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Reduced incidence of new-onset atrial fibrillation with angiotensin II receptor blockade: the VALUE trial

Schmieder, Roland E, Kjeldsen, Sverre E, Julius, Stevo, McInnes, Gordon T, Zanchetti, Alberto, Hua, Tsushung A·2008·Journal of Hypertension

Abstract

BACKGROUND: Atrial fibrillation (AF) is the most common arrhythmia and increases cardiovascular risk in hypertensive patients. Therefore, in the Valsartan Antihypertensive Long-term Use Evaluation (VALUE) a prespecified objective was to compare the effects of valsartan and amlodipine on new-onset AF. METHODS: A total of 15 245 hypertensive patients at high cardiovascular risk received valsartan 80-160 mg/day or amlodipine 5-10 mg/day combined with additional antihypertensive agents. Electrocardiograms were obtained every year and analyzed centrally for evidence of left ventricular hypertrophy and new-onset AF. RESULTS: At baseline, AF was diagnosed in 2.6% of 7649 valsartan recipients and 2.6% of 7596 amlodipine recipients. During antihypertensive treatment the incidence of at least one documented occurrence of new-onset AF was 3.67% with valsartan and 4.34% with amlodipine [unadjusted hazard ratio 0.843, [95% confidence interval (CI): 0.713, 0.997], P = 0.0455]. The incidence of persistent AF was 1.35% with valsartan and 1.97% with amlodipine [unadjusted hazard ratio 0.683 (95% CI: 0.525, 0.889), P = 0.0046]. CONCLUSIONS: Valsartan-based treatment reduced the development of new-onset AF, particularly sustained AF in hypertensive patients, compared with amlodipine-based therapy. These findings suggest that angiotensin II receptor blockers may result in greater benefits than calcium antagonists in hypertensive patients at risk of new-onset AF.

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Metadata

Authors
Schmieder, R. E., Kjeldsen, S. E., Julius, S., McInnes, G. T., Zanchetti, A., & Hua, T. A.
Venue
Journal of Hypertension
Published
2008-03
Volume
26
Issue
3
Pages
403-411
ISSN
0263-6352 (ISSN-L)
OpenAlex
W1978481506
Cited by
231
References
4
FWCI
19.58
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Reduced incidence of new-onset atrial fibrillation with angiotensin II receptor blockade: the VALUE trial. https://app.cochat.ai/papers/10.1097/hjh.0b013e3282f35c67
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Schmieder, R. E., Kjeldsen, S. E., Julius, S., McInnes, G. T., Zanchetti, A., & Hua, T. A. (2008). Reduced incidence of new-onset atrial fibrillation with angiotensin II receptor blockade: the VALUE trial. Journal of Hypertension. https://doi.org/10.1097/hjh.0b013e3282f35c67

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