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Cited by 77Bone fractures and treatmentsSpinal Fractures and Fixation TechniquesBone health and osteoporosis research

The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.

Late Dynamization by Reduced Fixation Stiffness Enhances Fracture Healing in a Rat Femoral Osteotomy Model

Claes, Lutz, Blakytny, Robert, Besse, John, Bausewein, Christine, Ignatius, Anita, Willie, Bettina·2011·Journal of Orthopaedic Trauma
DOI 10.1097/bot.0b013e3181e3d994
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Abstract

OBJECTIVES: This study evaluated the effect of late dynamization on callus stiffness and size in a rat diaphyseal femoral osteotomy model. It was hypothesized that late dynamization, after bony bridging, would enhance healing. METHODS: The external unilateral fixator was dynamized by removal of the inner fixator bar at either 3 weeks (D3 group) or 4 weeks (D4 group) postoperation. After 5 weeks, the rats were euthanized and healing was evaluated by biomechanical and densitometric methods. Published data of control groups, constant rigid (R group), and flexible fixation (F group) were included for comparison. RESULTS: Enhanced healing was observed in both the 3- and 4-week dynamized groups compared with the constant flexible and constant rigid fixation. Late dynamization after both 3 and 4 weeks postoperation led to a stiffer callus (percent flexural rigidity relative to the intact side and elastic modulus) with a smaller callus bone volume compared with the F group. Both late dynamized groups (D3 and D4) had a similar flexural rigidity and bone mineral density as that of the R group. However, the D4 group had a significantly greater elastic modulus and significantly smaller callus bone volume compared with the R group suggesting increased remodeling occurred in the D4 group indicative of more advanced healing. CONCLUSIONS: Late dynamization enhanced fracture healing in this animal model compared with a constant rigid or constant flexible fixation. Although results of the small animal study cannot directly be transferred to humans, these results indicate that once bony bridging has occurred, dynamization may accelerate bone remodeling processes.

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Crossref · 10.1097/bot.0b013e3181e3d994

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  • The mechanical demands for optimal healing change throughout the healing process from little to more movement and forces in the fracture gap.

    “The mechanical demands for optimal healing are known to change throughout the healing process from little to more movement and forces in the fracture gap (10–12).”

    From Methods to accelerate fracture healing – a narrative review from a clinical perspective (2024) · cites this paper as [12]

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Metadata

Authors
Claes, L., Blakytny, R., Besse, J., Bausewein, C., Ignatius, A., & Willie, B.
Affiliations
Universität Ulm (DE)
Corresponding author
  • Claes, Lutz
  • Blakytny, Robert
  • Besse, John
  • Bausewein, Christine
  • Ignatius, Anita
  • Willie, Bettina
ORCID
Venue
Journal of Orthopaedic Trauma
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2011-03
Volume
25
Issue
3
Pages
169-174
ISSN
0890-5339 (ISSN-L)
DOI
10.1097/bot.0b013e3181e3d994
OpenAlex
W2318378456
Cited by
75
References
33
Citations by year
2026: 5 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 8 · 2020: 10 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 6 · 2012: 6
FWCI
3.86
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Orthopaedic Trauma (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone fractures and treatments
  • Health Sciences › Medicine › Surgery › Spinal Fractures and Fixation Techniques
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
fracture healing, external fixation, callus stiffness, bone remodeling, elastic modulus, bending stiffness, femoral osteotomy
MeSH terms
Animals, Biomechanical Phenomena, Bony Callus, Densitometry, Disease Models, Animal, Equipment Design, Femoral Fractures, Femur, Fracture Fixation, Male, Movement, Osteotomy, Time Factors, Bone Density, Bone Remodeling, Fracture Healing, Rats, Wistar, Pliability, Rats

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