Development of myelination in the human fetal and infant cerebrum: A myelin basic protein immunohistochemical study
Abstract
The early development of myelination was studied by means of myelin basic protein (MBP) and luxol fast blue (LFB) stainings of large sections of the cerebral hemispheres. Myelination first occurs in the globus pallidus, pallidothalamic fibers of the posterior internal capsule and the thalamus at 25 weeks, which may be related to the cellular maturation in the globus pallidus and thalamus. Then myelination is observed in the striatum, and precentral and postcentral gyri at 35 weeks, and the anterior internal capsule and optic radiation at 37 weeks. Immunoreactivity with MBP is observed earlier and more strongly in the early myelination period than that with LFB. Thus, MBP may play an important role in myelination and its delay. The macroscopic positivity as to MBP as well as LFB staining may be related to the development of high signal intensity observed in a T1-weighted magnetic resonance imaging, which was observed 1 to 3 months after the first microscopic appearance of myelin.
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Myelination begins prenatally and is present in many regions at birth, especially primary sensory and motor pathways including the optic radiations and internal capsule.
“Postmortem studies of white-matter myelination in the human brain find that myelination begins prenatally and is present in many regions at the time of birth, especially primary sensory and motor pathways, including the optic radiations and internal capsule210, 211.”
From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [210]
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- Authors
- Hasegawa, M., Houdou, S., Mito, T., Takashima, S., Asanuma, K., & Ohno, T.
- Affiliations
- National Center of Neurology and Psychiatry (JP)
- Matsudo City Hospital (JP)
- Saitama Children's Medical Center (JP)
- Corresponding author
- Hasegawa, Motohiro
- Venue
- Brain and Development
- Publisher
- Elsevier BV
- Published
- 1992-01
- Volume
- 14
- Issue
- 1
- Pages
- 1-6
- ISSN
- 0387-7604 (ISSN-L)
- OpenAlex
- W2069023134
- Cited by
- 137
- References
- 16
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 7 · 2023: 7 · 2022: 5 · 2021: 7 · 2020: 5 · 2019: 8 · 2018: 8 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain and Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- myelination, myelin basic protein, fetal brain development, infant brain development, globus pallidus, thalamus, internal capsule, optic radiation, striatum, T1-weighted MRI signal intensity, cerebral hemispheres
- MeSH terms
- Amidines, Brain, Myelin Basic Protein, Female, Humans, Immunohistochemistry, Infant, Infant, Newborn, Myelin Sheath, Pregnancy, Staining and Labeling
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