Injectable Weight Loss Medications in Plastic Surgery: What We Know, Perioperative Considerations, and Recommendations for the Future
Open accessAbstract
Summary: Obesity is a major epidemic plaguing American society. Injectable subcutaneous medications initially designed for use in type 2 diabetes management, such as semaglutide and other glucagon-like peptide-1 receptor agonists, are rapidly gaining popularity for their effects on weight. These drugs (Ozempic, Wegovy, Saxenda, and Mounjaro) are ubiquitous on social media and are promoted by celebrities across all demographics. “Ozempic face” and “Ozempic butt” are now mainstream concepts highlighting the morphologic changes that occur with these medications. There is a paucity of literature available on the impact of these medications for plastic surgeons and their patients. As use becomes widespread, it is important for plastic surgeons to understand their indications, contraindications, appropriate perioperative management, and impact on plastic surgery procedures.
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Despite sharing a therapeutic class, individual GLP-1 RAs can exhibit diverse biological effects and safety profiles due to their distinct molecular structures and mechanisms of action.
“This approach is grounded in the understanding that despite sharing a therapeutic class, individual GLP-1 RAs can exhibit diverse biological effects and safety profiles due to their distinct molecular structures and mechanisms of action [1,4,5,6].”
From Assessment of Thyroid Carcinogenic Risk and Safety Profile of GLP1-RA Semaglutide (Ozempic) Therapy for Diabetes Mellitus and Obesity: A Systematic Literature Review (2024) · cites this paper as [1]
The Introduction (page not provided) says tirzepatide activates an additional receptor and has effects beyond those of semaglutide. The Risks section (page not provided) reports more diabetic-retinopathy complications with semaglutide than with other medications. These passages support differences in effects and safety profiles, but do not establish that distinct molecular structures cause those differences. (LLM, conf=0.86)
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- Authors
- O’Neill, E. S., Wiegmann, A. L., Parrella, N., Pittman, T., Hood, K., & Kurlander, D.
- Affiliations
- Rush University Medical Center (US)
- Private Practice, Somenek+Pittman MD, Washington, D.C.
- Corresponding author
- O’Neill, Elizabeth S.
- Wiegmann, Aaron L.
- Hood, Keith
- Kurlander, David
- Venue
- Plastic and Reconstructive Surgery - Global Open
- Published
- 2024-01
- Volume
- 12
- Issue
- 1
- Pages
- e5516
- ISSN
- 2169-7574 (ISSN-L)
- PMC
- PMC10807879
- OpenAlex
- W4391177837
- Cited by
- 43
- References
- 37
- Citations by year
- 2026: 15 · 2025: 17 · 2024: 11
- FWCI
- 12.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Plastic & Reconstructive Surgery Global Open (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Health Sciences › Medicine › Surgery › Body Contouring and Surgery
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Keywords
- semaglutide, GLP-1 receptor agonists, obesity, perioperative care, cosmetic surgery, body contouring, drug contraindications
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