Supplementation of Vitamin E, Vitamin C, and Zinc Attenuates Oxidative Stress in Burned Children: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
Abstract
The aim of this study was to investigate the effect of supplementation of vitamin E, vitamin C, and zinc on the oxidative stress in burned children. In a prospective double-blind placebo controlled pilot study, 32 patients were randomized as no supplementation (n = 15) or antioxidant supplementation (n = 17) groups. Supplementation consisted of the antioxidant mixture of vitamin C (1.5 times upper intake level), vitamin E (1.35 times upper intake level), and zinc (2.0 times recommended dietary allowance) administered during 7 days starting on the second day of admittance into the hospital. Energy requirement was calculated by the Curreri equation, and protein input was 3.0 g/kg of ideal body mass index (percentile 50). Total antioxidant capacity of plasma and malondialdehyde were used to monitor oxidative stress. The time of wound healing was evaluated as the main clinical feature. Patients (age 54.2 +/- 48.9 months, 65.6% males), who exhibited 15.5 +/- 6.7% of total burn area, showed no differences in age and sex, when compared with controls. Intake of the administered antioxidants was obviously higher in treated subjects (P = .005), and serum differences were confirmed for vitamin E and C, but not for zinc (P = .180). There was a decrease in lipid peroxidation (malondialdehyde level) (P = .006) and an increase in vitamin E concentrations in the antioxidant supplementation group (P = .016). The time of wound healing was lower in the supplemented group (P < .001). The antioxidant supplementation through vitamin E and C and the mineral zinc apparently enhanced antioxidant protection against oxidative stress and allowed less time for wound healing.
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Supplementation with both vitamin C and vitamin E improved the rate of wound healing in children with extensive burns.
“Supplementation with both vitamin C and vitamin E improved the rate of wound healing in children with extensive burns [171], and plasma vitamin C levels in smokers, abstaining smokers and non-smokers were positively associated with the rate of wound healing [162].”
From The Roles of Vitamin C in Skin Health. (2017) · cites this paper as [171]
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- Authors
- Barbosa, E., Faintuch, J., Machado Moreira, E. A., Gonçalves da Silva, V. R., Lopes Pereima, M. J., Martins Fagundes, R. L., & Filho, D. W.
- Affiliations
- Universidade Federal de Santa Catarina (BR)
- Universidade de São Paulo (BR)
- Venue
- Journal of Burn Care & Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-09
- Volume
- 30
- Issue
- 5
- Pages
- 859-866
- ISSN
- 1559-047X (ISSN-L)
- OpenAlex
- W2075521402
- Cited by
- 114
- References
- 39
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 9 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 9 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 11 · 2013: 11 · 2012: 4
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Burn Care & Research (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Burn Injury Management and Outcomes
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Keywords
- burns, pediatric burns, antioxidant supplementation, vitamin E, vitamin C, zinc, oxidative stress, lipid peroxidation, malondialdehyde, total antioxidant capacity, wound healing
- MeSH terms
- Adolescent, Analysis of Variance, Ascorbic Acid, Burns, Child, Child, Preschool, Double-Blind Method, Female, Humans, Male, Pilot Projects, Placebos, Prospective Studies, Vitamin E, Wound Healing, Zinc, Chi-Square Distribution, Treatment Outcome, Oxidative Stress, Statistics, Nonparametric
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