The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Differential response of the natriuretic peptide system to weight loss and exercise in overweight or obese patients
Abstract
OBJECTIVE: Relative atrial natriuretic peptide (ANP) deficiency has been implicated in the pathogenesis of obesity-associated cardiovascular and metabolic disease. We tested the hypothesis that more than 5% body weight reduction through 6 months hypocaloric dieting alters ANP release at rest and more so during exercise in overweight or obese patients. METHODS: Venous mid-regional pro-ANP concentration was assessed at rest and after incremental exhaustive exercise testing before and after weight reduction. We also measured natriuretic peptide receptor A and C mRNA expression in subcutaneous adipose tissue to gauge both ANP responsiveness and clearance mechanisms. RESULTS: The average weight reduction of 9.1 ± 3.8 kg was associated with reductions in visceral and subcutaneous abdominal fat mass, liver fat content, insulin resistance, and ambulatory blood pressure. However, mid-regional pro-ANP plasma concentrations were unchanged with weight loss (51 ± 24 vs. 53 ± 24 pmol/l). Exercise elicited similar acute mid-regional pro-ANP increases before and after weight loss. Adipose tissue natriuretic peptide receptor type A mRNA expression remained unchanged, whereas natriuretic peptide receptor type C mRNA decreased with weight loss. CONCLUSIONS: We conclude that physical exercise acutely increases ANP release in obese patients, whereas modest diet-induced weight loss primarily affects ANP clearance mechanisms. Interventions combining weight loss and regular physical exercise may be particularly efficacious in reversing obesity-associated relative natriuretic peptide deficiency.
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Self-citationNatriuretic peptides: a new lipolytic pathway in human adipocytes
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Mancia, G., Kreutz, R., Brunström, M., Burnier, M., Grassi, G., Januszewicz, A., Muiesan, M. L., Tsioufis, K., Agabiti-Rosei, E., Algharably, E. A. E., et al. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003480 · Cited by 3,473
Self-citationJordan, J., Birkenfeld, A. L., Melander, O., & Moro, C. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11081 · Cited by 68
Self-citationEffect of liraglutide on atrial natriuretic peptide, adrenomedullin, and copeptin in PCOS
Frøssing, S., Nylander, M., Kistorp, C., Skouby, S. O., & Faber, J. (2018) · Endocrine Connections · doi:10.1530/ec-17-0327 · Cited by 38
Metadata
- Authors
- Haufe, S., Kaminski, J., Utz, W., Haas, V., Mähler, A., Daniels, M. A., Birkenfeld, A. L., Lichtinghagen, R., Luft, F. C., Schulz-Menger, J., Engeli, S., & Jordan, J.
- Affiliations
- University of Potsdam (DE)
- Helios Hospital Berlin-Buch (DE)
- Max Delbrück Center (DE)
- Charité – Universitätsmedizin Berlin (DE)
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- Jordan, Jens
- ORCID
- Venue
- Journal of Hypertension
- Published
- 2015-07
- Volume
- 33
- Issue
- 7
- Pages
- 1458-1464
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W2328536287
- Cited by
- 41
- References
- 36
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 3 · 2020: 8 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 8 · 2015: 3
- FWCI
- 11.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Site cant be reached (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- atrial natriuretic peptide, obesity, weight loss, hypocaloric diet, physical activity, natriuretic peptide receptor A, NPR-C, adipose tissue, insulin resistance, visceral fat, liver fat, blood pressure
- MeSH terms
- Adipose Tissue, Adult, Diet, Reducing, Female, Humans, Insulin Resistance, Male, Middle Aged, Atrial Natriuretic Factor, Obesity, Rest, Weight Loss, Exercise, Receptors, Atrial Natriuretic Factor, Blood Pressure Monitoring, Ambulatory, Weight Reduction Programs
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