The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Efficacy of Tranexamic Acid in Pediatric Craniosynostosis Surgery: A Double-blind, Placebo-controlled Trial
Abstract
BACKGROUND: Extensive blood loss is common in pediatric craniosynostosis reconstruction surgery. Tranexamic acid (TXA) is increasingly used to reduce perioperative blood loss in various settings, but data on its efficacy are limited in children. The purpose of this randomized, double-blind, placebo-controlled, parallel trial was to evaluate the efficacy of TXA in pediatric craniosynostosis correction surgery. The primary and secondary outcome variables were reduction in perioperative blood loss and reduction in blood transfusion, respectively. METHODS: Forty-three children, ages 2 months to 6 yr, received either placebo or TXA in a loading dose of 50 mg·kg(-1), followed by an infusion of 5 mg·kg·h(-1) during surgery. TXA plasma concentrations were measured. RESULTS: The TXA group had significantly lower perioperative mean blood loss (65 vs. 119 ml·kg(-1), P < 0.001) and lower perioperative mean blood transfusion (33 vs. 56 ml· kg(-1), P = 0.006) compared to the placebo group. The mean difference between the TXA and placebo groups for total blood loss was 54 ml·kg(-1) (95% CI for the difference, 23-84 ml·kg(-1)) and for packed erythrocytes transfused was 23 ml·kg(-1) (95% CI for the difference, 7-39 ml·kg(-1)). TXA administration also significantly diminished (by two thirds) the perioperative exposure of patients to transfused blood (median, 1 unit vs. 3 units; P < 0.001). TXA plasma concentrations were maintained above the in vitro thresholds reported for inhibition of fibrinolysis (10 μg·ml(-1)) and plasmin-induced platelet activation (16 μg·ml(-1)) throughout the infusion. CONCLUSIONS: TXA is effective in reducing perioperative blood loss and transfusion requirement in children undergoing craniosynostosis reconstruction surgery.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“They have the advantage of requiring fewer skin incisions and less blood loss and are therefore considered less invasive and more child-friendly [64,65,66,67,68,69,70].”
From Isolated Sagittal Craniosynostosis: A Comprehensive Review (2024) · cites this paper as [65]
Citations
Cites
On the Kolmogorov-Smirnov Test for Normality with Mean and Variance Unknown
Lilliefors, H. W. (1967) · Journal of the American Statistical Association · doi:10.2307/2283970 · Cited by 4,530
Dunn, C. J., & Goa, K. L. (1999) · Drugs · doi:10.2165/00003495-199957060-00017 · Cited by 1,020
Stehling, L. C., Doherty, D. C., Faust, R. J., Greenburg, A. G., Harrison, C. R., Landers, D. F., Laros, R. K., Pierce, E. C., Prust, R. S., Rosenberg, A. D., et al. (1996) · PubMed · Cited by 894
Topical Application of Tranexamic Acid Reduces Postoperative Blood Loss in Total Knee Arthroplasty
Wong, J., Abrishami, A., Beheiry, H. E., Mahomed, N. N., Davey, J. R., Gandhi, R. A., Syed, K., Hasan, S. M. O., Silva, Y. D., & Chung, F. F. (2010) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.i.01518 · Cited by 491
Murkin, J. M., Falter, F., Granton, J. T., Young, G. B., Burt, C. C., & Chu, M. W. A. (2010) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181c92b23 · Cited by 369
Tranexamic Acid Reduces Intraoperative Blood Loss in Pediatric Patients Undergoing Scoliosis Surgery
Sethna, N. F., Zurakowski, D., Brustowicz, R. M., Bacsik, J., Sullivan, L. J., & Shapiro, F. (2005) · Anesthesiology · doi:10.1097/00000542-200504000-00006 · Cited by 302
A Randomized Trial of Tranexamic Acid to Reduce Blood Transfusion for Scoliosis Surgery
Neilipovitz, D., Murto, K., Hall, L. W., Barrowman, N. J., & Splinter, W. M. (2001) · Anesthesia & Analgesia · doi:10.1097/00000539-200107000-00018 · Cited by 256
Andersson, L. I., Nilsoon, I. M., COLLEEN, S., Granstrand, J. B., & Melander, B. (1968) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1968.tb20322.x · Cited by 247
Pharmacokinetics of Tranexamic Acid during Cardiopulmonary Bypass
Dowd, N. P., Karski, J. M., Cheng, D., Carroll, J. A., Lin, Y. A., James, R. L., & Butterworth, J. F. I. (2002) · Anesthesiology · doi:10.1097/00000542-200208000-00016 · Cited by 225
Henry, D. A., Carless, P. A., Fergusson, D. A., & Laupacis, A. (2008) · Canadian Medical Association Journal · doi:10.1503/cmaj.081109 · Cited by 183
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 313
Haemostatic effect of aprotinin during craniosynostotic surgery in children
GUNNARSSON, I., HLYNSSON, B. Ö., Rósmundsson, Þ., & Thorsteinsson, A. (2011) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2011.02490.x · Cited by 4
Craniofacial and Maxillofacial Surgery
Holzman, R. S. (2021) · Springer eBooks · doi:10.1007/978-3-030-60656-5_17 · Cited by 4
Perioperative Management to Minimize Blood Transfusion in Craniosynostosis Surgery
Kimoto, Y., Harada, A., Doi, Y., Kadono, Y., Maeno, K., Kyutoku, S., Ueda, K., & Kishima, H. (2025) · World Neurosurgery · doi:10.1016/j.wneu.2025.124713 · Cited by 3
Anestesia para craneosinostosis
Cárdenas, V. H. G., Martínez, M. V. V., Rueda, M. E. R., Guevara, N. S., Madrid, J. R. P., & Baquero, P. E. (2014) · Colombian Journal of Anesthesiology · doi:10.1016/j.rca.2014.02.003 · Cited by 3
Zhao, M., Luo, Y., Guo, Z., Mu, L., & Lu, J. (2023) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000009724 · Cited by 3
“Four 21,22,26,28 of the included studies provided speci fi c volume data for transfusion blood products during surgery.”
BackgroundMethodInfluentialRed blood cell transfusion threshold guidelines in pediatric neurosurgery
Azam, F., Neerukonda, S. V., Smith, P. D., Anand, S., Mittal, S., Bah, M. G., Barrie, U., Detchou, D. K. E. D., Aoun, S. G., & Braga, B. P. (2024) · Neurosurgical Review · doi:10.1007/s10143-024-02785-3 · Cited by 3
Anaesthesia in craniosynostosis
Cárdenas, V. H. G., Martínez, M. V. V., Rueda, M. E. R., Guevara, N. S., Madrid, J. R. P., & Baquero, P. E. (2014) · Colombian Journal of Anesthesiology · doi:10.1016/j.rcae.2014.02.007 · Cited by 3
Anesthesia Management in Craniosynostosis Surgery: A Retrospective, Single-center Experience
Karnik, P. P., Dave, N. M., & Sayed, M. (2021) · Journal of Research & Innovation in Anesthesia · doi:10.5005/jp-journals-10049-0107 · Cited by 3
Thakkar, K. D., Moorthy, R. K., Yadav, B., George, S., & Singh, G. (2022) · Child s Nervous System · doi:10.1007/s00381-022-05758-3 · Cited by 3
Patient sex and outcomes in children with life‐threatening hemorrhage
Kolodziej, J. H., Spinella, P. C., Brown, J. B., Lu, L., Josephson, C. D., Leonard, J. C., & Leeper, C. M. (2024) · Transfusion · doi:10.1111/trf.17805 · Cited by 4
Advances in pediatric neuroanesthesia practices
Benzon, H. A., Butler, C. G., & Soriano, S. G. (2024) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2024.04.005 · Cited by 3
Wachtel, C., Rothenberger, J. M., Nichlos, E., Ederer, I. A., Küenzlen, L., Souquet, J., & Rieger, U. M. (2025) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2025.02.055 · Cited by 3
Schertz, K., Smith, M. T., Karam, O., Demetres, M. R., Faraoni, D., Duron, V., Wu, Y. S., & Nellis, M. E. (2025) · Pediatric Anesthesia · doi:10.1111/pan.15137 · Cited by 3
“…[58] RCT Adenotonsillectomy Gianesello [59] RCT Spinal fusion Goldstein [60] RC Fronto-orbital advancement or cranial vault reconstruction Goobie [61] RCT Cranial vault reconstruction Goobie [62] RCT Spinal fusion Goobie [63] RCT Cranial vault reconstruction Goobie [64] RCT Spinal fusion Grant…”
Hochhold, C., Luckner, G., Strohmenger, U., Scholl‐Bürgi, S., & Paal, P. (2014) · Pediatric Anesthesia · doi:10.1111/pan.12344 · Cited by 3
King, I. C. C., Mellington, A. J., Hazari, A., & Jones, M. E. (2019) · European Journal of Plastic Surgery · doi:10.1007/s00238-019-01527-9 · Cited by 3
Diagnosis and Surgical Options for Craniosynostosis
Jha, R. T., Magge, S. N., & Keating, R. F. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-43140-8.00009-3 · Cited by 3
Anesthesia for Pediatric Plastic Surgery
Cladis, F. P., Grunwaldt, L. J., & Losee, J. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-34125-7.00032-2 · Cited by 3
Tranexamic Acid in Reconstructive Microsurgery: A Systematic Review and Meta-Analysis
Rothchild, E., Smith, I. T., & Ricci, J. A. (2025) · Journal of Reconstructive Microsurgery · doi:10.1055/a-2632-2621 · Cited by 2
Padilla, C., Farid, M., Smith, P. D., Darko, K., O’Leary, S. T., Levy, B. R., Barrie, U., Khan, H. A., Aoun, S. G., & Harter, D. H. (2025) · Neurosurgery · doi:10.1227/neu.0000000000003798 · Cited by 2
Rodriguez, G. C., Bajaj, A., Rai, P., Gamble, M. A., George, E., Qureshi, U., Hallman, T. G., & Gosain, A. K. (2025) · Plastic & Reconstructive Surgery Global Open · doi:10.1097/gox.0000000000007226 · Cited by 2
Kicker, J. S., Willson, D. F., Kelly, R., Jane, J. A., Roberts, S. E., & Conaway, M. R. (2014) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000000384 · Cited by 2
Updates in pediatric emergency medicine for 2021
Easter, J. S., & Petruzella, F. D. (2022) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2022.02.019 · Cited by 2
Zarour, S., Constantini, S., Roth, J., Friedman, S., Kirgner, I., Cohen, B., & Ekstein, M. P. (2023) · European Journal of Pediatrics · doi:10.1007/s00431-023-04805-8 · Cited by 2
Anesthetic Management of Pediatric Craniofacial Surgery and Methods of Reducing Blood Loss
Biricik, E., & Güneş, Y. (2014) · DergiPark (Istanbul University) · doi:10.17827/aktd.24404 · Cited by 2
Impact of hypothermia during craniosynostosis repair surgery
Cárdenas, V. H. G., Vanegas-Martínez, M. V., Rueda, M. E. R., Burbano-Paredes, C. C., & Pulido-Barbosa, N. T. (2016) · Colombian Journal of Anesthesiology · doi:10.1016/j.rcae.2016.04.007 · Cited by 2
[Prophylactic use of tranexamic acid in noncardiac surgery : Update 2017].
Waskowski, J., Schefold, J. C., & Stüber, F. (2019) · doi:10.7892/boris.122596 · Cited by 2
Nelson, O. K., Wu, L., Swanson, J. W., Hsu, G., Lambert, M. P., Obstfeld, A., Thottathil, P., Wohler, B. L., Stricker, P. A., Allan F. Simpao, M., et al. (2021) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000008106 · Cited by 2
(2012) · British Journal of Anaesthesia · doi:10.1093/bja/aer488 · Cited by 2
Abdelaziz, T. S. A., Elsayed, H. M., Salem, M. M., & Mahmoud, N. (2024) · Egyptian Journal of Anaesthesia · doi:10.1080/11101849.2024.2313414 · Cited by 2
“…to active plasmin, the proteolytic enzyme responsible for fibrin break-down, formation of FDP and D-dimer; So, TXA can decrease tissue oozing, intra-and postoperative bleeding after different surgeries as orthopedic, cardiac, obstetric surgeries [6–10], either in elective or emer-gencies [11,12].”
Hemorrhage Control and Thrombosis Following Severe Injury
Zimrin, A. B., Bai, Y., Holcomb, J. B., & Hess, J. R. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-2296-9.00045-2 · Cited by 2
Prophylaktische Anwendung von Tranexamsäure in der nichtkardialen Chirurgie
Waskowski, J., Schefold, J. C., & Stueber, F. (2018) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-018-0402-5 · Cited by 2
Arnold, P. D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-42974-0.00020-3 · Cited by 2
Goobie, S. M., & Faraoni, D. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316652947.005 · Cited by 2
Jin, S., Liu, Y., Zhu, S., Li, S., Chen, Z., & Zang, M. (2025) · Burns · doi:10.1016/j.burns.2025.107549 · Cited by 1
Patient Blood Management in Pediatric Patients: Current Strategies and Future Perspectives
Acar, S. O., & Tüfekçi, Ö. (2025) · Turkish Journal of Hematology · doi:10.4274/tjh.galenos.2025.2025.0301 · Cited by 1
“In a randomized, double-blind, placebo-controlled trial, TXA was shown to significantly reduce transfusion requirements in pediatric patients undergoing craniosynostosis surgery [48].”
Flaherty, E., Adegboye, O., & Miranda, B. H. (2026) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000012471 · Cited by 1
Koueik, J., Garland, C. B., Merhi, A. A., Larson, S. C., Henry, J., Cho, D. Y., Ahmed, R., & Iskandar, B. J. (2026) · Child s Nervous System · doi:10.1007/s00381-026-07227-7 · Cited by 1
“…strategies have been used to reduce blood loss associated with these procedures, including electrocautery [1], ultrasonic bone-cutting devices [4, 5], preoperative administration of erythropoietin (EPO) and iron therapy [6], tranexamic acid (TXA) [7, 8], and the use of cell salvage systems [9].”
Sunaga, A., Sugawar, Y., Gomi, A., Kamochi, H., Morishita, Y., Sowa, Y., & Yoshimura, K. (2026) · Plastic & Reconstructive Surgery Global Open · doi:10.1097/gox.0000000000007772 · Cited by 1
“28 We recently introduced its use and found it effective.”
Endoscopic management of unilateral coronal synostosis: impact on the fronto-orbital growth
Proctor, M. R., Desai, D., & Meara, J. G. (2026) · Child s Nervous System · doi:10.1007/s00381-026-07397-4 · Cited by 1
“It is now also standard for us to administer Tranexamic Acid in these cases, as the complication profile is so safe in babies [13].”
Sparkle, T., & Cameron, S. D. (2016) · American Journal of Case Reports · doi:10.12659/ajcr.896820 · Cited by 1
Blood-Sparing Techniques and the Perioperative Management of Blood Losses
Tosi, F., Pusateri, A., Mensi, S., & Garra, R. (2019) · Springer eBooks · doi:10.1007/978-3-319-31512-6_70-1 · Cited by 1
Hemostatic Agents and Blood Components Used to Stop Bleeding
Moffett, B. S., & Carroll, R. S. (2021) · Springer eBooks · doi:10.1007/978-3-030-56338-7_42 · Cited by 1
Spring-assisted minimally invasive repair of sagittal craniosynostosis
Governale, L. S., & Ching, J. A. (2021) · Neurosurgical Focus Video · doi:10.3171/2021.1.focvid20103 · Cited by 1
Javouhey, É. (2013) · Springer eBooks · doi:10.1007/978-2-8178-0407-1_9 · Cited by 1
Efficacy of Tranexamic Acid in Pediatric Craniofacial and Orthognathic Surgery: A Meta-Analysis
Al-Shaqsi, S. Z., Senkaiahliyan, S., Forrest, C. R., Der, T., & Phillips, J. H. (2022) · FACE · doi:10.1177/27325016211069674 · Cited by 1
Measuring coagulopathy in pediatric craniofacial surgery
Borst, A. J., Bonfield, C. M., Deenadayalan, P. S., Le, C., Meng, X., Sobey, J. H., & Reddy, S. K. (2023) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0000000000001234 · Cited by 1
Pereira, L., Oliveira, J., dos Santos, P. E. R., Polónia, P., Vaz, R. M., & Pereira, J. (2024) · Arquivos Brasileiros de Neurocirurgia Brazilian Neurosurgery · doi:10.1055/s-0044-1786049 · Cited by 1
Ali, A., Basaran, B., Çabaklı, G. T., Aydöseli, A., Sabancı, P. A., Sencer, A., Telci, L., & Akıncı, İ. Ö. (2015) · Acta Neurochirurgica · doi:10.1007/s00701-015-2441-5 · Cited by 1
Hemostatic Agents Used to Stop Bleeding
Beaty, R. S. (2016) · Springer eBooks · doi:10.1007/978-3-319-30726-8_34 · Cited by 1
Lee, B., Bae, M. I., Eum, D., Ntungi, A. M., Jun, B., & Min, K. T. (2020) · Anesthesia and Pain Medicine · doi:10.17085/apm.20010 · Cited by 1
“Blood loss (ml) was calculated using the following formulas [9]:”
MethodDiagnosis and Surgical Options for Craniosynostosis
Seruya, M., Magge, S. N., & Keating, R. F. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0701-4.00008-7 · Cited by 1
The Red Code: Management of Bleeding During or After Cleft Palate Surgery
Alvarez, E. C., Alvarez, D., & Iñiguez, A. (2022) · Surgical Atlas of Cleft Palate and Palatal Fistulae · doi:10.1007/978-981-15-8124-3_52 · Cited by 1
Anesthesia for Craniofacial Surgery
Lin, E. E., & Stricker, P. A. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316652947.011 · Cited by 1
Perioperative Hemostasis in Pediatric Surgery
Haas, T. (2014) · Springer eBooks · doi:10.1007/978-3-642-55004-1_16 · Cited by 1
Perioperative Care of the Pediatric Neurosurgical Patient
Vavilala, M. S., & Soriano, S. G. (2014) · Springer eBooks · doi:10.1007/978-1-4471-6359-6_10
Intraoperative strategies for transfusion‐free medicine
Tobias, J. D. (2014) · doi:10.1002/9781118554685.ch8
Faulcon, C., Desgranges, F., Vassal, O., Burgal, S., Tosetti, S., Dailler, F., Mottolèse, C., & CHASSARD, D. (2015) · Anesthésie & Réanimation · doi:10.1016/j.anrea.2015.05.005
What’s New in Craniosynostosis?
Dong, T. T., & Ferschl, M. B. (2015) · Current anesthesiology reports · doi:10.1007/s40140-015-0099-4
Faulcon, C., Desgranges, F., Vassal, O., Mahr, A., Burgal, S., Dailler, F., Mottolèse, C., & CHASSARD, D. (2014) · Annales Françaises d Anesthésie et de Réanimation · doi:10.1016/j.annfar.2014.07.103
Bellon, A., Silve, R., Desgranges, F., Cogniat, B., Burgal, S., Szathmári, A., Mottolèse, C., & CHASSARD, D. (2014) · Annales Françaises d Anesthésie et de Réanimation · doi:10.1016/j.annfar.2014.07.100
Revista Colombiana de Anestesiología
Navarro-Vargas, J. R., & Eslava-Schmalbach, J. H. (2016)
Studies on hemodynamics and coagulation in neuroanesthesia
Luostarinen, T. (2015) · Työväentutkimus Vuosikirja
Efficacy of Tranexamic Acid in Craniosynostosis Repair in an Infant
Rakić, G., Stanić, D., Uram-Benka, A., Simin, J., Draskovic, B. G., & Pandurov, M. (2015) · Indian Journal of Neurosurgery · doi:10.1055/s-0035-1568999
“2,7 It is difficult to assess the amount of blood volume lost intraoperatively due to child ’ s young age and the fact that a small amount of blood is collected by the suction.”
Impacto de la hipotermia durante la intervención quirúrgica de craneosinostosis
Cárdenas, V. H. G., Vanegas-Martínez, M. V., Rueda, M. E. R., Burbano-Paredes, C. C., & Pulido-Barbosa, N. T. (2016) · Colombian Journal of Anesthesiology · doi:10.1016/j.rca.2016.04.005
Stricker, P. A., & Hsu, G. (2015) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000001804
Antifibrinolytika–Tranexamsäure und Aprotinin
Singbartl, G., Singbartl, K., Todt, H., Schindler, E., Martin, K., & Tassani‐Prell, P. (2015) · Springer eBooks · doi:10.1007/978-3-662-47258-3_3
Massive blood transfusion in trauma care
Tobin, J. M. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781139814713.011
Initial management of the trauma patient
Smith, C. E. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781139814713.006
Anesthesia for Epilepsy Surgery
Gupta, N. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805299-0.00016-6
Factors influencing blood loss and allogeneic blood transfusion practice in craniosynostosis surgery
Stricker, P. A., Fiadjoe, J. E., & Jobes, D. R. (2012) · Pediatric Anesthesia · doi:10.1111/j.1460-9592.2011.03775.x
Anesthetic Challenges in Pediatric Craniofacial Surgeries
Chan, L. L. K. (2017) · Springer eBooks · doi:10.1007/978-3-319-41445-4_14
Soliman, D. E., Cladis, F. P., & Davis, P. J. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-2787-6.00021-8
Patient Blood Management in Craniofacial Surgery: Time for Improvement?
Muhly, W. T., Swanson, J. W., & Stricker, P. A. (2019) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000005702
Pediatric transfusion therapy and blood conservation
Machovec, K. A., & Weldon, B. C. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107375338.027
Management of Patient with Craniosynostosis
Krishnaney-Davison, R., Chhabada, S., & Castro, P. (2020) · Springer eBooks · doi:10.1007/978-981-15-0458-7_7
Congenital Abnormalities and Syndromes
Gentry, K. R., & Lynn, A. M. (2018) · Cambridge University Press eBooks · doi:10.1017/9781107707016.011
Jöhr, M. (2013) · Elsevier eBooks · doi:10.1016/b978-3-437-22832-2.00006-3
Anesthesia for Plastic and Craniofacial Surgery
Schindler, E., Martini, M., & Messing‐Jünger, M. (2020) · doi:10.1002/9781119371533.ch36
Revista Colombiana de Anestesiología
Giraldo, M. Z. (2013)
Year in Review: Synopsis of Selected Articles in Neuroanesthesia and Neurocritical Care from 2020
Esmail, T., Subramaniam, S., & Venkatraghavan, L. (2021) · Journal of Neuroanaesthesiology and Critical Care · doi:10.1055/s-0041-1725223
Craniosynostosis and Anesthetic Concerns
Lionel, K. R., Hrishi, A. P., & Ajayan, N. (2021) · Springer eBooks · doi:10.1007/978-981-16-3376-8_18
Blood Loss and Transfusion in Children Undergoing Neurosurgery
Mishra, R. K., & Rath, G. P. (2021) · Springer eBooks · doi:10.1007/978-981-16-3376-8_11
Linkugel, A. D., Yu, J. W., Kopar, P. K., Kodner, I. J., Brown, D., & Patel, K. B. (2021) · The Cleft Palate-Craniofacial Journal · doi:10.1177/10556656211062036
“Nevertheless, most or all patients undergoing open cranial vault remodeling require transfusion, even when prophylactic measures are used (Goobie et al., 2011, Vega et al., 2014).”
BackgroundThe Dura Split Technique in the Treatment of Craniosynostosis: Is It Still an Option?
Ripatti, L., Blair, R., & Serlo, W. S. (2022) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000008449
“In interpreting the results concerning intraoperative blood loss, 1 must bear in mind that methods of managing intraoperative blood loss have developed considerably from the 1970s to the 21st century.(9,10) Also, it has previously been reported that significant blood loss and the need for blood transfusions are common…”
BackgroundThe Red Code: Management of Bleeding During or After Cleft Palate Surgery
Alvarez, E. C., Alvarez, D., & Iñiguez, A. (2022) · Surgical Atlas of Cleft Palate and Palatal Fistulae · doi:10.1007/978-981-15-3889-6_52-2
Alvarez, E. C., Alvarez, D., & Iñiguez, A. (2022) · Surgical Atlas of Cleft Palate and Palatal Fistulae · doi:10.1007/978-981-15-3889-6_52-1
Kraniosinostoz Cerrahisinde Anestezi ve Transfüzyonun Değerlendirilmesi: Retrospektif Çalışma
Kılıçarslan, N., & Balkaya, A. N. (2022) · Sağlık Akademisi Kastamonu · doi:10.25279/sak.1021427
Ainsworth, S. B. (2020) · doi:10.1093/med/9780198840787.003.0032
Blood-Sparing Techniques and the Perioperative Management of Blood Losses
Tosi, F., Pusateri, A., Sensi, S., & Garra, R. (2020) · Springer eBooks · doi:10.1007/978-3-319-72168-2_70
Afroze, F., Cyr, A. S., & Gorti, A. (2022) · Springer eBooks · doi:10.1007/978-981-19-0954-2_36
Craniosynostosis of the coronal suture. Case report and literature review
Portilla, L. I. V., Blum, M. F. F., Idrovo, M. V. L., Pérez, G. C. L., & García, M. A. L. (2022) · Salud Ciencia y Tecnología · doi:10.56294/saludcyt2022107
Zittel, S., Ristow, O., Moratin, J., Rückschloß, T., Hoffmann, J., Damaty, A. E., Freudlsperger, C., & Engel, M. (2023) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000009282
What Drugs Decrease Perioperative Bleeding?
Andrawes, M. N. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-2768-1.00024-5
Hematology and Coagulation Disorders
Guzzetta, N. A., & Miller, B. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-34125-7.00047-4
Soto, E., Johnston, J. M., Niedermeier, K., Braswell, A. C., Rozelle, C. J., Grant, J. H., & Myers, R. P. (2023) · FACE · doi:10.1177/27325016231206114
“9,23,24 It is notable that as in our findings neither of the RCTs noted a significant difference in their use of FFP, platelets or cryoprecipitate between the TXA and placebo groups.”
ResultNeurosurgical and craniofacial procedures
Hunter, S. A., & Stricker, P. A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90459-9.00011-6
Застосування антифібринолітичної терапії у періопераційному періоді у дітей та дорослих
Faryna, L., & Biliaiev, A. V. (2023) · Ukrainian Scientific Medical Youth Journal · doi:10.32345/usmyj.4(142).2023.137-144
“Схожий ефект від призначення ТКК от - римали у пацієнтів дитячого віку із краніоси - ностозом (King M. et al. 2022, Goobie S. et al. 2011).”
Tanova, R., Vasileva, P., Yankov, D., Ferdinandov, D., Georgiev, S., & Lilyanov, N. (2024) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2024.2338424
“Four randomized controlled trials [7,11,13,15] and three retrospective studies [6,9,10] have shown a significant reduction in the amount of transfused blood. our results are most similar to those of Fenger-eriksen et al. [7], who demonstrated a drop in the intraoperative red blood cell transfusions…”
Craniosynostosis: Anesthetic Considerations—What the Pediatric Neurosurgeon Should Know
Ekstein, M. P., Roth, J., & Constantini, S. (2024) · Springer eBooks · doi:10.1007/978-3-031-69386-1_29
Sagittal Suture Synostosis: Distraction Osteogenesis, Key Points for the Neurosurgeons
Shim, K., & Park, E.-K. (2024) · Springer eBooks · doi:10.1007/978-3-031-69386-1_40
Metadata
- Authors
- Goobie, S. M., Meier, P. M., Pereira, L. M., McGowan, F. X., Prescilla, R. P., Scharp, L. A., Rogers, G. F., Proctor, M. R., Meara, J. G., Soriano, S. G., Zurakowski, D., & Sethna, N. F.
- Affiliations
- Boston Children's Hospital (US)
- Instructor in Anesthesia.
- Massachusetts College of Pharmacy and Health Sciences (US)
- Professor of Anesthesia.
- Research Technician, †† Professor.
- Assistant Professor.
- Associate Professor, Department of Plastic and Oral Surgery.
- Assistant Professor of Anaesthesia (Director of Biostatistics).
- Associate Professor of Anesthesia, Department of Anesthesia, Perioperative, and Pain Medicine.
- ORCID
- Venue
- Anesthesiology
- Published
- 2011-04-01
- Volume
- 114
- Issue
- 4
- Pages
- 862-871
- ISSN
- 0003-3022 (ISSN-L)
- OpenAlex
- W2016016217
- Cited by
- 313
- References
- 46
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 21 · 2023: 16 · 2022: 22 · 2021: 25 · 2020: 20 · 2019: 26 · 2018: 20 · 2017: 17 · 2016: 19 · 2015: 30 · 2014: 28 · 2013: 17 · 2012: 21
- FWCI
- 15.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Anesthesiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Blood transfusion and management
- Health Sciences › Medicine › Surgery › Craniofacial Disorders and Treatments
- Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
- Keywords
- tranexamic acid, pediatric craniosynostosis, perioperative blood loss, blood transfusion, fibrinolysis inhibition, plasma drug concentration, children
- MeSH terms
- Antifibrinolytic Agents, Blood Transfusion, Child, Child, Preschool, Craniosynostoses, Double-Blind Method, Female, Humans, Infant, Intraoperative Care, Male, Tranexamic Acid, Blood Loss, Surgical, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
