Cited by 329Skin Protection and AgingPhytochemicals and Antioxidant ActivitiesMedicinal Plant Research

Natural Antioxidants from Plant Extracts in Skincare Cosmetics: Recent Applications, Challenges and Perspectives

Open access
Hoang, Hien Thi, Moon, Ju-Young, Lee, Young-Chul·2021·Cosmetics

Abstract

In recent years, interest in the health effects of natural antioxidants has increased due to their safety and applicability in cosmetic formulation. Nevertheless, efficacy of natural antioxidants in vivo is less documented than their prooxidant properties in vivo. Plant extracts rich in vitamins, flavonoids, and phenolic compounds can induce oxidative damage by reacting with various biomolecules while also providing antioxidant properties. Because the biological activities of natural antioxidants differ, their effectiveness for slowing the aging process remains unclear. This review article focuses on the use of natural antioxidants in skincare and the possible mechanisms underlying their desired effect, along with recent applications in skincare formulation and their limitations.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/cosmetics8040106

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

No citation lists for this paper

No citation lists for this paper yet — checked again daily.

References 226 · Cited by 329

Research works printed but not linked: 120

  1. Abels, C.; Angelova-Fischer, I. Skin Care Products: Age-Appropriate Cosmetics. Curr. Probl. Dermatol. 2018, 54, 173-182. [CrossRef] [PubMed] · DOI
  2. Nilforoushzadeh, M.A.; Amirkhani, M.A.; Zarintaj, P.; Ms, A.S.M.; Mehrabi, T.; Alavi, S.; Sisakht, M.M. Skin care and rejuvenation by cosmeceutical facial mask. J. Cosmet. Dermatol. 2018, 17, 693-702. [CrossRef] [PubMed] · DOI
  3. Yosipovitch, G.; Misery, L.; Proksch, E.; Metz, M.; Ständer, S.; Schmelz, M. Skin Barrier Damage and Itch: Review of Mechanisms, Topical Management and Future Directions. Acta Derm. Venereol. 2019, 99, 1201-1209. [CrossRef] · DOI
  4. Husein el Hadmed, H.; Castillo, R.F. Cosmeceuticals: Peptides, proteins, and growth factors. J. Cosm. Dermatol. 2016, 15, 514-519. [CrossRef] [PubMed] · DOI
  5. Thiyagarasaiyar, K.; Goh, B.-H.; Jeon, Y.-J.; Yow, Y.-Y. Algae Metabolites in Cosmeceutical: An Overview of Current Applications and Challenges. Mar. Drugs 2020, 18, 323. [CrossRef] [PubMed] · DOI
  6. Veeresham, C. Natural products derived from plants as a source of drugs. J. Adv. Pharm. Technol. Res. 2012, 3, 200-201. [CrossRef] · DOI
  7. Fowler, J.F., Jr.; Woolery-Lloyd, H.; Waldorf, H.; Saini, R. Innovations in natural ingredients and their use in skin care. J. Drugs Dermatol. 2010, 9 (Suppl. S6), S72-S81. [PubMed]
  8. Jesumani, V.; Du, H.; Aslam, M.; Pei, P.; Huang, N. Potential Use of Seaweed Bioactive Compounds in Skincare-A Review. Mar. Drugs 2019, 17, 688. [CrossRef] [PubMed] · DOI
  9. Bowe, W.P. Advances in natural ingredients and their use in skin care. Introduction. J. Drugs Dermatol. 2013, 12, s122. [PubMed]
  10. Speit, G. How to assess the mutagenic potential of cosmetic products without animal tests? Mutat. Res. Toxicol. Environ. Mutagen. 2009, 678, 108-112. [CrossRef] [PubMed] · DOI
  11. Hameury, S.; Borderie, L.; Monneuse, J.; Skorski, G.; Pradines, D. Prediction of skin anti-aging clinical benefits of an association of ingredients from marine and maritime origins: Ex vivo evaluation using a label-free quantitative proteomic and customized data processing approach. J. Cosmet. Dermatol. 2018, 18, 355-370. [CrossRef] · DOI
  12. Sumpio, B.E.; Cordova, A.C.; Berke-Schlessel, D.W.; Qin, F.; Chen, Q.H. Green tea, the "Asian paradox," and cardiovascular disease. J. Am. Coll. Surg. 2006, 202, 813-825. [CrossRef] [PubMed] · DOI
  13. Trovato, M.; Ballabio, C. Botanical products: General aspects. In Food Supplements Containing Botanicals: Benefits, Side Effects and Regulatory Aspects; Springer: Cham, Switzerland, 2018; pp. 3-26.
  14. Koch, W.; Zagórska, J.; Marzec, Z.; Kukula-Koch, W. Applications of Tea (Camellia sinensis) and its Active Constituents in Cosmetics. Molecules 2019, 24, 4277. [CrossRef] [PubMed] · DOI
  15. Kottner, J.; Lichterfeld, A.; Blume-Peytavi, U. Maintaining skinintegrity in the aged: A systematic review. Br. J. Dermatol. 2013, 169, 528-542. [CrossRef] [PubMed] · DOI
  16. De Lima Cherubim, D.J.; Buzanello Martins, C.V.; Oliveira Fariña, L.; da Silva de Lucca, R.A. Polyphenols as natural antioxidants in cosmetics applications. J. Cosmet. Dermatol. 2020, 19, 33-37. [CrossRef] [PubMed] · DOI
  17. Silva, S.; Ferreira, M.; Oliveira, A.S.; Magalhaes, C.; Sousa, M.E.; Pinto, M.; Sousa Lobo, J.M.; Almeida, I.F. Evolution of the use of anti-oxidants in anti-ageing cosmetics. Int. J. Cosmet. Sci. 2019, 41, 378-386. [CrossRef] [PubMed] · DOI
  18. Babbush, K.; Babbush, R.; Khachemoune, A. The Therapeutic Use of Antioxidants for Melasma. J. Drugs Dermatol. 2020, 19, 788-792. [CrossRef] [PubMed] · DOI
  19. Augustyniak, A.; Bartosz, G.; Čipak, A.; Duburs, G.; Horáková, L.U.; Łuczaj, W.; Majekova, M.; Odysseos, A.D.; Rackova, L.; Skrzydlewska, E.; et al. Natural and synthetic antioxidants: An updated overview. Free Radic. Res. 2010, 44, 1216-1262. [CrossRef] [PubMed] · DOI · Paper page
  20. Kim, J.J.; Kim, K.S.; Yu, B.J. Optimization of Antioxidant and Skin-Whitening Compounds Extraction Condition from Tenebrio molitor Larvae (Mealworm). Molecules 2018, 23, 2340. [CrossRef] · DOI
  21. Zhang, S.; Duan, E. Fighting against skin aging: The way from bench to bedside. Cell Transplant. 2018, 27, 729-738. [CrossRef] [PubMed] · DOI · Paper page
  22. Farage, M.A.; Miller, K.W.; Elsner, P.; Maibach, H.I. Intrinsic and extrinsic factors in skin ageing: A review. Int. J. Cosmet. Sci. 2008, 30, 87-95. [CrossRef] [PubMed] · DOI · Paper page
  23. Rees, J.L. The Genetics of Sun Sensitivity in Humans. Am. J. Hum. Genet. 2004, 75, 739-751. [CrossRef] [PubMed] · DOI
  24. Krutmann, J.; Schikowski, T.; Morita, A.; Berneburg, M. Environmentally-Induced (Extrinsic) Skin Aging: Exposomal Factors and Underlying Mechanisms. J. Investig. Dermatol. 2021, 141, 1096-1103. [CrossRef] · DOI · Paper page
  25. Coppé, J.P.; Desprez, P.Y.; Krtolica, A.; Campisi, J. The senescence-associated secretory phenotype: The dark side of tumor suppres-sion. Annu. Rev. Pathol. Mech. Dis. 2010, 5, 99-118. [CrossRef] · DOI · Paper page
  26. Flament, F.; Bazin, R.; Qiu, H.; Ye, C.; Laquieze, S.; Rubert, V.; Decroux, A.; Simonpietri, E.; Piot, B. Solar exposure(s) and facial clinical signs of aging in Chinese women: Impacts upon age perception. Clin. Cosmet. Investig. Dermatol. 2015, 8, 75-84. [CrossRef] · DOI
  27. Morais, M.L.; Silva, A.C.; Araújo, C.R.; Esteves, E.A.; Dessimoni-Pinto, N.A. Determinação do potencial antioxidante in vitro de frutos do cerrado brasileiro. Rev. Bras. Fruticult. 2013, 35, 355-360. [CrossRef] · DOI
  28. Bose, B.; Choudhury, H.; Tandon, P.; Kumaria, S. Studies on secondary metabolite profiling, anti-inflammatory potential, in vitro photoprotective and skin-aging related enzyme inhibitory activities of Malaxis acuminata, a threatened orchid of nutraceutical importance. J. Photochem. Photobiol. B Biol. 2017, 173, 686-695. [CrossRef] · DOI
  29. Leopoldini, M.; Russo, N.; Toscano, M. The molecular basis of working mechanism of natural polyphenolic antioxidants. Food Chem. 2011, 125, 288-306. [CrossRef] · DOI
  30. Cavinato, M.; Waltenberger, B.; Baraldo, G.; Grade, C.V.; Stuppner, H.; Jansen-Dürr, P. Plant extracts and natural compounds used against UVB-induced photoaging. Biogerontology 2017, 18, 499-516. [CrossRef] [PubMed] · DOI · Paper page
  31. Pisoschi, A.M.; Pop, A. The Role of Antioxidants in the Chemistry of Oxidative Stress: A review. Eur. J. Med. Chem. 2015, 97, 55-74. [CrossRef] · DOI
  32. Aune, D. Plant Foods, Antioxidant Biomarkers, and the Risk of Cardiovascular Disease, Cancer, and Mortality: A Review of the Evidence. Adv. Nutr. 2019, 10, S404-S421. [CrossRef] · DOI
  33. Xu, D.-P.; Li, Y.; Meng, X.; Zhou, T.; Zhou, Y.; Zheng, J.; Zhang, J.-J.; Li, H.-B. Natural Antioxidants in Foods and Medicinal Plants: Extraction, Assessment and Resources. Int. J. Mol. Sci. 2017, 18, 96. [CrossRef] [PubMed] · DOI
  34. Jenab, M.; Riboli, E.; Ferrari, P.; Sabate, J.; Slimani, N.; Norat, T.; Friesen, M.; Tjonneland, A.; Olsen, A.; Overvad, K.; et al. Plasma and dietary vitamin C levels and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Carcinogenesis 2006, 27, 2250-2257. [CrossRef] · DOI
  35. Li, A.-N.; Li, S.; Zhang, Y.-J.; Xu, X.-R.; Chen, Y.-M.; Li, H.-B. Resources and Biological Activities of Natural Polyphenols. Nutrients 2014, 6, 6020-6047. [CrossRef] · DOI
  36. Salomone, F.; Godos, J.; Zelber-Sagi, S. Natural antioxidants for non-alcoholic fatty liver disease: Molecular targets and clinical perspectives. Liver Int. 2016, 36, 5-20. [CrossRef] [PubMed] · DOI
  37. Balmus, I.M.; Ciobica, A.; Trifan, A.; Stanciu, C. The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models. Saudi J. Gastroenterol. 2016, 22, 3-17. [CrossRef] · DOI
  38. Khan, B.A.; Mahmood, T.; Menaa, F.; Shahzad, Y.; Yousaf, A.M.; Hussain, T.; Ray, S.D. New Perspectives on the Efficacy of Gallic Acid in Cosmetics & Nanocosmeceuticals. Curr. Pharm. Des. 2019, 24, 5181-5187. [CrossRef] · DOI
  39. Neha, K.; Haider, R.; Pathak, A.; Yar, M.S. Medicinal prospects of antioxidants: A review. Eur. J. Med. Chem. 2019, 178, 687-704. [CrossRef] [PubMed] · DOI
  40. Valko, M.; Leibfritz, D.; Moncol, J.; Cronin, M.T.; Mazur, M.; Telser, J. Free Radicals and Antioxidants in Normal Physiological Functions and Human Disease. Int. J. Biochem. Cell Biol. 2007, 39, 44-84. [CrossRef] [PubMed] · DOI · Paper page
  41. Nalimu, F.; Oloro, J.; Kahwa, I.; Ogwang, P.E. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Futur. J. Pharm. Sci. 2021, 7, 1-21. [CrossRef] [PubMed] · DOI
  42. Burke, K.E. Protection From Environmental Skin Damage With Topical Antioxidants. Cl. Pharmacol. Ther. 2018, 105, 36-38. [CrossRef] [PubMed] · DOI
  43. Pandey, K.B.; Rizvi, S.I. Plant Polyphenols as Dietary Antioxidants in Human Health and Disease. Oxid. Med. Cell. Longev. 2009, 2, 270-278. [CrossRef] [PubMed] · DOI
  44. Cartea, M.E.; Francisco, M.; Soengas, P.; Velasco, P. Phenolic Compounds in Brassica Vegetables. Molecules 2010, 16, 251-280. [CrossRef] [PubMed] · DOI
  45. Rao, S.; Kurakula, M.; Mamidipalli, N.; Tiyyagura, P.; Patel, B.; Manne, R. Pharmacological Exploration of Phenolic Compound: Raspberry Ketone-Update 2020. Plants 2021, 10, 1323. [CrossRef] [PubMed] · DOI
  46. De Oliveira Raphaelli, C.; Azevedo, J.G.; dos Santos Pereira, E.; Vinholes, J.R.; Camargo, T.M.; Hoffmann, J.F.; Ribeiro, J.A.; Vizzotto, M.; Rombaldi, C.V.; Wink, M.R.; et al. Phenolic-rich apple extracts have photoprotective and anti-cancer effect in dermal cells. Phytomed. Plus. 2021, 1, 100112. [CrossRef] · DOI
  47. Rabelo, A.C.S.; Costa, D. A review of biological and pharmacological activities of Baccharis trimera. Chem. Interact. 2018, 296, 65-75. [CrossRef] · DOI
  48. Sikora, M.; Złotek, U.; Kordowska-Wiater, M.; Świeca, M. Effect of Basil Leaves and Wheat Bran Water Extracts on Antioxidant Capacity, Sensory Properties and Microbiological Quality of Shredded Iceberg Lettuce during Storage. Antioxidants 2020, 9, 355. [CrossRef] [PubMed] · DOI
  49. Anand, U.; Tudu, C.K.; Nandy, S.; Sunita, K.; Tripathi, V.; Loake, G.J.; Dey, A.; Proćków, J. Ethnodermatological use of medicinal plants in India: From ayurvedic formulations to clinical perspectives-A review. J. Ethnopharmacol. 2021, 284, 114744. [CrossRef] [PubMed] · DOI
  50. Curutchet, A.; Cozzano, S.; Tárrega, A.; Arcia, P. Blueberry pomace as a source of antioxidant fibre in cookies: Consumer's ex-pectations and critical attributes for developing a new product. Food Sci. Technol. Int. 2019, 25, 642-648. [CrossRef] [PubMed] · DOI
  51. Routray, W.; Orsat, V. Blueberries and Their Anthocyanins: Factors Affecting Biosynthesis and Properties. Compr. Rev. Food Sci. Food Saf. 2011, 10, 303-320. [CrossRef] · DOI
  52. Chaves-Gómez, J.L.; Cotes-Prado, A.M.; Gómez-Caro, S.; Restrepo-Díaz, H. Physiological Response of Cape Gooseberry Seedlings to Two Organic Additives and Their Mixture under Inoculation with Fusarium oxysporum f. sp. physali. HortScience 2020, 55, 55-62. [CrossRef] · DOI
  53. Hassanien, M.F.R.; Serag, H.M.; Qadir, M.S.; Ramadan, M.F. Cape gooseberry (Physalis peruviana) juice as a modulator agent for hepatocellular carcinoma-linked apoptosis and cell cycle arrest. Biomed. Pharmacother. 2017, 94, 1129-1137. [CrossRef] [PubMed] · DOI
  54. Zerres, S.; Stahl, W. Carotenoids in human skin. Biochim. Biophys. Acta BBA-Mol. Cell Biol. Lipids. 2020, 1865, 158588. [CrossRef] [PubMed] · DOI
  55. Pinto, D.; Vieira, E.F.; Peixoto, A.F.; Freire, C.; Freitas, V.; Costa, P.; Delerue-Matos, C.; Rodrigues, F. Optimizing the extraction of phenolic antioxidants from chestnut shells by subcritical water extraction using response surface methodology. Food Chem. 2020, 334, 127521. [CrossRef] [PubMed] · DOI
  56. Ribeiro, A.S.; Estanqueiro, M.; Oliveira, M.B.; Lobo, J.M.S. Main Benefits and Applicability of Plant Extracts in Skin Care Products. Cosmetics 2015, 2, 48-65. [CrossRef] · DOI
  57. Monteiro, Â.; Colomban, S.; Azinheira, H.G.; Guerra-Guimarães, L.; Silva, M.D.C.; Navarini, L.; Resmini, M. Dietary Antioxidants in Coffee Leaves: Impact of Botanical Origin and Maturity on Chlorogenic Acids and Xanthones. Antioxidants 2019, 9, 6. [CrossRef] · DOI
  58. Dos Santos, É.M.; de Macedo, L.M.; Tundisi, L.L.; Ataide, J.A.; Camargo, G.A.; Alves, R.C.; Oliveira, M.B.; Mazzola, P.G. Coffee by-products in topical formulations: A review. Trends Food Sci. Technol. 2021, 111, 280-291. [CrossRef] · DOI
  59. Sganzerla, W.G.; Ferreira, A.L.A.; Rosa, G.B.; Azevedo, M.S.; Ferrareze, J.P.; Komatsu, R.A.; Nunes, M.R.; Da Rosa, C.G.; Schmit, R.; Costa, M.D.; et al. Feijoa [Acca sellowiana (Berg) Burret] accessions characterization and discrimination by chemometrics. J. Sci. Food Agric. 2020, 100, 5373-5384. [CrossRef] [PubMed] · DOI
  60. Smeriglio, A.; Denaro, M.; De Francesco, C.; Cornara, L.; Barreca, D.; Bellocco, E.; Ginestra, G.; Mandalari, G.; Trombetta, D. Feijoa Fruit Peel: Micro-morphological Features, Evaluation of Phytochemical Profile, and Biological Properties of Its Essential Oil. Antioxidants 2019, 8, 320. [CrossRef] [PubMed] · DOI
  61. Fang, J.; Wang, Z.; Wang, P.; Wang, M. Extraction, structure and bioactivities of the polysaccharides from Ginkgo biloba: A review. Int. J. Biol. Macromol. 2020, 162, 1897-1905. [CrossRef] [PubMed] · DOI
  62. Wang, X.; Gong, X.; Zhang, H.; Zhu, W.; Jiang, Z.; Shi, Y.; Li, L. In vitro anti-aging activities of ginkgo biloba leaf extract and its chemical constituents. Food Sci. Technol. 2020, 40, 476-482. [CrossRef] · DOI
  63. Ma, Z.F.; Zhang, H.; Teh, S.S.; Wang, C.W.; Zhang, Y.; Hayford, F.; Wang, L.; Ma, T.; Dong, Z.; Zhang, Y.; et al. Goji Berries as a Potential Natural Antioxidant Medicine: An Insight into Their Molecular Mechanisms of Action. Oxid. Med. Cell. Longev. 2019, 2019, 2437397. [CrossRef] · DOI
  64. Medina, S.; Collado-González, J.; Ferreres, F.; Londoño-Londoño, J.; Jiménez-Cartagena, C.; Guy, A.; Durand, T.; Galano, J.M.; Gil- Izquierdo, Á. Potential of Physalis peruviana calyces as a low-cost valuable resource of phytoprostanes and phenolic com-pounds. J. Sci. Food Agric. 2019, 99, 2194-2204. [CrossRef] · DOI
  65. Nocetti, D.; Núñez, H.; Puente, L.; Espinosa, A.; Romero, F. Composition and biological effects of goldenberry byproducts: An overview. J. Sci. Food Agric. 2020, 100, 4335-4346. [CrossRef] · DOI
  66. Rauf, A.; Imran, M.; Butt, M.S.; Nadeem, M.; Peters, D.G.; Mubarak, M.S. Resveratrol as an anti-cancer agent: A review. Crit. Rev. Food Sci. Nutr. 2018, 58, 1428-1447. [CrossRef] [PubMed] · DOI
  67. Bito, T.; Okumura, E.; Fujishima, M.; Watanabe, F. Potential of Chlorella as a Dietary Supplement to Promote Human Health. Nutrients 2020, 12, 2524. [CrossRef] [PubMed] · DOI
  68. Dantas Silva, R.P.; Machado, B.A.; Barreto, G.D.; Costa, S.S.; Andrade, L.N.; Amaral, R.G.; Carvalho, A.A.; Padilha, F.F.; Barbosa, J.D.; Umsza-Guez, M.A. Antioxidant, antimicrobial, antiparasitic, and cytotoxic properties of various Brazilian propolis extracts. PLoS ONE 2017, 12, e0172585. [CrossRef] · DOI
  69. Berthon, J.-Y.; Kappes, R.N.; Bey, M.; Cadoret, J.-P.; Renimel, I.; Filaire, E. Marine algae as attractive source to skin care. Free. Radic. Res. 2017, 51, 555-567. [CrossRef] [PubMed] · DOI
  70. Carvalho, A.G.; Silva, K.A.; Silva, L.O.; Costa, A.M.; Akil, E.; Coelho, M.A.; Torres, A.G. Jussara berry (Euterpe edulis M.) oil-in-water emulsions are highly stable: The role of natural antioxidants in the fruit oil. J. Sci. Food Agric. 2019, 99, 90-99. [CrossRef] · DOI
  71. Lupatini, N.R.J.; Danopoulos, P.; Swikidisa, R.; Alves, P.V. Evaluation of the Antibacterial Activity of Green Propolis Extract and Meadowsweet Extract Against Staphylococcus aureus Bacteria: Importance in Would Care Compounding Preparations. Int. J. Pharm. Compd. 2016, 20, 333-337.
  72. Costanzo, G.; Iesce, M.R.; Naviglio, D.; Ciaravolo, M.; Vitale, E.; Arena, C. Comparative studies on different citrus cultivars: A re-valuation of waste mandarin components. Antioxidants 2020, 9, 517. [CrossRef] [PubMed] · DOI
  73. Braga, A.R.C.; Mesquita, L.M.D.S.; Martins, P.; Habu, S.; de Rosso, V.V. Lactobacillus fermentation of jussara pulp leads to the enzymatic conversion of anthocyanins increasing antioxidant activity. J. Food Compos. Anal. 2018, 69, 162-170. [CrossRef] · DOI
  74. Liu, N.; Li, X.; Zhao, P.; Zhang, X.; Qiao, O.; Huang, L.; Guo, L.; Gao, W. A review of chemical constituents and health-promoting effects of citrus peels. Food Chem. 2021, 365, 130585. [CrossRef] [PubMed] · DOI
  75. Umamahesh, K.; Gandhi, A.D.; Reddy, O.V. Ethnopharmacological Applications of Mango (Mangifera indica L.) Peel-A Review. Curr. Pharm. Biotechnol. 2020, 21, 1298-1303. [CrossRef] [PubMed] · DOI
  76. Patravale, V.; Mandawgade, S. Formulation and evaluation of exotic fat based cosmeceuticals for skin repair. Indian J. Pharm. Sci. 2008, 70, 539-542. [CrossRef] [PubMed] · DOI
  77. Safari, R.; Hoseinifar, S.H.; Van Doan, H.; Dadar, M. The effects of dietary Myrtle (Myrtus communis) on skin mucus immune parameters and mRNA levels of growth, antioxidant and immune related genes in zebrafish (Danio rerio). Fish. Shellfish Immunol. 2017, 66, 264-269. [CrossRef] [PubMed] · DOI
  78. Ozcan, O.; Ipekci, H.; Alev, B.; Ustundag, U.V.; Ak, E.; Sen, A.; Alturfan, E.E.; Sener, G.; Yarat, A.; Cetinel, S.; et al. Protective effect of Myrtle (Myrtus communis) on burn induced skin injury. Burns 2019, 45, 1856-1863. [CrossRef] [PubMed] · DOI
  79. Gorzynik-Debicka, M.; Przychodzen, P.; Cappello, F.; Kuban-Jankowska, A.; Gammazza, A.M.; Knap, N.; Wozniak, M.; Gorska- Ponikowska, M. Potential Health Benefits of Olive Oil and Plant Polyphenols. Int. J. Mol. Sci. 2018, 19, 686. [CrossRef] [PubMed] · DOI
  80. Danby, S.G.; AlEnezi, T.; Sultan, A.; Lavender, T.; Chittock, J.; Brown, K.; Cork, M.J. Effect of olive and sunflower seed oil on the adult skin barrier: Implications for neonatal skin care. Pediatr. Dermatol. 2013, 30, 42-50. [CrossRef] [PubMed] · DOI · Paper page
  81. Yap, J.Y.; Hii, C.L.; Ong, S.P.; Lim, K.H.; Abas, F.; Pin, K.Y. Effects of drying on total polyphenols content and antioxidant properties of Carica papaya leaves. J. Sci. Food Agric. 2020, 100, 2932-2937. [CrossRef] · DOI
  82. Sharma, A.; Bachheti, A.; Sharma, P.; Bachheti, R.K.; Husen, A. Phytochemistry, pharmacological activities, nanoparticle fabrication, commercial products and waste utilization of Carica papaya L.: A comprehensive review. Curr. Res. Biotechnol. 2020, 2, 145-160. [CrossRef] · DOI
  83. Drogoudi, P.; Gerasopoulos, D.; Kafkaletou, M.; Tsantili, E. Phenotypic characterization of qualitative parameters and antioxidant contents in peach and nectarine fruit and changes after jam preparation. J. Sci. Food Agric. 2017, 97, 3374-3383. [CrossRef] · DOI
  84. Noratto, G.; Porter, W.; Byrne, D.; Cisneros-Zevallos, L. Polyphenolics from peach (Prunus persica var. Rich Lady) inhibit tumor growth and metastasis of MDA-MB-435 breast cancer cells in vivo. J. Nutr. Biochem. 2014, 25, 796-800. [CrossRef] [PubMed] · DOI
  85. Gurbuz, N.; Uluişik, S.; Frary, A.; Frary, A.; Do ganlar, S. Health benefits and bioactive compounds of eggplant. Food Chem. 2018, 268, 602-610. [CrossRef] [PubMed] · DOI
  86. Topal, U.; Sasaki, M.; Goto, M.; Otles, S. Chemical compositions and antioxidant properties of essential oils from nine species of Turkish plants obtained by supercritical carbon dioxide extraction and steam distillation. Int. J. Food Sci. Nutr. 2008, 59, 619-634. [CrossRef] [PubMed] · DOI
  87. Ali, M.M.; Hashim, N.; Aziz, S.A.; Lasekan, O. Pineapple (Ananas comosus): A comprehensive review of nutritional values, volatile compounds, health benefits, and potential food products. Food Res. Int. 2020, 137, 109675. [CrossRef] · DOI
  88. Ajayi, A.M.; Coker, A.I.; Oyebanjo, O.T.; Adebanjo, I.M.; Ademowo, O.G. Ananas comosus (L) Merrill (pineapple) fruit peel extract demonstrates antimalarial, anti-nociceptive and anti-inflammatory activities in experimental models. J. Ethnopharmacol. 2021, 282, 114576. [CrossRef] [PubMed] · DOI
  89. Vučić, V.; Grabež, M.; Trchounian, A.; Arsić, A. Composition and Potential Health Benefits of Pomegranate: A Review. Curr. Pharm. Des. 2019, 25, 1817-1827. [CrossRef] · DOI
  90. Cervi, V.F.; Saccol, C.P.; Sari, M.H.M.; Martins, C.C.; da Rosa, L.S.; Ilha, B.D.; Soares, F.Z.; Luchese, C.; Wilhelm, E.A.; Cruz, L. Pullulan film incorporated with nanocapsules improves pomegranate seed oil anti-inflammatory and antioxidant effects in the treatment of atopic dermatitis in mice. Int. J. Pharm. 2021, 609, 121144. [CrossRef] [PubMed] · DOI
  91. Pasupuleti, V.R.; Sammugam, L.; Ramesh, N.; Gan, S.H. Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits. Oxid. Med. Cell. Longev. 2017, 2017, 1259510. [CrossRef] 100. · DOI
  92. Abdellatif, M.M.; Elakkad, Y.E.; Elwakeel, A.A.; Allam, R.M.; Mousa, M.R. Formulation and characterization of propolis and tea tree oil nanoemulsion loaded with clindamycin hydrochloride for wound healing: In-vitro and in-vivo wound healing assessment. Saudi Pharm. J. 2021. [CrossRef] 101. Vega, J.; Bonomi-Barufi, J.; Gómez-Pinchetti, J.L.; Figueroa, F.L. Cyanobacteria and Red Macroalgae as Potential Sources of Anti-oxidants and UV Radiation-Absorbing Compounds for Cosmeceutical Applications. Mar. Drugs 2020, 18, 659. [CrossRef] 102. Aslam, A.; Bahadar, A.; Liaqat, R.; Saleem, M.; Waqas, A.; Zwawi, M. Algae as an attractive source for cosmetics to counter envi-ronmental stress. Sci. Total Environ. 2021, 772, 144905. [CrossRef] [PubMed] 103. Septembre-Malaterre, A.; Stanislas, G.; Douraguia, E.; Gonthier, M.-P. Evaluation of nutritional and antioxidant properties of the tropical fruits banana, litchi, mango, papaya, passion fruit and pineapple cultivated in Réunion French Island. Food Chem. 2016, 212, 225-233. [CrossRef] [PubMed] 104. Al-Mqbali, L.R.A.; Hossain, M.A. Cytotoxic and antimicrobial potential of different varieties of ripe banana used traditionally to treat ulcers. Toxicol. Rep. 2019, 6, 1086-1090. [CrossRef] [PubMed] 105. Bonifácio-Lopes, T.; Boas, A.A.; Coscueta, E.R.; Costa, E.M.; Silva, S.; Campos, D.; Teixeira, J.A.; Pintado, M. Bioactive extracts from brewer's spent grain. Food Funct. 2020, 11, 8963-8977. [CrossRef] [PubMed] 106. Connolly, A.; Cermeño, M.; Alashi, A.M.; Aluko, R.E.; FitzGerald, R.J. Generation of phenolic-rich extracts from brewers' spent grain and characterisation of their in vitro and in vivo activities. Innov. Food Sci. Emerg. Technol. 2021, 68, 102617. [CrossRef] 107. Kocaadam, B.; Şanlier, N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit. Rev. Food Sci. Nutr. 2015, 57, 2889-2895. [CrossRef] [PubMed] 108. · DOI
  93. Manuguerra, S.; Caccamo, L.; Mancuso, M.; Arena, R.; Rappazzo, A.C.; Genovese, L.; Santulli, A.; Messina, C.M.; Maricchiolo, G. The antioxidant power of horseradish, Armoracia rusticana, underlies antimicrobial and antiradical effects, exerted in vitro. Nat. Prod. Res. 2018, 34, 1567-1570. [CrossRef] [PubMed] 116. · DOI
  94. Saleem, S.; Muhammad, G.; Hussain, M.A.; Altaf, M.; Bukhari, S.N. Withania somnifera L.: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective. Iran. J. Basic Med. Sci. 2020, 23, 1501. [PubMed] 117. Kim, D.Y.; Kim, M.K.; Kim, B.-W. The Antioxidant and Skin Whitening Effect of Withania somnifera (Winter Cherry). J. Food Hyg. Saf. 2015, 30, 258-264. [CrossRef] 118. Lupo, M.P. Antioxidants and vitamins in cosmetics. Clin. Dermatol. 2001, 19, 467-473. [CrossRef] 119. Shapiro, S.S.; Saliou, C. Role of vitamins in skin care. Nutrition 2001, 17, 839-844. [CrossRef] 120. Lobo, V.; Patil, A.; Phatak, A.; Chandra, N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn. Rev. 2010, 4, 118-126. [CrossRef] 121. De Oliveira Pinto, C.A.; Martins, T.E.; Martinez, R.M.; Freire, T.B.; Velasco, M.V.; Baby, A.R. Vitamin E in Human Skin: Functionality and Topical Products; InTech Open: London, UK, 2021. 122. · DOI · Paper page
  95. Tozer, S.; O'Mahony, C.; Hannah, J.; O'Brien, J.; Kelly, S.; Kosemund-Meynen, K.; Alexander-White, C. Aggregate exposure modelling of vitamin A from cosmetic products, diet and food supplements. Food Chem. Toxicol. 2019, 131, 110549. [CrossRef] [PubMed] 123. Gaspar, L.R.; Campos, P.M.B.G.M. A HPLC method to evaluate the influence of photostabilizers on cosmetic formulations containing UV-filters and vitamins A and E. Talanta 2010, 82, 1490-1494. [CrossRef] [PubMed] 124. · DOI
  96. Alaluf, S.; Heinrich, U.; Stahl, W.; Tronnier, H.; Wiseman, S. Dietary Carotenoids Contribute to Normal Human Skin Color and UV Photosensitivity. J. Nutr. 2002, 132, 399-403. [CrossRef] [PubMed] 129. · DOI
  97. Köpcke, W.; Krutmann, J. Protection from Sunburn with β-Carotene-A Meta-analysis. Photochem. Photobiol. 2008, 84, 284-288. [CrossRef] [PubMed] 130. · DOI · Paper page
  98. Chiu, C.-J.; Taylor, A. Nutritional antioxidants and age-related cataract and maculopathy. Exp. Eye Res. 2007, 84, 229-245. [CrossRef] 131. Zizola, C.F.; Frey, S.K.; Jitngarmkusol, S.; Kadereit, B.; Yan, N.; Vogel, S. Cellular Retinol-Binding Protein Type I (CRBP-I) Regulates Adipogenesis. Mol. Cell. Biol. 2010, 30, 3412-3420. [CrossRef] [PubMed] 132. Darlenski, R.; Surber, C.; Fluhr, J.W. Topical retinoids in the management of photodamaged skin: From theory to evidence-based practical approach. Br. J. Dermatol. 2010, 163, 1157-1165. [CrossRef] 133. Sorg, O.; Kuenzli, S.; Kaya, G.; Saurat, J.-H. Proposed mechanisms of action for retinoid derivatives in the treatment of skin aging. J. Cosmet. Dermatol. 2005, 4, 237-244. [CrossRef] [PubMed] 134. Sorg, O.; Saurat, J.-H. Topical Retinoids in Skin Ageing: A Focused Update with Reference to Sun-Induced Epidermal Vitamin A Deficiency. Dermatology 2014, 228, 314-325. [CrossRef] [PubMed] 135. Shao, Y.; He, T.; Fisher, G.J.; Voorhees, J.J.; Quan, T. Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo. Int. J. Cosmet. Sci. 2016, 39, 56-65. [CrossRef] · DOI · Paper page
  99. Rossetti, D.; Kielmanowicz, M.G.; Vigodman, S.; Hu, Y.P.; Chen, N.; Nkengne, A.; Oddos, T.; Fischer, D.; Seiberg, M.; Lin, C.B. A novel anti-ageing mechanism for retinol: Induction of dermal elastin synthesis and elastin fibre formation. Int. J. Cosmet. Sci. 2011, 33, 62-69. [CrossRef] [PubMed] 137. · DOI · Paper page
  100. Kligman, A.M.; Grove, G.L.; Hirose, R.; Leyden, J.J. Topical tretinoin for photoaged skin. J. Am. Acad. Dermatol. 1986, 15, 836-859. [CrossRef] 138. Bauer, E.A.; Seltzer, J.L.; Eisen, A.Z. Retinoic Acid Inhibition of Collagenase and Gelatinase Expression in Human Skin Fibroblast Cultures. Evidence for a Dual Mechanism. J. Investig. Dermatol. 1983, 81, 162-169. [CrossRef] 139. Michalak, M.; Pierzak, M.; Kręcisz, B.; Suliga, E. Bioactive Compounds for Skin Health: A Review. Nutrients 2021, 13, 203. [CrossRef] 140. Everts, H.B. Endogenous retinoids in the hair follicle and sebaceous gland. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 2012, 1821, 222-229. [CrossRef] [PubMed] 141. Mukherjee, S.; Date, A.; Patravale, V.; Korting, H.C.; Roeder, A.; Weindl, G. Retinoids in the treatment of skin aging: An overview of clinical efficacy and safety. Clin. Interv. Aging 2006, 1, 327-348. [CrossRef] 142. Dawson, M.I.; Hobbs, P.D.; Peterson, V.J.; Leid, M.; Lange, C.W.; Feng, K.C.; Chen, G.Q.; Gu, J.; Li, H.; Kolluri, S.K.; et al. Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity. Cancer Res. 2001, 61, 4723-4730. 143. Duvic, M.; Nagpal, S.; Asano, A.T.; Chandraratna, R.A. Molecular mechanisms of tazarotene action in psoriasis. J. Am. Acad. Dermatol. 1997, 37, S18-S24. [CrossRef] 144. Tanno, O.; Ota, Y.; Kitamura, N.; Katsube, T.; Inoue, S. Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br. J. Dermatol. 2000, 143, 524-531. [CrossRef] [PubMed] 145. · DOI
  101. Forbat, E.; Al-Niaimi, F.; Ali, F.R. Use of nicotinamide in dermatology. Clin. Exp. Dermatol. 2017, 42, 137-144. [CrossRef] [PubMed] 146. · DOI
  102. Bains, P.; Kaur, M.; Kaur, J.; Sharma, S. Nicotinamide: Mechanism of action and indications in dermatology. Indian J. Dermatol. Venereol. Leprol. 2018, 84, 234-237. [CrossRef] [PubMed] 147. · DOI
  103. Seemal Desai, M.D.; Eloisa Ayres, M.D.; Hana Bak, M.D.; Green, B.S.; PhDg, Q.Z. Effect of a tranexamic acid, kojic acid, and niacin-amide containing serum on facial dyschromia: A clinical evaluation. J. Drugs Dermatol. 2019, 18, 454-459. 148. Cosmetic Ingredient Review Expert Panel. Final report of the safety assessment of niacinamide and niacin. Int. J. Toxicol. 2005, 24, 1-31. 149.
  104. Caritá, A.C.; Fonseca-Santos, B.; Shultz, J.D.; Michniak-Kohn, B.; Chorilli, M.; Leonardi, G.R. Vitamin C: One compound, several uses. Advances for delivery, efficiency and stability. Nanomed. Nanotechnol. Biol. Med. 2020, 24, 102117. [CrossRef] [PubMed] 150. · DOI
  105. Sunil Kumar, B.V.; Singh, S.; Verma, R. Anticancer potential of dietary vitamin D and ascorbic acid: A review. Crit. Rev. Food Sci. Nutr. 2017, 57, 2623-2635. [CrossRef] [PubMed] 151. Lin, J.-Y.; Selim, M.; Shea, C.R.; Grichnik, J.M.; Omar, M.M.; Monteiro-Riviere, N.; Pinnell, S.R. UV photoprotection by combination topical antioxidants vitamin C and vitamin E. J. Am. Acad. Dermatol. 2003, 48, 866-874. [CrossRef] [PubMed] 152. Mastrangelo, D.; Pelosi, E.; Castelli, G.; Lo-Coco, F.; Testa, U. Mechanisms of anti-cancer effects of ascorbate: Cytotoxic activity and epigenetic modulation. Blood CellsMol. Dis. 2018, 69, 57-64. [CrossRef] [PubMed] 153. · DOI
  106. Shearer, M.J.; Bach, A.; Kohlmeier, M. Chemistry, nutritional sources, tissue distribution and metabolism of vitamin K with special reference to bone health. J. Nutr. 1996, 126, 1181S-1186S. [CrossRef] [PubMed] 163. Fitzmaurice, S.; Sivamani, R.; Isseroff, R. Antioxidant Therapies for Wound Healing: A Clinical Guide to Currently Commercially Available Products. Ski. Pharmacol. Physiol. 2011, 24, 113-126. [CrossRef] [PubMed] 164. Ghorbanzadeh, B.; Nemati, M.; Behmanesh, M.A.; Hemmati, A.A.; Houshmand, G. Topical vitamin K1promotes repair of full thickness wound in rat. Indian J. Pharmacol. 2014, 46, 409-412. [CrossRef] [PubMed] 165. · DOI
  107. Katiyar, S.K.; Afaq, F.; Azizuddin, K.; Mukhtar, H. Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mi-togen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol (-)-epigallocatechin-3-gallate. Toxicol. Appl. Pharmacol. 2001, 176, 110-117. [CrossRef] [PubMed] 171. Afaq, F.; Adhami, V.M.; Ahmad, N.; Mukhtar, H. Inhibition of ultraviolet B-mediated activation of nuclear factor κB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate. Oncogene 2003, 22, 1035-1044. [CrossRef] [PubMed] 172. Michna, L.; Lu, Y.-P.; Lou, Y.-R.; Wagner, G.C.; Conney, A.H. Stimulatory effect of oral administration of green tea and caffeine on locomotor activity in SKH-1 mice. Life Sci. 2003, 73, 1383-1392. [CrossRef] 173. Laine, A.-L. Resistance variation within and among host populations in a plant-pathogen metapopulation: Implications for regional pathogen dynamics. J. Ecol. 2004, 92, 990-1000. [CrossRef] 174. Afaq, F.; Adhami, V.M.; Ahmad, N. Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice. Toxicol. Appl. Pharmacol. 2003, 186, 28-37. [CrossRef] 175. Cao, C.; Lu, S.; Kivlin, R.; Wallin, B.; Card, E.; Bagdasarian, A.; Tamakloe, T.; Wang, W.J.; Song, X.; Chu, W.M.; et al. SIRT1 confers protection against UVB-and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes. J. Cell. Mol. Med. 2009, 13, 3632-3643. [CrossRef] [PubMed] 176. · DOI
  108. Thimmulappa, R.K.; Mai, K.H.; Srisuma, S.; Kensler, T.W.; Yamamoto, M.; Biswal, S. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. 2002, 62, 5196-5203. [PubMed] 177. Suh, J.H.; Shenvi, S.V.; Dixon, B.M.; Liu, H.; Jaiswal, A.K.; Liu, R.M.; Hagen, T.M. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc. Natl. Acad. Sci. USA 2004, 101, 3381-3386. [CrossRef] 178. Kubo, E.; Chhunchha, B.; Singh, P.; Sasaki, H.; Singh, D.P. Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress. Sci. Rep. 2017, 7, 14130. [CrossRef] [PubMed] 179. · DOI
  109. Heo, S.-J.; Ko, S.-C.; Cha, S.-H.; Kang, D.-H.; Park, H.-S.; Choi, Y.-U.; Kim, D.; Jung, W.-K.; Jeon, Y.-J. Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation. Toxicol. Vitr. 2009, 23, 1123-1130. [CrossRef] [PubMed] 185. · DOI
  110. Heo, S.-J.; Jeon, Y.-J. Protective effect of fucoxanthin isolated from Sargassum siliquastrum on UV-B induced cell damage. J. Photochem. Photobiol. B Biol. 2009, 95, 101-107. [CrossRef] 186. Hur, S.; Lee, H.; Kim, Y.; Lee, B.-H.; Shin, J.; Kim, T.-Y. Sargaquinoic acid and sargachromenol, extracts of Sargassum sagamianum, induce apoptosis in HaCaT cells and mice skin: Its potentiation of UVB-induced apoptosis. Eur. J. Pharmacol. 2008, 582, 1-11. [CrossRef] [PubMed] 187. · DOI
  111. Bałan, B.J.; Niemcewicz, M.; Kocik, J.; Jung, L.; Skopi ńska-Ró żewska, E.; Skopi ński, P. Oral administration of Aloe vera gel, an-ti-microbial and anti-inflammatory herbal remedy, stimulates cell-mediated immunity and antibody production in a mouse model. Cent. Eur. J. Immunol. 2014, 39, 125. [CrossRef] [PubMed] 188. · DOI
  112. Hęś, M.; Dziedzic, K.; Górecka, D.; Jędrusek-Goli ńska, A.; Gujska, E. Aloe vera (L.) Webb.: Natural sources of antioxidants-A review. Plant. Foods Hum. Nutr. 2019, 74, 255-265. [CrossRef] 189. Hajheidari, Z.; Saeedi, M.; Morteza-Semnani, K.; Soltani, A. Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: A randomized, double-blind, prospective trial. J. Dermatol. Treat. 2013, 25, 123-129. [CrossRef] [PubMed] 190. · DOI
  113. Kitture, R.; Ghosh, S.; More, P.A.; Date, K.; Gaware, S.; Datar, S.; Chopade, B.A.; Kale, S.N. Curcumin-Loaded, Self-Assembled Aloevera Template for Superior Antioxidant Activity and Trans-Membrane Drug Release. J. Nanosci. Nanotechnol. 2015, 15, 4039-4045. [CrossRef] [PubMed] 191. Arct, J.; Pytkowska, K. Flavonoids as components of biologically active cosmeceuticals. Clin. Dermatol. 2008, 26, 347-357. [CrossRef] 192. Maleki, S.J.; Crespo, J.F.; Cabanillas, B. Anti-inflammatory effects of flavonoids. Food Chem. 2019, 299, 125124. [CrossRef] 193. Procházková, D.; Boušová, I.; Wilhelmová, N. Antioxidant and prooxidant properties of flavonoids. Fitoterapia 2011, 82, 513-523. [CrossRef] [PubMed] 194. · DOI
  114. Weber, J.M.; Ruzindana-Umunyana, A.; Imbeault, L.; Sircar, S. Inhibition of adenovirus infection and adenain by green tea catechins. Antivir. Res. 2002, 58, 167-173. [CrossRef] 195. Alvesalo, J.; Vuorela, H.; Tammela, P.; Leinonen, M.; Saikku, P. Inhibitory effect of dietary phenolic compounds on Chlamydia pneumoniae in cell cultures. Biochem. Pharmacol. 2006, 71, 735-741. [CrossRef] [PubMed] 196. Subarnas, A.; Wagner, H. Analgesic and anti-inflammatory activity of the proanthocyanidin shellegueain A from Polypodium feei METT. Phytomedicine 2000, 7, 401-405. [CrossRef] 197. Mladěnka, P.; Zatloukalová, L.; Filipský, T.; Hrdina, R. Cardiovascular effects of flavonoids are not caused only by direct antiox-idant activity. Free Radic. Biol. Med. 2010, 49, 963-975. [CrossRef] [PubMed] 198. Kostelac, D.; Rechkemmer, G.; Briviba, K. Phytoestrogens Modulate Binding Response of Estrogen Receptors α and β to the Estrogen Response Element. J. Agric. Food Chem. 2003, 51, 7632-7635. [CrossRef] [PubMed] 199. · DOI
  115. Kuiper, G.G.J.M.; Lemmen, J.G.; Carlsson, B.; Corton, J.C.; Safe, S.H.; Van Der Saag, P.T.; Van Der Burg, B.; Gustafsson, J. Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β. Endocrinology 1998, 139, 4252-4263. [CrossRef] [PubMed] 200. Guardia, T.; Rotelli, A.E.; Juarez, A.O.; Pelzer, L.E. Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco 2001, 56, 683-687. [CrossRef] 201. Virgili, F.; Kobuchi, H.; Packer, L. Nitrogen monoxide (NO) metabolism antioxidant properties and modulation of inducible NO synthase activity in activated macrophages by procyanidins extracted from Pinus maritima (Pycnogenol). Free Radic. Biol. Med. 1998, 24, 1120-1129. [CrossRef] 202. Kempuraj, D.; Madhappan, B.; Christodoulou, S.; Boucher, W.; Cao, J.; Papadopoulou, N.; Cetrulo, C.L.; Theoharides, T.C. Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells. Br. J. Pharmacol. 2005, 145, 934-944. [CrossRef] 203. Marzocchella, L.; Fantini, M.; Benvenuto, M.; Masuelli, L.; Tresoldi, I.; Modesti, A.; Bei, R. Dietary Flavonoids: Molecular Mechanisms of Action as Anti-Inflammatory Agents. Recent Pat. Inflamm. Allergy Drug Discov. 2011, 5, 200-220. [CrossRef] [PubMed] 204. Kumazawa, Y.; Takimoto, H.; Matsumoto, T.; Kawaguchi, K. Potential Use of Dietary Natural Products, Especially Polyphenols, for Improving Type-1 Allergic Symptoms. Curr. Pharm. Des. 2014, 20, 857-863. [CrossRef] [PubMed] 205. Tanaka, T.; Takahashi, R. Flavonoids and Asthma. Nutrients 2013, 5, 2128-2143. [CrossRef] 206. Finn, D.F.; Walsh, J.J. Twenty-first century mast cell stabilizers. Br. J. Pharmacol. 2013, 170, 23-37. [CrossRef] [PubMed] 207. · DOI
  116. Gibis, M.; Zeeb, B.; Weiss, J. Formation, characterization, and stability of encapsulated hibiscus extract in multilayered liposomes. Food Hydrocoll. 2013, 38, 28-39. [CrossRef] 215. Kaur, C.D.; Saraf, S. Topical vesicular formulations of Curcuma longa extract on recuperating the ultraviolet radiation-damaged skin. J. Cosmet. Dermatol. 2011, 10, 260-265. [CrossRef] [PubMed] 216. Moulaoui, K.; Caddeo, C.; Manca, M.L.; Castangia, I.; Valenti, D.; Escribano, E.; Atmani, D.; Fadda, A.M.; Manconi, M. Identification and nanoentrapment of polyphenolic phytocomplex from Fraxinus angustifolia: In vitro and in vivo wound healing potential. Eur. J. Med. Chem. 2015, 89, 179-188. [CrossRef] [PubMed] 217. Takahashi, M.; Kitamoto, D.; Asikin, Y.; Takara, K.; Wada, K. Liposomes encapsulating Aloe vera leaf gel extract significantly en-hance proliferation and collagen synthesis in human skin cell lines. J. Oleo Sci. 2009, 58, 643-650. [CrossRef] 218. · DOI
  117. Aisha, A.F.; Majid, A.M.; Ismail, Z. Preparation and characterization of nano liposomes of Orthosiphon stamineus ethanolic extract in soybean phospholipids. BMC Biotechnol. 2014, 14, 23. [CrossRef] [PubMed] 219. · DOI
  118. Spigno, G.; Donsì, F.; Amendola, D.; Sessa, M.; Ferrari, G.; De Faveri, D.M. Nanoencapsulation systems to improve solubility and antioxidant efficiency of a grape marc extract into hazelnut paste. J. Food Eng. 2013, 114, 207-214. [CrossRef] 220. Tsai, W.C.; Li, W.C.; Yin, H.Y.; Yu, M.C.; Wen, H.W. Constructing liposomal nanovesicles of ginseng extract against hydrogen per-oxide-induced oxidative damage to L929 cells. Food Chem. 2012, 132, 744-751. [CrossRef] 221. Kwon, S.S.; Kim, S.Y.; Kong, B.J.; Kim, K.J.; Noh, G.Y.; Im, N.R.; Lim, J.W.; Ha, J.H.; Kim, J.; Park, S.N. Cell penetrating peptide conjugated liposomes as transdermal delivery system of Polygonum aviculare L. extract. Int. J. Pharm. 2015, 483, 26-37. [CrossRef] 222. · DOI
  119. Mahdi, E.S.; Sakeena, M.H.; Abdulkarim, M.F.; Sattar, M.A.; Noor, A.M.; Abdullah, G.Z. Formulation and in vitro release evaluation of newly synthesized palm kernel oil esters-based nanoemulsion delivery system for 30% ethanolic dried extract derived from local Phyllanthus urinaria for skin antiaging. Int. J. Nanomed. 2011, 6, 2499-2512. [CrossRef] [PubMed] 223. · DOI
  120. Zorzi, G.K.; Caregnato, F.F.; Moreira, J.C.F.; Teixeira, H.F.; Carvalho, E.L.S. Antioxidant Effect of Nanoemulsions Containing Extract of Achyrocline satureioides (Lam) D.C.-Asteraceae. AAPS PharmSciTech 2015, 17, 844-850. [CrossRef] [PubMed] · DOI · Paper page

Authors
Hoang, H. T., Moon, J.-Y., & Lee, Y.-C.
Affiliations
  • Gachon University (KR)
  • Hansung University (KR)
Corresponding author
  • Moon, Ju-Young
  • Lee, Young-Chul
Venue
Cosmetics
Publisher
MDPI AG
Published
2021-11-10
Volume
8
Issue
4
Pages
106
ISSN
2079-9284 (ISSN-L)
OpenAlex
W3213264976
Cited by
329
References
226
Citations by year
2026: 58 · 2025: 106 · 2024: 80 · 2023: 54 · 2022: 29 · 2021: 2
FWCI
36.67
Type
journal article
Language
en
Open access
Locations
  • Cosmetics (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
natural antioxidants, plant extracts, skin care products, flavonoids, phenolic compounds, oxidative damage, aging, cosmetic formulation, pro-oxidant activity, skin aging

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review