Lidocaine Patch (5%) in Treatment of Persistent Inguinal Postherniorrhaphy Pain: A Randomized, Double-blind, Placebo-controlled, Crossover Trial
Open accessAbstract
Background: Evidence-based pharmacological treatment options for patients with persistent inguinal postherniorrhaphy pain are lacking. Methods: Twenty-one male patients, with severe, unilateral, persistent inguinal postherniorrhaphy pain, participated in a randomized, double-blind, placebo-controlled crossover trial, receiving lidocaine patch (5%) and placebo patch treatments in periods of 14 days separated by a 14-day wash-out period. Pain intensities (at rest, during movement, and pressure evoked [Numerical Rating Scale]) were assessed before treatment and on the last 3 days of each treatment period. Patients were a priori divided into two subgroups based on quantitative sensory testing (+/− thermal “hyposensitivity”). Skin biopsies for intraepidermal nerve fiber density assessment were taken at baseline, and quantitative sensory testing was performed before and after each treatment period. The primary outcome was change in pain intensity assessed as the difference in summed pain intensity differences between lidocaine and placebo patch treatments. Results: There was no difference in summed pain intensity differences between lidocaine and placebo patch treatments in all patients (mean difference 6.2% [95% CI = −6.6 to 18.9%]; P = 0.33) or in the two subgroups (+/− thermal “hyposensitivity”). The quantitative sensory testing (n = 21) demonstrated an increased pressure pain thresholds after lidocaine compared with placebo patch treatment. Baseline intraepidermal nerve fiber density (n = 21) was lower on the pain side compared with the nonpain side (−3.8 fibers per millimeter [95% CI = −6.1 to −1.4]; P = 0.003). One patient developed mild erythema in the groin during both treatments. Conclusions: Lidocaine patch treatment did not reduce combined resting and dynamic pain ratings compared with placebo in patients with severe, persistent inguinal postherniorrhaphy pain.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A randomized, double-blind, placebo-controlled, cross-over trial among 21 male patients having unilateral severe persistent inguinal pain following herniorrhaphy showed no significant improvement with a 14-day application of a 5% lidocaine patch.
“A randomized, double-blind, placebo-controlled, cross-over trial among 21 male patient having unilateral severe persistent inguinal pain following herniorrhaphy, showed no significant improvement with a 14-day application of a 5% lidocaine patch [56].”
From Chronic postsurgical pain: current evidence for prevention and management (2018) · cites this paper as [56]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
The Pain Catastrophizing Scale: Development and validation.
Sullivan, M. J. L., Bishop, S. R., & Pivik, J. (1995) · Psychological Assessment · doi:10.1037//1040-3590.7.4.524 · Cited by 8,227 · see citing works
Central sensitization: implications for the diagnosis and treatment of pain
Woolf, C. J. (2011) · Pain · doi:10.1016/j.pain.2010.09.030 · Cited by 4,771 · see citing works
Persistent postsurgical pain: risk factors and prevention
Kehlet, H., Jensen, T. S., & Woolf, C. J. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68700-x · Cited by 4,086 · see citing works
Self-citationNeuropathic pain: diagnosis, pathophysiological mechanisms, and treatment
Baron, R., Binder, A., & Wasner, G. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70143-5 · Cited by 1,816 · see citing works
Dworkin, R. H., O'connor, A., Audette, J. F., Baron, R., Gourlay, G. K., Haanpää, M. L., Kent, J. L., Krane, E. J., Lebel, A., Levy, R. M., et al. (2010) · Mayo Clinic Proceedings · doi:10.4065/mcp.2009.0649 · Cited by 1,324 · see citing works
Bennett, M., Smith, B. H., Torrance, N., & Potter, J. (2005) · Journal of Pain · doi:10.1016/j.jpain.2004.11.007 · Cited by 693 · see citing works
Lidocaine patch: double-blind controlled study of a new treatment method for post-herpetic neuralgia
Rowbotham, M. C., Davies, P. S., Verkempinck, C., & Galer, B. S. (1996) · Pain · doi:10.1016/0304-3959(95)00146-8 · Cited by 525 · see citing works
Botulinum toxin type a induces direct analgesic effects in chronic neuropathic pain
Ranoux, D., Attal, N., Morain, F., & Bouhassira, D. (2008) · Annals of Neurology · doi:10.1002/ana.21427 · Cited by 456 · see citing works
Chronic pain after mesh repair of inguinal hernia: a systematic review
Nienhuijs, S. W., Staal, E., Strobbe, L. J. A., Rosman, C., Groenewoud, H., & Bleichrodt, R. P. (2007) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2007.02.012 · Cited by 416 · see citing works
Meier, T., Wasner, G. L., Faust, M., Küntzer, T., Ochsner, F., Hueppe, M., Bogousslavsky, J., & Baron, R. (2003) · Pain · doi:10.1016/s0304-3959(03)00317-8 · Cited by 367 · see citing works
Risk Factors for Long-term Pain After Hernia Surgery
nneby, U. F., Sandblom, G., Nordin, P., Nyr??n, O., & Gunnarsson, U. (2006) · Annals of Surgery · doi:10.1097/01.sla.0000218081.53940.01 · Cited by 366 · see citing works
Baron, R., Förster, M., & Binder, A. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70189-8 · Cited by 262 · see citing works
Gammaitoni, A. R., Álvarez, N. A., & Galer, B. S. (2003) · The Journal of Clinical Pharmacology · doi:10.1177/0091270002239817 · Cited by 201 · see citing works
Randomized control trial of topical clonidine for treatment of painful diabetic neuropathy
Campbell, C. M., Kipnes, M. S., Stouch, B. C., Brady, K. L., Kelly, M., Schmidt, W. K., Petersen, K. L., Rowbotham, M. C., & Campbell, J. N. (2012) · Pain · doi:10.1016/j.pain.2012.04.014 · Cited by 165 · see citing works
Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies
Vlčková, E., Bednařík, J., Dušek, L., Toyka, K. V., & Sommer, C. (2007) · Muscle & Nerve · doi:10.1002/mus.20889 · Cited by 158 · see citing works
Self-citationPain and Sensory Dysfunction 6 to 12 Months After Inguinal Herniotomy
Mikkelsen, T., Werner, M. U., Lassen, B., & Kehlet, H. (2004) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000115147.14626.c5 · Cited by 156 · see citing works
Self-citationPostherpetic neuralgia: Topical lidocaine is effective in nociceptor–deprived skin
Wasner, G. L., Kleinert, A., Binder, A., Schattschneider, J., & Baron, R. (2005) · Journal of Neurology · doi:10.1007/s00415-005-0717-z · Cited by 154 · see citing works
Basal Heat Pain Thresholds Predict Opioid Analgesia in Patients with Postherpetic Neuralgia
Edwards, R. R., Haythornthwaite, J. A., Tella, P. K., Max, M. B., & Raja, S. N. (2006) · Anesthesiology · doi:10.1097/00000542-200606000-00020 · Cited by 140 · see citing works
The Two-Period Crossover Design in Medical Research
Woods, J. R., Williams, J. G., & Tavel, M. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-110-7-560 · Cited by 139 · see citing works
Kalliomäki, M., Meyerson, J., Gunnarsson, U., Gordh, T., & Sandblom, G. (2007) · European Journal of Pain · doi:10.1016/j.ejpain.2007.05.006 · Cited by 130 · see citing works
Hans, G. H., Sabatowski, R., Binder, A., Boesl, I., Rogers, P. D., & Baron, R. (2009) · Current Medical Research and Opinion · doi:10.1185/03007990902901368 · Cited by 91 · see citing works
Lidocaine patch (5%) produces a selective, but incomplete block of Aδ and C fibers
Krumova, E. K., Zeller, M., Westermann, A., & Maier, C. (2011) · Pain · doi:10.1016/j.pain.2011.08.020 · Cited by 89 · see citing works
Functional and structural nerve fiber findings in heterozygote patients with Fabry disease
Møller, A. T., Bach, F. W., Feldt‐Rasmussen, U., Rasmussen, Å. K., Hasholt, L., He, L., Sommer, C., Kølvraa, S., Ballegaard, M., & Jensen, T. S. (2009) · Pain · doi:10.1016/j.pain.2009.06.032 · Cited by 82 · see citing works
Self-citationTopical pain management with the 5% lidocaine medicated plaster – a review
Mick, G., & Correa‐Illanes, G. (2012) · Current Medical Research and Opinion · doi:10.1185/03007995.2012.690339 · Cited by 81 · see citing works
Heterogeneous sensory processing in persistent postherniotomy pain
Aasvang, E. K., Brandsborg, B., Jensen, T. S., & Kehlet, H. (2010) · Pain · doi:10.1016/j.pain.2010.03.025 · Cited by 68 · see citing works
Self-citationHerrmann, D. N., Pannoni, V., Barbano, R. L., Pennella‐Vaughan, J., & Dworkin, R. H. (2005) · Muscle & Nerve · doi:10.1002/mus.20419 · Cited by 58 · see citing works
Vernon, M., Brandenburg, N. A., Alvir, J. M. J., Griesing, T. A., & Revicki, D. A. (2008) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2007.09.016 · Cited by 51 · see citing works
Lidocaine 5% Medicated Plaster
Garnock-Jones, K. P., & Keating, G. M. (2009) · Drugs · doi:10.2165/11203220-000000000-00000 · Cited by 45 · see citing works
Wehrfritz, A., Namerl, B., Ihmsenl, H., et al. (2011) · European Journal of Pain · doi:10.1016/j.ejpain.2011.03.011 · Cited by 43 · see citing works
Hans, G. H., Joukes, E., Verhulst, J., & VERCAUTEREN, M. P. (2009) · Current Medical Research and Opinion · doi:10.1185/03007990903282297 · Cited by 40 · see citing works
Treatment of Neuropathic Pain with 5% Lidocaine‐Medicated Plaster: Five Years of Clinical Experience
Delorme, C., Navez, M. L., Legout, V., Deleens, R., & Moyse, D. (2011) · Pain Research and Management · doi:10.1155/2011/359591 · Cited by 26 · see citing works
Tailored treatment of peripheral neuropathic pain
Sindrup, S. H., Finnerup, N. B., & Jensen, T. S. (2012) · Pain · doi:10.1016/j.pain.2012.06.002 · Cited by 13 · see citing works
How does topical lidocaine relieve pain
Campbell, J. N. (2011) · Pain · doi:10.1016/j.pain.2011.10.011 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Demant, D. T., Lund, K., Vollert, J., Maier, C., Segerdahl, M., Finnerup, N. B., Jensen, T. S., & Sindrup, S. H. (2014) · Pain · doi:10.1016/j.pain.2014.08.014 · Cited by 440 · see citing works
Chronic postsurgical pain: current evidence for prevention and management
Thapa, P., & Euasobhon, P. (2018) · The Korean Journal of Pain · doi:10.3344/kjp.2018.31.3.155 · Cited by 177 · see citing works
- Authors
- Bischoff, J. M., Petersen, M., Üçeyler, N., Sommer, C., Kehlet, H., & Werner, M. U.
- Affiliations
- University of Copenhagen (DK)
- Research Nurse
- Assistant Professor
- Universitätsklinikum Würzburg (DE)
- Venue
- Anesthesiology
- Published
- 2013-12
- Volume
- 119
- Issue
- 6
- Pages
- 1444-1452
- ISSN
- 0003-3022 (ISSN-L)
- OpenAlex
- W2103852840
- Cited by
- 53
- References
- 34
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 10 · 2017: 2 · 2016: 9 · 2015: 2 · 2014: 5
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Anesthesiology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- European Federation of Pharmaceutical Industries and Associations (FP7/20072013)
- European Commission (115007, 2007–2013, FP7 2007-2013, FP7/2007)
- Rigshospitalet
- Innovative Medicines Initiative (FP7/2007‐2013, 115007)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Surgery › Hernia repair and management
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- lidocaine patch, chronic postoperative pain, inguinal hernia repair, topical analgesia, quantitative sensory testing, pressure pain threshold, intraepidermal nerve fiber density
- MeSH terms
- Adult, Aged, Anesthetics, Local, Double-Blind Method, Female, Hernia, Inguinal, Humans, Lidocaine, Male, Middle Aged, Nerve Fibers, Pain Measurement, Postoperative Pain, Sensory Thresholds, Skin, Sleep Wake Disorders, Patient Satisfaction, Cross-Over Studies, Endpoint Determination, Transdermal Patch, Herniorrhaphy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
