The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.
Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness*
Open accessAbstract
BACKGROUND: Mechanical ventilation is a life-saving intervention used to provide adequate pulmonary ventilation in patients suffering from respiratory failure. However, prolonged mechanical ventilation is associated with significant diaphragmatic weakness resulting from both myofiber atrophy and contractile dysfunction. Although several signaling pathways contribute to diaphragm weakness during mechanical ventilation, it is established that oxidative stress is required for diaphragmatic weakness to occur. Therefore, identifying the site(s) of mechanical ventilation- induced reactive oxygen species production in the diaphragm is important. OBJECTIVE: These experiments tested the hypothesis that elevated mitochondrial reactive oxygen species emission is required for mechanical ventilation-induced oxidative stress, atrophy, and contractile dysfunction in the diaphragm. DESIGN: Cause and effect was determined by preventing mechanical ventilation-induced mitochondrial reactive oxygen species emission in the diaphragm of rats using a novel mitochondria-targeted antioxidant (SS-31). INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Compared to mechanically ventilated animals treated with saline, animals treated with SS-31 were protected against mechanical ventilation-induced mitochondrial dysfunction, oxidative stress, and protease activation in the diaphragm. Importantly, treatment of animals with the mitochondrial antioxidant also protected the diaphragm against mechanical ventilation-induced myofiber atrophy and contractile dysfunction. CONCLUSIONS: These results reveal that prevention of mechanical ventilation-induced increases in diaphragmatic mitochondrial reactive oxygen species emission protects the diaphragm from mechanical ventilation-induced diaphragmatic weakness. This important new finding indicates that mitochondria are a primary source of reactive oxygen species production in the diaphragm during prolonged mechanical ventilation. These results could lead to the development of a therapeutic intervention to impede mechanical ventilation-induced diaphragmatic weakness.
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“the use of a mitochondrial-targeted antioxidant peptide (SS-31) has been shown to inhibit ROS production and skeletal muscle atrophy in a variety of experimental animal models of inactivity (Min, Smuder, Kwon, Kavazis, Szeto, and Powers 2011;Powers, Hudson, Nelson, Talbert, Min, Szeto, Kavazis, and Smuder 2011)”
From Successful aging: Advancing the science of physical independence in older adults (2015) · cites this paper as Powers et al. 2011
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Metadata
- Authors
- Powers, S. K., Hudson, M. B., Nelson, W. B., Talbert, E. E., Min, K., Szeto, H. H., Kavazis, A. N., & Smuder, A. J.
- Affiliations
- University of Florida (US)
- ORCID
- Venue
- Critical Care Medicine
- Published
- 2011-07
- Volume
- 39
- Issue
- 7
- Pages
- 1749-1759
- ISSN
- 0090-3493 (ISSN-L)
- PMC
- PMC4995067
- OpenAlex
- W2059026617
- Cited by
- 255
- References
- 38
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 16 · 2023: 9 · 2022: 11 · 2021: 23 · 2020: 21 · 2019: 16 · 2018: 21 · 2017: 15 · 2016: 22 · 2015: 22 · 2014: 19 · 2013: 20 · 2012: 16
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL087839)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- mechanical ventilation, diaphragmatic weakness, mitochondria-targeted antioxidants, SS-31, mitochondrial reactive oxygen species, oxidative stress, diaphragm atrophy, contractile dysfunction, protease activation, mitochondrial dysfunction, respiratory failure
- MeSH terms
- Tripartite Motif Proteins, Actins, Animals, Calpain, Diaphragm, Female, Hydrogen Peroxide, Mitochondria, Muscle, Muscle Contraction, Muscle Proteins, Muscular Atrophy, Oligopeptides, Respiration, Artificial, Rats, Sprague-Dawley, Oxidative Stress, Muscle Fibers, Skeletal, Muscle Weakness, Ubiquitin-Protein Ligases, SKP Cullin F-Box Protein Ligases, Rats, Caspase 3
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