Current status of interleukin-10 and regulatory T-cells in cancer

Interleukin-10 and the Interleukin-10 Receptor

Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Park, J., Adoro, S., Guinter, T. I., Erman, B., Alag, A., Catálfamo, M., Kimura, M. Y., Cui, Y., Lucas, P. J., Gress, R. E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1840 · Cited by 5,835

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., & Toda, M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.3.1151 · Cited by 5,608 · cited 1×

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265

A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039

IL-10 inhibits cytokine production by activated macrophages

Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3815 · Cited by 2,888

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

Fiorentino, D. F., Bond, M. W., & Mosmann, T. R. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.170.6.2081 · Cited by 2,733

Toll Pathway-Dependent Blockade of CD4 + CD25 + T Cell-Mediated Suppression by Dendritic Cells

Pasare, C., & Medzhitov, R. M. (2003) · Science · doi:10.1126/science.1078231 · Cited by 2,000

Inflammation and Colon Cancer

Terzić, J., Grivennikov, S., Karin, E., & Karin, M. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.01.058 · Cited by 1,974

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

Ghiringhelli, F., Apetoh, L., Tesniere, A., Aymeric, L., Ma, Y., Ortiz, C., Vermaelen, K., Panaretakis, T., Mignot, G., Ullrich, E., et al. (2009) · Nature Medicine · doi:10.1038/nm.2028 · Cited by 1,898

Interleukin-10

Moore, K. W., O’Garra, A., Malefyt, R. D. W., Vieira, P., & Mosmann, T. R. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.001121 · Cited by 1,883

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

Rioux, J. D., Xavier, R. J., Taylor, K. D., Silverberg, M. S., Goyette, P., Huett, A., Green, T., Kuballa, P., Barmada, M. M., Datta, L. W., et al. (2007) · Nature Genetics · doi:10.1038/ng2032 · Cited by 1,769

B cells regulate autoimmunity by provision of IL-10

Fillatreau, S., Sweenie, C. H., McGeachy, M. J., Gray, D., & Anderton, S. M. (2002) · Nature Immunology · doi:10.1038/ni833 · Cited by 1,647

CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

Janssen, E. M., Lemmens, E. E., Wolfe, T., Christen, U., von Herrath, M. G., & Schoenberger, S. P. (2003) · Nature · doi:10.1038/nature01441 · Cited by 1,635

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

Asseman, C., Mauze, S., Leach, M. W., Coffman, R. L., & Powrie, F. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.7.995 · Cited by 1,617

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

Yang, X. O., Pappu, B. P., Nurieva, R., Akimzhanov, A., Kang, H. S., Chung, Y., Ma, L., Shah, B., Panopoulos, A. D., Schluns, K. S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2007.11.016 · Cited by 1,605

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W. R., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.017 · Cited by 1,586

Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory

Shedlock, D. J., & Shen, H. (2003) · Science · doi:10.1126/science.1082305 · Cited by 1,450

Adenoma–linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

Grivennikov, S. I., Wang, K., Mucida, D., Stewart, C. A., Schnabl, B., Jauch, D., Taniguchi, K., Yu, G.-Y., Österreicher, C. H., Hung, K. E., et al. (2012) · Nature · doi:10.1038/nature11465 · Cited by 1,327

Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity

Curiel, T. J., Wei, S., Dong, H., Alvarez, X., Cheng, P., Mottram, P., Krzysiek, R., Knutson, K. L., Daniel, B., Zimmermann, M. C., et al. (2003) · Nature Medicine · doi:10.1038/nm863 · Cited by 1,314

Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

Sun, J. C., & Bevan, M. J. (2003) · Science · doi:10.1126/science.1083317 · Cited by 1,213

Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans

Roncarolo, M. G., Gregori, S., Battaglia, M., Bacchetta, R., Fleischhauer, K., & Levings, M. K. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00420.x · Cited by 1,206

Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen

Akbari, O., DeKruyff, R. H., & Umetsu, D. T. (2001) · Nature Immunology · doi:10.1038/90667 · Cited by 1,196

Regulatory T cells in the control of immune pathology

Maloy, K. J., & Powrie, F. M. (2001) · Nature Immunology · doi:10.1038/ni0901-816 · Cited by 1,177

Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer

Tosolini, M., Kirilovsky, A., Mlecnik, B., Fredriksen, T., Mauger, S., Bindea, G., Berger, A., Bruneval, P., Fridman, W.-H., Pagès, F., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2907 · Cited by 1,146

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

Dardalhon, V., Awasthi, A., Kwon, H., Galileos, G., Gao, W., Sobel, R. A., Mitsdoerffer, M., Strom, T. B., Elyaman, W., Ho, I.-C., et al. (2008) · Nature Immunology · doi:10.1038/ni.1677 · Cited by 1,122

Th17 and regulatory T cells in mediating and restraining inflammation

Littman, D. R., & Rudensky, A. Y. (2010) · Cell · doi:10.1016/j.cell.2010.02.021 · Cited by 1,039

Tumor-Infiltrating FOXP3 + T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer

Salama, P. R., Phillips, M. R., Grieu, F., Morris, M. J., Zeps, N., Joseph, D. J., Platell, C. F. E., & Iacopetta, B. J. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.7229 · Cited by 1,025

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

Marie, J. C., Letterio, J. J., Gavin, M. A., & Rudensky, A. Y. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042276 · Cited by 986

Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

Chaudhry, A., Samstein, R. M., Treuting, P., Liang, Y., Pils, M. C., Heinrich, J.-M., Jack, R. S., Wunderlich, F. T., Brüning, J. C., Müller, W., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.018 · Cited by 980

Interleukin-10 Therapy—Review of a New Approach

Asadullah, K., Sterry, W., & Volk, H. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.4 · Cited by 941

Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production

Prete, G. D., Carli, M., Almerigogna, F., Giudizi, M. G., Biagiotti, R., & Romagnani, S. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.2.353 · Cited by 927

Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells

Groux, H., Bigler, M., de Vries, J. D., & Roncarolo, M. (1996) · Journal of Experimental Medicine · doi:10.1084/jem.184.1.19 · Cited by 876

Tumor-specific Th17-polarized cells eradicate large established melanoma

Muranski, P. J., Boni, A., Antony, P. A., Cassard, L., Irvine, K. R., Kaiser, A., Paulos, C. M., Palmer, D. C., Touloukian, C. E., Ptak, K., et al. (2008) · Blood · doi:10.1182/blood-2007-11-120998 · Cited by 864

Prevention of Arthritis by Interleukin 10–producing B Cells

Mauri, C., Gray, D., Mushtaq, N., & Londei, M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021293 · Cited by 858

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

Murai, M., Turovskaya, O., Kim, G., Madan, R., Karp, C. L., Cheroutre, H., & Kronenberg, M. (2009) · Nature Immunology · doi:10.1038/ni.1791 · Cited by 851

SOCS3 negatively regulates IL-6 signaling in vivo

Croker, B. A., Krebs, D. L., Zhang, J.-G., Wormald, S., Willson, T. A., Stanley, E. G., Robb, L., Greenhalgh, C. J., Förster, I., Clausen, B. E., et al. (2003) · Nature Immunology · doi:10.1038/ni931 · Cited by 840

T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity

Martín‐Orozco, N., Muranski, P. J., Chung, Y., Yang, X. O., Yamazaki, T., Lu, S., Hwu, P., Restifo, N. P., Overwijk, W. W., & Dong, C. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.014 · Cited by 829

HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help

Grakoui, A., Shoukry, N. H., Woollard, D. J., Han, J., Hanson, H. L., Ghrayeb, J., Murthy, K. K., Rice, C. M., & Walker, C. M. (2003) · Science · doi:10.1126/science.1088774 · Cited by 824

Type 1 T regulatory cells

Roncarolo, M. G., Bacchetta, R., Bordignon, C., Narula, S. K., & Levings, M. K. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1820105.x · Cited by 814

A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells

Awasthi, A., Carrier, Y., Peron, J. P. S., Bettelli, E., Kamanaka, M., Flavell, R. A., Kuchroo, V. K., Oukka, M., & Weiner, H. L. (2007) · Nature Immunology · doi:10.1038/ni1541 · Cited by 804

Characterization of Dendritic Cells that Induce Tolerance and T Regulatory 1 Cell Differentiation In Vivo

Wakkach, A., Fournier, N., Brun, V., Breittmayer, J., Cottrez, F., & Groux, H. (2003) · Immunity · doi:10.1016/s1074-7613(03)00113-4 · Cited by 788

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

Stumhofer, J. S., Silver, J. S., Laurence, A. D. J., Porrett, P. M., Harris, T. H., Turka, L. A., Ernst, M., Saris, C. J. M., O’Shea, J. J., & Hunter, C. A. (2007) · Nature Immunology · doi:10.1038/ni1537 · Cited by 777

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

Vieira, P., Malefyt, R. D. W., Dang, M. N., Johnson, K. E., KASTELEIN, R. A., Fiorentino, D. F., Devriès, J., Roncarolo, M., Mosmann, T. R., & Moore, K. W. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.4.1172 · Cited by 740

CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms

Maloy, K. J., Salaün, L., Cahill, R., Dougan, G., Saunders, N. J. S. G., & Powrie, F. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021345 · Cited by 740

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

Chen, Z. J., Laurence, A. D. J., Kanno, Y., Pacher-Zavisin, M. C., Zhu, B., Tato, C. M., Yoshimura, A., Hennighausen, L. G., & O’Shea, J. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600666103 · Cited by 663

Control of TH17 cells occurs in the small intestine

Esplugues, E., Huber, S., Gagliani, N., Hauser, A. E., Town, T., Wan, Y. Y., O’Connor, W., Rongvaux, A., van Rooijen, N., Haberman, A. M., et al. (2011) · Nature · doi:10.1038/nature10228 · Cited by 660

Prognostic Value of Tumor-Infiltrating CD4+ T-Cell Subpopulations in Head and Neck Cancers

Badoual, C., Hans, S., Rodriguez, J., Peyrard, S., Klein, C., Agueznay, N. E. H., Mosseri, V., Laccourreye, O., Bruneval, P., Fridman, W. H., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1886 · Cited by 630

Shaping Gene Expression in Activated and Resting Primary Macrophages by IL-10

Lang, R., Patel, D. H., Morris, J. J., Rutschman, R., & Murray, P. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2253 · Cited by 621

Pathogen-specific T Regulatory 1 Cells Induced in the Respiratory Tract by a Bacterial Molecule that Stimulates Interleukin 10 Production by Dendritic Cells

McGuirk, P., McCann, C., & Mills, K. H. G. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011288 · Cited by 617

TH1 cells control themselves by producing interleukin-10

O’Garra, A., & Vieira, P. (2007) · Nature reviews. Immunology · doi:10.1038/nri2097 · Cited by 614

Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation

Malefyt, R. D. W., Yssel, H., & de Vries, J. E. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.11.4754 · Cited by 610

Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner

Huber, S., Gagliani, N., Esplugues, E., O'Connor, W., Huber, F. J., Chaudhry, A., Kamanaka, M., Kobayashi, Y., Booth, C. J., Rudensky, A. Y., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.01.020 · Cited by 602

Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10

Maynard, C. L., Harrington, L. E., Janowski, K. M., Oliver, J. R., Zindl, C. L., Rudensky, A. Y., & Weaver, C. T. (2007) · Nature Immunology · doi:10.1038/ni1504 · Cited by 599

IFN-α and IL-10 Induce the Differentiation of Human Type 1 T Regulatory Cells

Levings, M. K., Sangregorio, R., Galbiati, F., Squadrone, S., Malefyt, R. D. W., & Roncarolo, M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.9.5530 · Cited by 595

Conventional T-bet+Foxp3− Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection

Jankovic, D. L., Kullberg, M. C., Feng, C. G., Goldszmid, R. S., Collazo, C. M., Wilson, M. D., Wynn, T. A., Kamanaka, M., Flavell, R. A., & Sher, A. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062175 · Cited by 590

CD4+CD25−Foxp3− Th1 cells are the source of IL-10–mediated immune suppression in chronic cutaneous leishmaniasis

Anderson, C. F., Oukka, M., Kuchroo, V. K., & Sacks, D. L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061886 · Cited by 571

How Tolerogenic Dendritic Cells Induce Regulatory T Cells

Maldonado, R., & von Andrian, U. H. (2010) · Advances in immunology · doi:10.1016/b978-0-12-380995-7.00004-5 · Cited by 566

Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery

Ito, T., Hanabuchi, S., Wang, Y.-H., Park, W. R., Arima, K., Bover, L. C., Qin, F. X.-F., Gilliet, M. F., & Liu, Y. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.018 · Cited by 565

The Role of Interleukin (IL)-10 in the Persistence of Leishmania major in the Skin after Healing and the Therapeutic Potential of Anti–IL-10 Receptor Antibody for Sterile Cure

Belkaid, Y., Hoffmann, K. F., Mendez, S., Kamhawi, S., Udey, M. C., Wynn, T. A., & Sacks, D. L. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.10.1497 · Cited by 557

IL-10–producing and naturally occurring CD4+ Tregs: limiting collateral damage

O’Garra, A., Vieira, P. L., Vieira, P., & Goldfeld, A. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci23215 · Cited by 530

Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27–stimulated T cells

Fitzgerald, D. C., Zhang, G.-X., El-Behi, M., Fonseca-Kelly, Z., Li, H., Yu, S., Saris, C. J. M., Gran, B., Ciric, B., & Rostami, A. (2007) · Nature Immunology · doi:10.1038/ni1540 · Cited by 529

Ly‐1 B (B‐1) cells are the main source of B cell‐derived interleukin 10

O’Garra, A., Chang, R., Go, N. F., Hastings, R., Haughton, G., & Howard, M. (1992) · European Journal of Immunology · doi:10.1002/eji.1830220314 · Cited by 525

Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8+ T Cells Resulting in a Failure to Lyse Tumor Cells

Steinbrink, K., Jonuleit, H., Müller, G., Schuler, G., Knop, J., & Enk, A. (1999) · Blood · doi:10.1182/blood.v93.5.1634 · Cited by 509

Tumour‐infiltrating T‐cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review

Nosho, K., Baba, Y., Tanaka, N., Shima, K., Hayashi, M., Meyerhardt, J. A., Giovannucci, E., Dranoff, G., Fuchs, C. S., & Ogino, S. (2010) · The Journal of Pathology · doi:10.1002/path.2774 · Cited by 502

Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells

Pot, C., Jin, H., Awasthi, A., Liu, S. M., Lai, C.-Y., Madan, R., Sharpe, A. H., Karp, C. L., Miaw, S., Ho, I., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901233 · Cited by 480

Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells.

Go, N. F., Castle, B. E., Barrett, R., KASTELEIN, R. A., Dang, W., Mosmann, T. R., Moore, K. W., & Howard, M. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.6.1625 · Cited by 475

A Toll-Like Receptor 2 Ligand Stimulates Th2 Responses In Vivo, via Induction of Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and c-Fos in Dendritic Cells

Dillon, S. M., Agrawal, A., Dyke, T. E. V., Landreth, G. E., McCauley, L. K., Koh, A. J., Maliszewski, C. R., Akira, S., & Pulendran, B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.8.4733 · Cited by 469

Specific Inhibition of Cyclooxygenase 2 Restores Antitumor Reactivity by Altering the Balance of IL-10 and IL-12 Synthesis

Stolina, M., Sharma, S. P., Lin, Y., Dohadwala, M., Gardner, B. K., Luo, J., Zhu, L. X., Kronenberg, M., Miller, P. W., Portanova, J. P., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.1.361 · Cited by 465

CD4+ and CD8+ anergic T cells induced by interleukin-10–treated human dendritic cells display antigen-specific suppressor activity

Steinbrink, K., Graulich, E., Kubsch, S., Knop, J., & Enk, A. (2002) · Blood · doi:10.1182/blood.v99.7.2468 · Cited by 448

Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response

MURRAY, P. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.01.010 · Cited by 436

Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment

Gajewski, T. F., Woo, S., Zha, Y., Spaapen, R. M., Zheng, Y., Corrales, L. P., & Spranger, S. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.02.009 · Cited by 429

Recombinant Human IL-10 Prevents the Onset of Diabetes in the Nonobese Diabetic Mouse

Pennline, K. J., Roque-Gaffney, E., & Monahan, M. (1994) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1994.1068 · Cited by 428

The Role of IL-10 and TGF-β in the Differentiation and Effector Function of T Regulatory Cells

Levings, M. K., Bacchetta, R., Schulz, U., & Roncarolo, M. G. (2002) · International Archives of Allergy and Immunology · doi:10.1159/000067596 · Cited by 423

IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance

Mumm, J. B., Emmerich, J., Zhang, X., Chan, I., Wu, L., Mauze, S., Blaisdell, S., Basham, B., Dai, J., Grein, J., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.11.003 · Cited by 418

Diversity in the contribution of interleukin‐10 to T‐cell‐mediated immune regulation

Maynard, C. L., & Weaver, C. T. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00711.x · Cited by 413

Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis

Scott-Browne, J. P., Shafiani, S., Tucker-Heard, G., Ishida-Tsubota, K., Fontenot, J. D., Rudensky, A. Y., Bevan, M. J., & Urdahl, K. B. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062105 · Cited by 408

Interleukin-10 and the immune response against cancer: a counterpoint

D, S. M. M., Marincola, F. M., & Young, H. A. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0705358 · Cited by 407

The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription

Murray, P. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500419102 · Cited by 395

Expression of Interleukin-10 in Intestinal Lymphocytes Detected by an Interleukin-10 Reporter Knockin tiger Mouse

Kamanaka, M., Kim, S. T., Wan, Y. Y., Sutterwala, F. S., Lara-Tejero, M., Galán, J. E., Harhaj, E., & Flavell, R. A. (2006) · Immunity · doi:10.1016/j.immuni.2006.09.013 · Cited by 392

IL-10: a novel cytotoxic T cell differentiation factor

Chen, W. F., & Zlotnik, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.2.528 · Cited by 385

Mechanisms of interleukin‐10‐mediated immune suppression

Akdiş, C. A., & Blaser, K. (2001) · Immunology · doi:10.1046/j.1365-2567.2001.01235.x · Cited by 381

Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II–restricted cytotoxic T lymphocytes

Mucida, D., Husain, M. M., Muroi, S., van Wijk, F., Shinnakasu, R., Naoe, Y., Reis, B. S., Huang, Y., Lambolez, F., Docherty, M., et al. (2013) · Nature Immunology · doi:10.1038/ni.2523 · Cited by 376

Interleukin-10 production by effector T cells: Th1 cells show self control

Trinchieri, G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070104 · Cited by 373

Inhibitory and Stimulatory Effects of IL-10 on Human CD8+ T Cells

Groux, H., Bigler, M., de Vries, J. E., & Roncarolo, M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.7.3188 · Cited by 373

IL-10, a novel growth cofactor for mature and immature T cells.

MacNeil, I. A., Suda, T., Moore, K. W., Mosmann, T. R., & Zlotnik, A. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.12.4167 · Cited by 360

High frequency of tumor‐infiltrating FOXP3+ regulatory T cells predicts improved survival in mismatch repair‐proficient colorectal cancer patients

Frey, D. M., Droeser, R. A., Viehl, C. T., Zlobec, I., Lugli, A., Zingg, U., Oertli, D., Kettelhack, C., Terracciano, L., & Tornillo, L. (2009) · International Journal of Cancer · doi:10.1002/ijc.24989 · Cited by 351

Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10

O’Garra, A., Stapleton, G., Dhar, V., Pearce, M. K., Schumacher, J., Rugo, H. S., Barbls, D., Stall, A. M., Cupp, J., Moore, K. W., et al. (1990) · International Immunology · doi:10.1093/intimm/2.9.821 · Cited by 344

Reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibody

Vicari, A. P., Chiodoni, C., Vaure, C., Aït-Yahia, S., Dercamp, C., Matsos, F., Reynard, O., Taverne, C., Merle, P., Colombo, M. P., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020732 · Cited by 343

IL-10 production in cutaneous basal and squamous cell carcinomas. A mechanism for evading the local T cell immune response

Kim, J., Modlin, R. L., Moy, R. L., Dubinett, S. M., McHugh, T. M., Nickoloff, B. J., & Uyemura, K. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.4.2240 · Cited by 323

Adenomatous Polyps Are Driven by Microbe-Instigated Focal Inflammation and Are Controlled by IL-10–Producing T Cells

Dennis, K. L., Wang, Y., Blatner, N. R., Wang, S., Saadalla, A. M., Trudeau, E., Roers, A., Weaver, C. T., Lee, J. J., Gilbert, J. A., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1511 · Cited by 318

Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A

Santo, C. D., Arscott, R., Booth, S., Karydis, I., Jones, M., Asher, R. G., Salio, M., Middleton, M. R., & Cerundolo, V. (2010) · Nature Immunology · doi:10.1038/ni.1942 · Cited by 316

Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis

Shafiani, S., Tucker-Heard, G., Kariyone, A., Takatsu, K., & Urdahl, K. B. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091885 · Cited by 316

Immunogenic (tum-) variants of mouse tumor P815: cloning of the gene of tum- antigen P91A and identification of the tum- mutation.

Plaen, E. D., Lurquin, C., Pel, A. V., Mariamé, B., Szikora, J., Wölfel, T., Sibille, C., Chomez, P., & Boon, T. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.7.2274 · Cited by 309

CD4+ CD25+ Regulatory T Lymphocytes Inhibit Microbially Induced Colon Cancer in Rag2-Deficient Mice

Erdman, S. E., Poutahidis, T., Tomczak, M. F., Rogers, A. B., Cormier, K. S., Plank, B., Horwitz, B. H., & Fox, J. G. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63863-1 · Cited by 303

The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice.

den Eynde, B. J. V., Lethé, B., Pel, A. V., Plaen, E. D., & Boon, T. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.6.1373 · Cited by 298

Human interleukin-10 can directly inhibit T-cell growth

Taga, K., Mostowski, H., & Tosato, G. (1993) · Blood · doi:10.1182/blood.v81.11.2964.2964 · Cited by 288

Macrophages and Myeloid Dendritic Cells, but Not Plasmacytoid Dendritic Cells, Produce IL-10 in Response to MyD88- and TRIF-Dependent TLR Signals, and TLR-Independent Signals

Boonstra, A., Rajsbaum, R., Holman, M. J., Marques, R., Asselin‐Paturel, C., Pereira, J. P., Bates, E. E. M., Akira, S., Vieira, P., Liu, Y., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.7551 · Cited by 288

CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion

Kavanagh, B., O'Brien, S., Lee, D., Hou, Y., Weinberg, V., Rini, B., Allison, J. P., Small, E. J., & Fong, L. (2008) · Blood · doi:10.1182/blood-2007-11-125435 · Cited by 256

In the Absence of IL-12, CD4+ T Cell Responses to Intracellular Pathogens Fail to Default to a Th2 Pattern and Are Host Protective in an IL-10−/− Setting

Jankovic, D. L., Kullberg, M. C., Hieny, S. E., Caspar, P., Collazo, C. M., & Sher, A. (2002) · Immunity · doi:10.1016/s1074-7613(02)00278-9 · Cited by 252

Mast cells are an essential hematopoietic component for polyp development

Gounaris, E. G., Erdman, S. E., Restaino, C. R., Gurish, M. F., Friend, D. S., Gounari, F., Lee, D. M., Zhang, G., Glickman, J. N., Shin, K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704620104 · Cited by 251

A Transgenic Model to Analyze the Immunoregulatory Role of IL-10 Secreted by Antigen-Presenting Cells

Groux, H., Cottrez, F., Rouleau, M., Mauze, S., Antonenko, S. V., Hurst, S. D., McNeil, T., Bigler, M., Roncarolo, M., & Coffman, R. L. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1723 · Cited by 246

The multifaceted relationship between IL-10 and adaptive immunity: putting together the pieces of a puzzle

D, S. M. M., Marincola, F. M., Rossi, C. R., Nitti, D., & Lise, M. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2003.11.001 · Cited by 246

Th17 Cells Upregulate Polymeric Ig Receptor and Intestinal IgA and Contribute to Intestinal Homeostasis

Cao, A., Yao, S., Gong, B., Elson, C. O., & Cong, Y. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200955 · Cited by 244

Cell intrinsic mechanisms of T‐cell inhibition and application to cancer therapy

Peggs, K. S., Quezada, S. A., & Allison, J. P. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00649.x · Cited by 232

The significant role of mast cells in cancer

Khazaie, K., Blatner, N. R., Khan, M. W., Gounari, F., Gounaris, E. G., Dennis, K. L., Bonertz, A., Tsai, F., Strouch, M. J., Cheon, E. C., et al. (2011) · Cancer and Metastasis Reviews · doi:10.1007/s10555-011-9286-z · Cited by 230

Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism.

Zheng, L., Ojcius, D. M., Garaud, F., Roth, C., Maxwell, E., Li, Z., Rong, H., Chen, J., Wang, X., Catino, J. J., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.579 · Cited by 230

Microbial Recognition Via Toll-Like Receptor-Dependent and -Independent Pathways Determines the Cytokine Response of Murine Dendritic Cell Subsets to CD40 Triggering

Edwards, A. D., Manickasingham, S. P., Spörri, R., Diebold, S. S., Schulz, O., Sher, A., Kaisho, T., Akira, S., & Sousa, C. R. E. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.3652 · Cited by 229

Type 17 CD8+ T cells display enhanced antitumor immunity

Hinrichs, C. S., Kaiser, A., Paulos, C. M., Cassard, L., Sanchez-Perez, L. A., Heemskerk, B., Wrzesinski, C., Borman, Z. A., Muranski, P. J., & Restifo, N. P. (2009) · Blood · doi:10.1182/blood-2009-02-203935 · Cited by 226

Expression of RORγt Marks a Pathogenic Regulatory T Cell Subset in Human Colon Cancer

Blatner, N. R., Mulcahy, M. F., Dennis, K. L., Scholtens, D. M., Bentrem, D. J., Phillips, J. D., Ham, S., Sandall, B. P., Khan, M. W., Mahvi, D. M., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004566 · Cited by 219

Anti-CTLA-4 therapy results in higher CD4 + ICOS hi T cell frequency and IFN-γ levels in both nonmalignant and malignant prostate tissues

Chen, H., Liakou, C. I., Kamat, A., Pettaway, C., Ward, J. F., Tang, D. N., Sun, J., Jungbluth, A. A., Troncoso, P., Logothetis, C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813175106 · Cited by 218

Regulatory (FoxP3+) T-cell Tumor Infiltration Is a Favorable Prognostic Factor in Advanced Colon Cancer Patients Undergoing Chemo or Chemoimmunotherapy

Correale, P., Rotundo, M. S., Vecchio, M. T. D., Remondo, C., Migali, C., Ginanneschi, C., Tsang, K. Y., Licchetta, A., Mannucci, S., Loiacono, L., et al. (2010) · Journal of Immunotherapy · doi:10.1097/cji.0b013e3181d32f01 · Cited by 217

Intestinal Effector T Cells in Health and Disease

Maynard, C. L., & Weaver, C. T. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.012 · Cited by 215

Interleukin 10 Secretion and Impaired Effector Function of Major Histocompatibility Complex Class II–restricted T Cells Anergized In Vivo

Buer, J., Lanoue, A., Franzke, A., Cordier, C., von Boehmer, H., & Sarukhan, A. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.2.177 · Cited by 214

Th1/Th2 balance in cancer, transplantation and pregnancy

Shurin, M. R., Lü, L., Kaliński, P., Stewart‐Akers, A. M., & Lotze, M. T. (1999) · Springer Seminars in Immunopathology · doi:10.1007/bf00812261 · Cited by 214

Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation

Piconese, S., Gri, G., Tripodo, C., Musio, S., Gorzanelli, A., Frossi, B., Pedotti, R., Pucillo, C. E. M., & Colombo, M. P. (2009) · Blood · doi:10.1182/blood-2009-05-220004 · Cited by 211

CD4+CD25+ Regulatory Lymphocytes Induce Regression of Intestinal Tumors in ApcMin/+ Mice

Erdman, S. E., Sohn, J. J., Rao, V. P., Nambiar, P. R., Ge, Z., Fox, J. G., & Schauer, D. B. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3104 · Cited by 211

Interleukin-10 promotes the maintenance of antitumor CD8+ T-cell effector function in situ

Fujii, S., Shimizu, K., Shimizu, T., & Lotze, M. T. (2001) · Blood · doi:10.1182/blood.v98.7.2143 · Cited by 208

IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses

Meyaard, L., Hovenkamp, E., Otto, S. A., & Miedema, F. F. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.8.2776 · Cited by 207

Systemic administration of cellular IL-10 induces an effective, specific, and long-lived immune response against established tumors in mice

Berman, R. M., Suzuki, T., Tahara, H., Robbins, P. D., Narula, S. K., & Lotze, M. T. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.1.231 · Cited by 205

Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regulates its own production.

Seder, R. A., Marth, T., Sieve, M. C., Strober, W., Letterio, J. J., Roberts, A. B., & Kelsall, B. L. (1998) · PubMed · Cited by 202

Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice

Marten, K., Bremer, C., Khazaie, K., Sameni, M., Sloane, B. F., Tung, C., & Weissleder, R. (2002) · Gastroenterology · doi:10.1053/gast.2002.30990 · Cited by 200

Starting at the Beginning: New Perspectives on the Biology of Mucosal T Cells

Cheroutre, H. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104522 · Cited by 199

Interleukin 10 inhibits T cell alloreaction induced by human dendritic cells

Caux, C., Massacrier, C., Vanbervliet, B., Barthélémy, C., Liu, Y.-J., & Banchereau, J. (1994) · International Immunology · doi:10.1093/intimm/6.8.1177 · Cited by 192

T-Regulatory Cells Shift from a Protective Anti-Inflammatory to a Cancer-Promoting Proinflammatory Phenotype in Polyposis

Gounaris, E. G., Blatner, N. R., Dennis, K. L., Magnusson, F. C., Gurish, M. F., Strom, T. B., Beckhove, P., Gounari, F., & Khazaie, K. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0304 · Cited by 192

CD4+ T Cell Clones Producing both Interferon-γ and Interleukin-10 Predominate in Bronchoalveolar Lavages of Active Pulmonary Tuberculosis Patients

Gerosa, F., Nisii, C., Righetti, S., Micciolo, R., Marchesini, M., Cazzadori, A., & Trinchieri, G. (1999) · Clinical Immunology · doi:10.1006/clim.1999.4752 · Cited by 190

Cytolytic T-cell clones against an autologous human melanoma: specificity study and definition of three antigens by immunoselection.

Knuth, A. K., Wölfel, T., Klehmann, E., Boon, T., & Büschenfelde, K. H. M. Z. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2804 · Cited by 188

Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory

Giovarelli, M., Musiani, P., Modesti, A., Dellabona, P., Casorati, G., Allione, A., Consalvo, M., Cavallo, F., Pierro, F. D., & Giovanni, C. D. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.6.3112 · Cited by 180

A molecular basis for T cell suppression by IL‐10: CD28‐associated IL‐10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3‐kinase binding

Akdiş, C. A., Joss, A., Akdiş, M., Faith, A., & Blaser, K. (2000) · The FASEB Journal · doi:10.1096/fj.99-0874fje · Cited by 180

Regulatory Role of T Cells Producing both Interferon γ and Interleukin 10 in Persistent Infection

Trinchieri, G. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.10.f53 · Cited by 164

Interleukin-10 Increases Th1 Cytokine Production and Cytotoxic Potential in Human Papillomavirus-Specific CD8+Cytotoxic T Lymphocytes

Santin, A. D., Hermonat, P. L., Ravaggi, A., Bellone, S., Pecorelli, S. L., Roman, J. J., Parham, G. P., & Cannon, M. J. (2000) · Journal of Virology · doi:10.1128/jvi.74.10.4729-4737.2000 · Cited by 161

On the cellular basis of immunological T cell memory

Bruno, L., Kirberg, J., & von Boehmer, H. (1995) · Immunity · doi:10.1016/1074-7613(95)90077-2 · Cited by 159

Human Transferrin Receptor Gene as a Marker Gene for MR Imaging

Moore, A. V., Josephson, L., Bhorade, R. M., Basilion, J. P., & Weissleder, R. (2001) · Radiology · doi:10.1148/radiol.2211001784 · Cited by 156

Gut Barrier Dysfunction in the ApcMin/+ Mouse Model of Colon Cancer Cachexia

Puppa, M. J., White, J. P., Sato, S., Cairns, M., Baynes, J., & Carson, J. (2011) · Biochimica et Biophysica Acta · doi:10.1016/j.bbadis.2011.08.010 · Cited by 156

Stromal regulatory T-cells are associated with a favourable prognosis in gastric cancer of the cardia

Haas, M., Dimmler, A., Hohenberger, W., Grabenbauer, G. G., Niedobitek, G., & Distel, L. V. (2009) · BMC Gastroenterology · doi:10.1186/1471-230x-9-65 · Cited by 154

Antimetastatic and Antitumor Activities of Interleukin 10 in a Murine Model of Breast Cancer

Kundu, N., Beaty, T. L., Jackson, M. J., & Fulton, A. M. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.8.536 · Cited by 154

Factors Involved in the Differentiation of TGF-β-Producing Cells from Naive CD4+ T Cells: IL-4 and IFN-γ Have Opposing Effects, While TGF-β Positively Regulates Its Own Production

Seder, R. A., Marth, T., Sieve, M. C., Strober, W., Letterio, J. J., Roberts, A. B., & Kelsall, B. L. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.12.5719 · Cited by 153

Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid

Khazaie, K., Zadeh, M., Khan, M. W., Bere, P., Gounari, F., Dennis, K., Blatner, N. R., Owen, J. L., Klaenhammer, T. R., & Mohamadzadeh, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207230109 · Cited by 151

In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction

Blatner, N. R., Bonertz, A., Beckhove, P., Cheon, E. C., Krantz, S. B., Strouch, M. J., Weitz, J., Koch, M., Halverson, A. L., Bentrem, D. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913683107 · Cited by 144

Presence of Foxp3 expression in tumor cells predicts better survival in HER2-overexpressing breast cancer patients treated with neoadjuvant chemotherapy

Ladoire, S., Arnould, L., Mignot, G., Coudert, B. P., Rébé, C., Chalmin, F., Vincent, J., Bruchard, M., Chauffert, B., Martin, F., et al. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0831-1 · Cited by 137

IL-23 receptor (IL-23R) gene protects against pediatric Crohnʼs disease

Dubinsky, M. C., Wang, D., Picornell, Y., Wrobel, I. T., Katzir, L., Quiros, A., Dutridge, D., Wahbeh, G. T., Silber, G. H., Bahar, R., et al. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20126 · Cited by 136

IL-4 and IL-10 Antagonize IL-12-Mediated Protection Against Acute Vaccinia Virus Infection with a Limited Role of IFN-γ and Nitric Oxide Synthetase 2

van den Broek, M. F., Bachmann, M. F., Köhler, G., Barner, M., Escher, R., Zinkernagel, R. M., & Köpf, M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.1.371 · Cited by 131

Distinct Transcriptional Programs Activated by Interleukin-10 with or without Lipopolysaccharide in Dendritic Cells: Induction of the B Cell-Activating Chemokine, CXC Chemokine Ligand 131

Perrier, P., Martínez, F., Locati, M., Bianchi, G., Nebuloni, M., Vago, G., Bazzoni, F., Sozzani, S., Allavena, P., & Mantovani, A. (2003) · Journal of Immunology · doi:10.4049/jimmunol.172.11.7031 · Cited by 130

Modifications of CD8+ T Cell Function during In Vivo Memory or Tolerance Induction

Tanchot, C., Guillaume, S., Delon, J., Bourgeois, C., Franzke, A., Sarukhan, A., Trautmann, A., & Rocha, B. (1998) · Immunity · doi:10.1016/s1074-7613(00)80563-4 · Cited by 130

Control of intestinal homeostasis by regulatory T cells and dendritic cells

Coombes, J. L., & Maloy, K. J. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.01.001 · Cited by 127

Re‐examination of the immunosuppressive mechanisms mediating non‐cure of Leishmania infection in mice

Sacks, D. L., & Anderson, C. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00185.x · Cited by 126

FoxP3+ Regulatory T Cells Suppress Effector T-Cell Function at Pathologic Site in Miliary Tuberculosis

Sharma, P. K., Saha, P. K., Singh, A. R., Sharma, S. K., Ghosh, B., & Mitra, D. K. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200804-529oc · Cited by 126

The Interleukin‐23 / Interleukin‐17 axis in intestinal inflammation

Maloy, K. J. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.01950.x · Cited by 121

The SLAM family of immune-cell receptors

Veillette, A., & Latour, S. (2003) · Current Opinion in Immunology · doi:10.1016/s0952-7915(03)00041-4 · Cited by 121

The impact of CD4+CD25+ Treg on tumor specific CD8+ T cell cytotoxicity and cancer

Khazaie, K., & von Boehmer, H. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.11.006 · Cited by 121

IL-12 induces human T cells secreting IL-10 with IFN-γ

Windhagen, A., Anderson, D. E., Carrizosa, A., Williams, R. E., & Hafler, D. A. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.3.1127 · Cited by 119

IL-10 inhibits CD28 and ICOS costimulations of T cells via src homology 2 domain—containing protein tyrosine phosphatase 1

Taylor, A., Akdiş, M., Joss, A., Akkoç, T., Wenig, R., Colonna, M., Daigle, I., Flory, E., Blaser, K., & Akdiş, C. A. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.004 · Cited by 119

Mechanisms of allergen‐specific immunotherapy

Akdiş, C. A., & Blaser, K. (2000) · Allergy · doi:10.1034/j.1398-9995.2000.00120.x · Cited by 119

B-Cell-Derived IL-10: Production and Function

Burdin, N., Rousset, F., & Banchereau, J. (1997) · Methods · doi:10.1006/meth.1996.0393 · Cited by 115

Constitutive IL-10 Production Accounts for the High NK Sensitivity, Low MHC Class I Expression, and Poor Transporter Associated with Antigen Processing (TAP)-1/2 Function in the Prototype NK Target YAC-1

Petersson, M., Charo, J., Salazar‐Onfray, F., Noffz, G., Mohaupt, M., Qin, Z., Klein, G., Blankenstein, T. J. F., & Kiessling, R. W. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.5.2099 · Cited by 109

Live Imaging of Cysteine-Cathepsin Activity Reveals Dynamics of Focal Inflammation, Angiogenesis, and Polyp Growth

Gounaris, E. G., Tung, C., Restaino, C. R., Maehr, R., Köhler, R. H., Joyce, J. A., Plough, H. L., Barrett, T. A., Weissleder, R., & Khazaie, K. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002916 · Cited by 108

HLA-G and IL-10 expression in human cancer—different stories with the same message

Urosevic, M., & Dummer, R. (2003) · Seminars in Cancer Biology · doi:10.1016/s1044-579x(03)00024-5 · Cited by 105

Tyk2 Negatively Regulates Adaptive Th1 Immunity by Mediating IL-10 Signaling and Promoting IFN-γ-Dependent IL-10 Reactivation

Shaw, M. H., Freeman, G. J., Scott, M. F., Fox, B. A., Bzik, D. J., Belkaid, Y., & Yap, G. S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.12.7263 · Cited by 105

IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity.

Lee, M. S., Mueller, R., Wicker, L. S., Peterson, L. B., & Sarvetnick, N. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2663 · Cited by 105

The Production of IL-10 by Human Regulatory T Cells Is Enhanced by IL-2 through a STAT5-Responsive Intronic Enhancer in the IL-10 Locus

Tsuji‐Takayama, K., Suzuki, M., Yamamoto, M., Harashima, A., Okochi, A., Otani, T., Inoue, T., Sugimoto, A., Toraya, T., Takeuchi, M., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.3897 · Cited by 97

IL-12 synergizes with IL-2 and other stimuli in inducing IL-10 production by human T cells

Jeannin, P., Delneste, Y., Seveso, M., Life, P. F., & Bonnefoy, J. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.9.3159 · Cited by 93

Identification of a T cell subset capable of both IFN-gamma and IL-10 secretion in patients with chronic Borrelia burgdorferi infection.

Pohl‐Koppe, A., Balashov, K. E., Steere, A. C., Logigian, E. L., & Hafler, D. A. (1998) · PubMed · Cited by 91

Interleukin-10 in the regulation of T cell-induced colitis

Annacker, O., Asseman, C., Read, S., & Powrie, F. M. (2003) · Journal of Autoimmunity · doi:10.1016/s0896-8411(03)00045-3 · Cited by 89

How to improve the immunogenicity of chemotherapy and radiotherapy

Ma, Y., Conforti, R., Aymeric, L., Locher, C., Kepp, O., Kroemer, G., & Zitvogel, L. (2011) · Cancer and Metastasis Reviews · doi:10.1007/s10555-011-9283-2 · Cited by 88

IL-10 production differentially influences the magnitude, quality, and protective capacity of Th1 responses depending on the vaccine platform

Darrah, P. A., Hegde, S. T., Patel, D. T., Lindsay, R. W. B., Chen, L., Roederer, M., & Seder, R. A. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092532 · Cited by 86

A Synthetic Peptide Homologous to Functional Domain of Human IL-10 Down-Regulates Expression of MHC Class I and Transporter Associated with Antigen Processing 1/2 in Human Melanoma Cells

Kurte, M., López, M. N., Aguirre, A., Escobar, A. F., Aguillón, J. C., Charo, J., Larsen, C. G., Kiessling, R. W., & Salazar‐Onfray, F. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1731 · Cited by 85

Identification of a T Cell Subset Capable of both IFN-γ and IL-10 Secretion in Patients with Chronic Borrelia burgdorferi Infection

Pohl‐Koppe, A., Balashov, K. E., Steere, A. C., Logigian, E. L., & Hafler, D. A. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.4.1804 · Cited by 79

Regulatory T-cell stability and plasticity in mucosal and systemic immune systems

Murai, M., Krause, P., Cheroutre, H., & Kronenberg, M. (2010) · Mucosal Immunology · doi:10.1038/mi.2010.27 · Cited by 74

Anti-CTLA-4 treatment induces IL-10-producing ICOS + regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis

Coquerelle, C., Oldenhove, G., Acolty, V., Denoeud, J., Vansanten, G., Verdebout, J., Mellor, A. L., Bluestone, J. A., & Moser, M. (2009) · Gut · doi:10.1136/gut.2008.162842 · Cited by 71

Antigenic heterogeneity of a human melanoma tumor detected by autologous CTL clones

Degiovanni, G., Lahaye, T., Hérin, M., Hainaut, P., & Boon, T. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180503 · Cited by 64

Mechanism of IL-10-Induced T Cell Inactivation in Allergic Inflammation and Normal Response to Allergens

Akdiş, C. A., Joss, A., Akdiş, M., & Blaser, K. (2001) · International Archives of Allergy and Immunology · doi:10.1159/000053704 · Cited by 62

Interleukin-12: a cytokine with therapeutic potential in oncology and infectious diseases.

Gately, M. K., Gubler, U., Brunda, M. J., Nadeau, R. R., Anderson, T. D., Lipman, J. M., & Sarmiento, U. M. (1994) · PubMed · Cited by 60

CXC chemokine receptor 4 expression and stromal cell‐derived factor‐1α‐induced chemotaxis in CD4+ T lymphocytes are regulated by interleukin‐4 and interleukin‐10

Jinquan, T., Quan, S., Jacobi, H., MADSEN, H. O., Glue, C., Skov, P. S., Malling, H., & Poulsen, L. K. (2000) · Immunology · doi:10.1046/j.1365-2567.2000.00954.x · Cited by 53

Down regulation of T-cell-derived IL-10 production by low-dose cyclophosphamide treatment in tumor-bearing rats restores in vitro normal lymphoproliferative response

Matar, P., Rozados, V. R., Gervasoni, S. I., & Scharovsky, O. G. (2001) · International Immunopharmacology · doi:10.1016/s1567-5769(00)00028-x · Cited by 53

Pegylated IL‐10 induces cancer immunity: The surprising role of IL‐10 as a potent inducer of IFN‐γ‐mediated CD8+ T cell cytotoxicity

Mumm, J. B., & Oft, M. (2013) · BioEssays · doi:10.1002/bies.201300004 · Cited by 53

Priming in the Presence of IL-10 Results in Direct Enhancement of CD8+ T Cell Primary Responses and Inhibition of Secondary Responses

Kang, S. S., & Allen, P. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.9.5382 · Cited by 49

Cutting Edge: The Transcription Factor Kruppel-Like Factor 4 Regulates the Differentiation of Th17 Cells Independently of RORγt

Lebson, L. A., Gocke, A. R., Rosenzweig, J. M., Alder, J. K., Civin, C. I., Calabresi, P. A., & Whartenby, K. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002750 · Cited by 49

IL-10 enhances IL-2-induced proliferation and cytotoxicity by human intestinal lymphocytes

Ebert, E. C. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01147.x · Cited by 41

Prognostic Value of CD25 Expression on Lymphocytes and Tumor Cells in Squamous-Cell Carcinoma of the Head and Neck

Loose, D., Signore, A., Bonanno, E., Vermeersch, H., Dierckx, R., Deron, P. B., & de Wiele, C. V. (2008) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2007.0373 · Cited by 35

Inhibition of interleukin-10 (IL-10) production from MOPC 315 tumor cells by IL-10 antisense oligodeoxynucleotides enhances cell-mediated immune responses

Kim, B.-G., Joo, H., Chung, I.-S., Chung, H. Y., Woo, H.-J., & Yun, Y. (2000) · Cancer Immunology Immunotherapy · doi:10.1007/s002620000123 · Cited by 34

IL-10 suppresses CD2-mediated T cell activation via SHP-1

Taylor, A., Verhagen, J., Akkoç, T., Wenig, R., Flory, E., Blaser, K., Akdiş, M., & Akdiş, C. A. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.07.031 · Cited by 32

Current developments with peptide-based human tumor vaccines

Khazaie, K., Bonertz, A., & Beckhove, P. (2009) · Current Opinion in Oncology · doi:10.1097/cco.0b013e328331a78e · Cited by 32

Regulatory T Lymphocytes Are Associated with Less Aggressive Histologic Features in Microsatellite-Unstable Colorectal Cancers

Tougeron, D., Maby, P., Elie, N., Fauquembergue, É., Pessot, F. L., Cornic, M., Sabourin, J., Michel, P., Frébourg, T., & Latouche, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061001 · Cited by 25

T cell receptors in an IL-10-secreting amino acid copolymer-specific regulatory T cell line that mediates bystander immunosuppression

Zhang, H., Stern, J. N. H., & Strominger, J. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813197106 · Cited by 8

Untitled work

Tsuchihashi (2000) · doi:10.1002/1521-4141(200006)30:6

Untitled work

(1999) · doi:10.1002/(sici)1521-4141(199909)29:09

Therapeutic cancer vaccines

Melief, C. J. M., van Hall, T., Arens, R., OSSENDORP, F. A., & van der Burg, S. H. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80009 · Cited by 1,192

Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing

Kharaziha, M., Baidya, A., & Annabi, N. (2021) · Advanced Materials · doi:10.1002/adma.202100176 · Cited by 735

The Evasion Mechanisms of Cancer Immunity and Drug Intervention in the Tumor Microenvironment

Kim, S. K., & Cho, S. W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.868695 · Cited by 502

Balancing the immune response in the brain: IL-10 and its regulation

Lobo‐Silva, D., Carriche, G. M., Castro, A. G., Roque, S., & Saraiva, M. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0763-8 · Cited by 445

Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches

Tufail, M., Jiang, C., & Li, N. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02280-1 · Cited by 454

IL-10 in cancer: Just a classical immunosuppressive factor or also an immunostimulating one?

Berti, F. C. B., & de Oliveira, K. B. (2018) · AIMS Allergy and Immunology · doi:10.3934/allergy.2018.2.88 · Cited by 24

Interleukin-10 and the immune response against cancer: a counterpoint

D, S. M. M., Marincola, F. M., & Young, H. A. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0705358 · Cited by 407

Effect of IL-10 in tumor

Zhou, J., & Tao, L. (2013) · Guoji zhongliuxue zazhi · doi:10.3760/cma.j.issn.1673-422x.2013.03.006

Interleukin 10 in the tumor microenvironment: a target for anticancer immunotherapy

Sato, T., Terai, M., Tamura, Y., Alexeev, V. Y., Mastrangelo, M. J., & Selvan, S. R. (2011) · Immunologic Research · doi:10.1007/s12026-011-8262-6 · Cited by 287

Role of IL-10 in Cancer

Marincola, F. M. (2006) · CRC Press eBooks · doi:10.1201/9781498713405-21