Update on cardiac stem cell therapy in heart failure
Abstract
PURPOSE OF REVIEW: Presentation of the current status of cardiac stem cell therapy for the treatment of ischaemic heart failure by highlighting recent clinical results and introducing ongoing trials. Furthermore, necessary upcoming procedural adjustments are discussed. RECENT FINDINGS: During the last decade, stem cell application in the setting of ischaemic heart failure has been evaluated in phase I and II clinical trials, proving safety and feasibility of this approach. Functional results gained so far indicate moderate benefits. However, conclusive evaluation of cell therapy will not be possible before completion of ongoing phase III multicentre trials. Moreover, questions regarding the optimal cell population for treatment in a chronic setting and the favourable time-point of cell delivery have not been ultimately answered. SUMMARY: Cell therapy for the treatment of ischaemic heart failure needs to be evaluated separately from the setting of acute myocardial infarction. In parallel with upcoming clinical evaluation in large-scale trials, further optimization of the 'cell product' regarding the favourable cell type and periprocedural processing, as well as route and time-point of application, is mandatory.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Cardiac stem cell therapy is relatively well tolerated and feasible.
“Those studies have proven that cardiac stem cell therapy is relatively well tolerated and feasible (152).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [152]
Cites
Bone marrow cells regenerate infarcted myocardium
Orlic, D., Kajstura, J., Chimenti, S., Jakoniuk, I., Anderson, S. M., Li, B., Pickel, J. M., McKay, R. D. G., Nadal‐Ginard, B., Bodine, D. M., et al. (2001) · Nature · doi:10.1038/35070587 · Cited by 5,149 · see citing works
Evidence for Cardiomyocyte Renewal in Humans
Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., et al. (2009) · Science · doi:10.1126/science.1164680 · Cited by 3,130 · see citing works
Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells
Jackson, K. A., Majka, S. M., Wang, H., Pocius, J. S., Hartley, C. J., Majesky, M. W., Entman, M. L., Michael, L. H., Hirschi, K. K., & Goodell, M. A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12150 · Cited by 1,960 · see citing works
Transcoronary Transplantation of Progenitor Cells after Myocardial Infarction
Aßmus, B., Honold, J., Schächinger, V., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa051779 · Cited by 1,040 · see citing works
The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) Trial
Menasché, P., Alfieri, O., Janssens, S. P., McKenna, W. J., Reichenspurner, H. C., Trinquart, L., Vilquin, J., Marolleau, J., Seymour, B., Larghero, J., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.734103 · Cited by 952 · see citing works
Freyman, T. M., Polin, G. M., Osman, H. E., Crary, J., Lü, M., Cheng, L., Palasis, M., & Wilensky, R. L. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi818 · Cited by 610 · see citing works
Stamm, C., Kleine, H., Choi, Y., et al. (2007) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2006.08.077 · Cited by 380 · see citing works
Strauer, B. E., Brehm, M. U., Zeus, T., et al. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.01.069 · Cited by 380 · see citing works
Self-citationAntiarrhythmic Engineering of Skeletal Myoblasts for Cardiac Transplantation
Abraham, M. R., Henrikson, C. A., Tung, L., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000174794.22491.a0 · Cited by 281 · see citing works
Prokopi, M., Pula, G., Mayr, U., Devue, C., Gallagher, J., Xiao, Q., Boulanger, C. M., Westwood, N., Urbich, C., Willeit, J., et al. (2009) · Blood · doi:10.1182/blood-2009-02-205930 · Cited by 273 · see citing works
Cheng, K., Li, T., Malliaras, K. G., Davis, D. R., Zhang, Y., & Marbán, E. (2010) · Circulation Research · doi:10.1161/circresaha.109.212589 · Cited by 242 · see citing works
Strauer, B. E., Yousef, M., & Schannwell, C. M. (2010) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq095 · Cited by 237 · see citing works
Self-citationHendrikx, M., Hensen, K., Clijsters, C., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.000505 · Cited by 236 · see citing works
SDF-1α as a therapeutic stem cell homing factor in myocardial infarction
Ghadge, S. K., Mühlstedt, S., Özcelik, C., & Bäder, M. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.09.011 · Cited by 219 · see citing works
10 Years of Intracoronary and Intramyocardial Bone Marrow Stem Cell Therapy of the Heart
Strauer, B. E., & Steinhoff, G. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.016 · Cited by 211 · see citing works
Self-citationPerin, E. C., Silva, G. V., Henry, T. D., Cabreira-Hansen, M. D. G., Moore, W. H., Coulter, S., Herlihy, J. P., Fernandes, M. R., Cheong, B., Flamm, S. D., et al. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.01.028 · Cited by 179 · see citing works
Cardiac cell therapy: Lessons from clinical trials
Menasché, P. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.06.010 · Cited by 172 · see citing works
Trachtenberg, B. H., Velazquez, D. L., Williams, A. R., McNiece, I., Fishman, J. E., Nguyen, K., Rouy, D., Altman, P. A., Schwarz, R., Mendizabal, A. M., et al. (2011) · American Heart Journal · doi:10.1016/j.ahj.2010.11.024 · Cited by 135 · see citing works
Preconditioning and Stem Cell Survival
Haider, H. K., & Ashraf, M. (2009) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-009-9161-2 · Cited by 129 · see citing works
Mesenchymal Stem Cells for Cardiac Cell Therapy
Choi, Y., Kurtz, A., & Stamm, C. (2010) · Human Gene Therapy · doi:10.1089/hum.2010.211 · Cited by 118 · see citing works
Electrophysiological Challenges of Cell-Based Myocardial Repair
Chen, H.-S. V., Kim, C., & Mercola, M. A. (2009) · Circulation · doi:10.1161/circulationaha.107.751412 · Cited by 111 · see citing works
Hu, S., Liu, S., Zheng, Z., Yuan, X., Li, L., Lu, M., Shen, R., Duan, F., Zhang, X., Li, ., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.01.037 · Cited by 105 · see citing works
Mocini, D., Staibano, M., Mele, L., et al. (2005) · American Heart Journal · doi:10.1016/j.ahj.2005.02.001 · Cited by 103 · see citing works
Aßmus, B., Tonn, T., Seeger, F. H., Yoon, C., Leistner, D. M., Klotsche, J., Schächinger, V., Seifried, E., Zeiher, A. M., & Dimmeler, S. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.10.059 · Cited by 100 · see citing works
Donndorf, P., Kundt, G., Kaminski, A., Yerebakan, C., Liebold, A., Steinhoff, G., & Glass, Ä. (2011) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2010.12.013 · Cited by 76 · see citing works
Self-citationFukushima, S., Coppen, S. R., Lee, J., Yamahara, K., Felkin, L. E., Terracciano, C. M., Barton, P. J. R., Yacoub, M. H., & Suzuki, K. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003071 · Cited by 70 · see citing works
Veltman, C. E., Soliman, O. I. I., Geleijnse, M. L., et al. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn171 · Cited by 69 · see citing works
The therapeutic potential of stem cells in heart disease
Strauer, B. E., Brehm, M., & Schannwell, C. M. (2007) · Cell Proliferation · doi:10.1111/j.1365-2184.2008.00480.x · Cited by 46 · see citing works
Self-citationAutologous Bone Marrow-Derived Stem Cells for Ischemic Heart Failure: Regenerate-Ihd Trial
Yeo, C., & Mathur, A. (2008) · Regenerative Medicine · doi:10.2217/17460751.4.1.119 · Cited by 40 · see citing works
Bai, Y., Sun, T., & Ye, P. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.05.001 · Cited by 38 · see citing works
Wen, Y., Li, M., Xie, J., et al. (2011) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2011.560567 · Cited by 36 · see citing works
Duffy, G. P., D'Arcy, S., Ahsan, T., Nerem, R. M., O’Brien, T., & Barry, F. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0623 · Cited by 35 · see citing works
SDF-1:CXCR4 Axis Is Fundamental for Tissue Preservation and Repair
Penn, M. S. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.100803 · Cited by 35 · see citing works
Imaging approaches for the study of cell-based cardiac therapies
Lau, J. F., Anderson, S. A., Adler, E., & Frank, J. A. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.227 · Cited by 31 · see citing works
A safety and feasibility study of cell therapy in dilated cardiomyopathy
Martino, H. F., de Oliveira, P. S., Souza, F. C. D. C. C., et al. (2010) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2010007500093 · Cited by 29 · see citing works
Kim, S. K., Pak, H., Park, J. H., et al. (2010) · Cardiology in the Young · doi:10.1017/s1047951110000132 · Cited by 25 · see citing works
Stem Cell Therapy for Myocardial Infarction: Are We Missing Time?
ter Horst, K. W. (2010) · Cardiology · doi:10.1159/000318840 · Cited by 25 · see citing works
Larose, É., Proulx, G., Voisine, P., et al. (2009) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.22204 · Cited by 14 · see citing works
Repair of the Damaged Heart by Bone Marrow Cells: From Experimental Evidence to Clinical Hope
Ang, K., Shenje, L. T., Srinivasan, L., et al. (2006) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.05.047 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Wound repair and regeneration: Mechanisms, signaling, and translation
Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562 · see citing works
- Authors
- Donndorf, P., Strauer, B.-E., & Steinhoff, G.
- Affiliations
- Universitätsmedizin Rostock (DE)
- Corresponding author
- Donndorf, Peter
- ORCID
- Steinhoff, Gustav
- Venue
- Current Opinion in Cardiology
- Published
- 2012-03
- Volume
- 27
- Issue
- 2
- Pages
- 154-160
- ISSN
- 0268-4705 (ISSN-L)
- OpenAlex
- W2333769157
- Cited by
- 18
- References
- 39
- Citations by year
- 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2014: 3 · 2013: 4 · 2012: 6
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- cardiac stem cell therapy, ischemic heart failure, cell therapy clinical trials, cell processing, feasibility and safety
- MeSH terms
- Heart Failure, Humans, Treatment Outcome, Myocardial Ischemia, Stem Cell Transplantation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
