Cited by 24Blood Pressure and Hypertension StudiesCardiovascular Health and Disease PreventionSodium Intake and Health

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Prognostic significance of on-treatment home and clinic blood pressure for predicting cardiovascular events in hypertensive patients in the HONEST study

Abstract

OBJECTIVE: We investigated the prognostic significance of morning home SBP (MHSBP) and clinic SBP (CSBP) at baseline and during follow-up in on-treatment hypertensive patients. METHODS: In the Home blood pressure measurement with Olmesartan Naive patients to Establish Standard Target blood pressure study, more than 20 000 Japanese hypertensive patients who started treatment with olmesartan were followed for cardiovascular events for 2 years. MHSBP and CSBP measured at baseline and during follow-up were compared in terms of the prognostic significance in predicting cardiovascular events. RESULTS: The analysis included 21 591 patients (50.6% female; average age 64.9 years; mean follow-up 2.02 years; and 280 cardiovascular events). The mean MHSBP and CSBP were 151.2 and 153.6 mmHg at baseline and 135.2 and 135.2 mmHg during follow-up. Hazard ratios per 1 mmHg increase were 1.011 (95% confidence interval 1.004-1.019) and 1.006 (1.000-1.012) at baseline, and 1.039 (1.029-1.049) and 1.026 (1.016-1.036) during follow-up. When MHSBP and CSBP at baseline and during follow-up were included in the same model, only MHSBP during follow-up was identified as a significant predictive factor. The concordance index of all blood pressure variables showed reasonable discrimination abilities, and that of mean during follow-up were higher than that of SBP at baseline. The results of net reclassification improvement analyses showed that follow-up MHSBP had better reclassification ability than follow-up CSBP. CONCLUSION: SBP during follow-up (as compared with SBP at baseline), particularly MHSBP (as compared with CSBP), had better prognostic significance in predicting cardiovascular events in Japanese hypertensive patients during a 2-year clinical study.

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Research works printed but not linked: 14

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  2. Bobrie, 2004, Cardiovascular prognosis of ‘masked hypertension’ detected by blood pressure self-measurement in elderly treated hypertensive patients, JAMA, 291, 1342, 10.1001/jama.291.11.1342 · DOI · Paper page
  3. Niiranen, 2010, Home-measured blood pressure is a stronger predictor of cardiovascular risk than office blood pressure: the Finn-Home study, Hypertension, 55, 1346, 10.1161/HYPERTENSIONAHA.109.149336 · DOI · Paper page
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Metadata

Authors
Shimada, K., Kario, K., Kushiro, T., Teramukai, S., Zenimura, N., Ishikawa, Y., Okuda, Y., & Saito, I.
Affiliations
Jichi Medical University (JP)
Corresponding author
Shimada, Kazuyuki
Venue
Journal of Hypertension
Published
2016-08
Volume
34
Issue
8
Pages
1520-1527
ISSN
0263-6352 (ISSN-L)
OpenAlex
W2425970564
Cited by
24
References
2
Citations by year
2026: 2 · 2025: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 1
FWCI
2.75
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Daiichi-Sankyo
  • Daiichi Sankyo Europe
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
Keywords
home blood pressure monitoring, morning systolic blood pressure, office blood pressure, hypertension, cardiovascular events, prognostic factors, olmesartan, antihypertensive therapy, Japanese hypertensive patients, net reclassification improvement
MeSH terms
Aged, Antihypertensive Agents, Blood Pressure, Blood Pressure Determination, Cardiovascular Diseases, Female, Humans, Hypertension, Imidazoles, Japan, Male, Middle Aged, Office Visits, Prognosis, Self Care, Tetrazoles

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