Current status of interleukin-10 and regulatory T-cells in cancer

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A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

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Mechanistic insights into resistance mechanisms to T cell engagers

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A xylorhamnoarabinogalactan I from Bael (Aegle marmelos L.) modulates UV/DMBA induced skin cancer via galectin-3 & gut microbiota

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Tumor progression locus 2 (TPL2) in tumor-promoting Inflammation, Tumorigenesis and Tumor Immunity

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Effects of web-based cognitive behavioral stress management and health promotion interventions on neuroendocrine and inflammatory markers in men with advanced prostate cancer: A randomized controlled trial

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Identification of a Prognosis-Related Risk Signature for Bladder Cancer to Predict Survival and Immune Landscapes

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Ca2+-Activated K+ Channel KCa3.1 as a Therapeutic Target for Immune Disorders

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Competing endogenous RNA network analysis of CD274, IL‑10 and FOXP3 co‑expression in laryngeal squamous cell carcinoma

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Engineering for Success: Approaches to Improve Chimeric Antigen Receptor T Cell Therapy for Solid Tumors

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Integrating Biological Advances Into the Clinical Management of Breast Cancer Related Lymphedema

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Spice-Derived Bioactive Compounds Confer Colorectal Cancer Prevention via Modulation of Gut Microbiota

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Circulating cytokine dynamics as potential biomarker of response to anti-PD-1 immunotherapy in BRAFwt MM patients

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Bilirubin Attenuates ER Stress-Mediated Inflammation, Escalates Apoptosis and Reduces Proliferation in the LS174T Colonic Epithelial Cell Line

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Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions

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Engineered algae microrobots as photosynthetic living materials promote T cells’ anti-tumor immunity

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Fine-Tuning the Tumour Microenvironment: Current Perspectives on the Mechanisms of Tumour Immunosuppression

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Targeting PARG induces tumor cell growth inhibition and antitumor immune response by reducing phosphorylated STAT3 in ovarian cancer

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Mechanistic rationales for combining immunotherapy with radiotherapy

Chi, A., & Nguyen, N. P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1125905 · Cited by 25

Interleukin-10 Induces Expression of Neuroendocrine Markers and PDL1 in Prostate Cancer Cells

Samiea, A., Yoon, J. S. J., Ong, C. J., Zoubeidi, A., Chamberlain, T. C., & Mui, A. (2020) · Prostate Cancer · doi:10.1155/2020/5305306 · Cited by 22

Enhanced Expression of miR-181b in B Cells of CLL Improves the Anti-Tumor Cytotoxic T Cell Response

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Immunostimulatory biomaterials to boost tumor immunogenicity

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Interleukin‑18 and ‑10 may be associated with lymph node metastasis in breast cancer

Ma, T., & Kong, M. (2021) · Oncology Letters · doi:10.3892/ol.2021.12515 · Cited by 21

Vitamin D3Supplementation Promotes Regulatory T-Cells to Maintain Immune Homeostasis After Surgery for Early Stages of Colorectal Cancer

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Enhancement of fibroblast activation protein α-based vaccines and adenovirus boost immunity by cyclophosphamide through inhibiting IL-10 expression in 4T1 tumor bearing mice

Qiu, X., Geng, F., Zhang, F.-F., Liu, C., Xu, P., Lu, Z.-Z., Zhang, H., Kong, W., & Yu, X. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.07.054 · Cited by 21

The immune-modulation and gut microbiome structure modification associated with long-term dietary supplementation of Lactobacillus rhamnosus using 16S rRNA sequencing analysis

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Immunotherapy for pancreatic cancer: chasing the light at the end of the tunnel

Brouwer, T. P., Vahrmeijer, A. L., & de Miranda, N. F. C. C. (2021) · Cellular Oncology · doi:10.1007/s13402-021-00587-z · Cited by 21

Protein biomarkers in cervicovaginal lavages for detection of endometrial cancer

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DNA vaccines as promising immuno-therapeutics against cancer: a new insight

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The Comparison of Exosome and Exosomal Cytokines between Young and Old Individuals with or without Gastric Cancer

Im, K., Baek, J., Kwon, W. S., Rha, S. Y., Hwang, K. W., Kim, U., & Min, H. (2018) · International journal of gerontology · doi:10.1016/j.ijge.2018.03.013 · Cited by 20

Interleukin-33 pretreatment promotes metastatic growth of murine melanoma by reducing the cytotoxic capacity of CD8+ T cells and enhancing regulatory T cells

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Mechanisms of tumor-induced T cell immune suppression and therapeutics to counter those effects

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Characterization of Aging-Related Genes to Predict Prognosis and Evaluate the Tumor Immune Microenvironment in Malignant Melanoma

Zeng, N., Guo, C., Wang, Y., Li, L., Chen, X., Gao, S., Jiang, F., & Cao, B. (2022) · Journal of Oncology · doi:10.1155/2022/1271378 · Cited by 16

Enhancing Efficacy of TCR-engineered CD4+ T Cells Via Coexpression of CD8α

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Genetic associations of the interleukin locus at 1q32.1 with clinical outcomes of cutaneous melanoma

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Stimulatory role of interleukin 10 in CD8 + T cells through STATs in gastric cancer

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Foxp3 expression in CD4+CD25+Foxp3+ regulatory T cells promotes development of colorectal cancer by inhibiting tumor immunity

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CDH1 overexpression predicts bladder cancer from early stage and inversely correlates with immune infiltration

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Serum and Glucocorticoid-Inducible Kinase 1 (SGK1) in NSCLC Therapy

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Deletion of cystathionine-γ-lyase in bone marrow-derived cells promotes colitis-associated carcinogenesis

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Host kinin B1 receptor plays a protective role against melanoma progression

Maria, A. G., Dillenburg-Pilla, P., Reis, R. I., Floriano, E. M., Tefé‐Silva, C., Ramos, S. G., Pesquero, J. B., Nahmias, C., & Costa-Neto, C. M. (2016) · Scientific Reports · doi:10.1038/srep22078 · Cited by 16

CD137 Costimulation Enhances the Antitumor Activity of Vγ9Vδ2-T Cells in IL-10-Mediated Immunosuppressive Tumor Microenvironment

Pei, Y., Xiang, Z., Wen, K., Tu, C. R., Wang, X., Zhang, Y., Mu, X., Liu, Y., & Tu, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.872122 · Cited by 15

The Protein Secretome Is Altered in Rectal Cancer Tissue Compared to Normal Rectal Tissue, and Alterations in the Secretome Induce Enhanced Innate Immune Responses

Heeran, A. B., Dunne, M. R., Morrissey, M. E., Buckley, C. E., Clarke, N. E., Cannon, A., Donlon, N. E., Nugent, T. S., Durand, M., Dunne, C., et al. (2021) · Cancers · doi:10.3390/cancers13030571 · Cited by 15

Combination therapy for mCRPC with immune checkpoint inhibitors, ADT and vaccine: A mathematical model

Siewe, N., & Friedman, A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262453 · Cited by 15

Enhancement of the Colorectal Chemopreventive and Immunization Potential of Northern Thai Purple Rice Anthocyanin Using the Biotransformation by β-Glucosidase-Producing Lactobacillus

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CXCR3 May Help Regulate the Inflammatory Response in Acute Lung Injury via a Pathway Modulated by IL-10 Secreted by CD8 + CD122+ Regulatory T Cells

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Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential

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IL-17A–Producing γδT Cells Inhibit the Formation of Malignant Pleural Effusions

Wei, X., Pei, X., Liu, Y., Wu, X., Shi, H., & Zhou, Q. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0201oc · Cited by 14

Novel therapeutic regimens for urethane‐induced early lung cancer in rats: Combined cisplatin nanoparticles with vitamin‐ D3

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Novel tumour antigens and the development of optimal vaccine design

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The Tumor-Immune Response Is Not Compromised by Mesenchymal Stromal Cells in Humanized Mice

Moquin‐Beaudry, G., Colas, C., Li, Y., Bazin, R., Guimond, J. V., Haddad, É., & Beausejour, C. M. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900807 · Cited by 14

Investigation of anticancer and anti-inflammatory efficacies of novel metal complexes: Spectroscopic and thermal characterization, computational investigation, and docking simulation

Elsayed, G. H., Rizk, M. G., Fahim, A. M., & Mahmoud, N. H. (2025) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2025.115427 · Cited by 13

Increased circulating monocyte MDSCs positively correlate with serum Interleukin-10 in metastatic melanoma patients

Martinović, K. M., Vuletić, A. M., Miletić, N. T., Nedeljković, M., Babović, N. L., Matković, S., & Jurišić, V. (2023) · Innate Immunity · doi:10.1177/17534259231172079 · Cited by 13

IL-10 Plays a Pivotal Role in Tamoxifen-Induced Spasmolytic Polypeptide-Expressing Metaplasia in Gastric Mucosa

Lee, C., Lee, H., Hwang, S. Y., Moon, C. M., & Hong, S. N. (2017) · Gut and Liver · doi:10.5009/gnl16454 · Cited by 13

Amalgamation of PI3K and EZH2 blockade synergistically regulates invasion and angiogenesis: combination therapy for glioblastoma multiforme

Mishra, V. S., Kumar, N., V, Raza, M., & Sehrawat, S. (2020) · Oncotarget · doi:10.18632/oncotarget.27842 · Cited by 13

Applications of Multifunctional Hydrogel in Tissue Engineering and Regenerative Medicine

Lyu, J., Liu, X., Yang, Q., Zhang, Y., & Wang, X. (2026) · MedComm · doi:10.1002/mco2.70602 · Cited by 12

Immunomodulatory effects of soluble CD5 on experimental tumor models

Simões, I., Aranda, F., Carreras, E., Andrés, M. V., Casadó‐Llombart, S., Martínez, V. G., & Lozano, F. (2017) · Oncotarget · doi:10.18632/oncotarget.22564 · Cited by 12

The Underexplored Landscape of Hypoxia-Inducible Factor 2 Alpha and Potential Roles in Tumor Macrophages: A Review

Steinberger, K. J., & Eubank, T. D. (2023) · Oxygen · doi:10.3390/oxygen3010005 · Cited by 15

Primary Laryngeal Cancer-derived miR-193b Induces Interleukin-10-expression Monocytes

Zhang, S., Guo, Y., Zhang, C., Gao, W., Wen, S., Huangfu, H., & Wang, B. (2014) · Cancer Investigation · doi:10.3109/07357907.2014.988344 · Cited by 12

Metastatic colon adenocarcinoma has a significantly elevated expression of IL-10 compared with primary colon adenocarcinoma tumors

Townsend, M. H., Felsted, A. M., Piccolo, S., Robison, R. A., & O'Neill, K. L. (2017) · Cancer Biology & Therapy · doi:10.1080/15384047.2017.1360453 · Cited by 12

Lect2 deficiency is characterised by altered cytokine levels and promotion of intestinal tumourigenesis

Greenow, K. R., Zverev, M., May, S., Kendrick, H. D., Williams, G. T., Phesse, T. J., & Parry, L. (2018) · Oncotarget · doi:10.18632/oncotarget.26335 · Cited by 12

Effects of hexavalent chromium on mouse splenic T lymphocytes

Dai, L., Xu, W., Li, H., Frank, J. A., He, C., Zhang, Z., & Chen, G. (2017) · Toxicology in Vitro · doi:10.1016/j.tiv.2017.09.006 · Cited by 12

Do the Th17 Cells Play a Role in the Pathogenesis of Leptospirosis?

Bandara, K., Gunasekara, C. P., Weerasekera, M. M., Marasinghe, C., Ranasinghe, N., & Fernando, N. (2018) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2018/9704532 · Cited by 12

Micro RNA-98 interferes with expression interleukin-10 in peripheral B cells of patients with lung cancer

Li, Y., Rong, J., Qin, J., He, J.-Y., Chen, H.-G., & Huang, S.-H. (2016) · Scientific Reports · doi:10.1038/srep32754 · Cited by 12

Molecular Characterization of Primary and Metastatic Colon Cancer Cells to Identify Therapeutic Targets with Natural Compounds

Jothimani, G., Ganesan, H., Pathak, S., & Banerjee, A. (2022) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026622666220401161511 · Cited by 11

Heterologous Vaccination and Checkpoint Blockade Synergize To Induce Antileukemia Immunity

Manlove, L. S., Schenkel, J. M., Manlove, K. R., Pauken, K. E., Williams, R. T., Vezys, V., & Farrar, M. A. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600130 · Cited by 11

Exploring the evolution of T cell function and diversity across different stages of non-small cell lung cancer

Chang, C. (2024) · American Journal of Cancer Research · doi:10.62347/aryh6451 · Cited by 10

CD40 agonist engineered immunosomes modulated tumor microenvironment and showed pro-immunogenic response, reduced toxicity, and tumor free survival in mice bearing glioblastoma

Gaur, V., Tyagi, W., Das, S., Ganguly, S., & Bhattacharyya, J. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122688 · Cited by 10

The effect of interleukin 10 polymorphisms on breast cancer susceptibility in Han women in Shaanxi Province

Li, M., Yue, C., Zuo, X., Jin, G., Wang, G., Guo, H., Wu, F., Huang, S., & Zhao, X. (2020) · PLoS ONE · doi:10.1371/journal.pone.0232174 · Cited by 10

A peptide derived from interleukin-10 exhibits potential anticancer activity and can facilitate cell targeting of gold nanoparticles loaded with anticancer therapeutics

Chang, C., Yang, C.-H., Chuang, C.-H., Jiang, S., Hwang, Y.-M., Liou, J.-W., & Hsu, H. (2023) · Communications Chemistry · doi:10.1038/s42004-023-01079-x · Cited by 11

Metformin partially reverses the inhibitory effect of co-culture with ER-/PR-/HER2+ breast cancer cells on biomarkers of monocyte antitumor activity

Dahmani, Z., Addou-Klouche, L., Gizard, F., Dahou, S., Messaoud, A., Djebri, N. C., Benaissti, M. I., Mostefaoui, M., Terbeche, H., Nouari, W., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0240982 · Cited by 12

Ebi3 Binding to IFN-γ and IL-10 Limits Their Function

Scott, E. N., Ye, C., Yano, H., Lipatova, Z., Brunazzi, E. A., Vignali, K. M., Workman, C. J., & Vignali, D. A. A. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2400236 · Cited by 9

The “double-edged sword” effect of cytokines in cancer: coexisting opportunities and challenges

Yin, X., Zhang, W., Wang, G., Liu, Y., Dai, B., & Yue, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1701405 · Cited by 10

LC-PDA-MS and GC-MS Analysis of Scorzonera hispanica Seeds and Their Effects on Human Breast Cancer Cell Lines

Lendzion, K., Gornowicz, A., Strawa, J. W., Bielawska, K., Czarnomysy, R., Popławska, B., Bielawski, K., Tomczyk, M., Miltyk, W., & Bielawska, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911584 · Cited by 9

Development of a peptide-based tumor-activated checkpoint inhibitor for cancer immunotherapy

Zhao, Z., Fetse, J., Mamani, U., Guo, Y., Li, Y., Patel, P., Liu, Y., Lin, C., Li, Y., Mustafa, B., et al. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.12.051 · Cited by 9

Bromodomain-containing protein 4 regulates interleukin-34 expression in mouse ovarian cancer cells

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IL-10 Signaling Elicited by Nivolumab-Induced Activation of the MAP Kinase Pathway Does Not Fully Contribute to Nivolumab-Modulated Heterogeneous T Cell Responses

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PDL-1/PDL-2 Blockade in Mice Dendritic Cells by RNAI Techniques to Induce Antitumor Immunity

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Binding of the placental growth factor to VEGF receptor type 1 modulates human T cell functions

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Targeting T regulatory (T reg ) cells in immunotherapy-resistant cancers

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Exploring the Link between Inflammatory Biomarkers and Head and Neck Cancer: Understanding the Impact of Smoking as a Cancer-Predisposing Factor

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Cytotoxic Activity of Isoniazid Derivative in Human Breast Cancer Cells

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The past, present, and future of immunotherapy for bladder tumors

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How to Monitor the Neuroimmune Biological Response in Patients Affected by Immune Alteration-Related Systemic Diseases

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Treatment with lentiviral vectors encoding shRNA against interleukin 10 modulates the immunosuppressive activity of murine colon carcinoma‑associated myeloid‑derived suppressor cells

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Effects of 15-lipoxygenase overexpressing adipose tissue mesenchymal stem cells on the Th17 / Treg plasticity

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Interplay between ceRNA and Epigenetic Control of microRNA: Modelling Approaches with Application to the Role of Estrogen in Ovarian Cancer

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Tripartite antigen-agnostic combination immunotherapy cures established poorly immunogenic tumors

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Cytokines and Lymphoid Populations as Potential Biomarkers in Locally and Borderline Pancreatic Adenocarcinoma

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Time‑series clustering of cytokine expression after transarterial chemoembolization in patients with hepatocellular carcinoma

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Zerumbone mediates apoptosis and induces secretion of proinflammatory cytokines in breast carcinoma cell culture.

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Development of Anti-Inflammatory Agents Utilizing DC-SIGN Mediated IL-10 Secretion in Autoimmune and Immune-Mediated Disorders: Bridging Veterinary and Human Health

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The Role of IL‐6, IL‐10 and CRP in Gastrointestinal Cancers

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Modulating tumor mechanics and vascular barriers to enhance chemotherapy efficacy in pancreatic tumors and melanoma

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Circulating Inflammatory Biomarkers Predict Pain Change Following Exercise-Induced Shoulder Injury: Findings From the Biopsychosocial Influence on Shoulder Pain Preclinical Trial

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Influencing factors and solution strategies of chimeric antigen receptor T-cell therapy (CAR–T) cell immunotherapy

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Schistosoma mansoni soluble egg antigen suppresses colorectal cancer growth in vitro and in vivo

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Establishment and validation of five autophagy-related signatures for predicting survival and immune microenvironment in glioma

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Prognostic modeling of the immune-centric transcriptome reveals interleukin signaling candidates contributing to differential patient outcomes

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Circulating interleukin-10 levels and human papilloma virus and Epstein–Barr virus-associated cancers: evidence from a Mendelian randomization meta-analysis based on 11,170 subjects

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Divergent Crosstalk Between Microglia and T Cells in Brain Cancers: Implications for Novel Therapeutic Strategies

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IL-10 in cancer: Just a classical immunosuppressive factor or also an immunostimulating one?

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Interleukin-10 and the immune response against cancer: a counterpoint

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Effect of IL-10 in tumor

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Interleukin 10 in the tumor microenvironment: a target for anticancer immunotherapy

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Role of IL-10 in Cancer

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