Exercise-induced oxidative stress: Friend or foe?

Powers, Scott K.; Deminice, Rafael; Ozdemir, Mustafa; Yoshihara, Toshinori; Bomkamp, Matthew P.; Hyatt, Hayden

doi:10.1016/j.jshs.2020.04.001

Cited by 655Exercise and Physiological ResponsesAntioxidant Activity and Oxidative StressCardiovascular and exercise physiology

Exercise-induced oxidative stress: Friend or foe?

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Powers, Scott K., Deminice, Rafael, Ozdemir, Mustafa, Yoshihara, Toshinori, Bomkamp, Matthew P., Hyatt, Hayden·2020·Journal of Sport and Health Science

DOI 10.1016/j.jshs.2020.04.001PMC PMC7498668

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Abstract

The first report demonstrating that prolonged endurance exercise promotes oxidative stress in humans was published more than 4 decades ago. Since this discovery, many ensuing investigations have corroborated the fact that muscular exercise increases the production of reactive oxygen species (ROS) and results in oxidative stress in numerous tissues including blood and skeletal muscles. Although several tissues may contribute to exercise-induced ROS production, it is predicted that muscular contractions stimulate ROS production in active muscle fibers and that skeletal muscle is a primary source of ROS production during exercise. This contraction-induced ROS generation is associated with (1) oxidant damage in several tissues (e.g., increased protein oxidation and lipid peroxidation), (2) accelerated muscle fatigue, and (3) activation of biochemical signaling pathways that contribute to exercise-induced adaptation in the contracting muscle fibers. While our understanding of exercise and oxidative stress has advanced rapidly during the last decades, questions remain about whether exercise-induced increases in ROS production are beneficial or harmful to health. This review addresses this issue by discussing the site(s) of oxidant production during exercise and detailing the health consequences of exercise-induced ROS production.

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Muscle exercise increases production of ROS such as H2O2, leading to oxidative stress in many tissues, including skeletal muscle.
“Muscle exercise increases the production of ROS (e.g., hydrogen peroxide (H2O2)), leading to oxidative stress in many tissues, including skeletal muscle [52].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [52]

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Authors: Powers, S. K., Deminice, R., Ozdemir, M., Yoshihara, T., Bomkamp, M. P., & Hyatt, H.
Affiliations: University of Florida (US)
Universidade Estadual de Londrina (BR)
Corresponding author: Ozdemir, Mustafa
ORCID: Powers, Scott K.
Deminice, Rafael
Ozdemir, Mustafa
Yoshihara, Toshinori
Bomkamp, Matthew P.
Hyatt, Hayden
Venue: Journal of Sport and Health Science
Publisher: Elsevier BV
Published: 2020-09
Volume: 9
Issue: 5
Pages: 415-425
ISSN: 2213-2961 (ISSN-L)
2095-2546
DOI: 10.1016/j.jshs.2020.04.001
PMC: PMC7498668
OpenAlex: W3022014008
Cited by: 655
References: 129
Citations by year: 2026: 93 · 2025: 135 · 2024: 121 · 2023: 129 · 2022: 103 · 2021: 68 · 2020: 6
FWCI: 9.40
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Journal of sport and health science/Journal of Sport and Health Science (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Japan Society for the Promotion of Science (17K01765, 23K20366)
Topics: Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: exercise-induced oxidative stress, reactive oxygen species, skeletal muscle, muscle contraction, protein oxidation, lipid peroxidation, muscle fatigue, exercise adaptation
MeSH terms: Adaptation, Physiological, Animals, Antioxidants, Humans, Muscle Contraction, Oxidation-Reduction, Exercise, Reactive Oxygen Species, Oxidative Stress, Muscle, Skeletal, Muscle Fibers, Skeletal, Muscle Fatigue

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Exercise-induced oxidative stress: Friend or foe?

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