020 · Cited by 19
Use of Tranexamic Acid in Gender-Affirming Mastectomy Reduces Rates of Postoperative Hematoma and Seroma
Rifkin, W. J., Parker, A. C., & Bluebond‐Langner, R. (2023) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000010892 · Cited by 18
Tranexamic Acid Treatment Decreases Hidden Blood Loss in Total Knee Arthroplasty
Chen, X., Zhu, X., Yang, S., Lin, W., & Wang, L. (2015) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000000230 · Cited by 18
Pediatric Epilepsy Surgery
Koh, J. L., Egan, B., & McGraw, T. T. (2012) · Anesthesiology Clinics · doi:10.1016/j.anclin.2012.05.001 · Cited by 18
Eficácia de diferentes doses e esquemas de administração de ácido tranexâmico em cirurgias ortopédicas de grande porte: estudo randomizado
Ravi, S., Venkatraman, R., Karthik, K., & Pushparani, A. (2020) · Brazilian Journal of Anesthesiology · doi:10.1016/j.bjan.2020.03.013 · Cited by 17
Anesthesia for intracranial surgery in infants and children
McClain, C. D., & Soriano, S. G. (2014) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000112 · Cited by 17
Impact of multidisciplinary engagement in a quality improvement blood conservation protocol for craniosynostosis
Kurlander, D. E., Ascha, M., Marshall, D. C., Wang, D. D., Ascha, M. S., Tripi, P. A., Reeves, H. M., Downes, K. A., Ahuja, S. P., Rotta, A. T., et al. (2020) · Journal of Neurosurgery Pediatrics · doi:10.3171/2020.4.peds19633 · Cited by 17
Intra- and Postoperative Blood Loss and Transfusion Requirements in Children Undergoing Craniofacial Surgery
D’Amore, A. L., Rasmussen, M., Christensen, L., von Öettingen, G., Nørholt, S. E., Krogh, L., Hvas, A., Juul, N., & Eriksen, C. F. (2019) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000005492 · Cited by 16
Optimizing Blood Loss and Management in Craniosynostosis Surgery: A Systematic Review of Outcomes Over the Last 40 Years
Coombs, D. M., Knackstedt, R. W., & Patel, N. V. (2022) · The Cleft Palate-Craniofacial Journal · doi:10.1177/10556656221116007 · Cited by 16
Tranexamic Acid Dosing in Craniosynostosis Surgery: A Systematic Review with Meta-analysis
O’Donnell, D., Vazquez, S. M., Greisman, J. D., Uddin, A., Graifman, G., Dominguez, J. F., Zellner, E., & Muh, C. R. (2022) · Plastic & Reconstructive Surgery Global Open · doi:10.1097/gox.0000000000004526 · Cited by 16
Absence of Tachycardia During Hypotension in Children Undergoing Craniofacial Reconstruction Surgery
Stricker, P. A., Lin, E. E., Fiadjoe, J. E., Sussman, E. M., & Jobes, D. R. (2012) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318253708c · Cited by 16
ε‐Aminocaproic acid versus tranexamic acid in children undergoing complex cranial vault reconstruction for repair of craniosynostosis
Borst, A. J., Bonfield, C. M., Deenadayalan, P. S., Le, C., Xu, M., Sobey, J. H., & Reddy, S. K. (2021) · Pediatric Blood & Cancer · doi:10.1002/pbc.29093 · Cited by 16
Hematological profile and transfusion requirement during hysteroscopic myomectomy: A comparative study between oxytocin and tranexamic acid infusion
Mousa, S. A., Yassen, A. M., Alhadary, H. S., Sadek, E. F., & Abdel‐Hady, E. (2012) · Egyptian Journal of Anaesthesia · doi:10.1016/j.egja.2011.12.003 · Cited by 15
“This is in agreement with the previous findings that showed no significant changes, both in the preoperative as well as the post operative values of PT and PTT when tranexamic acid was used versus placebo in pediatric craniosynostosis surgery [27].”
Result
Tranexamic Acid in Infantile Craniosynostosis Surgery: Friend or Foe?
Danforth, R. M., Cook, J. A., Bennett, W. E., Tholpady, S. S., & Gerety, P. A. (2020) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000007245 · Cited by 15
Tranexamic acid administered during cesarean delivery in high-risk patients: maternal pharmacokinetics, pharmacodynamics, and coagulation status
Seifert, S. M., Lumbreras-Marquez, M. I., Goobie, S. M., Carusi, D. A., Fields, K. G., Bateman, B. T., & Farber, M. K. (2022) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2022.06.001 · Cited by 15
Tranexamic Acid Decreases Blood Transfusion Burden in Open Craniosynostosis Surgery Without Operative Compromise
Lu, V. M., Goyal, A., & Daniels, D. J. (2018) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000004875 · Cited by 15
The Road to Transfusion-free Craniosynostosis Repair in Children Less Than 24 Months Old: A Quality Improvement Initiative
Beethe, A. B., Spitznagel, R. A., Kugler, J. A., Goeller, J. K., Franzen, M. H., Hamlin, R. J., Lockhart, T. J., Lyden, E. R., Glogowski, K. R., & LeRiger, M. M. (2020) · Pediatric Quality and Safety · doi:10.1097/pq9.0000000000000331 · Cited by 14
A protocol of situation-dependent transfusion, erythropoietin and tranexamic acid reduces transfusion in fronto-orbital advancement for metopic and coronal craniosynostosis
Escher, P. J., Tu, A., Kearney, S. L., Linabery, A. M., Petronio, J. A., Kebriaei, M. A., Chinnadurai, S., & Tibesar, R. J. (2020) · Child s Nervous System · doi:10.1007/s00381-020-04654-y · Cited by 14
“Numerous pharmacologic and non-pharmacologic strategies for transfusion reduction have been investigated, including erythropoietin (EPO), tranexamic acid (TXA), acute normovolemic hemodilution (ANH) and others [12, 13, 26, 32].”
BackgroundMethodInfluential
Population pharmacokinetics of ε-aminocaproic acid in adolescents undergoing posterior spinal fusion surgery
Stricker, P. A., Gastonguay, M. R., Singh, D., Fiadjoe, J. E., Sussman, E. M., Pruitt, E. Y., Goebel, T. K., & Zuppa, A. F. (2015) · British Journal of Anaesthesia · doi:10.1093/bja/aeu459 · Cited by 14
Effect of Tranexamic Acid on the Reduction of Blood Loss in Craniosynostosis Surgery: A Systematic Review and Meta-analysis
Alabdulkarim, A., Qurashi, A. A. A., Odeh, N. B., Hashemi, A. S. A., Arbili, L., AlSwealh, M. S., Shakir, M. N., Banser, S. M., Sharaf, L. A., Alkhonizy, S. W., et al. (2023) · Plastic & Reconstructive Surgery Global Open · doi:10.1097/gox.0000000000005021 · Cited by 13
The role of tranexamic acid in prevention of hemorrhage in major spinal surgeries
Seddighi, A., Nikouei, A., Seddighi, A. S., Zali, A., Tabatabaei, S. M., Yourdkhani, F., Naimian, S., & Razavian, I. (2015) · Asian Journal of Neurosurgery · doi:10.4103/1793-5482.165791 · Cited by 13
“There are few studies about the role of antifibrinolytic therapy in spinal procedures,([17,18]) especially in our country.”
Background
Strategies for Blood Product Management, Reducing Transfusions, and Massive Blood Transfusion
Coté, C. J., Grabowski, E. F., & Stowell, C. P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-42974-0.00012-4 · Cited by 13
Current Practices in Tranexamic Acid Administration for Pediatric Trauma Patients in the United States
Cornelius, B., Cummings, E. D., Assercq, M., Rizzo, E., Gennuso, S. A., & Cornelius, A. P. (2021) · Journal of Trauma Nursing · doi:10.1097/jtn.0000000000000553 · Cited by 13
“A double-blinded study of craniosynostosis patients utilizing a 50-mg/kg bolus, followed by a 5 mg/kg/hr infusion, found 50% lower blood loss and lower transfusion requirements (Goobie et al., 2011).”
Method
Tranexamic Acid in Craniosynostosis Surgery: A Systematic Review and Meta-Analysis
Varidel, A., & Marucci, D. D. (2021) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000008123 · Cited by 13
Role of tranexamic acid in craniosynostosis surgery: Systematic review and meta-analysis
Zapata-Copete, J. A., Gómez‐Ospina, J. C., García‐Perdomo, H. A., & Caycedo, D. J. (2021) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2021.11.064 · Cited by 13
Intraoperative optimization to decrease postoperative PRBC transfusion in children undergoing craniofacial reconstruction
Nguyen, T. T., Lam, H. V., Phillips, M. L., Edwards, C., & Austin, T. M. (2014) · Pediatric Anesthesia · doi:10.1111/pan.12600 · Cited by 13
Tranexamic Acid in Pediatric Hemorrhagic Trauma
Borgman, M. A., & Nishijima, D. K. (2022) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000003775 · Cited by 12
Role of tranexamic acid (TXA) in plastic and reconstructive surgery: A national perspective
Rohrich, R. J., Brown, S., Brown, T., & Taub, P. J. (2024) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2024.09.085 · Cited by 12
Ulnar Artery Thrombosis Following Tranexamic Acid Administration for Craniosynostosis Repair
Chung, E., & Karlberg, H. (2018) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000004905 · Cited by 12
“Variable dosing regimens have been described in the literature with a median loading dose of 50 mg/kg and a median infusion rate of 5 mg/kg per hour in patients receiving cranial vault reconstructive surgery.(5) Thus, our patient received a dose well within the accepted range previously published for TXA.”
Background
Tranexamic Acid in Craniomaxillofacial Surgery: A Meta-Analysis and Systematic Review
Fu, R., Liu, C., Yan, Y., Suo, L., Xie, Y., Li, Q., & Huang, R. (2021) · Facial Plastic Surgery & Aesthetic Medicine · doi:10.1089/fpsam.2020.0590 · Cited by 12
Systemic Tranexamic Acid for Reduced Postoperative Blood Loss and Less Bleeding Complications in Fleur-de-lis Abdominoplasty and Apronectomy
Wachtel, C., Rothenberger, J. M., Ederer, I. A., Souquet, J., & Rieger, U. M. (2024) · Aesthetic Plastic Surgery · doi:10.1007/s00266-024-03992-5 · Cited by 11
The Use of Tranexamic Acid in Breast Reduction and Abdominoplasty: A Review of a Multicenter Federated Electronic Health Record Database
Habarth-Morales, T. E., Isch, E. L., Zavitsanos, A. P., Wride, W. M., Davis, H. D., Rios-Diaz, A. J., Broach, R. B., Fischer, J. P., Serletti, J. M., Azoury, S. C., et al. (2024) · Aesthetic Surgery Journal Open Forum · doi:10.1093/asjof/ojae077 · Cited by 11
Prophylactic fibrinogen concentrate administration in surgical correction of paediatric craniosynostosis
Machotta, A., Huisman, E. J., Appel, I. M., Luijnenburg, S. E., López‐Yurda, M., Cnossen, M. H., & van Ommen, C. H. (2020) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000001332 · Cited by 11
Tranexamic acid in plastic surgery: routes of administration and dosage considerations
AlGhanim, K., Al‐Youha, S., AlWazzan, A., & Alhamad, S. (2021) · European Journal of Plastic Surgery · doi:10.1007/s00238-021-01794-5 · Cited by 11
“Of these, nine were retrospective cohort studies [29–31, 34, 35, 38–40, 42], and six were randomized controlled clinical trials [32, 33, 36, 37, 41, 43].”
Background
Thromboelastometry during intraoperative transfusion of fresh frozen plasma in pediatric neurosurgery
Luostarinen, T., Silvasti-Lundell, M., Medeiros, T., Romani, R., Hernesniemi, J. A., & Niemi, T. (2012) · Journal of Anesthesia · doi:10.1007/s00540-012-1400-z · Cited by 11
Association of postoperative furosemide use with a reduced blood transfusion rate in sagittal craniosynostosis surgery
Harroud, A., Weil, A. G., Turgeon, J. P., Mercier, C., & Crevier, L. (2015) · Journal of Neurosurgery Pediatrics · doi:10.3171/2015.5.peds14666 · Cited by 11
Surgical decision making around paediatric preoperative anaemia in low-income and middle-income countries
Charuvila, S., Davidson, S. E., Thachil, J. V., & Lakhoo, K. (2019) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(19)30197-x · Cited by 11
Effect of Tranexamic Acid on Coagulation and Fibrin Clot Properties in Children Undergoing Craniofacial Surgery
Eriksen, C. F., Lindholm, A. D., Krogh, L., Hell, T., Berger, M., Hermann, M., Fries, D. R., Juul, N., Rasmussen, M., & Hvas, A. (2020) · Thrombosis and Haemostasis · doi:10.1055/s-0039-3402762 · Cited by 11
Efficacy and Safety of Antifibrinolytic Drugs in Pediatric Surgery: A Systematic Review
Hovgesen, N. T., Larsen, J. B., Eriksen, C. F., Hansen, A. K., & Hvas, A. (2021) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0040-1721736 · Cited by 11
Tranexamic Acid in Elective Craniosynostosis Surgery
Holcomb, J. B. (2011) · Anesthesiology · doi:10.1097/aln.0b013e3182110083 · Cited by 11
Reducing Blood Losses and Transfusion Requirements in Craniosynostosis Surgery
Vergnaud, E., Vecchione, A., Blanot, S., DiRocco, F., Arnaud, É., Rénier, D., & Meyer, P. G. (2012) · Anesthesiology · doi:10.1097/aln.0b013e3182449fc8 · Cited by 11
Intravenous Tranexamic Acid is Associated With a Clinically Significant Reduction in Blood Loss in Craniosynostosis Surgery
Varidel, A., Cooper, M., Loughran, J., Menezes, M. J., & Marucci, D. D. (2021) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000008234 · Cited by 10
“The protocol used at the study hospital was based on Goobie et al study.(12) The common protocol implemented was a preoperative bolus of 15 ml/kg and a continuous intraoperative infusion of 5 ml/kg.”
Method
Randomized, controlled trial of two tranexamic acid dosing protocols in adult spinal deformity surgery
Clohisy, J. C. F., Lenke, L. G., Dafrawy, M. H. E., Wolfe, R. C., Frazier, E. P., & Kelly, M. P. (2022) · Spine Deformity · doi:10.1007/s43390-022-00539-z · Cited by 10
Intravenous Application of Tranexamic Acid in Patients Undergoing Plastic Surgery: A Systematic Review and Meta-analysis with GRADE Quality Assessment
Wang, S., Yang, J., & Lin, L. (2023) · Aesthetic Plastic Surgery · doi:10.1007/s00266-023-03637-z · Cited by 10
Evaluation of anesthesia in endoscopic strip craniectomy: A review of 121 patients
Arts, S., Delye, H., van Lindert, E. J., Blok, L., Borstlap, W. A., & Driessen, J. J. (2018) · Pediatric Anesthesia · doi:10.1111/pan.13414 · Cited by 10
“For example, by combining the directly measured blood loss with a calculation based on a formula.(22,23)”
Method
Geographic Financial Analysis of Craniosynostosis Surgery in the United States
Kalmar, C. L., Zapatero, Z. D., Kosyk, M. S., Bartlett, S. P., & Taylor, J. A. (2022) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000008627 · Cited by 10
Pediatric Blood Management Protocol in Cranial Vault Surgery
Kelley, J. P., Boville, B. M., Sterken, D. J., Sanfilippo, D. J., Fahrenkopf, M. P., Kelpin, J. P., Polley, J. W., Mann, R. J., & Girotto, J. A. (2019) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000005563 · Cited by 10
“Tranexamic acid use has been supported in randomized controlled studies showing both decreased transfusion rates and decreased postoperative adverse events.(11,23) The institution of this PBM protocol increased the use of TXA from 0% to 84% (26/ 31 patients) 13% (4 patients) received aminocaproic acid rather than TXA…”
Method
Prophylactic administration of tranexamic acid combined with thromboelastography-guided hemostatic algorithm reduces allogeneic transfusion requirements during pediatric resective epilepsy surgery: A randomized controlled trial
Zhang, T., Feng, H., Xiao, W. L., Li, J., Liu, Q., Feng, X., Qi, D., Fan, X., Shan, Y., Yu, T., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.916017 · Cited by 9
“…that prophylactic TXA use can reduce blood loss and transfusion requirements in surgeries for pediatric scoliosis, cardiac, and craniosynostosis without apparent morbidity or mortality (Dadure et al., 2011; Goobie et al., 2011; Pasquali et al., 2012; McNicol et al., 2016; Goobie et al., 2018).”
Background
Economic Aspects and Organization
Görlinger, K., & Kozek‐Langenecker, S. A. (2014) · Springer eBooks · doi:10.1007/978-3-642-55004-1_24 · Cited by 9
Stereolithographic skull models in the surgical planning of fronto-supraorbital bar advancement for non-syndromic trigonocephaly
van Nunen, D. P. F., Janssen, L. E., Stubenitsky, B. M., Han, K. S., & Muradin, M. S. M. (2014) · Journal of Cranio-Maxillofacial Surgery · doi:10.1016/j.jcms.2014.01.017 · Cited by 9
“Given the inherent difficulty of accurately measuring perioperative blood loss in craniosynostosis surgery (Stricker et al., 2010; Goobie et al. 2011), a second estimate of the perioperative blood loss was calculated following the methodology of Kearney et al. (1989) (Table 1).”
Method
The management of blood loss in non-syndromic craniosynostosis patients undergoing barrel stave osteotomy
Küçük, A., Tümtürk, A., Gergin, I. S., Oral, Ş., Görkem, S. B., Kurtsoy, A., Madenoğlu, H., & Öktem, İ. S. (2015) · Turkish Neurosurgery · doi:10.5137/1019-5149.jtn.14751-15.2 · Cited by 9
South African Society of Anaesthesiologists Perioperative Patient Blood Management Guidelines 2020
Wise, R., Bishop, D. G., Gibbs, M., Govender, K., James, M. F., Kabambi, K. F., Louw, V. J., Mdladla, N., Moipalai, L., Chakane, P. M., et al. (2020) · Southern African Journal of Anaesthesia and Analgesia · doi:10.36303/sajaa.2020.26.6.s1 · Cited by 9
Achondroplasia and Multiple-Suture Craniosynostosis
Albino, F. P., Wood, B. C., Oluigbo, C. O., Lee, A. C., Oh, A. K., & Rogers, G. F. (2014) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000001267 · Cited by 9
“One significant challenge related to the treatment of our patient was the massive intraoperative blood loss; the blood loss occurred primarily during the craniotomy portions of the patient and was calculated at 280% of his total blood volume.(14,15) The formulas and values used for the calculation are as follows:”
Method
Care Standardization Reduces Blood Donor Exposures and Transfusion in Complex Cranial Vault Reconstruction
Muhly, W. T., Tan, J. M., Hsu, G., Sesok‐Pizzini, D. A., Fiadjoe, J. E., Taylor, J. A., Bartlett, S. P. P., & Stricker, P. A. (2018) · Hospital Pediatrics · doi:10.1542/hpeds.2018-0027 · Cited by 9
Blood transfusion trends by disease category in the United States, 2000 to 2014
Roberts, N. L. S., James, S. L., Delaney, M., & Fitzmaurice, C. (2020) · Transfusion and Apheresis Science · doi:10.1016/j.transci.2020.103012 · Cited by 8
“5 rates as observed in our study is possibly related to the multimodal approaches aimed to reduce the need for blood transfusions in the perioperative setting like the use of tranexamic acid, treatment of preoperative anemia, optimization of hydration, or minimally invasive surgical techniques [25,26].”
Background
The Effect of Tranexamic Acid and Controlled Hypotension on Perioperative Blood Loss in Craniosynostosis Surgery
Farsani, D. M., Mazaheri, Z., & Shafa, A. (2023) · Anesthesiology and Pain Medicine · doi:10.5812/aapm-130462 · Cited by 8
“In this regard, numerous studies were performed and are in progress, indicating successful outcomes of TXA for controlling blood loss during craniosynostosis surgery (1, 7, 34-36), which is consistent with our”
Background
Management of perioperative bleeding in children. Step by step review
Giraldo, M. Z. (2012) · Colombian Journal of Anesthesiology · doi:10.1016/j.rcae.2012.10.006 · Cited by 8
Reduction of transfusion requirements in pediatric craniosynostosis surgery by a new local hemostatic agent
Stehrer, R., Hunger, S., Schotten, K., Parsaei, B., Malek, M., Jacob, M., Geiselseder, G., & Meier, J. M. (2016) · Journal of Cranio-Maxillofacial Surgery · doi:10.1016/j.jcms.2016.06.028 · Cited by 8
“…group, the mean amount of perioperatively transfused PRBC was 54 ml/kg, which is comparable to findings in other studies (Stricker et al., 2010, Goobie et al., 2011, van Uitert et al., 2011, Oppenheimer et al., 2014), in contrast to a rate of 25 ml/kg in the SeraSeal® group resulting in a…”
BackgroundResult
An evaluation of the mixed pediatric unit for blood loss replacement in pediatric craniofacial surgery
Mogensen, S., Lübenow, N., Nilsson, P., Engquist, H., Knutsson, F., Enblad, P., Nowinski, D. J., & Frykholm, P. (2017) · Pediatric Anesthesia · doi:10.1111/pan.13140 · Cited by 8
Intraoperative Blood and Coagulation Factor Replacement During Neurosurgery
Zhou, J. J., Chen, T., & Nakaji, P. (2018) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2018.06.006 · Cited by 8
Comparison of different dosage regimes of epsilon aminocaproic acid on blood loss in children undergoing craniosynostosis surgery
Nguyen, T. T., Lam, H. V., Austin, T. M., Stricker, P. A., Tunceroglu, H., & Schoenecker, J. G. (2019) · Pediatric Anesthesia · doi:10.1111/pan.13671 · Cited by 8
Plastic and Reconstructive Surgery
Stricker, P. A., Fiadjoe, J. E., & Lerman, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-42974-0.00035-5 · Cited by 8
Effects of Tranexamic Acid on Bleeding in Pediatric Surgeries: A Systematic Review and Meta-Analysis
Wei, Y., Zhang, Y., Jin, T., Wang, H., Li, J., & Zhang, D. (2021) · Frontiers in Surgery · doi:10.3389/fsurg.2021.759937 · Cited by 7
Efficacy of different doses and timing of tranexamic acid in major orthopedic surgeries: a randomized trial
Ravi, S., Venkatraman, R., Karthik, K., & Pushparani, A. (2020) · Brazilian Journal of Anesthesiology (English Edition) · doi:10.1016/j.bjane.2020.06.008 · Cited by 7
“Idade (anos) 51,15 (15,4) 53,7 (16,72) 52,8 (15,9) 53,32 (19,99) 51 (15,4) 0,927a”
Transfusion support: Considerations in pediatric populations
McCormick, M. C., & Delaney, M. (2020) · Seminars in Hematology · doi:10.1053/j.seminhematol.2020.07.003 · Cited by 7
Anesthesia for Neurosurgery
Vavilala, M. S., Soriano, S. G., & Krane, E. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-34125-7.00028-0 · Cited by 7
Perioperative morbidity
Thiele, R. H., Huffmyer, J. L., & Raphael, J. (2012) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e3283552af9 · Cited by 7
Central Retinal Artery Occlusion Following Prone Transcranial Surgery for Craniosynostosis and Discussion of Risk Factors
Roumeliotis, G. A., Campbell, S., Das, S., Hildebrand, G. D., Issa, P. C., Jayamohan, J., Lawrence, T. P., Magdum, S. A., Wall, S. A., & Johnson, D. (2020) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000006512 · Cited by 7
“In 2 double-blind, placebo-controlled trials tranexamic acid use during calvarial remodeling procedures was found to significantly decrease intraoperative blood loss and transfusion rates and was not associated with thromboembolic events.(19,20) Similarly, retrospective cohort studies describing the adverse events ass…”
Background
Postoperative cerebral arterial thrombosis following cranial surgery in an infant
Sjoblom, M. D., Busso, V. O., Linscott, L. L., & Sadhasivam, S. (2013) · Pediatric Anesthesia · doi:10.1111/pan.12270 · Cited by 7
Efficacy and safety of sagittal synostosis surgery in older (> 12 months) patients: a systematic review and meta-analysis
Gutierrez-Pineda, F., Franklin, B. A., Punukollu, A., García, G. A. G., Duque, O. E. M., Renteria, H. A., Perez, J. F. P., & Gonzalez, I. A. (2024) · Child s Nervous System · doi:10.1007/s00381-024-06472-y · Cited by 6
“Our findings also revealed high transfusion rates during the perioperative period among the evaluated patients, consistent with existing literature that highlights the significant blood loss and transfusion requirements associated with [40, 41].”
Antifibrinolytics Are Not Associated With Reduced Blood Loss in Minimally-Invasive Endoscopic-Assisted Craniectomy for Repair of Single-Suture Craniosynostosis
Sobey, J. H., Menser, C. C., Hartzog, A. J., Hocking, K. M., Niconchuk, J. A., Bonfield, C. M., Stricker, P. A., & Reddy, S. K. (2021) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000008378 · Cited by 6
Epsilon Aminocaproic Acid’s Safety and Efficacy in Pediatric Surgeries Including Craniosynostosis Repair: A Review of the Literature
Bolufer, A., Iwai, T., Baughn, C., Clark, A. C., & Olavarria, G. (2022) · Cureus · doi:10.7759/cureus.25185 · Cited by 6
Temperance With Tranexamic Acid: Increased Risk of Venous Thromboembolism in Abdominoplasty
Mess, S. A., & Stephanos, K. (2024) · Aesthetic Surgery Journal Open Forum · doi:10.1093/asjof/ojae044 · Cited by 6
Treatment of bleeding upper aerodigestive tract tumor—A novel approach with antifibrinolytic agent
Low, T.-H. H., Huang, J., Reid, C., Elliott, M., & Clark, J. R. (2013) · The Laryngoscope · doi:10.1002/lary.24064 · Cited by 6
Open Craniosynostosis Surgery
Kurnik, N. M., Bristol, R. E., Maneri, C., Singhal, R., & Singh, D. (2017) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000003803 · Cited by 6
“Finally, even though TXA can reduce the amount of blood transfused in craniosynostosis operations, it does not eliminate the need for transfusion.(4,5) Because of the incomplete success of blood conservation strategies and the difficulty associated with autologous blood donation, many centers use techniques to minimiz…”
Background
Perioperative Management and Factors Associated With Transfusion in Cranial Vault Reconstruction
Hall, B. R., Barrientos, S., Flores, L. E., Cemaj, S., Kugler, J. A., & Miller, J. J. (2019) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000005666 · Cited by 6
“With regards to the efficacy of antifibrinolytic agents, our results are in accordance with 2 randomized clinical trials which were both published in 2011.(13,14) Dadure and colleagues reduced both the transfusion incidence (70% versus 37%) and volume (16.”
BackgroundResultInfluential
Management of perioperative bleeding in children. Step by step review☆
Giraldo, M. Z. (2013) · Colombian Journal of Anesthesiology · doi:10.1097/01819236-201341010-00009 · Cited by 6
An Audit of the Statistical Validity of Conclusions of Clinical Superiority in Anaesthesia Journals
Gibbs, N. M., & Weightman, W. M. (2014) · Anaesthesia and Intensive Care · doi:10.1177/0310057x1404200509 · Cited by 5
Clinical Practice Patterns in Nonsyndromic Craniosynostosis: A Review of Continuous Certification Tracer Data From the American Board of Plastic Surgery
Yuksel, S. S., Kearney, A. M., Taub, P. J., & Gosain, A. K. (2021) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000007592 · Cited by 5
Comparison of Perioperative Anesthetic Concerns in Simple and Complex Craniosynostosis Cases: A Retrospective Study
Menon, G., George, M., Kumar, P., Nair, S., Udayakumaran, S., Krishnadas, A., Subash, P., & Vasudevan, A. (2022) · Journal of Neuroanaesthesiology and Critical Care · doi:10.1055/s-0041-1740203 · Cited by 5
The Top 100 Most-Cited Publications in Clinical Craniofacial Research
Braud, S. C., Treger, D., Lizardi, J. J., Boghosian, T., ElAbd, R., Arakelians, A. R. L., Jabori, S. K., & Thaller, S. R. (2024) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000010185 · Cited by 5
“12,33 LIMITATIONS Bibliometric analysis is a powerful tool for analyzing the impact of research; however, there are shortcomings worth discussing.”
Method
Optimizing Perioperative Red Blood Cell Utilization and Wastage in Pediatric Craniofacial Surgery
Reddy, S. K., Volpi-Abadie, J., Gordish‐Dressman, H., Chao, J. W., Luban, N. L. C., & Deutsch, N. (2020) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000006523 · Cited by 5
“Goobie et al conducted a double-blind, placebo-controlled trial in 2011 to study the efficacy of tranexamic acid and found significantly lower total blood loss, RBC transfusion volume, and decreased blood donor exposures in patients who received tranexamic acid.(7) These findings have been corroborated by other author…”
Result
Blood Conservation and Transfusion Medicine
Nemergut, M. E., Haile, D. T., Mauermann, W. J., & Flick, R. P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-34125-7.00020-6 · Cited by 5
Antifibrinolytics as a Patient Blood Management Modality in Craniosynostosis Surgery: Current Concepts and a View to the Future
Varidel, A., Meara, J. G., Proctor, M. R., & Goobie, S. M. (2023) · Current anesthesiology reports · doi:10.1007/s40140-023-00567-z · Cited by 5
Unexpected higher blood loss associated with higher dose ϵ-aminocaproic acid in pediatric scoliosis surgery
Lam, H. V., Austin, T. M., Nguyen, T. T., Martus, J. E., & Schoenecker, J. G. (2018) · Journal of Pediatric Orthopaedics B · doi:10.1097/bpb.0000000000000545 · Cited by 5
Hemorrhage Control and Thrombosis Following Severe Injury
Zimrin, A. B., Bai, Y., Holcomb, J. B., & Hess, J. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-46202-0.00040-6 · Cited by 6
Clearing the Smoke: The Evidence behind Risk of Electrocautery Smoke and Mitigation Strategies
Tyle, M. R., Olafson, A., Hiro, M. E., & Payne, W. G. (2024) · Plastic & Reconstructive Surgery Global Open · doi:10.1097/gox.0000000000006039 · Cited by 4
Part II: Blood Transfusion and Donor Exposure in the Surgical Management of Trigonocephaly Patients: A Protocol From Alder Hey Craniofacial Unit
Rapaport, B. H. J., Burnside, G., Parks, C., Duncan, C. A., Richardson, D., Ellenbogen, J. R., Sinha, A., Craig, R., Diwan, R., & Hennedige, A. A. (2023) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000009878 · Cited by 4
“37,38 The theoretical risk of increased arterial and venous thrombosis have not been borne out in the evidence although it has been noted that previous studies may have been underpowered in this regard.”
Background
Tranexamic Acid: Safeguarding Children with Craniosynostosis from Bleeding. A Review Article
Firdaus, K. M., Andriyanto, L., Muhammad, A. J., & Bisri, T. (2024) · The Cleft Palate-Craniofacial Journal · doi:10.1177/10556656241239527 · Cited by 4
Tranexamic Acid is Associated With Reduced Blood Loss and Transfusion Requirement in Pediatric Midface Reconstruction
Manasyan, A., Roohani, I., Wolfe, E. M., Turk, M., Urata, M. M., & Hammoudeh, J. A. (2024) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2024.10.021 · Cited by 4
Manejo del sangrado perioperatorio en niños. Revisión paso a paso
Giraldo, M. Z. (2012) · Colombian Journal of Anesthesiology · doi:10.1016/j.rca.2012.07.011 · Cited by 4
Efficacy of Tranexamic Acid in Pediatric Craniosynostosis Surgery
Goobie, S. M., Meier, P. M., Pereira, L. M., McGowan, F. X. J., Prescilla, R. P., Scharp, L. A., Rogers, G. F., Proctor, M. R., Meara, J. G., Soriano, S. G., et al. (2011) · Survey of Anesthesiology · doi:10.1097/01.sa.0000407025.78528.81 · Cited by 4
Orthopedic and Spine Surgery
Wilton, N. C. T., & Anderson, B. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-42974-0.00032-x · Cited by 4
Use of Subcutaneous Injection of Epinephrine and Triamcinolone with Tranexamic Acid Reduces Blood Loss, Transfusion Rates, and Length of Stay in Open Sagittal Craniosynostosis Repair
Ackerman, L. L., Snider, A. A., & Ye, J. (2023) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000009443 · Cited by 4
Epsilon aminocaproic acid is associated with acute kidney injury after life‐threatening hemorrhage in children
Kolodziej, J. H., Leeper, C. M., Leonard, J. C., Josephson, C. D., Zenati, M. S., & Spinella, P. C. (2023) · Transfusion · doi:10.1111/trf.17373 · Cited by 4

Authors: Goobie, S. M., Meier, P. M., Pereira, L. M., McGowan, F. X., Prescilla, R. P., Scharp, L. A., Rogers, G. F., Proctor, M. R., Meara, J. G., Soriano, S. G., Zurakowski, D., & Sethna, N. F.
Affiliations: Boston Children's Hospital (US)
Instructor in Anesthesia.
Massachusetts College of Pharmacy and Health Sciences (US)
Professor of Anesthesia.
Research Technician, †† Professor.
Assistant Professor.
Associate Professor, Department of Plastic and Oral Surgery.
Assistant Professor of Anaesthesia (Director of Biostatistics).
Associate Professor of Anesthesia, Department of Anesthesia, Perioperative, and Pain Medicine.
ORCID: Goobie, Susan M.
Meier, Petra M.
Pereira, Luis M.
McGowan, Francis X.
Prescilla, Randy P.
Rogers, Gary F.
Proctor, Mark R.
Meara, John G.
Soriano, Sulpicio G.
Zurakowski, David
Sethna, Navil F.
Venue: Anesthesiology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2011-04-01
Volume: 114
Issue: 4
Pages: 862-871
ISSN: 0003-3022 (ISSN-L)
DOI: 10.1097/aln.0b013e318210fd8f
OpenAlex: W2016016217
Cited by: 313
References: 46
Citations by year: 2026: 10 · 2025: 13 · 2024: 21 · 2023: 16 · 2022: 22 · 2021: 25 · 2020: 20 · 2019: 26 · 2018: 20 · 2017: 17 · 2016: 19 · 2015: 30 · 2014: 28 · 2013: 17 · 2012: 21
FWCI: 15.44
Type: journal article
Language: en
Open access: closed
Locations: Anesthesiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Blood transfusion and management
Health Sciences › Medicine › Surgery › Craniofacial Disorders and Treatments
Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
Keywords: tranexamic acid, pediatric craniosynostosis, perioperative blood loss, blood transfusion, fibrinolysis inhibition, plasma drug concentration, children
MeSH terms: Antifibrinolytic Agents, Blood Transfusion, Child, Child, Preschool, Craniosynostoses, Double-Blind Method, Female, Humans, Infant, Intraoperative Care, Male, Tranexamic Acid, Blood Loss, Surgical, Treatment Outcome

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Efficacy of Tranexamic Acid in Pediatric Craniosynostosis Surgery: A Double-blind, Placebo-controlled Trial

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