The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Differential response of the natriuretic peptide system to weight loss and exercise in overweight or obese patients
Abstract
OBJECTIVE: Relative atrial natriuretic peptide (ANP) deficiency has been implicated in the pathogenesis of obesity-associated cardiovascular and metabolic disease. We tested the hypothesis that more than 5% body weight reduction through 6 months hypocaloric dieting alters ANP release at rest and more so during exercise in overweight or obese patients. METHODS: Venous mid-regional pro-ANP concentration was assessed at rest and after incremental exhaustive exercise testing before and after weight reduction. We also measured natriuretic peptide receptor A and C mRNA expression in subcutaneous adipose tissue to gauge both ANP responsiveness and clearance mechanisms. RESULTS: The average weight reduction of 9.1 ± 3.8 kg was associated with reductions in visceral and subcutaneous abdominal fat mass, liver fat content, insulin resistance, and ambulatory blood pressure. However, mid-regional pro-ANP plasma concentrations were unchanged with weight loss (51 ± 24 vs. 53 ± 24 pmol/l). Exercise elicited similar acute mid-regional pro-ANP increases before and after weight loss. Adipose tissue natriuretic peptide receptor type A mRNA expression remained unchanged, whereas natriuretic peptide receptor type C mRNA decreased with weight loss. CONCLUSIONS: We conclude that physical exercise acutely increases ANP release in obese patients, whereas modest diet-induced weight loss primarily affects ANP clearance mechanisms. Interventions combining weight loss and regular physical exercise may be particularly efficacious in reversing obesity-associated relative natriuretic peptide deficiency.
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Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Angiotensin-neprilysin inhibition versus enalapril in heart failure
McMurray, J. J. V., Packer, M., Desai, A. S., Gong, J., Lefkowitz, M. P., Rizkala, A. R., Rouleau, J. L., Shi, V. C., Solomon, S. D., Swedberg, K., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409077 · Cited by 6,957
Impact of Obesity on Plasma Natriuretic Peptide Levels
Wang, T. J., Larson, M. G., Levy, D., Benjamin, E. J., Leip, E. P., Wilson, P. W. F., & Vasan, R. S. (2004) · Circulation · doi:10.1161/01.cir.0000112582.16683.ea · Cited by 1,022
Bordicchia, M., Liu, D., Amri, E.-Z., Ailhaud, G., Dessì-Fulgheri, P., Zhang, C., Takahashi, N., Sarzani, R., & Collins, S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59701 · Cited by 872
Suga, S., Nakao, K., Hosoda, K., Mukoyama, M., Ogawa, Y., Shirakami, G., Arai, H., Saito, Y., Kambayashi, Y., & Inouye, K. (1992) · Endocrinology · doi:10.1210/endo.130.1.1309330 · Cited by 739
Weight Loss and the Renin-Angiotensin-Aldosterone System
Engeli, S., Böhnke, J., Gorzelniak, K., Janke, J., Schling, P., Bäder, M., Luft, F. C., & Sharma, A. M. (2005) · Hypertension · doi:10.1161/01.hyp.0000154361.47683.d3 · Cited by 627
Self-citationNatriuretic peptides: a new lipolytic pathway in human adipocytes
Sengenès, C., Berlan, M., de Glisezinski, I., Lafontan, M., & Galitzky, J. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.10.1345 · Cited by 531
Kim, M., Platt, M. J., Shibasaki, T., Quaggin, S. E., Backx, P. H., Seino, S., Simpson, J. A., & Drucker, D. J. (2013) · Nature Medicine · doi:10.1038/nm.3128 · Cited by 514
Verdich, C., Toubro, S., Buemann, B., Lysgård Madsen, J., Juul Holst, J., & Astrup, A. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801655 · Cited by 434
Das, S. R., Drazner, M. H., Dries, D. L., Vega, G. L., Stanek, H. G., Abdullah, S. M., Canham, R. M., Chung, A. K., Leonard, D., Wians, F. H., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.555573 · Cited by 433
Association between adiponectin and mediators of inflammation in obese women
Engeli, S., Feldpausch, M., Gorzelniak, K., Hartwig, F., Heintze, U., Janke, J., Möhlig, M., Pfeiffer, A. F. H., Luft, F. C., & Sharma, A. M. (2003) · Diabetes · doi:10.2337/diabetes.52.4.942 · Cited by 422
Self-citationNewton‐Cheh, C., Larson, M. G., Vasan, R. S., Levy, D. A., Bloch, K. D., Surti, A., Guiducci, C., Kathiresan, S., Benjamin, E. J., Struck, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.328 · Cited by 397
Immunoluminometric Assay for the Midregion of Pro-Atrial Natriuretic Peptide in Human Plasma
Morgenthaler, N. G., Struck, J., Thomas, B., & Bergmann, A. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2003.021204 · Cited by 336
Miyashita, K., Itoh, H., Tsujimoto, H., Tamura, N., Fukunaga, Y., Sone, M., Yamahara, K., Taura, D., Inuzuka, M., Sonoyama, T., et al. (2009) · Diabetes · doi:10.2337/db09-0393 · Cited by 288 · cited 3×
“Weight loss reduced adipose NPR-C expression in rodents [5,17].”
BackgroundNatriuretic peptides in cardiovascular diseases: current use and perspectives
Volpe, M., Rubattu, S., & Burnett, J. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht466 · Cited by 278
Expression of natriuretic peptide receptors in human adipose and other tissues
Sarzani, P., Dessı̀-Fulgheri, P., Paci, V. M., Espinosa, E., & RAPPELLI, A. (1996) · Journal of Endocrinological Investigation · doi:10.1007/bf03349021 · Cited by 254
Tsukamoto, O., Fujita, M., Kato, M., Yamazaki, S., Asano, Y., Ogai, A., Okazaki, H., Asai, M., Nagamachi, Y., Maeda, N., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.02.038 · Cited by 251
Beneficial Cardiovascular Effects of Bariatric Surgical and Dietary Weight Loss in Obesity
Rider, O. J., Francis, J. M., Ali, M. K., Petersen, S. E., Robinson, M., Robson, M. D., Byrne, J. P., Clarke, K., & Neubauer, S. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.02.086 · Cited by 204
Natriuretic peptides enhance the oxidative capacity of human skeletal muscle
Engeli, S., Birkenfeld, A. L., Badin, P.-M., Bourlier, V., Louche, K., Viguerie, N., Thalamas, C., Montastier, É., Larrouy, D., Harant, I., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64526 · Cited by 197
Self-citationDessı̀-Fulgheri, P., Sarzani, R., Tamburrini, P., Moraca, A., Espinosa, E., Cola, G., Giantomassi, L., & RAPPELLI, A. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715120-00074 · Cited by 195
Thirty-One Novel Biomarkers as Predictors for Clinically Incident Diabetes
Salomaa, V. V., Havulinna, A. S., Saarela, O., Zeller, T., Jousilahti, P., Jula, A. M., Münzel, T. F., Aromaa, A., Evans, A., Kuulasmaa, K., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010100 · Cited by 167
Lipid Mobilization with Physiological Atrial Natriuretic Peptide Concentrations in Humans
Birkenfeld, A. L., Boschmann, M., Moro, C., Adams, F., Heusser, K., Franke, G., Berlan, M., Luft, F. C., Lafontan, M., & Jordan, J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1953 · Cited by 165
Self-citationMagnusson, M., Jujić, A., Hedblad, B., Engström, G., Persson, M., Struck, J., Morgenthaler, N. G., Nilsson, P. M., Newton‐Cheh, C., Wang, T. J., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2425 · Cited by 149
Metabolic actions of natriuretic peptides and therapeutic potential in the metabolic syndrome
Schlueter, N., de Sterke, A., Willmes, D. M., Spranger, J., Jordan, J., & Birkenfeld, A. L. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.04.007 · Cited by 149
Self-citationAtrial Natriuretic Peptide Induces Postprandial Lipid Oxidation in Humans
Birkenfeld, A. L., Budziarek, P., Boschmann, M., Moro, C., Adams, F., Franke, G., Berlan, M., Marqués, M.-A., Sweep, F. C. G. J., Luft, F. C., et al. (2008) · Diabetes · doi:10.2337/db08-0649 · Cited by 146
Self-citationAtrial natriuretic peptide is negatively regulated by microRNA-425
Arora, P. K., Wu, C., Khan, A. M., Bloch, D. B., Davis‐Dusenbery, B. N., Ghorbani, A., Spagnolli, E., Martinez, A., Ryan, A., Tainsh, L. T., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67383 · Cited by 127
Fasting inhibits natriuretic peptides clearance receptor expression in rat adipose tissue
Sarzani, R., Paci, V. M., Zingaretti, C. M., Pierleoni, C., Cinti, S., Cola, G., RAPPELLI, A., & Dess??-Fulgheri, P. (1995) · Journal of Hypertension · doi:10.1097/00004872-199511000-00004 · Cited by 104
Atrial Natriuretic Peptide and Adiponectin Interactions in Man
Birkenfeld, A. L., Boschmann, M., Engeli, S., Moro, C., Arafat, A. M., Luft, F. C., & Jordan, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043238 · Cited by 90
Self-citationViljanen, A. P. M., Karmi, A., Borra, R., Pärkkä, J. P., Saunavaara, V., Parkkola, R. K., Läutamaki, R., Järvisalo, M. J., Taittonen, M. T., Rönnemaa, T., et al. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.02.025 · Cited by 73
Dessı̀-Fulgheri, P., Sarzani, R., Serenelli, M., Tamburrini, P., Spagnolo, D., Giantomassi, L., Espinosa, E., & RAPPELLI, A. (1999) · Hypertension · doi:10.1161/01.hyp.33.2.658 · Cited by 71
Asferg, C. L., Nielsen, S. J., Andersen, U. B., Linneberg, A., Møller, D. V., Hedley, P. L., Christiansen, M., Goetze, J. P., Esler, M., & Jeppesen, J. L. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00791 · Cited by 58
The Mammalian INDY Homolog Is Induced by CREB in a Rat Model of Type 2 Diabetes
Neuschäfer‐Rube, F., Lieske, S., Kuna, M., Henkel, J., Perry, R. J., Erion, D. M., Pesta, D. H., Willmes, D. M., Brachs, S., von Loeffelholz, C., et al. (2013) · Diabetes · doi:10.2337/db13-0749 · Cited by 41
Self-citationThe Effects of Exercise on Natriuretic Peptides in Individuals without Heart Failure
Hamasaki, H. (2016) · Sports · doi:10.3390/sports4020032 · Cited by 41
Morabito, D., Vallotton, M. B., & Lang, U. (2001) · Journal of Investigative Medicine · doi:10.2310/6650.2001.33895 · Cited by 38
Khaleghi, M., Saleem, U., Morgenthaler, N. G., Turner, S. T., Bergmann, A., Struck, J., Mosley, T. H., & Kullo, I. J. (2009) · American Journal of Hypertension · doi:10.1038/ajh.2009.8 · Cited by 22
Biomarker Changes During Acute Heart Failure Treatment
Boyer, B., Hart, K. W., Sperling, M. I., et al. (2011) · Congestive Heart Failure · doi:10.1111/j.1751-7133.2011.00256.x · Cited by 16
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Metadata
- Authors
- Haufe, S., Kaminski, J., Utz, W., Haas, V., Mähler, A., Daniels, M. A., Birkenfeld, A. L., Lichtinghagen, R., Luft, F. C., Schulz-Menger, J., Engeli, S., & Jordan, J.
- Affiliations
- University of Potsdam (DE)
- Helios Hospital Berlin-Buch (DE)
- Max Delbrück Center (DE)
- Charité – Universitätsmedizin Berlin (DE)
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- Jordan, Jens
- ORCID
- Venue
- Journal of Hypertension
- Published
- 2015-07
- Volume
- 33
- Issue
- 7
- Pages
- 1458-1464
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W2328536287
- Cited by
- 41
- References
- 36
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 3 · 2020: 8 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 8 · 2015: 3
- FWCI
- 11.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Site cant be reached (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- atrial natriuretic peptide, obesity, weight loss, hypocaloric diet, physical activity, natriuretic peptide receptor A, NPR-C, adipose tissue, insulin resistance, visceral fat, liver fat, blood pressure
- MeSH terms
- Adipose Tissue, Adult, Diet, Reducing, Female, Humans, Insulin Resistance, Male, Middle Aged, Atrial Natriuretic Factor, Obesity, Rest, Weight Loss, Exercise, Receptors, Atrial Natriuretic Factor, Blood Pressure Monitoring, Ambulatory, Weight Reduction Programs
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