Rapid eye movement sleep debt accrues in mice exposed to volatile anesthetics
Open accessAbstract
Background: General anesthesia has been likened to a state in which anesthetized subjects are locked out of access to both rapid eye movement (REM) sleep and wakefulness. Were this true for all anesthetics, a significant REM rebound after anesthetic exposure might be expected. However, for the intravenous anesthetic propofol, studies demonstrate that no sleep debt accrues. Moreover, preexisting sleep debts dissipate during propofol anesthesia. To determine whether these effects are specific to propofol or are typical of volatile anesthetics, the authors tested the hypothesis that REM sleep debt would accrue in rodents anesthetized with volatile anesthetics. Methods: Electroencephalographic and electromyographic electrodes were implanted in 10 mice. After 9-11 days of recovery and habituation to a 12 h:12 h light-dark cycle, baseline states of wakefulness, nonrapid eye movement sleep, and REM sleep were recorded in mice exposed to 6 h of an oxygen control and on separate days to 6 h of isoflurane, sevoflurane, or halothane in oxygen. All exposures were conducted at the onset of light. Results: Mice in all three anesthetized groups exhibited a significant doubling of REM sleep during the first 6 h of the dark phase of the circadian schedule, whereas only mice exposed to halothane displayed a significant increase in nonrapid eye movement sleep that peaked at 152% of baseline. Conclusion: REM sleep rebound after exposure to volatile anesthetics suggests that these volatile anesthetics do not fully substitute for natural sleep. This result contrasts with the published actions of propofol for which no REM sleep rebound occurred.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In rodents deprived of sleep, inhaled anesthetics meet the requirement for slow-wave sleep.
“inhaled anesthetics satisfy the need for slow-wave sleep in rodents that had undergone sleep deprivation [106–108].”
From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [108]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Breakdown of cortical effective connectivity during sleep
Massimini, M., Ferrarelli, F., Huber, R., Esser, S. K., Singh, H., & Tononi, G. (2005) · Science · doi:10.1126/science.1117256 · Cited by 1,534 · see citing works
General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal
Franks, N. P. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2372 · Cited by 1,266 · see citing works
Alkire, M. T., Hudetz, A. G., & Tononi, G. (2008) · Science · doi:10.1126/science.1149213 · Cited by 1,245 · see citing works
Decoupling of the brain's default mode network during deep sleep
Horovitz, S. G., Braun, A. R., Carr, W. S., Picchioni, D., Balkin, T. J., Fukunaga, M., & Duyn, J. H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901435106 · Cited by 685 · see citing works
Boveroux, P., Vanhaudenhuyse, A., Bruno, M.-A., Noirhomme, Q., Lauwick, S., Luxen, A., Degueldre, C., Plenevaux, A., Schnakers, C., Phillips, C., et al. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181f697f5 · Cited by 630 · see citing works
The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway
Nelson, L. E., Guo, T. Z., Lu, J., Saper, C. B., Franks, N. P., & Maze, M. (2002) · Nature Neuroscience · doi:10.1038/nn913 · Cited by 568 · see citing works
Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness
Ferrarelli, F., Massimini, M., Sarasso, S., Casali, A., Riedner, B. A., Angelini, G., Tononi, G., & Pearce, R. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913008107 · Cited by 554 · see citing works
The Homeostatic Regulation of Sleep Need Is under Genetic Control
Franken, P., Chollet, D., & Tafti, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02610.2001 · Cited by 551 · see citing works
Sleep Loss and REM Sleep Loss are Hyperalgesic
Roehrs, T., Hyde‐Nolan, M. E., Blaisdell, B., Greenwald, M. K., & Roth, T. G. (2006) · SLEEP · doi:10.1093/sleep/29.2.145 · Cited by 492 · see citing works
Fiset, P., Paus, T., Daloze, T., Plourde, G., Meuret, P., Bonhomme, V., Hajj-Ali, N., Backman, S. B., & Evans, A. C. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05506.1999 · Cited by 475 · see citing works
Propofol Anesthesia and Sleep: A High-Density EEG Study
Murphy, M., Bruno, M.-A., Riedner, B. A., Boveroux, P., Noirhomme, Q., Landsness, E. C., Brichant, J.-F., Phillips, C., Massimini, M., Laureys, S., et al. (2011) · Sleep · doi:10.1093/sleep/34.3.283 · Cited by 418 · see citing works
Alkire, M. T., Haier, R. J., & Fallon, J. H. (2000) · Consciousness and Cognition · doi:10.1006/ccog.1999.0423 · Cited by 391 · see citing works
An essential role for orexins in emergence from general anesthesia
Kelz, M. B., Sun, Y., Chen, J., Cheng Meng, Q., Moore, J. T., Veasey, S. C., Dixon, S., Thornton, M., Funato, H., & Yanagisawa, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707146105 · Cited by 341 · see citing works
Self-citationEffect of sleep deprivation on sleep and EEG power spectra in the rat
Borbély, A. A., Tobler, I., & Hanagasioglu, M. (1984) · Behavioural Brain Research · doi:10.1016/0166-4328(84)90186-4 · Cited by 340 · see citing works
A Systemic Review of Obstructive Sleep Apnea and Its Implications for Anesthesiologists
Chung, S. A., Yuan, H., & Chung, F. F. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318187c83a · Cited by 319 · see citing works
Anesthesia with Abdominal Surgery Leads to Intense REM Sleep during the First Post-operative Week
Knill, R. L., Moote, C. A., Skinner, M. I., & Rose, E. (1990) · Anesthesiology · doi:10.1097/00000542-199007000-00009 · Cited by 319 · see citing works
Human regional cerebral glucose metabolism during non-rapid eye movement sleep in relation to waking
Nofzinger, E. A., Buysse, D. J., Miewald, J. M., Meltzer, C. C., Price, J. C., Sembrat, R. C., Ombao, H., Reynolds, C. F., Monk, T. H., Hall, M., et al. (2002) · Brain · doi:10.1093/brain/awf103 · Cited by 295 · see citing works
Hans, P., Dewandre, P.-Y., Brichant, J. F., & Bonhomme, V. L. (2004) · British Journal of Anaesthesia · doi:10.1093/bja/aei047 · Cited by 271 · see citing works
Sleep, Anesthesiology, and the Neurobiology of Arousal State Control
Lydic, R., & Baghdoyan, H. A. (2005) · Anesthesiology · doi:10.1097/00000542-200512000-00024 · Cited by 251 · see citing works
Friedman, E. B., Sun, Y., Moore, J. T., Hung, H.-T., Meng, Q. C., Perera, P., Joiner, W. J., Thomas, S. A., Eckenhoff, R. G., Sehgal, A., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011903 · Cited by 218 · see citing works
Self-citationImas, O. A., Ropella, K. M., Ward, B. D., Wood, J. D., & Hudetz, A. G. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.06.018 · Cited by 189 · see citing works
Lee, U., Kim, S., Noh, G., Choi, B., Hwang, E., & Mashour, G. A. (2009) · Consciousness and Cognition · doi:10.1016/j.concog.2009.04.004 · Cited by 183 · see citing works
Antkowiak, B. (1999) · Anesthesiology · doi:10.1097/00000542-199908000-00025 · Cited by 171 · see citing works
Unrecognized Sleep Apnea in the Surgical Patient
Kaw, R. K., Michota, F. A., Jaffer, A. K., Ghamande, S. A., Auckley, D. H., & Golish, J. A. (2006) · CHEST Journal · doi:10.1378/chest.129.1.198 · Cited by 166 · see citing works
(2004) · PubMed · Cited by 164 · see citing works
Sleep and its homeostatic regulation in mice lacking the adenosine A 1 receptor
Stenberg, D., Litonius, E. S., Halldner, L., Johansson, B. A., Fredholm, B. B., & Porkka‐Heiskanen, T. (2003) · Journal of Sleep Research · doi:10.1046/j.0962-1105.2003.00367.x · Cited by 152 · see citing works
Recovery from Sleep Deprivation Occurs during Propofol Anesthesia
Tung, A., Bergmann, B. M., Herrera, S., Cao, D., & Mendelson, W. B. (2004) · Anesthesiology · doi:10.1097/00000542-200406000-00014 · Cited by 151 · see citing works
Midazolam Changes Cerebral Blood Flow in Discrete Brain Regions
Veselis, R. A., Reinsel, R. A., Beattie, B. J., Mawlawi, O. R., Feshchenko, V. A., DiResta, G. R., Larson, S. M., & Blasberg, R. G. (1997) · Anesthesiology · doi:10.1097/00000542-199711000-00015 · Cited by 141 · see citing works
Tung, A., Szafran, M. J., Bluhm, B., & Mendelson, W. B. (2002) · Anesthesiology · doi:10.1097/00000542-200210000-00024 · Cited by 112 · see citing works
Ouyang, M., Hellman, K. M., Abel, T. G., & THOMAS, S. A. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00226.2004 · Cited by 111 · see citing works
An Automated System for Recording and Analysis of Sleep in Mice
Veasey, S. C., Valladares, O., Fenik, P., Kapfhamer, D., Sanford, L. D., Benington, J. H., & Bućan, M. (2000) · SLEEP · doi:10.1093/sleep/23.8.1c · Cited by 109 · see citing works
Sleep homeostasis in the rat in the light and dark period
Vyazovskiy, V. V., Achermann, P., & Tobler, I. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.05.001 · Cited by 105 · see citing works
Tung, A., & Mendelson, W. B. (2004) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.01.003 · Cited by 95 · see citing works
Sleep–wake behavior and responses of interleukin-6-deficient mice to sleep deprivation
Morrow, J. D., & Opp, M. R. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2004.02.003 · Cited by 85 · see citing works
Prolonged Sedation with Propofol in the Rat Does Not Result in Sleep Deprivation
Tung, A., Lynch, J. P., & Mendelson, W. B. (2001) · Anesthesia & Analgesia · doi:10.1097/00000539-200105000-00028 · Cited by 81 · see citing works
II Sleep neurobiology: relevance for mechanistic studies of anaesthesia
Lydic, R., & Biebuyck, J. F. (1994) · British Journal of Anaesthesia · doi:10.1093/bja/72.5.506 · Cited by 74 · see citing works
Pal, D., Lipinski, W. J., Walker, A. J., Turner, A. M., & Mashour, G. A. (2011) · Anesthesiology · doi:10.1097/aln.0b013e318204e064 · Cited by 71 · see citing works
Antunes, L. M., Golledge, H., Roughan, J. V., & Flecknell, P. A. (2003) · Veterinary Anaesthesia and Analgesia · doi:10.1046/j.1467-2995.2003.00085.x · Cited by 68 · see citing works
Isoflurane Anesthesia Causes a Transient Alteration in Nocturnal Sleep
Moote, C. A., & Knill, R. L. (1988) · Anesthesiology · doi:10.1097/00000542-198809000-00007 · Cited by 68 · see citing works
Prolonged effects of 24-h total sleep deprivation on sleep and sleep EEG in the rat
Schwierin, B., Borbély, A. A., & Tobler, I. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(98)01006-4 · Cited by 62 · see citing works
Kubota, T., Anzawa, N., Hirota, K., Yoshida, H., Kushikata, T., & MATSUKI, A. (1999) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03013235 · Cited by 59 · see citing works
Gross, B. A., Walsh, C. M., Turakhia, A. A., Booth, V., Mashour, G. A., & Poe, G. R. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.07.009 · Cited by 58 · see citing works
Isoflurane Anesthesia Does Not Satisfy the Homeostatic Need for Rapid Eye Movement Sleep
Mashour, G. A., Lipinski, W. J., Matlen, L. B., Walker, A. J., Turner, A. M., Schoen, W., Lee, U., & Poe, G. R. (2010) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181d3e861 · Cited by 58 · see citing works
Effects of anesthesia on the response to sleep deprivation
Nelson, A. B., Faraguna, U., Tononi, G., & Cirelli, C. (2010) · Sleep · doi:10.1093/sleep/33.12.1659 · Cited by 56 · see citing works
Fully automated sleep deprivation in mice as a tool in sleep research
Fenzl, T., Romanowski, C. P. N., Flachskamm, C., Honsberg, K., Boll, E., Höhne, A., & Kimura, M. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.07.007 · Cited by 55 · see citing works
Effect of volatile anesthetics on interhemispheric EEG cross-approximate entropy in the rat
Hudetz, A. G. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03358-9 · Cited by 51 · see citing works
Tănase, D., Baghdoyan, H. A., & Lydic, R. (2003) · Anesthesiology · doi:10.1097/00000542-200304000-00018 · Cited by 46 · see citing works
Disruption of Diacylglycerol Kinase Delta (DGKD) Associated with Seizures in Humans and Mice
Leach, N. T., Sun, Y., Michaud, S., Zheng, Y. Z., Ligon, K. L., Ligon, A. H., Sander, T., Korf, B. R., Lu, W., Harris, D. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/513019 · Cited by 45 · see citing works
Self-citationSleep-dependent directional coupling between human neocortex and hippocampus
Wagner, T., Axmacher, N., Lehnertz, K., Elger, C. E., & Fell, J. (2009) · Cortex · doi:10.1016/j.cortex.2009.05.012 · Cited by 43 · see citing works
High throughput modular chambers for rapid evaluation of anesthetic sensitivity
Sun, Y., Chen, J., Pruckmayr, G. T., Baumgardner, J. E., Eckmann, D. M., Eckenhoff, R. G., & Kelz, M. B. (2006) · BMC Anesthesiology · doi:10.1186/1471-2253-6-13 · Cited by 41 · see citing works
Self-citationHalothane-induced Hypnosis Is Not Accompanied by Inactivation of Orexinergic Output in Rodents
Gompf, H. S., Chen, J., Sun, Y., Yanagisawa, M., Aston‐Jones, G., & Kelz, M. B. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181b764b3 · Cited by 37 · see citing works
Self-citationNeurochemical Modulators of Sleep and Anesthetic States
Dort, C. J. V., Baghdoyan, H. A., & Lydic, R. (2008) · International Anesthesiology Clinics · doi:10.1097/aia.0b013e318181a8ca · Cited by 33 · see citing works
Orth, M., Bravo, E., Barter, L. S., Carstens, E. E., & Antognini, J. F. (2006) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000205752.00303.94 · Cited by 26 · see citing works
Exogenous adenosine potentiates hypnosis induced by intravenous anaesthetics
Kaputlu, I., Şadan, G., & Özdem, S. S. (1998) · Anaesthesia · doi:10.1046/j.1365-2044.1998.00330.x · Cited by 23 · see citing works
Chamberlin, N. L., & Eikermann, M. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181f69825 · Cited by 21 · see citing works
Effects of Isoflurane Anesthesia on Post-Anesthetic Sleep-Wake Architectures in Rats
Jang, H.-S., Jung, J. J., Jang, K.-H., & Lee, M. (2010) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2010.14.5.291 · Cited by 12 · see citing works
Murine auto- and cross-tolerance to volatile anaesthetics
Chalon, J., Tang, C.-K., Roberts, C. S., Walpert, L., Hoffman, C., Ramanathan, S., & Turndorf, H. (1983) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03013800 · Cited by 10 · see citing works
The night of intense REM sleep after anesthesia and surgery increases urinary catecholamines.
Rl, K., Mi, S., Novick, T., Vandenberghe, H., & Moote, C. A. (1990) · PubMed · Cited by 10 · see citing works
Campbell, J. L., Gu, Q., Guo, D., & Nash, H. A. (2009) · Journal of Neurogenetics · doi:10.3109/01677060903177800 · Cited by 8 · see citing works
Effects of isoflurane and ketamine on sleep in rabbits
Takahashi, S., MATSUKI, A., & MATSUKI, A. (2001) · Psychiatry and Clinical Neurosciences · doi:10.1046/j.1440-1819.2001.00840.x · Cited by 7 · see citing works
Tolerance to Isoflurane Does Not Occur in Developing Xenopus laevis Tadpoles
Milutinovic, P. S., Zhao, J., & Sonner, J. M. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31818ca33e · Cited by 5 · see citing works
THE STUDY OF NATURAL SLEEP AFTER GENERAL ANAESTHESIA IN THE CAT
YANAGIDA, H., & Yamamura, H. (1972) · British Journal of Anaesthesia · doi:10.1093/bja/44.12.1229 · Cited by 5 · see citing works
Anesthesia and sleep medicine: an opportunity to be mutually informative?
Karan, S., Perlis, M. L., & Ward, D. S. (2007) · Seminars in Anesthesia Perioperative Medicine and Pain · doi:10.1053/j.sane.2007.06.002 · Cited by 4 · see citing works
RECEPTORS AND TRANSMEMBRANE SIGNALLING: CELLULAR AND MOLECULAR ASPECTS OF ANAESTHESIA
Halsey, M. J., Roberts, C., & STRUNIN, L. (1993) · British Journal of Anaesthesia · doi:10.1093/bja/71.1.1 · Cited by 3 · see citing works
Time in General Anesthesia: Depriving the Homeostat?
Daley, J. T., & Kelz, M. B. (2010) · SLEEP · doi:10.1093/sleep/33.12.1583 · Cited by 3 · see citing works
Self-citationMatthews, R. L. (1990) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03007476 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Neural Circuits Underlying General Anesthesia and Sleep
Moody, O. A., Zhang, E. R., Vincent, K. F., Kato, R., Melonakos, E. D., Nehs, C. J., & Solt, K. (2021) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000005361 · Cited by 165 · see citing works
The Biology of General Anesthesia from Paramecium to Primate
Kelz, M. B., & Mashour, G. A. (2019) · Current Biology · doi:10.1016/j.cub.2019.09.071 · Cited by 151 · see citing works
Self-citationPostoperative Respiratory Muscle Dysfunction
Sasaki, N., Meyer, M. J., & Eikermann, M. (2013) · Anesthesiology · doi:10.1097/aln.0b013e318288834f · Cited by 142 · see citing works
Brain energetics during the sleep-wake cycle
DiNuzzo, M., & Nedergaard, M. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.09.010 · Cited by 130 · see citing works
Brain areas that influence general anesthesia
Leung, L. S., Luo, T., Ma, J., & Herrick, I. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.08.001 · Cited by 126 · see citing works
Mang, G. M., Dürst, T., Bürki, H., Imobersteg, S., Abramowski, D., Schuepbach, E., Hoyer, D., Fendt, M., & Gee, C. E. (2012) · SLEEP · doi:10.5665/sleep.2232 · Cited by 103 · see citing works
Vanini, G., Bassana, M., Mast, M., Mondino, A., Cerda, I. H., Phyle, M., Chen, V., Colmenero, A. V., Hambrecht‐Wiedbusch, V. S., & Mashour, G. A. (2020) · Current Biology · doi:10.1016/j.cub.2019.12.063 · Cited by 96 · see citing works
How does general anaesthesia affect the circadian clock?
Poulsen, R. C., Warman, G. R., SLEIGH, J. W., Ludin, N. M., & Cheeseman, J. F. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.12.002 · Cited by 87 · see citing works
Sleep Disturbances After General Anesthesia: Current Perspectives
Luo, M., Song, B., & Zhu, J. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00629 · Cited by 89 · see citing works
Escape From Oblivion: Neural Mechanisms of Emergence From General Anesthesia
Kelz, M. B., García, P. S., Mashour, G. A., & Solt, K. (2019) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000004006 · Cited by 74 · see citing works
Self-citationBasal Forebrain Cholinergic Activity Modulates Isoflurane and Propofol Anesthesia
Luo, T., Cai, S., Qin, Z.-X., Yang, S., Shu, Y. L., Liu, C., Zhang, Y., Zhang, L., Zhou, L., Yu, T., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.559077 · Cited by 55 · see citing works
Safavynia, S. A., Keating, G. L., Speigel, I. A., Fidler, J. A., Kreuzer, M., Rye, D. B., Jenkins, A., & García, P. S. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001134 · Cited by 53 · see citing works
Garrity, A. G., Botta, S., Lazar, S. B., Swor, E. C., Vanini, G., Baghdoyan, H. A., & Lydic, R. (2014) · SLEEP · doi:10.5665/sleep.4328 · Cited by 48 · see citing works
Hou, J., Shen, Q., Wan, X., Zhao, B., Wu, Y., & Xia, Z. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.01.038 · Cited by 47 · see citing works
Song, B., Li, Y., Teng, X., Li, X., Yang, Y., & Zhu, J. (2020) · Nature and Science of Sleep · doi:10.2147/nss.s257896 · Cited by 44 · see citing works
Distinct effects of IPSU and suvorexant on mouse sleep architecture
Hoyer, D., Dürst, T., Fendt, M., Jacobson, L. H., Betschart, C., Hintermann, S., Behnke, D., Cotesta, S., Laue, G., Ofner, S., et al. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00235 · Cited by 42 · see citing works
Song, B., Li, Y., Teng, X., Li, X., Yang, Y., & Zhu, J. (2019) · Nature and Science of Sleep · doi:10.2147/nss.s225041 · Cited by 39 · see citing works
Optimizing Sedation Management to Promote Early Mobilization for Critically Ill Children
Saliski, M., & Kudchadkar, S. R. (2015) · Journal of Pediatric Intensive Care · doi:10.1055/s-0035-1563543 · Cited by 38 · see citing works
Sleep and Anesthesia Interactions: A Pharmacological Appraisal
Scharf, M. T., & Kelz, M. B. (2012) · Current anesthesiology reports · doi:10.1007/s40140-012-0007-0 · Cited by 39 · see citing works
Self-citationVacas, S., Kurien, P. A., & Maze, M. (2013) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2012.11.009 · Cited by 34 · see citing works
Effects of propofol and sevoflurane on social and anxiety-related behaviours in sleep-deprived rats
Zhu, J., Chen, C., Wu, J., He, M., Li, S., Fang, Y., Zhou, Y., Xu, H., Sadigh‐Eteghad, S., Manyande, A., et al. (2023) · British Journal of Anaesthesia · doi:10.1016/j.bja.2023.05.025 · Cited by 32 · see citing works
Kushikata, T., Sawada, M., Niwa, H., Kudo, T., Kudo, M., Tonosaki, M., & Hirota, K. (2016) · Journal of Anesthesia · doi:10.1007/s00540-016-2161-x · Cited by 32 · see citing works
Liu, H., Yang, C., Wang, X., Yu, B., Han, Y., Wang, X., Wang, Z., Zhang, M., & Wang, H. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14798 · Cited by 30 · see citing works
Han, B., McCarren, H. S., O’Neill, D., & Kelz, M. B. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000383 · Cited by 28 · see citing works
Self-citationKikuchi, T., Tan, H., Mihara, T., Uchimoto, K., Mitsushima, D., Takase, K., Morita, S., Goto, T., Andoh, T., & Kamiya, Y. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.062 · Cited by 27 · see citing works
Effect of basal forebrain somatostatin and parvalbumin neurons in propofol and isoflurane anesthesia
Cai, S., Tang, A., Luo, T., Yang, S., Yang, H., Liu, C., Shu, Y. L., Pan, Y., Zhang, Y., Zhou, L., et al. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13635 · Cited by 26 · see citing works
Interfaces of Sleep and Anesthesia
Mashour, G. A., & Pal, D. (2012) · Anesthesiology Clinics · doi:10.1016/j.anclin.2012.05.003 · Cited by 26 · see citing works
Li, S., Song, B., Yang, L., & Zhu, J. (2021) · Nature and Science of Sleep · doi:10.2147/nss.s300803 · Cited by 24 · see citing works
Progress in modelling of brain dynamics during anaesthesia and the role of sleep-wake circuitry
Nguyen, G., & Postnova, S. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114388 · Cited by 21 · see citing works
McEntire, D., Kirkpatrick, D. R., Kerfeld, M. J., Hambsch, Z. J., Reisbig, M. D., Agrawal, D. K., & Youngblood, C. F. (2014) · Expert Review of Clinical Pharmacology · doi:10.1586/17512433.2014.966815 · Cited by 20 · see citing works
Selvadurai, S., Maynes, J. T., Donnell, C. M., Cushing, S. L., Propst, E. J., Lorenzo, A. J., Lim, A. S. P., Meltzer, L. J., Lu, Z., Horner, R. L., et al. (2018) · SLEEP · doi:10.1093/sleep/zsy094 · Cited by 19 · see citing works
Preoptic Area Modulation of Arousal in Natural and Drug Induced Unconscious States
Reitz, S. L., & Kelz, M. B. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.644330 · Cited by 18 · see citing works
Self-citationSleep Homeostasis and General Anesthesia
Gardner, B., Strus, E., Meng, Q. C., Coradetti, T., Naidoo, N. N., Kelz, M. B., & Williams, J. A. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000939 · Cited by 16 · see citing works
Self-citationManzella, F. M., Joksimovic, S. M., Orfila, J. E., Fine-Raquet, B., Dietz, R. M., Sampath, D., Fiedler, H. K., Tešić, V., Atluri, N., Raol, Y. H., et al. (2020) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.00026 · Cited by 16 · see citing works
Is Hydrogen Sulfide-Induced Suspended Animation General Anesthesia?
Li, R. Q., McKinstry-Wu, A. R., Moore, J. T., Caltagarone, B. M., Eckenhoff, M. F., Eckenhoff, R. G., & Kelz, M. B. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.187237 · Cited by 16 · see citing works
Self-citationZhao, Y., Ye, C., He, Y., Bao, M., Liu, Y., & Yan, M. (2025) · The Journal of Arthroplasty · doi:10.1016/j.arth.2025.06.009 · Cited by 15 · see citing works
Electroacupuncture: A New Approach for Improved Postoperative Sleep Quality After General Anesthesia
Luo, M., Song, B., & Zhu, J. (2020) · Nature and Science of Sleep · doi:10.2147/nss.s261043 · Cited by 15 · see citing works
The efficacy of acupuncture in postoperative sleep quality: a literature review
Song, B., Luo, M., & Zhu, J. (2020) · Sleep And Breathing · doi:10.1007/s11325-020-02187-x · Cited by 15 · see citing works
Luo, T., Wang, Y., Qin, J., Liu, Z., & Liu, M. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12675 · Cited by 15 · see citing works
Disruption of Rapid Eye Movement Sleep Homeostasis in Adolescent Rats after Neonatal Anesthesia
Lunardi, N., Sica, R., Atluri, N., Salvati, K. A., Keller, C., Beenhakker, M. P., Goodkin, H. P., & Zuo, Z. (2019) · Anesthesiology · doi:10.1097/aln.0000000000002660 · Cited by 15 · see citing works
Yang, K., Shao, X., Lv, X., Yang, F., Shen, Q., Fang, J., & Chen, W. (2022) · Laparoscopic Endoscopic and Robotic Surgery · doi:10.1016/j.lers.2022.06.001 · Cited by 14 · see citing works
The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia
Luppi, A. I., Spindler, L. R. B., Menon, D. K., & Stamatakis, E. A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.643871 · Cited by 14 · see citing works
Pontine Control of Rapid Eye Movement Sleep and Fear Memory
Wen, Y., Yang, W. J., Guo, C. N., Qiu, M. H., Kroeger, D., Niu, J. G., Zhan, S. Q., Yang, X. F., Gisabella, B., Vetrivelan, R., et al. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14123 · Cited by 13 · see citing works
Differences Between Natural Sleep and the Anesthetic State
Date, A. R., Bashir, K., Uddin, A., & Nigam, C. (2020) · Future Science OA · doi:10.2144/fsoa-2020-0149 · Cited by 13 · see citing works
Silverstein, B. H., Parkar, A., Groenhout, T., Fracz, Z., Fryzel, A. M., Fields, C. W., Nelson, A. G., Liu, T., Vanini, G., Mashour, G. A., et al. (2023) · British Journal of Anaesthesia · doi:10.1016/j.bja.2023.11.014 · Cited by 13 · see citing works
Zhang, H., Wheat, H., Wang, P., Jiang, S., Baghdoyan, H. A., Neubig, R. R., Shi, X., & Lydic, R. (2016) · SLEEP · doi:10.5665/sleep.5450 · Cited by 12 · see citing works
Song, J., Um, Y. H., Kim, T. W., Kim, S., Kwon, S. Y., & Hong, S. (2018) · Sleep Medicine Research · doi:10.17241/smr.2018.00164 · Cited by 12 · see citing works
Oxidative stress in relation to serotonin under general anaesthesia in dogs undergoing ovariectomy
Bruschetta, G., Leonardi, F., Licata, P., Iannelli, N. M., Fernández, R., Bruno, F., Messina, L., & Costa, G. L. (2024) · Veterinary Quarterly · doi:10.1080/01652176.2024.2379319 · Cited by 11 · see citing works
Song, B., & Zhu, J. (2021) · Sleep And Breathing · doi:10.1007/s11325-021-02361-9 · Cited by 10 · see citing works
Nelson, M. J., Yu, D. A., Ha, A. V. H., Wakefield, M. R., & Fang, Y. (2025) · Clocks & Sleep · doi:10.3390/clockssleep7030029 · Cited by 10 · see citing works
Tai, C.-Y., Liu, H.-Y., Cata, J. P., Dai, Y., Chen, M., Chen, J., Chen, T., Wu, H.-L., Cherng, Y., Li, C.-C., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11123360 · Cited by 7 · see citing works
Chen, N., Sun, P., Li, C., Xing, X.-X., Li, M., Sun, Z.-J., Li, H.-J., Mu, D.-L., & Wang, D. (2025) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2025.111875 · Cited by 6 · see citing works
Tan, W., Wang, Z., Ma, H., Jin, F., & Lu, H.-W. (2017) · Journal of Clinical Monitoring and Computing · doi:10.1007/s10877-016-9974-x · Cited by 6 · see citing works
RetractedWang, X., Xiong, B., Wu, T., Liu, X., Li, K., Wang, S., Deng, M., & Peng, M. (2024) · Sleep Medicine · doi:10.1016/j.sleep.2024.07.022 · Cited by 5 · see citing works
General anesthesia alters the diversity and composition of the lung microbiota in rat
Yang, R.-Z., Liang, M., Lin, S., Weng, J., Hu, J., Lin, S.-Z., Wu, X., & Zeng, K. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115381 · Cited by 5 · see citing works
Isoflurane anesthesia and sleep deprivation trigger delayed and selective sleep alterations
Joyce, L., Mas, C. C., Meedt, V., Kreuzer, M., Schneider, G. H., & Fenzl, T. (2024) · Scientific Reports · doi:10.1038/s41598-024-64975-9 · Cited by 5 · see citing works
Neuroplasticity and brain health: insights from natural torpor
Shi, Z., Wang, X., Duan, W., Du, Y., Ling, S., Zhang, Z., Wang, G., Zhao, D., Ding, J., Zhang, K., et al. (2025) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.70069 · Cited by 4 · see citing works
Imamura, T., Wasilczuk, A. Z., Reitz, S. L., Lian, J., Imamura, M., Keenan, B. T., Shimizu, N., Pack, A. I., & Kelz, M. B. (2025) · British Journal of Anaesthesia · doi:10.1016/j.bja.2025.02.035 · Cited by 4 · see citing works
Self-citationSleep Deprivation Increases the Anesthetic Potency of Sevoflurane Regardless of Duration
Qian, H., Zhou, Q., Cui, N., & Zhang, S. (2022) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2105135 · Cited by 4 · see citing works
Joyce, L., Nuttall, R., Kreuzer, M., Rammes, G., Schneider, G. H., & Fenzl, T. (2025) · SLEEP · doi:10.1093/sleep/zsaf287 · Cited by 3 · see citing works
Atluri, N., Dulko, E., Jedrusiak, M., Klos, J., Osuru, H. P., Davis, E. M., Beenhakker, M. P., Kapur, J., Zuo, Z., & Lunardi, N. (2023) · Anesthesiology · doi:10.1097/aln.0000000000004893 · Cited by 3 · see citing works
Neonatal exposure to a neuroactive steroid alters low-frequency oscillations in the subiculum
Fine-Raquet, B., Manzella, F. M., Joksimovic, S. M., Dietz, R. M., Orfila, J. E., Sampath, D., Tešić, V., Atluri, N., Covey, D. F., Raol, Y. H., et al. (2023) · Experimental Biology and Medicine · doi:10.1177/15353702231177009 · Cited by 3 · see citing works
Effects of Anesthetics, Operative Pharmacotherapy, and Recovery from Anesthesia
Anastasian, Z. H., & Gaudet, J. G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-32106-8.00001-7 · Cited by 3 · see citing works
Roles of motor and cortical activity in sleep rebound in rat
Wen, Y., Lv, Y., Niu, J., Xin, C., Cui, L., Vetrivelan, R., & Lu, J. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14881 · Cited by 2 · see citing works
Zheng, F., Zheng, Z.-H., Wang, W., Zhu, K., Xing, H.-L., & Ding, L.-M. (2021) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-021-02847-1 · Cited by 2 · see citing works
The effects of intensive care environment on postoperative nightmare
Sonobe, S., Inoue, S., & Kawaguchi, M. (2016) · Journal of Anesthesia · doi:10.1007/s00540-016-2237-7 · Cited by 2 · see citing works
Александрович, М. Н., Kicherova, O. A., Эдуардовна, В. Т., Reichert, L. I., Doyan, Y. I., & Анатольевна, С. В. (2024) · Journal of clinical practice · doi:10.17816/clinpract630310 · Cited by 1 · see citing works
Oh, T. K., Park, H. Y., & Song, I. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.09.027 · Cited by 1 · see citing works
Isoflurane Exposure Influence on Sleep Architecture in a Rat Model of Alzheimer’s Disease
Kreuzer, M., Keating, G. L., Sinon, C. G., Fenzl, T., Schneider, G. H., Rye, D. B., & García, P. S. (2025) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000007717 · Cited by 1 · see citing works
Yang, R., Lin, S., Huang, L., Weng, J., Liu, Q., Chen, H., Ruan, N., & Zeng, K. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71447 · Cited by 1 · see citing works
Maher, E. A., Maher, M., & Mahmoud, A. A. A. (2015) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.4103/1110-1083.170657 · Cited by 1 · see citing works
Volatile Anesthesia Does Not Satisfy Rapid Eye Movement Sleep Debt
Lichtor, J. L., & Lydic, R. (2011) · Anesthesiology · doi:10.1097/aln.0b013e31822ddf30 · Cited by 1 · see citing works
Ralph Lydic, Ph.D., Recipient of the 2012 Excellence in Research Award
Tremper, K. K. (2012) · Anesthesiology · doi:10.1097/aln.0b013e31826a4d5f
0934 EVALUATING THE EFFECTS OF GENERAL ANESTHESIA ON SLEEP IN CHILDREN UNDERGOING ELECTIVE SURGERY
Selvadurai, S., Maynes, J. T., Donnell, C. M., Cushing, S. L., Propst, E. J., Lorenzo, A. J., Meltzer, L. J., Lim, A. S. P., Horner, R. L., & Narang, I. (2017) · SLEEP · doi:10.1093/sleepj/zsx050.933
NEW PERSPECTIVE IN STUDYING PROPOFOL AND SLEEP INTERACTION: A PILOT STUDY
Maher, M. A., Maher, E. A., Refaat, A., Hussein, M., Ebied, R. S., & Helmy, A. H. (2017) · Journal of the Egyptian Society of Parasitology · doi:10.12816/0049781
Morgan, P. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717547817.792952825
La anestesia general y el sueño fisiológico, una visión fenomenológica integradora
Tapia, L. F., Voullième, P. S., & Faúndez, G. (2022) · Revista Chilena de Anestesia · doi:10.25237/revchilanestv5101071114
Lin, C., Gu, H. B., Lu, G., Miao, L.-Y., & Chen, C. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4690504
Jedrusiak, M., Davis, E. M., Dulko, E., & Lunardi, N. (2026) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000008274
- Authors
- Pick, J., Chen, Y., Moore, J. T., Sun, Y., Wyner, A. J., Friedman, E. B., & Kelz, M. B.
- Affiliations
- University of Pennsylvania (US)
- Venue
- Anesthesiology
- Published
- 2011-10-01
- Volume
- 115
- Issue
- 4
- Pages
- 702-712
- ISSN
- 0003-3022 (ISSN-L)
- PMC
- PMC3178044
- OpenAlex
- W1965014070
- Cited by
- 79
- References
- 66
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 5 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 6
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Anesthesiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (K08GM077357, GM077357, GM088156, R01GM088156)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Keywords
- REM sleep rebound, volatile anesthetics, isoflurane, sevoflurane, halothane, propofol, sleep deprivation, NREM sleep, mice
- MeSH terms
- Sevoflurane, Anesthesia, Inhalation, Animals, Electrodes, Implanted, Electroencephalography, Electromyography, Halothane, Isoflurane, Male, Methyl Ethers, Mice, Inbred C57BL, Sleep, Sleep Deprivation, Sleep, REM, Propofol, Polysomnography, Anesthetics, Inhalation, Anesthetics, Intravenous, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
