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Cited by 608

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey

Slikker, W., Zou, X., Hotchkiss, C. E., Divine, R. L., Sadovova, N., Twaddle, N. C., Doerge, D. R., Scallet, A. C., Patterson, T. A., Hanig, J. P., Paule, M. G., Wang, C.·2007·Toxicological Sciences
DOI 10.1093/toxsci/kfm084
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Abstract

Ketamine is widely used as a pediatric anesthetic. Studies in developing rodents have indicated that ketamine-induced anesthesia results in brain cell death. Additional studies are needed to determine if ketamine anesthesia results in brain cell death in the nonhuman primate and if so, to begin to define the stage of development and the duration of ketamine anesthesia necessary to produce brain cell death. Rhesus monkeys (N = 3 for each treatment and control group) at three stages of development (122 days of gestation and 5 and 35 postnatal days [PNDs]) were administered ketamine intravenously for 24 h to maintain a surgical anesthetic plane, followed by a 6-h withdrawal period. Similar studies were performed in PND 5 animals with 3 h of ketamine anesthesia. Animals were subsequently perfused and brain tissue processed for analyses. Ketamine (24-h infusion) produced a significant increase in the number of caspase 3-, Fluoro-Jade C- and silver stain-positive cells in the cortex of gestational and PND 5 animals but not in PND 35 animals. Electron microscopy indicated typical nuclear condensation and fragmentation in some neuronal cells, and cell body swelling was observed in others indicating that ketamine-induced neuronal cell death is most likely both apoptotic and necrotic in nature. Ketamine increased N-methyl-D-aspartate (NMDA) receptor NR1 subunit messenger RNA in the frontal cortex where enhanced cell death was apparent. Earlier developmental stages (122 days of gestation and 5 PNDs) appear more sensitive to ketamine-induced neuronal cell death than later in development (35 PNDs). However, a shorter duration of ketamine anesthesia (3 h) did not result in neuronal cell death in the 5-day-old monkey.

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Metadata

Authors
Slikker, W., Zou, X., Hotchkiss, C. E., Divine, R. L., Sadovova, N., Twaddle, N. C., Doerge, D. R., Scallet, A. C., Patterson, T. A., Hanig, J. P., Paule, M. G., & Wang, C.
Venue
Toxicological Sciences
Publisher
Oxford University Press (OUP)
Published
2007-04-10
Volume
98
Issue
1
Pages
145-158
ISSN
  • 1096-0929 (ISSN-L)
  • 1096-6080
DOI
10.1093/toxsci/kfm084
OpenAlex
W2096356147
Cited by
608
References
53
FWCI
8.19
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey. https://app.cochat.ai/papers/10.1093/toxsci/kfm084
The paper
Slikker, W., Zou, X., Hotchkiss, C. E., Divine, R. L., Sadovova, N., Twaddle, N. C., Doerge, D. R., Scallet, A. C., Patterson, T. A., Hanig, J. P., Paule, M. G., & Wang, C. (2007). Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey. Toxicological Sciences. https://doi.org/10.1093/toxsci/kfm084

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.