Adverse Effects of Antenatal Glucocorticoids on Cerebral Myelination in Sheep
Abstract
OBJECTIVE: To determine in fetal sheep the effect of betamethasone on myelination in relation to stage of myelination, number of treatment courses, dose, and route of administration. METHODS: Fetal expression of myelin basic protein (MBP), a marker of mature oligodendrocytes and myelin, was determined between 0.27 and 0.93 gestation. Short-term betamethasone effects were examined 24 hours after one maternal intramuscular treatment course (weight adjusted to equal the clinical dose of 2 x 8 mg betamethasone to a 70-kg woman) at 0.63, 0.75, and 0.87 gestation or after continuous 48-hour fetal intravenous infusion at 0.75 and 0.87 gestation. Lasting effects were examined 20 days after one and two treatment courses weight-adapted to the clinical dose of 2 x 8 mg or 2 x 12 mg betamethasone at 0.75 gestation. RESULTS: Myelin basic protein immunoreactivity was first detected in the internal capsule at 0.53 gestation, followed by the centrum semiovale, the superficial white matter, and corpus callosum at 0.63 gestation. Within 24 hours after treatment, betamethasone reduced the number of mature oligodendrocytes and MBP immunoreactivity. The effect decreased with gestational age. Maternal and fetal betamethasone administration had similar effects. Loss of MBP immunoreactivity was not reversed 20 days after two treatment courses, independent of dose. CONCLUSION: Betamethasone-induced delayed cerebral myelination is dependent on the stage of brain development in sheep. Betamethasone-related disturbances in myelination and any potential contribution to childhood behavior deficits need to be confirmed in clinical studies.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Underdosing raises the risk of RDS, while overdosing increases neurodevelopmental toxicity, such as cognitive impairment, by up to 1.8-fold in exposed infants.
“Underdosing raises the risk of RDS, while overdosing increases neurodevelopmental toxicity, such as cognitive impairment, by up to 1.8-fold in exposed infants (3).”
From Placenta-pulmonary coupling-guided multimodal AI for fetal lung maturity staging and individualized glucocorticoid therapy (2026) · cites this paper as [3]
Cites
1 retracted
Owen, D., Andrews, M. H., & Matthews, S. G. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.10.004 · Cited by 207 · see citing works
RetractedA Simple Sequentially Rejective Multiple Test Procedure
(1979) · Scandinavian Journal of Statistics · doi:10.2307/4615733 · Cited by 21,526 · see citing works
Liggins, G. C., & Howie, R. N. (1972) · Pediatrics · doi:10.1542/peds.50.4.515 · Cited by 2,544 · see citing works
Comparative aspects of the brain growth spurt
Dobbing, J., & Sands, J. (1979) · Early Human Development · doi:10.1016/0378-3782(79)90022-7 · Cited by 2,506 · see citing works
Back, S. A., Luo, N. L., Borenstein, N. S., Levine, J. M., Volpe, J. J., & Kinney, H. C. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01302.2001 · Cited by 936 · see citing works
PREMATURE DELIVERY OF FOETAL LAMBS INFUSED WITH GLUCOCORTICOIDS
LIGGINS, G. C. (1969) · Journal of Endocrinology · doi:10.1677/joe.0.0450515 · Cited by 817 · see citing works
Barrès, A., Lazar, M. A., & RAFF, M. C. (1994) · Development · doi:10.1242/dev.120.5.1097 · Cited by 593 · see citing works
Repeated antenatal corticosteroids: Size at birth and subsequent development
French, N., Hagan, R., Evans, S. F., Godfrey, M., & Newnham, J. P. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70160-2 · Cited by 556 · see citing works
Schmithorst, V. J., Wilke, M., Dardzinski, B. J., & Holland, S. K. (2005) · Human Brain Mapping · doi:10.1002/hbm.20149 · Cited by 382 · see citing works
Long-term outcomes after repeat doses of antenatal corticosteroids
Wapner, R. J., Sorokin, Y., Mele, L., Johnson, F., Dudley, D. J., Spong, C. Y., Peaceman, A. M., Leveno, K. J., Malone, F., Caritis, S. N., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa071453 · Cited by 336 · see citing works
Outcomes at 2 Years of Age after Repeat Doses of Antenatal Corticosteroids
Crowther, C. A., Doyle, L. W., Haslam, R. R., Hiller, J. E., Harding, J. E., & Robinson, J. S. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa071152 · Cited by 286 · see citing works
Banks, B. A., Cnaan, A., Morgan, M., Parer, J., Merrill, J., Ballard, P., & Ballard, R. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70517-x · Cited by 283 · see citing works
Repeated antenatal corticosteroids: Effects on cerebral palsy and childhood behavior
French, N., Hagan, R., Evans, S. F., Mullan, A., & Newnham, J. P. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2003.12.016 · Cited by 279 · see citing works
Sternberger, N. H., Itoyama, Y., Kies, M. W., & Webster, H. D. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.5.2521 · Cited by 270 · see citing works
Repeated prenatal corticosteroids delay myelination in the ovine central nervous system
Dunlop, S. A., Archer, M. A., Quinlivan, J. A., Beazley, L. D., & Newnham, J. P. (1997) · The Journal of Maternal-Fetal Medicine · doi:10.1002/(sici)1520-6661(199711/12)6:6 · Cited by 228 · see citing works
The foetal sheep: Morphogenesis of the nervous system and histochemical aspects of myelination
Barlow, R. M. (1969) · The Journal of Comparative Neurology · doi:10.1002/cne.901350302 · Cited by 217 · see citing works
Dalziel, S. R., Lim, V. K., Lambert, A. J., McCarthy, D., Parag, V., Rodgers, A., & Harding, J. E. (2005) · BMJ · doi:10.1136/bmj.38576.494363.e0 · Cited by 199 · see citing works
Twenty-Year Follow-Up of Antenatal Corticosteroid Treatment
Dessens, A. B., Haas, H. S., & Koppe, J. G. (2000) · PEDIATRICS · doi:10.1542/peds.105.6.e77 · Cited by 189 · see citing works
How and why do the two cerebral hemispheres interact?
Hoptman, M. J., & Davidson, R. J. (1994) · Psychological Bulletin · doi:10.1037/0033-2909.116.2.195 · Cited by 185 · see citing works
Glucocorticoids and progestins signal the initiation and enhance the rate of myelin formation
Chan, J. R., Phillips, L. J., & Gläser, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10459 · Cited by 177 · see citing works
Derks, J. B., Giussani, D. A., Jenkins, S. L., Wentworth, R. A., Visser, G. H. A., Padbury, J. F., & Nathanielsz, P. W. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp021922 · Cited by 168 · see citing works
Self-citationThe Effects of Repeated Antenatal Glucocorticoid Therapy on the Developing Brain
Modi, N., Lewis, H., Al-Naqeeb, N., Ajayi-Obe, M., Doré, C. J., & Rutherford, M. (2001) · Pediatric Research · doi:10.1203/00006450-200111000-00008 · Cited by 160 · see citing works
Abbasi, S., Hirsch, D., Davis, J. M., Tolosa, J. E., Stouffer, N. O., Debbs, R. H., & Gerdes, J. S. (2000) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2000.104789 · Cited by 155 · see citing works
Huang, W.-L., Harper, C., Evans, S., Newnham, J., & Dunlop, S. (2001) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(01)00026-0 · Cited by 147 · see citing works
Effects of antenatal dexamethasone administration in the infant: Long-term follow-up
(1984) · The Journal of Pediatrics · doi:10.1016/s0022-3476(84)81009-4 · Cited by 145 · see citing works
Hasegawa, M., Houdou, S., Mito, T., Takashima, S., Asanuma, K., & Ohno, T. (1992) · Brain and Development · doi:10.1016/s0387-7604(12)80271-3 · Cited by 137 · see citing works
Sequence of oligodendrocyte development in the human fetal telencephalon
Jakovčevski, I., & Zečević, N. (2004) · Glia · doi:10.1002/glia.20134 · Cited by 135 · see citing works
Antonow‐Schlorke, I., Schwab, M., Li, C. Y., & Nathanielsz, P. W. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.025700 · Cited by 124 · see citing works
Self-citationBack, S. A., Riddle, A., & Hohimer, A. R. (2006) · Journal of Child Neurology · doi:10.1177/08830738060210070101 · Cited by 115 · see citing works
Kumar, S., Cole, R., Chiappelli, F., & de Vellis, J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.17.6807 · Cited by 109 · see citing works
Hartman, B. K., Agrawal, H. C., Kalmbach, S., & Shearer, W. T. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901880206 · Cited by 109 · see citing works
Synthetic glucocorticoids: antenatal administration and long-term implications.
Sloboda, D., Challis, J., Moss, T., & Newnham, J. (2005) · Current pharmaceutical design · doi:10.2174/1381612053507873 · Cited by 106 · see citing works
MEADOW, W. L. (2003) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(03)00510-6 · Cited by 100 · see citing works
Antenatal glucocorticoids and growth: single versus multiple doses in animal and human studies
Newnham, J. P., & Moss, T. J. M. (2001) · Seminars in Neonatology · doi:10.1053/siny.2001.0064 · Cited by 97 · see citing works
Schmand, B. A., Neuvel, J., Haas, H. S., Hoeks, J., Treffers, P. E., & Koppe, J. G. (1990) · PEDIATRICS · doi:10.1542/peds.86.1.58 · Cited by 94 · see citing works
Developmental partitioning of myelin basic protein into membrane microdomains
DeBruin, L. S., Haines, J. D., Wellhauser, L. A., Radeva, G., Schonmann, V., Bienzle, D., & Harauz, G. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20452 · Cited by 81 · see citing works
Multiple courses of antenatal steroids: risks and benefits
Walfisch, A. (2001) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(01)01368-0 · Cited by 80 · see citing works
Fetal body weight and the development of the control of the cardiovascular system in fetal sheep
Frasch, M. G., Müller, T. M., Wicher, C., Weiss, C., Löhle, M., Schwab, K., Schubert, H., Nathanielsz, P. W., Witte, O. W., & Schwab, M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.124800 · Cited by 60 · see citing works
Self-citationSchwab, M. G., Antonow‐Schlorke, I., Kühn, B., Müller, T. M., Schubert, H., Walter, B. L., Sliwka, U., & Nathanielsz, P. W. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0497k.x · Cited by 47 · see citing works
Self-citationCell Biology and Pathology of Myelin: Evolving Biological Concepts and Therapeutic Approaches
Juurlink, B. H. J., Doucette, J. R., Devon, R. M., & Verge, V. M. K. (1997) · The Neuroscientist · doi:10.1177/107385849700300111 · Cited by 46 · see citing works
Gardner, D. S., Fowden, A. L., & Giussani, D. A. (2002) · Circulation · doi:10.1161/01.cir.0000033827.48974.c8 · Cited by 42 · see citing works
Quinlivan, J. A., Dunlop, S. A., Newnham, J. P., Evans, S. F., & Beazley, L. (1999) · UWA Profiles and Research Repository (UWA) · Cited by 39 · see citing works
Early expression of proteolipid protein in human fetal and infantile cerebri
Iai, M., Yamamura, T., & Takashima, S. (1997) · Pediatric Neurology · doi:10.1016/s0887-8994(97)00099-4 · Cited by 35 · see citing works
Antonow‐Schlorke, I., Kühn, B., Müller, T. H., Schubert, H., Sliwka, U., Nathanielsz, P. W., & Schwab, M. G. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01605-0 · Cited by 32 · see citing works
Self-citationFletcher, A. J. W., Hong, X., Wu, W. X., Nathanielsz, P. W., McGARRIGLE, H. H. G., Fowden, A. L., & Giussani, D. A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00158.2003 · Cited by 28 · see citing works
Self-citationPosttranscriptional Regulation of Myelin Protein Gene Expressiona
Campagnoni, A. T., Verdi, J. M., Verity, A. N., Amur-Umarjee, S. G., & Byravan, S. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb15608.x · Cited by 28 · see citing works
Quinlivan, J. A., Dunlop, S., Newnham, J. P., Evans, S. F., & Beazley, L. (1999) · UWA Profiles and Research Repository (UWA) · Cited by 24 · see citing works
Schwab, M. G., Coksaygan, T., Samtani, M. N., Jusko, W. J., & Nathanielsz, P. W. (2006) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000232815.80648.01 · Cited by 19 · see citing works
Self-citationColberg, C., Antonow‐Schlorke, I., Müller, T. M., Schubert, H., Witte, O. W., & Schwab, M. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.04.052 · Cited by 16 · see citing works
Self-citationRocha, E., Totten, S., Hammond, R. R., Han, V. K. M., & Richardson, B. S. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.01.049 · Cited by 13 · see citing works
Antonow‐Schlorke, I., Müller, T. M., Brodhun, M., Wicher, C., Schubert, H., Nathanielsz, P. W., Witte, O. W., & Schwab, M. G. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.10.898 · Cited by 11 · see citing works
Self-citationNg, S. M., Turner, M. A., Gamble, C. L., Didi, M., Victor, S., Malamateniou, C., Parkes, L. M., Tietze, A., Gregory, L. J., Sluming, V., et al. (2008) · BMC Pediatrics · doi:10.1186/1471-2431-8-26 · Cited by 4 · see citing works
(2006) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000190363.13536.c5 · Cited by 3 · see citing works
Flagged first, then by citations
1 of the 55 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Glucocorticoids, prenatal stress and the programming of disease
Harris, A., & Seckl, J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.06.007 · Cited by 871 · see citing works
Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus
Chetty, S., Friedman, A., Taravosh-Lahn, K., Kirby, E. D., Mirescu, C., Guo, F., Krupik, D., Nicholas, A., Geraghty, A., Krishnamurthy, A., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.190 · Cited by 245 · see citing works
Fetal Glucocorticoid Exposure Is Associated with Preadolescent Brain Development
Davis, E. P., Sandman, C. A., Buß, C., Wing, D. A., & Head, K. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.009 · Cited by 203 · see citing works
Braun, T., Challis, J. R., Newnham, J. P., & Sloboda, D. M. (2013) · Endocrine Reviews · doi:10.1210/er.2013-1012 · Cited by 196 · see citing works
Maternal hormonal milieu influence on fetal brain development
Miranda, A., & Sousa, N. (2018) · Brain and Behavior · doi:10.1002/brb3.920 · Cited by 191 · see citing works
Waffarn, F., & Davis, E. P. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.06.012 · Cited by 148 · see citing works
Chronic Lung Disease in the Preterm Infant. Lessons Learned from Animal Models
Hilgendorff, A., Reiss, I. K. M., Ehrhardt, H., Eickelberg, O., & Alvira, C. M. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0014tr · Cited by 148 · see citing works
Does prenatal stress alter the developing connectome?
Scheinost, D., Sinha, R., Cross, S., Kwon, S. H., Sze, G. K., Constable, R. T., & Ment, L. R. (2016) · Pediatric Research · doi:10.1038/pr.2016.197 · Cited by 143 · see citing works
Li, Y., Gonzalez, P., & Zhang, L. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.05.010 · Cited by 131 · see citing works
Responses of Glial Cells to Stress and Glucocorticoids
Jáuregui-Huerta, F., Ruvalcaba-Delgadillo, Y., González-Pérez, Ó., González-Castañeda, R. E., Garcı́a‐Estrada, J., & Luquı́n, S. (2010) · Current Immunology Reviews · doi:10.2174/157339510791823790 · Cited by 127 · see citing works
Prenatal maternal cortisol concentrations predict neurodevelopment in middle childhood
Davis, E. P., Head, K., Buß, C., & Sandman, C. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.10.005 · Cited by 110 · see citing works
Dennis, E. L., Disner, S. G., Fani, N., Salminen, L. E., Logue, M. W., Clarke‐Rubright, E. K., Haswell, C. C., Averill, C. L., Baugh, L. A., Bomyea, J. A., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0631-x · Cited by 108 · see citing works
Howell, B., McCormack, K. M., Grand, A. P., Sawyer, N. T., Zhang, X., Maestripieri, D., Hu, X. P., & Sánchez, M. M. (2013) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-3-21 · Cited by 107 · see citing works
Preventing Brain Injury in the Preterm Infant—Current Controversies and Potential Therapies
Yates, N. J., Gunn, A. J., Bennet, L., Dhillon, S. K., & Davidson, J. O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041671 · Cited by 101 · see citing works
Repeated antenatal corticosteroid treatment: a systematic review and meta-analysis
Peltoniemi, O. M., Kari, M. A., & Hallman, M. (2011) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/j.1600-0412.2011.01132.x · Cited by 72 · see citing works
Victoria, N. C., & Murphy, A. Z. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.07.017 · Cited by 67 · see citing works
Long, N., Ford, S. P., & Nathanielsz, P. W. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.12.014 · Cited by 60 · see citing works
Self-citationChao, L. L., Tosun, D., Woodward, S. H., Kaufer, D., & Neylan, T. C. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00333 · Cited by 56 · see citing works
Deshmukh, M., & Patole, S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248774 · Cited by 54 · see citing works
Steroids and Injury to the Developing Brain
Malaeb, S., & Stonestreet, B. (2014) · Clinics of Perinatology · doi:10.1016/j.clp.2013.09.006 · Cited by 47 · see citing works
Maturana, C. J., Aguirre, A., & Sáez, J. C. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22409 · Cited by 51 · see citing works
Salpietro, V., Polizzi, A., Rosa, G. D., Romeo, A. C., Dipasquale, V., Morabito, P., Chirico, V., Arrigo, T., & Ruggieri, M. (2014) · International Journal of Endocrinology · doi:10.1155/2014/282489 · Cited by 51 · see citing works
Developmental origins of infant stress reactivity profiles: A multi‐system approach
Rash, J. A., Thomas, J. C., Campbell, T. S., Letourneau, N. L., Granger, D. A., Giesbrecht, G. F., & the APrON Study Team (2016) · Developmental Psychobiology · doi:10.1002/dev.21403 · Cited by 50 · see citing works
Frasch, M. G., Lobmaier, S. M., Stampalija, T., Desplats, P., Pallarés, M. E., Pastor, V. E., Brocco, M. A., Wu, H., Schulkin, J. A., Herry, C. L., et al. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.026 · Cited by 43 · see citing works
Fitzgerald, E., Boardman, J. P., & Drake, A. J. (2018) · Current Genomics · doi:10.2174/1389202919666171229144807 · Cited by 44 · see citing works
Neural plasticity and the K ennard principle: does it work for the preterm brain?
Bennet, L., van den Heuij, L. G., Dean, J. M., Drury, P. P., Wassink, G., & Gunn, A. J. (2013) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12135 · Cited by 40 · see citing works
Kemp, M. W., Saito, M., Usuda, H., Molloy, T. J., Miura, Y., Sato, S., Watanabe, S., Clarke, M. W., Fossler, M. J., Scmidt, A., et al. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.08.017 · Cited by 40 · see citing works
Antenatal glucocorticoids: where are we after forty years?
McKinlay, C. J. D., Dalziel, S. R., & Harding, J. E. (2014) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174414000579 · Cited by 38 · see citing works
Prenatal drug exposure and neurodevelopmental programming of glucocorticoid signalling
Franks, A. L., Berry, K. J., & DeFranco, D. B. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12786 · Cited by 39 · see citing works
Neonatal injury rapidly alters markers of pain and stress in rat pups
Victoria, N. C., Karom, M. C., Eichenbaum, H., & Murphy, A. Z. (2013) · Developmental Neurobiology · doi:10.1002/dneu.22129 · Cited by 38 · see citing works
Ancestral experience as a game changer in stress vulnerability and disease outcomes
Metz, G. A. S., Ng, J. W. Y., Kovalchuk, I., & Olson, D. M. (2015) · BioEssays · doi:10.1002/bies.201400217 · Cited by 36 · see citing works
Prévention des complications de la prématurité par l’administration anténatale de corticoïdes
Schmitz, T. (2016) · Journal de gynécologie, obstétrique et biologie de la reproduction. Supplément/Journal de gynécologie obstétrique et biologie de la reproduction · doi:10.1016/j.jgyn.2016.09.008 · Cited by 34 · see citing works
for the BETADOSE study group and the GROG (Groupe de Recherche en Gynécologie Obstétrique), Schmitz, T., Alberti, C., Ursino, M., Baud, O., & Aupiais, C. (2019) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-019-2206-x · Cited by 29 · see citing works
Evidence for adverse effect of perinatal glucocorticoid use on the developing brain
Chang, Y. P. (2014) · Korean Journal of Pediatrics · doi:10.3345/kjp.2014.57.3.101 · Cited by 30 · see citing works
Glucocorticoids and Preterm Hypoxic-Ischemic Brain Injury: The Good and the Bad
Bennet, L., Davidson, J. O., Koome, M. E., & Gunn, A. J. (2012) · Journal of Pregnancy · doi:10.1155/2012/751694 · Cited by 26 · see citing works
Hutcheon, J. A., Harper, S. B., Liauw, J., Skoll, A., Srour, M., & Strumpf, E. (2020) · PLoS Medicine · doi:10.1371/journal.pmed.1003435 · Cited by 25 · see citing works
Jenkins, S. I., Pickard, M. R., Khong, M., Smith, H., Mann, C. L. A., Emes, R. D., & Chari, D. M. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400167n · Cited by 23 · see citing works
Analgesia for Early-Life Pain Prevents Deficits in Adult Anxiety and Stress in Rats
Victoria, N. C., Karom, M. C., & Murphy, A. Z. (2014) · Developmental Neuroscience · doi:10.1159/000366273 · Cited by 22 · see citing works
Combined Antioxidant and Glucocorticoid Therapy for Safer Treatment of Preterm Birth
Garrud, T. A. C., & Giussani, D. A. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.02.003 · Cited by 21 · see citing works
Maternal cortisol during pregnancy is related to infant cardiac vagal control
Rash, J. A., Campbell, T. S., Letourneau, N. L., & Giesbrecht, G. F. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.01.024 · Cited by 20 · see citing works
Kütük, M. S., Şahin, M., Görkem, S. B., Doğanay, S., & Öztürk, A. (2017) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2017.1369519 · Cited by 18 · see citing works
Hermes, M., Antonow‐Schlorke, I., Hollstein, D., Kuehnel, S., Rakers, F., Frauendorf, V., Dreiling, M., Rupprecht, S., Schubert, H., Witte, O. W., et al. (2019) · Stress · doi:10.1080/10253890.2019.1652266 · Cited by 18 · see citing works
Self-citationMüller, J. J., Antonow‐Schlorke, I., Kroegel, N., Rupprecht, S., Rakers, F., Witte, O. W., & Schwab, M. G. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.024 · Cited by 17 · see citing works
Self-citationShields, A., Thomson, M., Winter, V. T., Coalson, J. J., & Rees, S. M. (2012) · Pediatric Research · doi:10.1038/pr.2012.18 · Cited by 16 · see citing works
Dennis, E. L., Disner, S. G., Fani, N., Salminen, L. E., Logue, M. W., Clarke‐Rubright, E. K., Haswell, C. C., Averill, C. L., Baugh, L. A., Bomyea, J. A., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/677153 · Cited by 16 · see citing works
Glucocorticosteroids Effects on Brain Development in the Preterm Infant: A Role for Microglia?
Zinni, M., Pansiot, J., Billion, E., Baud, O., & Mairesse, J. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210517112913 · Cited by 15 · see citing works
Bottari, S. A., Lamb, D. G., Murphy, A. J., Porges, E. C., Rieke, J. D., Harciarek, M., Datta, S., & Williamson, J. B. (2021) · Brain Injury · doi:10.1080/02699052.2021.1927186 · Cited by 15 · see citing works
Kim, J., Kim, Y. J., & Chang, Y. P. (2013) · Europe PMC (PubMed Central) · Cited by 15 · see citing works
Lengel, D., Romm, Z. L., Bostwick, A., Huh, J. W., Snyder, N. W., Smith, G. M., & Raghupathi, R. (2022) · Journal of Neurotrauma · doi:10.1089/neu.2022.0012 · Cited by 14 · see citing works
Intrauterine Programmierung von Störungen der Hirnfunktion im späteren Leben
Schwab, M. (2009) · Gyn�kologisch-geburtshilfliche Rundschau · doi:10.1159/000184442 · Cited by 13 · see citing works
Self-citationYawno, T., Mortale, M., Sutherland, A. E., Jenkin, G., Wallace, E. M., Walker, D. W., & Miller, S. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.05.031 · Cited by 13 · see citing works
Neurocognitive sequelae of antenatal corticosteroids in a late preterm rabbit model
van der Merwe, J., der Veeken, L. V., Inversetti, A., Galgano, A., Valenzuela, I. J., Salaets, T., Ferraris, S., Vercauteren, T. K., Toelen, J., & Deprest, J. A. (2021) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2021.11.1370 · Cited by 13 · see citing works
Feng, Y., Famuyide, M. E., & Bhatt, A. (2013) · PubMed · Cited by 12 · see citing works
Does Antenatal Betamethasone Alter White Matter Brain Development in Growth Restricted Fetal Sheep?
Sutherland, A. E., Yawno, T., Castillo-Meléndez, M., Allison, B. J., Malhotra, A. K., Polglase, G. R., Cooper, L. J., Jenkin, G., & Miller, S. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00100 · Cited by 10 · see citing works
Navalón, P., Campos-Berga, L., Buesa, J., Lizarán, M., Ghosn, F., Almansa, B., Moreno-Giménez, A., Vento, M., Diago, V., & García‐Blanco, A. (2023) · American Journal of Obstetrics & Gynecology MFM · doi:10.1016/j.ajogmf.2023.100918 · Cited by 9 · see citing works
Basal serum cortisol concentration in very low birth weight infants
Hwang, J. H., Lee, B. S., Kim, C. Y., Jung, E., Kim, E. A., & Kim, K. S. (2019) · Pediatrics & Neonatology · doi:10.1016/j.pedneo.2019.03.003 · Cited by 9 · see citing works
Gestational protein restriction alters early amygdala neurochemistry in male offspring
Torres, D. B., Lopes, A., Rodrigues, A. J., Lopes, M. G., Ventura‐Silva, A. P., Sousa, N., Gontijo, J. A. R., & Boer, P. A. (2022) · Nutritional Neuroscience · doi:10.1080/1028415x.2022.2131064 · Cited by 7 · see citing works
Mancino, D. N., Leicaj, M. L., Lima, A. E., Roig, P., Guennoun, R., Schumacher, M., Nicola, A. F. D., & Garay, L. I. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105820 · Cited by 7 · see citing works
Frasch, M. G., Schulkin, J. A., Metz, G. A. S., & Antonelli, M. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809468-6.00032-2 · Cited by 8 · see citing works
Kitanishi, R., Matsuda, T., Watanabe, S., Saito, M., Hanita, T., Watanabe, T., & KOBAYASHI, Y. (2014) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.234.299 · Cited by 6 · see citing works
Kamat, A. A., Kramer, P., & Soisson, A. P. (2002) · PubMed · Cited by 6 · see citing works
Age-dependent effects of prenatal dexamethasone exposure on immune responses in male rats
Chou, M.-Y., Huang, L.-T., Tain, Y.-L., Kuo, H.-C., Tiao, M.-M., Sheen, J.-M., Chen, C.-C., Hung, P.-L., Hsieh, K.-S., & Yu, H.-R. (2017) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.241.225 · Cited by 5 · see citing works
Development of somatosensory‐evoked potentials in foetal sheep: effects of betamethasone
Anegroaie, P., Frasch, M. G., Rupprecht, S., Antonow‐Schlorke, I., Müller, T. M., Schubert, H., Witte, O. W., & Schwab, M. G. (2016) · Acta Physiologica · doi:10.1111/apha.12795 · Cited by 5 · see citing works
Self-citationMiguel-Hidalgo, J. J. (2023) · PubMed · doi:10.14670/hh-18-476 · Cited by 8 · see citing works
Kozik, V., Dreiling, M., Müller, D., Tiedge, O., Schneider, R., Thiel, S., Bellenberg, B., Krieger, B., Lukas, C., Mentzel, H., et al. (2025) · Neurology · doi:10.1212/wnl.0000000000214217 · Cited by 3 · see citing works
Self-citationPrenatal corticosteroid use and offspring neurological outcomes
Yan, Y., Wang, J., & Lei, X. (2025) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2025.107564 · Cited by 3 · see citing works
Encephalopathy of the Preterm—Clinical Aspects
Inder, T. E., & Volpe, J. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-10513-5.00020-6 · Cited by 3 · see citing works
Corticoïdes prénatals : effets néonatals d’une deuxième cure
Schmitz, T. (2010) · Archives de Pédiatrie · doi:10.1016/s0929-693x(10)70908-8 · Cited by 3 · see citing works
Zhai, Z. W., Yip, S. W., Morie, K. P., Sinha, R., Mayes, L. C., & Potenza, M. N. (2018) · American Journal on Addictions · doi:10.1111/ajad.12710 · Cited by 2 · see citing works
Masjosthusmann, S., Tigges, J., Fritsche, E., & Koch, K. (2021) · Advances in neurotoxicology · doi:10.1016/bs.ant.2020.12.002 · Cited by 2 · see citing works
Kozik, V., Schwab, M. G., Thiel, S., Hellwig, K., Rakers, F., & Dreiling, M. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.830057 · Cited by 2 · see citing works
Self-citationChawanpaiboon, S., Pooliam, J., & Chuchotiros, M. (2022) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-022-05209-6 · Cited by 2 · see citing works
Gómez‐Pinedo, U., Matías‐Guiu, J. A., Ojeda-Hernández, D. D., de la Fuente-Martín, S., Kamal, O. M. F., Benito‐Martín, M. S., Selma-Calvo, B., Montero‐Escribano, P., & Matías‐Guiu, J. (2023) · Cells · doi:10.3390/cells12111515 · Cited by 2 · see citing works
Is 25 mm the correct mid‐trimester cut‐off for cervical shortening among asymptomatic women?
Lauterbach, R., Bachar, G., Justman, N., Siegler, Y., Khatib, N., Weiner, Z., & Vitner, D. (2022) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.14396 · Cited by 1 · see citing works
Chawanpaiboon, S., Pooliam, J., & Chuchotiros, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-27608-3 · Cited by 1 · see citing works
Nwaiser, F. A., Bekhet, G. M., & Sedky, A. M. (2022) · Indian Journal of Animal Research · doi:10.18805/ijar.bf-1458 · Cited by 1 · see citing works
Genomic glucocorticoid action in embryonic mouse neural stem cells
Berry, K. J., Chandran, U. R., Mu, F., Deochand, D. K., Lei, T., Pagin, M., Nicolis, S. K., Monaghan, A. P., Rogatsky, I., & DeFranco, D. B. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.111864 · Cited by 1 · see citing works
Acharyya, S., Acharyya, K., & Haldar, A. (2020) · JOURNAL OF PEDIATRIC CRITICAL CARE · doi:10.4103/jpcc.jpcc_113_20 · Cited by 1 · see citing works
Kim, B., Kostaki, A., & Matthews, S. G. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.26.586671 · Cited by 1 · see citing works
Ma, B., Ran, J., Pan, T., Yan, F., Yue, Z., Yao, Y., Li, Y., & Nie, F. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1791481
“This empirical approach leads to significant trade-offs: Underdosing raises the risk of RDS, while overdosing increases neurodevelopmental toxicity, such as cognitive impairment, by up to 1.8-fold in exposed infants (3).”
InfluentialTao, T., Bo, B., LU, L., ̆, Y., Tuanmei, Wang, Jian, J. I. A. N., -, L., Xingfang, Dingan, et al. (2010) · 中国神经再生研究：英文版
Role of cardiac FoxO1 in conditions of insulin resistance, nutrient excess, and diabetes
Puthanveetil, P. (2012) · cIRcle (University of British Columbia) · doi:10.14288/1.0072615
Perinatal Nicotine Exposure and Programming of HIE Sensitive Phenotype in Neonatal Rat Brains
Li, Y. (2013) · The Scholars Repository - LLU (Loma Linda University)
Kim, B., Kostaki, A., & Matthews, S. G. (2025) · Journal of Neuroendocrinology · doi:10.1111/jne.13499
Hardy, I. S., Gagnon, A., Croft, E. K., Tremblay, L., Lebel, R., Roy‐Lacroix, M., Takser, L., Ouellet, A., & Gris, D. (2025) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2025.107523
Herselman, M. F., Hislop, T., McBride, S. D., Lock, M. C., Morrison, J. L., & Gatford, K. L. (2026) · JMIR Research Protocols · doi:10.2196/84522
Glucocorticoid therapy during pregnancy in domestic animals
Arroyo, E. (2026) · The Veterinary Journal · doi:10.1016/j.tvjl.2026.106945
A Single Neonatal Injury Induces Life-Long Adaptations In Stress And Pain Responsiveness
Victoria, N. C. (2022) · Digital Archive @ GSU · doi:10.57709/4563965
- Authors
- Antonow-Schlorke, I., Helgert, A., Gey, C., Coksaygan, T., Schubert, H., Nathanielsz, P. W., Witte, O. W., & Schwab, M.
- Affiliations
- Friedrich Schiller University Jena (DE)
- The University of Texas at San Antonio Health Science Center (US)
- Venue
- Obstetrics & Gynecology
- Published
- 2009-01
- Volume
- 113
- Issue
- 1
- Pages
- 142-151
- ISSN
- 0029-7844 (ISSN-L)
- OpenAlex
- W2324910294
- Cited by
- 88
- References
- 55
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 3 · 2019: 8 · 2018: 4 · 2017: 3 · 2016: 7 · 2015: 4 · 2014: 8 · 2013: 10 · 2012: 6
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-55416, R01HL055416)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Keywords
- antenatal glucocorticoids, betamethasone, myelin basic protein, oligodendrocytes, fetal brain development, fetal sheep, glucocorticoid adverse effects, dose dependence, gestational age
- MeSH terms
- Animals, Betamethasone, Brain, Corpus Callosum, Myelin Basic Protein, Female, Fetal Blood, Fetus, Glucocorticoids, Myelin Sheath, Oligodendroglia, Pregnancy, Sheep, Domestic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
