The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Annual or biennial CT screening versus observation in heavy smokers: 5-year results of the MILD trial
Abstract
The efficacy and cost-effectiveness of low-dose spiral computed tomography (LDCT) screening in heavy smokers is currently under evaluation worldwide. Our screening program started with a pilot study on 1035 volunteers in Milan in 2000 and was followed up in 2005 by a randomized trial comparing annual or biennial LDCT with observation, named Multicentric Italian Lung Detection. This included 4099 participants, 1723 randomized to the control group, 1186 to biennial LDCT screening, and 1190 to annual LDCT screening. Follow-up was stopped in November 2011, with 9901 person-years for the pilot study and 17 621 person-years for Multicentric Italian Lung Detection. Forty-nine lung cancers were detected by LDCT (20 in biennial and 29 in the annual arm), of which 17 were identified at baseline examination; 63% were of stage I and 84% were surgically resectable. Stage distribution and resection rates were similar in the two LDCT arms. The cumulative 5-year lung cancer incidence rate was 311/100 000 in the control group, 457 in the biennial, and 620 in the annual LDCT group (P=0.036); lung cancer mortality rates were 109, 109, and 216/100 000 (P=0.21), and total mortality rates were 310, 363, and 558/100 000, respectively (P=0.13). Total mortality in the pilot study was similar to that observed in the annual LDCT arm at 5 years. There was no evidence of a protective effect of annual or biennial LDCT screening. Furthermore, a meta-analysis of the four published randomized trials showed similar overall mortality in the LDCT arms compared with the control arm.
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Cites
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Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening
The National Lung Screening Trial Research Team (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1102873 · Cited by 11,064
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Management of Lung Nodules Detected by Volume CT Scanning
van Klaveren, R. J., Oudkerk, M., Prokop, M., Scholten, E. T., Nackaerts, K., Vernhout, R., van Iersel, C. A., van den Bergh, K. A. M., van 't Westeinde, S., van der Aalst, C., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0906085 · Cited by 820
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Self-citationBassler, D. (2010) · JAMA · doi:10.1001/jama.2010.310 · Cited by 611
Computed Tomography Screening and Lung Cancer Outcomes
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Cited by
Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial
de Koning, H. J., van der Aalst, C. M., de Jong, P. A., Scholten, E. T., Nackaerts, K., Heuvelmans, M. A., Lammers, J.-W. J., Weenink, C., Yousaf-Khan, U., Horeweg, N., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1911793 · Cited by 3,624
European position statement on lung cancer screening
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Self-citationPastorino, U., Silva, M., Sestini, S., Sabia, F., Boeri, M., Cantarutti, A., Sverzellati, N., Sozzi, G., Corrao, G., & Marchianò, A. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz117 · Cited by 523
Self-citationAdams, S. J., Stone, E., Baldwin, D. R., Vliegenthart, R., Lee, P., & Fintelmann, F. J. (2023) · The Lancet · doi:10.1016/s0140-6736(22)01694-4 · Cited by 467
Mazzone, P. J., Silvestri, G. A., Patel, S., Kanne, J. P., Kinsinger, L. S., Wiener, R. S., Soo Hoo, G., & Detterbeck, F. C. (2018) · Chest · doi:10.1016/j.chest.2018.01.016 · Cited by 348
Metadata
- Authors
- Pastorino, U., Rossi, M., Rosato, V., Marchianò, A., Sverzellati, N., Morosi, C., Fabbri, A., Galeone, C., Negri, E., Sozzi, G., Pelosi, G., & La Vecchia, C.
- Venue
- European Journal of Cancer Prevention
- Published
- 2012-05
- Volume
- 21
- Issue
- 3
- Pages
- 308-315
- ISSN
- 0959-8278 (ISSN-L)
- OpenAlex
- W1991563667
- Cited by
- 414
- References
- 27
- FWCI
- 27.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pastorino, U., Rossi, M., Rosato, V., Marchianò, A., Sverzellati, N., Morosi, C., Fabbri, A., Galeone, C., Negri, E., Sozzi, G., Pelosi, G., & La Vecchia, C. (2012). Annual or biennial CT screening versus observation in heavy smokers: 5-year results of the MILD trial. European Journal of Cancer Prevention. https://doi.org/10.1097/cej.0b013e328351e1b6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
