The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Oral L-Carnitine Supplementation Increases Trimethylamine-N-oxide but Reduces Markers of Vascular Injury in Hemodialysis Patients
Abstract
OBJECTIVES: Food or supplement-derived L-carnitine is changed to trimethylamine (TMA) by interstinal microbiota, which is further metabolized to trimethylamine-N-oxide (TMAO), being involved in the promotion of atherosclerosis in animal models. Meanwhile, carnitine deficiency has played a role in accelerated atherosclerosis in hemodialysis (HD) patients. However, effects of oral L-carnitine supplementation on circulating levels of TMAO and markers of vascular injury and oxidative stress in patients on HD remain unclear. In this study, we addressed the issue. METHODS: Thirty-one HD patients with carnitine deficiency were treated with oral L-carnitine (900 mg/d) for 6 months. At baseline and after treatment, clinical variables including circulating levels of carnitine fractions, TMA, TMAO, advanced glycation end products (AGE), soluble forms of intracellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), and malondialdehyde (MDA) were measured. RESULTS: Oral L-carnitine supplementation significantly increased total, free, acyl carnitine, and plasma TMA and TMAO levels, whereas it decreased markers of vascular injury and oxidative stress such as sICAM-1, sVCAM-1, and MDA levels. TMA and TMAO levels at baseline were correlated with each other, and free carnitine was independently associated with TMAO levels. Furthermore, change in AGE values from baseline ([INCREMENT]AGE) was positively correlated with [INCREMENT]sICAM-1 (P = 0.043) and was a sole independent determinant of [INCREMENT]sICAM-1 (R = 0.133, P = 0.043). CONCLUSIONS: This study demonstrated that although oral L-carnitine supplementation was associated with increased TMAO levels, it might be beneficial on vascular injury in patients on HD. Vasculoprotective properties of L-carnitine supplementation in HD patients might be ascribed partly to its inhibitory actions on AGE.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Supplementation with L-carnitine seems to improve some features of CVD [68] although it raises plasma TMAO and TMA levels [69]”
From Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target (2018) · cites this paper as [69]
In the citing paper
“Although oral supplementation of L-carnitine was associated with increased plasma TMAO concentrations, it decreased vascular injury markers and oxidative stress markers in hemodialysis patients (43).”
From Trimethylamine N -Oxide, the Microbiome, and Heart and Kidney Disease (2017) · cites this paper as [43]
Citations
Cites
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,400
Ridker, P. M., Hennekens, C. H., Roitman-Johnson, B., Stampfer, M. J., & Allen, J. (1998) · The Lancet · doi:10.1016/s0140-6736(97)09032-6 · Cited by 1,229
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
Suzuki, H. I., Kurihara, Y., Takeya, M., Kamada, N., Kataoka, M., Jishage, K., Ueda, O., Sakaguchi, H., Higashi, T., Suzuki, T., et al. (1997) · Nature · doi:10.1038/386292a0 · Cited by 1,226
Self-citationNakashima, Y., Raines, E. W., Plump, A. S., Breslow, J. L., & Ross, R. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.5.842 · Cited by 917
ICAM-1 signaling in endothelial cells
Lawson, C., & Wolf, S. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70004-0 · Cited by 685
Expression of intercellular adhesion molecule-1 in atherosclerotic plaques.
Poston, R. N., Haskard, D. O., Coucher, J., Gall, N. P., & Johnson-Tidey, R. R. (1992) · PubMed Central · Cited by 583
Soluble P-Selectin and the Risk of Future Cardiovascular Events
Ridker, P. M., Buring, J. E., & Rifai, N. (2001) · Circulation · doi:10.1161/01.cir.103.4.491 · Cited by 564
Collins, R. G., Velji, R., Guevara, J., Hicks, J. M., Chan, L., & Beaudet, A. L. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.1.189 · Cited by 507
Research works printed but not linked: 3
- Ascunce, 2013, Tex Heart Inst J, 40, 104
- Preiss, 2007, 61, 697
- Poston, 1992, Am J Pathol, 140, 665
Cited by
Sorted by citations
Janeiro, M., Ramírez, M., Milagro, F., Martínez, J., & Solas, M. (2018) · Nutrients · doi:10.3390/nu10101398 · Cited by 631
Intestinal Microbiota in Cardiovascular Health and Disease
Tang, W. H. W., Bäckhed, F., Landmesser, U., & Hazen, S. L. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.03.024 · Cited by 524
Trimethylamine N -Oxide, the Microbiome, and Heart and Kidney Disease
Zeisel, S. H., & Warrier, M. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064732 · Cited by 475
Fennema, D., Phillips, I. R., & Shephard, E. A. (2016) · Drug Metabolism and Disposition · doi:10.1124/dmd.116.070615 · Cited by 355
TMAO: A small molecule of great expectations
Ufnal, M., Żądło‐Dobrowolska, A., & Ostaszewski, R. (2015) · Nutrition · doi:10.1016/j.nut.2015.05.006 · Cited by 327
Liu, Y., & Dai, M. (2020) · Mediators of Inflammation · doi:10.1155/2020/4634172 · Cited by 235
Trimethylamine- N -Oxide: Friend, Foe, or Simply Caught in the Cross-Fire?
Cho, C. E., & Caudill, M. A. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.10.005 · Cited by 220
Wernimont, S. M., Radosevich, J., Jackson, M. I., Ephraim, E., Badri, D. V., MacLeay, J. M., Jewell, D. E., & Suchodolski, J. S. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01266 · Cited by 244
Arias, N., Arboleya, S., Allison, J., Kaliszewska, A., Higarza, S. G., Gueimonde, M., & Arias, J. L. (2020) · Nutrients · doi:10.3390/nu12082340 · Cited by 210
Host-microbiome interactions: Gut-Liver axis and its connection with other organs
Anand, S., & Mande, S. S. (2022) · npj Biofilms and Microbiomes · doi:10.1038/s41522-022-00352-6 · Cited by 201
Collins, H. L., Drazul-Schrader, D., Sulpizio, A. C., Koster, P. D., Williamson, Y., Adelman, S. J., Owen, K., Sanli, T., & Bellamine, A. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.10.108 · Cited by 189
Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis
Tomášová, L., Konopelski, P., & Ufnal, M. (2016) · Molecules · doi:10.3390/molecules21111558 · Cited by 161
Enoki, Y., Watanabe, H., Arake, R., Fujimura, R., Ishiodori, K., Imafuku, T., Nishida, K., Sugimoto, R., Nagao, S., Miyamura, S., et al. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12202 · Cited by 158
Trimethylamine N-Oxide in Relation to Cardiometabolic Health—Cause or Effect?
Papandreou, C., Moré, M. I., & Bellamine, A. (2020) · Nutrients · doi:10.3390/nu12051330 · Cited by 157
Gut microbes in cardiovascular diseases and their potential therapeutic applications
Jin, L., Shi, X., Yang, J., Zhao, Y., Xue, L., Xu, L., & Cai, J. (2020) · Protein & Cell · doi:10.1007/s13238-020-00785-9 · Cited by 143
Huć, T., Drapała, A., Gawryś-Kopczyńska, M., Konop, M., Maksymiuk, K. M., Zaorska, E., Samborowska, E., Wyczałkowska-Tomasik, A., Pączek, L., Dadlez, M., et al. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00536.2018 · Cited by 134
Trimethylamine N -oxide: A harmful, protective or diagnostic marker in lifestyle diseases?
Nowiński, A., & Ufnal, M. (2017) · Nutrition · doi:10.1016/j.nut.2017.08.001 · Cited by 132
The bright and the dark sides of L-carnitine supplementation: a systematic review
Sawicka, A. K., Renzi, G., & Olek, R. A. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00377-2 · Cited by 113
TMA, A Forgotten Uremic Toxin, but Not TMAO, Is Involved in Cardiovascular Pathology
Jaworska, K., Hering, D., Mosieniak, G., Bielak-Żmijewska, A., Pilz, M., Konwerski, M., Gąsecka, A., Kapłon‐Cieślicka, A., Filipiak, K. J., Sikora, E., et al. (2019) · Toxins · doi:10.3390/toxins11090490 · Cited by 106
Organic Cation Transporters in Human Physiology, Pharmacology, and Toxicology
Samodelov, S. L., Kullak-Ublick, G. A., Gai, Z., & Visentin, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217890 · Cited by 97
Flavin-containing monooxygenases in aging and disease: Emerging roles for ancient enzymes
Rossner, R., Kaeberlein, M. R., & Leiser, S. F. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.779678 · Cited by 81
Oktaviono, Y. H., Lamara, A. D., Saputra, P. B. T., Arnindita, J. N., Pasahari, D., Saputra, M. E., & Suasti, N. M. A. (2023) · Biomolecules and Biomedicine · doi:10.17305/bb.2023.8893 · Cited by 92
Phillips, I. R., & Shephard, E. A. (2019) · Xenobiotica · doi:10.1080/00498254.2019.1643515 · Cited by 72
Association of advanced glycation end products with sarcopenia and frailty in chronic kidney disease
Yabuuchi, J., Ueda, S., Yamagishi, S., Nohara, N., Nagasawa, H., Wakabayashi, K., Matsui, T., Higashimoto, Y., Kadoguchi, T., Otsuka, T., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-74673-x · Cited by 66
Self-citationȘerban, M.-C., Sahebkar, A., Mikhailidis, D. P., Toth, P. P., Jones, S. R., Muntner, P., Blaha, M. J., Andrica, F., Martin, S. S., Borza, C., et al. (2016) · Scientific Reports · doi:10.1038/srep19188 · Cited by 65
Tacconi, E., Palma, G., Biase, D. D., Luciano, A., Barbieri, M., de Nigris, F., & Bruzzese, F. (2023) · Nutrients · doi:10.3390/nu15030563 · Cited by 62
The gut-blood barrier permeability – A new marker in cardiovascular and metabolic diseases?
Ufnal, M., & Pham, K. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.11.012 · Cited by 55
Samulak, J. J., Sawicka, A. K., Hartmane, D., Grı̄nberga, S., Pugovičs, O., Łysiak−Szydłowska, W., & Olek, R. A. (2018) · Annals of Nutrition and Metabolism · doi:10.1159/000495037 · Cited by 54
Kotani, K., Șerban, M.-C., Penson, P. E., Lippi, G., & Banach, M. (2016) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2016.1188055 · Cited by 50
Ozola, M., Vilšķe̅rsts, R., Korzh, S., Cirule, H., Sevostjanovs, E., Dambrova, M., & Makrecka‐Kuka, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.622741 · Cited by 53
Stroke and Vascular Cognitive Impairment: The Role of Intestinal Microbiota Metabolite TMAO
Tu, R., & Xia, J. (2024) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230203140805 · Cited by 47
Bordoni, L., Sawicka, A. K., Szarmach, A., Winklewski, P. J., Olek, R. A., & Gabbianelli, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031047 · Cited by 49
Dongoran, R. A., Lin, T., Byekyet, A., Tang, S., Yang, J., & Liu, C. (2020) · Biomolecules · doi:10.3390/biom10121689 · Cited by 46
Intestinal Microbiota Metabolism and Atherosclerosis
Liu, T.-X., Niu, H.-T., & Zhang, S.-Y. (2015) · Chinese Medical Journal · doi:10.4103/0366-6999.167362 · Cited by 43
Ufnal, M., & Nowiński, A. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.109271 · Cited by 41
Luo, Z., Yu, X., Wang, C., Zhao, H., Wang, X., & Guan, X. (2023) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-023-00984-y · Cited by 41
Lipoprotein(a): Current Evidence for a Physiologic Role and the Effects of Nutraceutical Strategies
Santos, H. O., KONES, R. J., Rumana, U., Earnest, C. P., Izidoro, L. F. M., & Macedo, R. C. O. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.06.002 · Cited by 42
Effects of Toxic AGEs (TAGE) on Human Health
Takeuchi, M., Sakai, A., Takata, T., Takino, J.-I., & Koriyama, Y. (2022) · Cells · doi:10.3390/cells11142178 · Cited by 40
Self-citationOnyszkiewicz, M., Jaworska, K., & Ufnal, M. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370219900898 · Cited by 39
Wu, D., Cao, M., Peng, J., Li, N., Yi, S., Song, L., Wang, X., Zhang, M., & Zhao, J. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.11.032 · Cited by 37
Methods to investigate advanced glycation end-product and their application in clinical practice
Corica, D., Pepe, G., Currò, M., Aversa, T., Tropeano, A., Ientile, R., & Wasniewska, M. G. (2021) · Methods · doi:10.1016/j.ymeth.2021.12.008 · Cited by 38
Taguchi, K., Fukami, K., Elias, B. C., & Brooks, C. R. (2021) · Toxins · doi:10.3390/toxins13050361 · Cited by 40
Self-citationBacterial-Induced Blood Pressure Reduction: Mechanisms for the Treatment of Hypertension via the Gut
Cookson, T. A. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.721393 · Cited by 36
Kalagi, N. A., Abbott, K. A., Alburikan, K. A., Alkofide, H., Stojanovski, E., & Garg, M. L. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz012 · Cited by 27
Olek, R. A., Samulak, J. J., Sawicka, A. K., Hartmane, D., Grı̄nberga, S., Pugovičs, O., & Łysiak−Szydłowska, W. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/6247169 · Cited by 27
Obrenovich, M. E., Siddiqui, B., McCloskey, B., & Reddy, V. P. (2020) · Microorganisms · doi:10.3390/microorganisms8040490 · Cited by 29
Modification of hygroscopicity and tabletability of l -carnitine by a cocrystallization technique
Pang, Z., Weng, X., Wei, Y., Gao, Y., Zhang, J., & Qian, S. (2021) · CrystEngComm · doi:10.1039/d0ce01820a · Cited by 24
Metabonomic profiling of chronic intermittent hypoxia in a mouse model
Conotte, S., Tassin, A., Conotte, R., Colet, J., Boudjeltia, K. Z., & Legrand, A. (2018) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2018.02.015 · Cited by 24
Trimethylamine N-Oxide (TMAO) and cancer risk: Insights into a possible link
Saha, B., Banerjee, A., Pathak, R., Duttaroy, A. K., & Pathak, S. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118592 · Cited by 25
Bertuccioli, A., Cardinali, M., Biagi, M., Moricoli, S., Morganti, I., Zonzini, G. B., & Rigillo, G. (2021) · Microorganisms · doi:10.3390/microorganisms9122427 · Cited by 26
Yu, J., Zhang, T., Gao, X., Xue, C., Xu, J., & Wang, Y. (2017) · RSC Advances · doi:10.1039/c7ra10248h · Cited by 21
Lin, T., Tang, S., Liao, P.-Y., Dongoran, R. A., Yang, J., & Liu, C. (2019) · Nutrition · doi:10.1016/j.nut.2019.03.019 · Cited by 20
Endogenous Roles of Mammalian Flavin-Containing Monooxygenases
Phillips, I. R., & Shephard, E. A. (2019) · Catalysts · doi:10.3390/catal9121001 · Cited by 19
Egg Intake in Chronic Kidney Disease
Tallman, D. A., Sahathevan, S., Karupaiah, T., & Khosla, P. (2018) · Nutrients · doi:10.3390/nu10121945 · Cited by 22
Human Gut Microbiota in Cardiovascular Disease
Ronen, D., Rokach, Y., Abedat, S., Qadan, A., Daana, S., Amir, O., & Asleh, R. (2024) · Comprehensive physiology · doi:10.1002/cphy.c230012 · Cited by 28
Samulak, J. J., Sawicka, A. K., Samborowska, E., & Olek, R. A. (2019) · Nutrients · doi:10.3390/nu11061322 · Cited by 18
Hardin, S. J., Singh, M., Eyob, W., Molnar, J., Homme, R. P., George, A. K., & Tyagi, S. C. (2019) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm.2019.03.518 · Cited by 17
Yano, J., Kaida, Y., Maeda, T., Hashida, R., Tonan, T., Nagata, S., Hazama, T., Nakayama, Y., Ito, S., Kurokawa, Y., et al. (2020) · Therapeutic Apheresis and Dialysis · doi:10.1111/1744-9987.13576 · Cited by 17
Self-citationAbrahamsen, R. K., Lund, A. M., & Rasmussen, J. (2023) · JIMD Reports · doi:10.1002/jmd2.12383 · Cited by 14
Lifestyle and Lipoprotein(a) Levels: Does a Specific Counseling Make Sense?
Fogacci, F., Micoli, V. D., Sabouret, P. F., Giovannini, M., & Cicero, A. F. G. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13030751 · Cited by 16
Nagasawa, H., Suzuki, S., Kobayashi, T., Otsuka, T., Okuma, T., Matsushita, S., Amano, A., Shimizu, Y., Suzuki, Y., & Ueda, S. (2024) · Hypertension Research · doi:10.1038/s41440-024-01895-1 · Cited by 11
Self-citationThe origin of trimethylamine- N-oxide (TMAO) and its role in development of atherosclerosis
He, Z., & Chen, Z. (2018) · Journal of Food Bioactives · doi:10.31665/jfb.2018.2138 · Cited by 12
Jamshidi, K., Abdollahzad, H., Nachvak, M., Rezaei, M., Golpayegani, M. R., & Sharifi‐Zahabi, E. (2020) · Journal of Blood Medicine · doi:10.2147/jbm.s252105 · Cited by 11
Shimizu, M., Suemizu, H., Mizuno, S., Kusama, T., Miura, T., Uehara, S., & Yamazaki, H. (2018) · The Journal of Toxicological Sciences · doi:10.2131/jts.43.387 · Cited by 9
Self-citationOmics Approaches To Probe Microbiota and Drug Metabolism Interactions
Nichols, R. G., Hume, N. E., Smith, P. B. W., Peters, J. M., & Patterson, A. D. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00236 · Cited by 10
Tahara, A., Tahara, N., Yamagishi, S., Honda, A., Igata, S., Nitta, Y., Bekki, M., Nakamura, T., Sugiyama, Y., Sun, J., et al. (2017) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2017.1318117 · Cited by 10
Self-citationNagasawa, H., Ueda, S., Otsuka, T., Kaifu, K., Ono, S., Okuma, T., Kobayashi, T., Matsushita, S., Kasai, T., Dohi, T., et al. (2021) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2021.06.007 · Cited by 9
Self-citationDiet-mediated metaorganismal relay biotransformation: health effects and pathways
Li, Y., Cao, H., Wang, X., Guo, L., Ding, X., Zhao, W., & Zhang, F. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.2004993 · Cited by 9
Chen, S., & Liang, Y. (2022) · Life · doi:10.3390/life12030380 · Cited by 8
Kaida, Y., Taguchi, K., & Fukami, K. (2025) · Nutrients · doi:10.3390/nu17132084 · Cited by 5
Self-citationShimizu, M., & Yamazaki, H. (2017) · The Journal of Toxicological Sciences · doi:10.2131/jts.42.485 · Cited by 5
Self-citationSenthong, V., Kiatchoosakun, S., Wongvipaporn, C., Phetcharaburanin, J., Sritara, P., Phrommintikul, A., CORE Investigators, Sritara, P., Yamwong, S., Srimahachota, S., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-71479-z · Cited by 4
Bell, J. S. (2021) · Digital Commons - USU (Utah State University) · doi:10.26076/5508-73fe · Cited by 4
Gut Microbiota: A New Marker of Cardiovascular Disease
Pontarollo, G., Kiouptsi, K., Bayer, F., & Reinhardt, C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00028-0 · Cited by 2
Shimizu, M., Nii, A., Uno, Y., & Yamazaki, H. (2025) · Drug Metabolism and Disposition · doi:10.1016/j.dmd.2025.100140 · Cited by 2
Self-citationShimizu, M., Shimura, Y., & Yamazaki, H. (2025) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b25-00526 · Cited by 1
Self-citationRegulation of Trimethylamine N-oxide in Treatment of Cardiometabolic Diseases. Doctoral Thesis
Ozola, M. (2023) · doi:10.25143/prom-rsu_2023-16_dt · Cited by 1
Misawa, H., Yamadera, S., Nakamura, Y., Inagaki, M., Oguchi, T., Tsuji, Y., Tsuji, M., Ohsawa, I., Gotoh, H., & Kiuchi, Y. (2025) · Renal Replacement Therapy · doi:10.1186/s41100-025-00631-w
Nakayama, N. (2026) · Springer eBooks · doi:10.1007/978-981-95-7797-2_9
Anti-inflammatory, Antioxidant, and Anti-apoptotic Effects of Carnitine
Nakayama, N. (2026) · Springer eBooks · doi:10.1007/978-981-95-7797-2_7
Olek, R. A., & Radak, Z. O. (2026) · European Journal of Applied Physiology · doi:10.1007/s00421-026-06297-4
WHO-Recommended Exercise Dose Is Associated With Slower Epigenetic Aging in Older AdultsPreprint
Torma, F., Jókai, M., Babszky, G., Bábszky, Z., Farkas, G., Mozaffaritabar, S., Zhou, L., Koltai, E., Kneffel, Z., Pavlik, G., et al. (2026) · medRxiv · doi:10.64898/2026.09.02.26361502
Metadata
- Authors
- Fukami, K., Yamagishi, S.-I., Sakai, K., Kaida, Y., Yokoro, M., Ueda, S., Wada, Y., Takeuchi, M., Shimizu, M., Yamazaki, H., & Okuda, S.
- Affiliations
- Kurume University (JP)
- Kanazawa Medical University (JP)
- Showa Pharmaceutical University (JP)
- Corresponding author
- Fukami, Kei
- Sakai, Kazuko
- Kaida, Yusuke
- Yokoro, Miyuki
- Ueda, Seiji
- Okuda, Seiya
- ORCID
- Venue
- Journal of Cardiovascular Pharmacology
- Published
- 2015-03
- Volume
- 65
- Issue
- 3
- Pages
- 289-295
- ISSN
- 0160-2446 (ISSN-L)
- OpenAlex
- W2328568033
- Cited by
- 84
- References
- 33
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 10 · 2020: 14 · 2019: 11 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 3
- FWCI
- 7.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cardiovascular Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (26860487)
- Topics
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- carnitine supplementation, trimethylamine N-oxide, trimethylamine, hemodialysis, carnitine deficiency, vascular injury, advanced glycation end products, oxidative stress, soluble ICAM-1, soluble VCAM-1, malondialdehyde, gut microbiota, atherosclerosis, vascular protection
- MeSH terms
- Administration, Oral, Aged, Carnitine, Deficiency Diseases, Female, Renal Dialysis, Humans, Japan, Kidney Diseases, Male, Malondialdehyde, Methylamines, Middle Aged, Time Factors, Biomarkers, Case-Control Studies, Treatment Outcome, Glycation End Products, Advanced, Oxidative Stress, Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, Dietary Supplements, Vascular System Injuries
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
