Cited by 289T-cell and B-cell ImmunologyCytokine Signaling Pathways and InteractionsImmune cells in cancer

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Current status of interleukin-10 and regulatory T-cells in cancer

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Dennis, Kristen L., Blatner, Nichole R., Gounari, Fotini, Khazaie, Khashayarsha·2013·Current Opinion in Oncology

DOI 10.1097/cco.0000000000000006PMC PMC4322764

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Abstract

PURPOSE OF REVIEW: Tumor growth elicits antigen-specific cytotoxic as well as immune suppressive responses. Interleukin-10 (IL-10) is a key immune-suppressive cytokine produced by regulatory T-cells and by helper T-cells. Here, we review pleiotropic functions of IL-10 that impact the immune pathology of cancer. RECENT FINDINGS: The role of IL-10 in cancer has become less certain with the knowledge of its immune stimulatory functions. IL-10 is needed for T-helper cell functions, T-cell immune surveillance, and suppression of cancer-associated inflammation. By promoting tumor-specific immune surveillance and hindering pathogenic inflammation, IL-10 is emerging as a key cytokine in the battle of the host against cancer. SUMMARY: IL-10 functions at the cross-roads of immune stimulation and immune suppression in cancer. Immunological mechanisms of action of IL-10 can be ultimately exploited to develop novel and effective cancer therapies.

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Authors: Dennis, K. L., Blatner, N. R., Gounari, F., & Khazaie, K.
Affiliations: Northwestern University (US)
University of Chicago (US)
Corresponding author: Khazaie, Khashayarsha
ORCID: Gounari, Fotini
Khazaie, Khashayarsha
Venue: Current Opinion in Oncology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2013-11
Volume: 25
Issue: 6
Pages: 637-645
ISSN: 1040-8746 (ISSN-L)
DOI: 10.1097/cco.0000000000000006
PMC: PMC4322764
OpenAlex: W2085138770
Cited by: 289
References: 189
Citations by year: 2026: 13 · 2025: 29 · 2024: 23 · 2023: 16 · 2022: 29 · 2021: 35 · 2020: 33 · 2019: 24 · 2018: 26 · 2017: 18 · 2016: 23 · 2015: 13 · 2014: 7
FWCI: 1.25
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Current Opinion in Oncology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA160436)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: IL-10, regulatory T cells, tumor immunology, immunosuppression, T helper cells, tumor surveillance, tumor inflammation, immunostimulation, cancer therapy
MeSH terms: Animals, Antigens, Neoplasm, Dendritic Cells, Female, Humans, Immune Tolerance, Lymphocyte Activation, Male, Neoplasms, T-Lymphocyte Subsets, Interleukin-10, Cell Line, Tumor, Cell Proliferation, T-Lymphocytes, Regulatory, Mice, Immunomodulation

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