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Maternal Exposure to the Dutch Famine Before Conception and During Pregnancy: Quality of Life and Depressive Symptoms in Adult Offspring
Open accessAbstract
BACKGROUND: Gestational exposure to famine has been associated with several chronic diseases in adulthood, but few studies in humans have related prenatal famine exposure to health-related quality of life. We used the circumstances of the Dutch Famine of 1944-1945 (during which official rations were <900 kcal/day for 24 weeks) to assess whether exposure to famine prior to conception or at specified stages of pregnancy was related to self-reported health-related quality of life and depressive symptoms in adulthood. METHODS: We studied 923 individuals, including persons born in western Holland between January 1945 and March 1946, persons born in the same 3 institutions in 1943 and 1947 and same-sex siblings of persons in series 1 or 2. Between 2003 and 2005 (mean age: 59 years), we assessed self-reported quality of life with the Short Form 36 questionnaire and derived mental and physical component scores. Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression scale. RESULTS: Mean mental and physical component scores were 52.4 (SD = 9.4) and 48.9 (9.0), respectively. The mean depression score was 11.6 (7.4). Age-, sex-, and schooling-adjusted estimates for mutually adjusted exposures were -2.48 for the mental component score with exposure before conception (95% confidence interval = -4.46 to -0.50) and 0.07 with exposure during pregnancy (-1.15 to 1.29). Adjusted estimates for the physical component score were 1.26 with exposure before conception (-0.67 to 3.19) and -0.73 with exposure during pregnancy (-1.94 to 0.48). Adjusted estimates for the depression score were 2.07 with exposure before conception (0.60 to 3.54) and 0.96 with exposure during pregnancy (0.09 to 1.88). There was no evidence of heterogeneity of effects by specific periods of pregnancy exposed to famine. CONCLUSIONS: A mother's exposure to famine prior to conception of her offspring was associated with lower self-reported measures of mental health and quality of life in her adult offspring.
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“Prenatal famine exposure corresponds with long-term variation in cognitive and emotional regulation consistent with altered neural and glucocorticoid signaling pathways (69, 70).”
From Epigenetic changes associated with multi-generational trauma: characterization, mechanisms, and therapeutics (2026) · cites this paper as [70]
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“In famine-exposed populations, chronic undernutrition has been associated with alterations in neurodevelopmental and stress-regulatory systems.”
From Epigenetic changes associated with multi-generational trauma: characterization, mechanisms, and therapeutics (2026) · cites this paper as [70]
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Cites
(1994) · Medical Entomology and Zoology · Cited by 4,156
Persistent epigenetic differences associated with prenatal exposure to famine in humans
Heijmans, B. T., Tobi, E. W., Stein, A. D., Putter, H., Blauw, G. J., Susser, E. S., Slagboom, P. E., & Lumey, L. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806560105 · Cited by 3,082
Self-citationAaronson, N. K., Muller, M., Cohen, P. D. A., Essink-Bot, M.-L., Fekkes, M., Sanderman, R., Sprangers, M. A. G., te Velde, A., & Verrips, E. (1998) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(98)00097-3 · Cited by 2,276
Ware, J. E., Kosinski, M. R., Bayliss, M. S., McHorney, C. A., Rogers, W. H., & Raczek, A. E. (1995) · PubMed · Cited by 1,734
Quality of life measurement: bibliographic study of patient assessed health outcome measures
Garratt, A., Schmidt, L., Mackintosh, A., & Fitzpatrick, R. M. (2002) · BMJ · doi:10.1136/bmj.324.7351.1417 · Cited by 1,206
The Dutch Famine and Its Long-Term Consequences for Adult Health
Roseboom, T., de Rooij, S., & Painter, R. (2006) · Early Human Development · doi:10.1016/j.earlhumdev.2006.07.001 · Cited by 1,137
Beekman, A. T. F., Deeg, D. J. H., van Limbeek, J., Braam, A. W., VRIES, M. Z. D., & van Tilburg, W. (1997) · Psychological Medicine · doi:10.1017/s0033291796003510 · Cited by 1,135
Mazets, E. P., Golenetskii, S. V., Il’Inskii, V. N., Панов, В. Н., Аптекарь, Р. Л., Gur’yan, Y. A., Proskura, M. P., Sokolov, I. A., Sokolova, Z. Y., Kharitonova, T. V., et al. (1982) · Springer eBooks · doi:10.1007/978-94-009-7960-4_2 · Cited by 896
Schizophrenia After Prenatal Famine
Susser, E. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830010027005 · Cited by 741
Self-citationKloosterman, G. J. (1970) · International Journal of Gynecology & Obstetrics · doi:10.1002/j.1879-3479.1970.tb00313.x · Cited by 638
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Prenatal Famine and Adult Health
Lumey, L. H., Stein, A. D., & Susser, E. (2011) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-031210-101230 · Cited by 474
Self-citationSex Differences in Vulnerability and Resilience to Stress Across the Life Span
Hodes, G. E., & Epperson, C. N. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.028 · Cited by 417
The persisting effect of maternal mood in pregnancy on childhood psychopathology
O'Donnell, K. J., Glover, V., Barker, E. D., & O'Connor, T. G. (2014) · Development and Psychopathology · doi:10.1017/s0954579414000029 · Cited by 425
Soubry, A., Schildkraut, J. M., Murtha, A. P., Wang, F. M., Huang, Z., Bernal, A. J., Kurtzberg, J., Jirtle, R. L., Murphy, S. K., & Hoyo, C. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-29 · Cited by 364
Tobi, E. W., Slieker, R. C., Luijk, R., Dekkers, K. F., Stein, A. D., Xu, K. M., Biobank-based Integrative Omics Studies Consortium, Slagboom, P. E., van Zwet, E. W., Lumey, L. H., et al. (2018) · Science Advances · doi:10.1126/sciadv.aao4364 · Cited by 284
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Metadata
- Authors
- Stein, A. D., Pierik, F. H., Verrips, G. H. W., Susser, E. S., & Lumey, L. H.
- Affiliations
- Emory University (US)
- Netherlands Organisation for Applied Scientific Research (NL)
- New York State Psychiatric Institute (US)
- Columbia University (US)
- Corresponding author
- Lumey, L H.
- Venue
- Epidemiology
- Published
- 2009-11
- Volume
- 20
- Issue
- 6
- Pages
- 909-915
- ISSN
- 1044-3983 (ISSN-L)
- PMC
- PMC3850290
- OpenAlex
- W1966866532
- Cited by
- 103
- References
- 29
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 10 · 2018: 8 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 8 · 2013: 6 · 2012: 5
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- TNO Repository (submittedVersion)
- Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL067914)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- Dutch famine, prenatal famine exposure, health-related quality of life, depressive symptoms, mental health, physical health, adult offspring
- MeSH terms
- Depression, Female, Fertilization, Humans, Male, Middle Aged, Netherlands, Pregnancy, Quality of Life, Surveys and Questionnaires, Starvation, Maternal Exposure, Adult Children, History, 20th Century
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