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Cited by 130Cervical and Thoracic MyelopathySpine and Intervertebral Disc PathologyVeterinary Orthopedics and Neurology

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Cervical Myelopathy: A Clinical and Radiographic Evaluation and Correlation to Cervical Spondylotic Myelopathy

Harrop, James S., Naroji, Swetha, Maltenfort, Mitchell, Anderson, D. Greg, Albert, Todd, Ratliff, John K., Ponnappan, Ravi K., Rihn, Jeffery A., Smith, Harvey E., Hilibrand, Alan, Sharan, Ashwini D., Vaccaro, Alexander·2010·Spine
DOI 10.1097/brs.0b013e3181b723af
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Abstract

STUDY DESIGN: Retrospective analysis of a cohort of patients treated between April 2006 and January 2008, and diagnosed with cervical degenerative disease. OBJECTIVE: To determine the correlation of the clinical findings associated with cervical myelopathy to the presence of spinal cord compression or cord signal abnormalities on magnetic resonance imaging (MRI). SUMMARY OF BACKGROUND DATA: There are numerous reports describing the radiographic features of cervical spondylosis, however, no publication specifically describes the association between the physical signs of cervical myelopathy and the presenting imaging findings. METHODS: Myelopathy was defined as the presence of greater than one long-tract sign localized to the cervical spinal cord (Hoffman or Babinski signs, clonus, hyper-reflexia, crossed abductor sign, and/or gait dysfunction) on physical examination in the absence of other neurologic condition(s). The presence of these signs, MRI imaging features of spinal cord compression and hyperintense T2 intraparenchymal cord signal abnormality, and patient demographics were recorded. RESULTS: One hundred three patients met inclusion criteria (age >18, symptomatic cervical degenerative disease and complete neurologic assessment). Of these, 54 had clinical findings of cervical myelopathy. Radiographic features of cord compression were present in 62% of patients, and 84% had myelopathy on examination. No patients without cord compression presented with myelopathy (P < 0.0001). Thirty-five percent of the patients presented with hyperintense signal on T2 MRI within the spinal cord parenchyma. This finding correlated with the presence of myelopathy (P < 0.0001). Multivariate analysis on the subset with cord compression indicates that the likelihood of myelopathy increased with the presence of cord signal hyperintensity (odds ratio [OR], 11.4), sensory loss (OR, 16.9), and age (OR, 1.10 per year). CONCLUSION: The diagnosis of cervical myelopathy is based on presenting symptoms and physical examination. This analysis illustrates that radiographic cervical spinal cord compression and hyperintense T2 intraparen chymal signal abnormalities correlate with the presence of myelopathic findings on physical examination.

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Crossref · 10.1097/brs.0b013e3181b723af

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Research works printed but not linked: 3

  1. Hashizume, 1980, Acta Pathol Jpn, 30, 255
  2. Lyu, 2004, J Neurol Neurosurg Psychiatry, 75, 256
  3. Matsunaga, 2004, J Neurosurg, 100, 245

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Metadata

Authors
Harrop, J. S., Naroji, S., Maltenfort, M., Anderson, D. G., Albert, T., Ratliff, J. K., Ponnappan, R. K., Rihn, J. A., Smith, H. E., Hilibrand, A., Sharan, A. D., & Vaccaro, A.
Affiliations
Thomas Jefferson University (US)
Corresponding author
Harrop, James S.
ORCID
Venue
Spine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2010-03
Volume
35
Issue
6
Pages
620-624
ISSN
0362-2436 (ISSN-L)
DOI
10.1097/brs.0b013e3181b723af
OpenAlex
W2082174064
Cited by
130
References
24
Citations by year
2026: 7 · 2025: 10 · 2024: 14 · 2023: 12 · 2022: 5 · 2021: 11 · 2020: 14 · 2019: 10 · 2018: 7 · 2017: 8 · 2016: 9 · 2015: 7 · 2014: 6 · 2013: 2 · 2012: 1
FWCI
3.39
Type
journal article
Language
en
Open access
closed
Locations
  • Spine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Cervical and Thoracic Myelopathy
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Spine and Intervertebral Disc Pathology
  • Health Sciences › Veterinary › Small Animals › Veterinary Orthopedics and Neurology
Keywords
cervical myelopathy, cervical spondylosis, spinal cord compression, T2 hyperintensity, long tract signs, Babinski sign, sensory impairment, cervical spine degeneration
MeSH terms
Adult, Aged, Cervical Vertebrae, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Radiography, Retrospective Studies, Spinal Cord Compression, Spinal Cord Diseases, Multivariate Analysis, Logistic Models, Spondylosis

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