The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Ketamine-induced Neuroapoptosis in the Fetal and Neonatal Rhesus Macaque Brain
Open accessAbstract
Background: Exposure of rhesus macaque fetuses for 24 h or neonates for 9 h to ketamine anesthesia causes neuroapoptosis in the developing brain. The current study clarifies the minimum exposure required for and the extent and spatial distribution of ketamine-induced neuroapoptosis in rhesus fetuses and neonates. Method: Ketamine was administered by IV infusion for 5 h to postnatal day 6 rhesus neonates or to pregnant rhesus females at 120 days' gestation (full term = 165 days). Three hours later, fetuses were delivered by cesarean section, and the fetal and neonatal brains were studied for evidence of apoptotic neurodegeneration, as determined by activated caspase-3 staining. Results: Both the fetal (n = 3) and neonatal (n = 4) ketamine-exposed brains had a significant increase in apoptotic profiles compared with drug-naive controls (fetal n = 4; neonatal n = 5). Loss of neurons attributable to ketamine exposure was 2.2 times greater in fetuses than in neonates. The pattern of neurodegeneration in fetuses was different from that in neonates, and all subjects exposed at either age had a pattern characteristic for that age. Conclusion: The developing rhesus macaque brain is sensitive to the apoptogenic action of ketamine at both a fetal and neonatal age, and exposure duration of 5 h is sufficient to induce a significant neuroapoptosis response at either age. The pattern of neurodegeneration induced by ketamine in fetuses was different from that in neonates, and loss of neurons attributable to ketamine exposure was 2.2 times greater in the fetal than neonatal brains.
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Cites
Comparative aspects of the brain growth spurt
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Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain
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Self-citationJevtovic-Todorovic, V., Hartman, R. E., Izumi, Y., Benshoff, N. D., Dikranian, K., Zorumski, C. F., Olney, J. W., & Wozniak, D. F. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00876.2003 · Cited by 1,983
Self-citationEthanol-Induced Apoptotic Neurodegeneration and Fetal Alcohol Syndrome
Ikonomidou, C., Bittigau, P., Ishimaru, M. J., Wozniak, D. F., Koch, C., Genz, K., Price, M. T., Stefovska, V., Hörster, F., Tenkova, T., et al. (2000) · Science · doi:10.1126/science.287.5455.1056 · Cited by 1,371
Self-citationEarly Exposure to Anesthesia and Learning Disabilities in a Population-based Birth Cohort
Wilder, R. T., Flick, R. P., Sprung, J., Katusic, S. K., Barbaresi, W. J., Mickelson, C., Gleich, S. J., Schroeder, D. R., Weaver, A. L., & Warner, D. O. (2009) · Anesthesiology · doi:10.1097/01.anes.0000344728.34332.5d · Cited by 1,364
Antiepileptic drugs and apoptotic neurodegeneration in the developing brain
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Self-citationFetal Alcohol Spectrum Disorders: An Overview with Emphasis on Changes in Brain and Behavior
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Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey
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Isoflurane-induced Neuroapoptosis in the Neonatal Rhesus Macaque Brain
Brambrink, A. M., Evers, A. S., Avidan, M. S., Farber, N. B., Smith, D. J., Zhang, X., Dissen, G. A., Creeley, C. E., & Olney, J. W. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181d049cd · Cited by 594
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Creeley, C., Dikranian, K., Dissen, G., Martin, L., Olney, J., & Brambrink, A. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet173 · Cited by 468
Self-citationAnesthetic Neurotoxicity — Clinical Implications of Animal Models
Rappaport, B. A., Suresh, S., Hertz, S., Evers, A. S., & Orser, B. A. (2015) · New England Journal of Medicine · doi:10.1056/nejmp1414786 · Cited by 327
Self-citationIsoflurane‐induced apoptosis of oligodendrocytes in the neonatal primate brain
Brambrink, A. M., Back, S. A., Riddle, A., Gong, X., Moravec, M. D., Dissen, G. A., Creeley, C. E., Dikranian, K. T., & Olney, J. W. (2012) · Annals of Neurology · doi:10.1002/ana.23652 · Cited by 264
Self-citationMechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148
Metadata
- Authors
- Brambrink, A. M., Evers, A. S., Avidan, M. S., Farber, N. B., Smith, D. J., Martin, L. D., Dissen, G. A., Creeley, C. E., & Olney, J. W.
- Venue
- Anesthesiology
- Published
- 2012-02-01
- Volume
- 116
- Issue
- 2
- Pages
- 372-384
- ISSN
- 0003-3022 (ISSN-L)
- OpenAlex
- W2165399323
- Cited by
- 425
- References
- 39
- FWCI
- 9.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Brambrink, A. M., Evers, A. S., Avidan, M. S., Farber, N. B., Smith, D. J., Martin, L. D., Dissen, G. A., Creeley, C. E., & Olney, J. W. (2012). Ketamine-induced Neuroapoptosis in the Fetal and Neonatal Rhesus Macaque Brain. Anesthesiology. https://doi.org/10.1097/aln.0b013e318242b2cd
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