The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Periodontal bacteria and hypertension: the oral infections and vascular disease epidemiology study (INVEST)
Open accessAbstract
OBJECTIVE: Chronic infections, including periodontal infections, may predispose to cardiovascular disease. We investigated the relationship between periodontal microbiota and hypertension. METHODS AND RESULTS: Six hundred and fifty-three dentate men and women with no history of stroke or myocardial infarction were enrolled in INVEST. We collected 4533 subgingival plaque samples (average of seven samples per participant). These were quantitatively assessed for 11 periodontal bacteria using DNA-DNA checkerboard hybridization. Cardiovascular risk factor measurements were obtained. Blood pressure and hypertension (SBP > or =140 mmHg, DBP > or =90 mmHg or taking antihypertensive medication, or self-reported history) were each regressed on the level of bacteria: considered causative of periodontal disease (etiologic bacterial burden); associated with periodontal disease (putative bacterial burden); and associated with periodontal health (health-associated bacterial burden). All analyses were adjusted for age, race/ethnicity, sex, education, BMI, smoking, diabetes, low-density lipoprotein and high-density lipoprotein cholesterol. Etiologic bacterial burden was positively associated with both blood pressure and prevalent hypertension. Comparing the highest and lowest tertiles of etiologic bacterial burden, SBP was 9 mmHg higher, DBP was 5 mmHg higher (P for linear trend was less than 0.001 in each case), and the odds ratio for prevalent hypertension was 3.05 (95% confidence interval 1.60-5.82) after multivariable adjustment. CONCLUSION: Our data provide evidence of a direct relationship between the levels of subgingival periodontal bacteria and both SBP and DBP as well as hypertension prevalence.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These findings were not confirmed in four studies.[51][52][53][54]”
From Periodontitis is associated with hypertension: a systematic review and meta-analysis (2020) · cites this paper as [51]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2002) · Civil War Book Review · Cited by 12,198
Microbial complexes in subgingival plaque
Socransky, S. S., Haffajee, A. D., Cugini, M. A., Smith, C., & Kent, R. L. (1998) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.1998.tb02419.x · Cited by 5,050
Bacterial Diversity in Human Subgingival Plaque
Paster, B. J., Boches, S. K., Galvin, J. L., Ericson, R. E., Lau, C. N., Levanos, V. A., Sahasrabudhe, A., & Dewhirst, F. E. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.12.3770-3783.2001 · Cited by 2,008
Case Definitions for Use in Population‐Based Surveillance of Periodontitis
Page, R. C., & Eke, P. I. (2007) · Journal of Periodontology · doi:10.1902/jop.2007.060264 · Cited by 1,473
Primary Prevention of Ischemic Stroke
Goldstein, L. B., Adams, R. J., Alberts, M. J., Appel, L. J., Brass, L. M., Bushnell, C., Culebras, A., DeGraba, T. J., Gorelick, P. B., Guyton, J. R., et al. (2006) · Stroke · doi:10.1161/01.str.0000223048.70103.f1 · Cited by 1,376
Self-citationTreatment of periodontitis and endothelial function
Tonetti, M. S., D'Aiuto, F., Nibali, L., Donald, A., Storry, C., Parkar, M., Suvan, J., Hingorani, A. D., Vallance, P., & Deanfield, J. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063186 · Cited by 1,326
Assessment of Risk for Periodontal Disease. I. Risk Indicators for Attachment Loss
Grossi, S. G., Zambon, J. J., Ho, A. W., Koch, G. G., Dunford, R. G., Machtei, E. E., Norderyd, O. M., & Genco, R. J. (1994) · Journal of Periodontology · doi:10.1902/jop.1994.65.3.260 · Cited by 1,127
C-Reactive Protein and the Risk of Developing Hypertension
Sesso, H. D. (2003) · JAMA · doi:10.1001/jama.290.22.2945 · Cited by 1,013
The breadth of bacterial diversity in the human periodontal pocket and other oral sites
Paster, B. J., Olsen, I., Aas, J. A., & Dewhirst, F. E. (2006) · Periodontology 2000 · doi:10.1111/j.1600-0757.2006.00174.x · Cited by 862
Macy, E. M., Hayes, T. E., & Tracy, R. P. (1997) · Clinical Chemistry · doi:10.1093/clinchem/43.1.52 · Cited by 797
"Checkerboard" DNA-DNA hybridization.
Socransky, S. S., Smith, C., Martin, L., Paster, B. J., Dewhirst, F. E., & Levin, A. E. (1994) · PubMed · Cited by 725
Collaborators, N. M. S. S., Sacco, R. L., Boden-Albala, B. M., Gan, R., Chen, X., Kargman, D. E., Shea, S., Paik, M. C., & Hauser, W. A. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009445 · Cited by 722
Self-citationThe Protective Effect of Moderate Alcohol Consumption on Ischemic Stroke
Sacco, R. (1999) · JAMA · doi:10.1001/jama.281.1.53 · Cited by 525
Self-citationMeta-analysis of periodontal disease and risk of coronary heart disease and stroke
Janket, S., Baird, A. E., Chuang, S.-K., & Jones, J. A. (2003) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1067/moe.2003.107 · Cited by 501
Periodontal Microbiota and Carotid Intima-Media Thickness
Desvarieux, M., Demmer, R. T., Rundek, T., Boden-Albala, B. M., Jacobs, D. R., Sacco, R. L., & Papapanou, P. N. (2005) · Circulation · doi:10.1161/01.cir.0000154582.37101.15 · Cited by 489
Self-citationAcute-phase Inflammatory Response to Periodontal Disease in the US Population
Slade, G. D., Offenbacher, S., Beck, J. D., HEISS, G. M., & Pankow, J. S. (2000) · Journal of Dental Research · doi:10.1177/00220345000790010701 · Cited by 458
C-reactive protein and the risk of developing hypertension
Sesso, H. D., Buring, J. E., Rifai, N., Blake, G., Gaziano, J. M., & Ridker, R. M. (2004) · ACC Current Journal Review · doi:10.1016/j.accreview.2004.02.025 · Cited by 430
Short-term Effects of Intensive Periodontal Therapy on Serum Inflammatory Markers and Cholesterol
D’Aiuto, F., Nibali, L., Parkar, M. H., Suvan, J. E., & Tonetti, M. S. (2005) · Journal of Dental Research · doi:10.1177/154405910508400312 · Cited by 416
Beck, J. D., Elter, J. R., Heiss, G., Couper, D., Mauriello, S. M., & Offenbacher, S. (2001) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/hq1101.097803 · Cited by 414
Relationship Between Periodontal Disease, Tooth Loss, and Carotid Artery Plaque
Desvarieux, M., Demmer, R. T., Rundek, T., Boden-Albala, B. M., Jacobs, D. R., Papapanou, P. N., & Sacco, R. L. (2003) · Stroke · doi:10.1161/01.str.0000085086.50957.22 · Cited by 386
Self-citationEvidence of bacterial etiology: a historical perspective
Socransky, S. S., & Haffajee, A. D. (1994) · Periodontology 2000 · doi:10.1111/j.1600-0757.1994.tb00016.x · Cited by 375
Amar, S., Gokce, N., Morgan, S., Loukideli, M., Van Dyke, T. E., & Vita, J. A. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000078603.90302.4a · Cited by 361
Slade, G. D., Ghezzi, E. M., HEISS, G. M., Beck, J. D., Riché, E. L., & Offenbacher, S. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.10.1172 · Cited by 318
Wu, T., Trevisan, M., Genco, R. J., Falkner, K. L., Dorn, J. P., & Sempos, C. T. (2000) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010203 · Cited by 295
Consensus Report Periodontal Diseases: Pathogenesis and Microbial Factors
(1996) · Annals of Periodontology · doi:10.1902/annals.1996.1.1.926 · Cited by 283
Role of bacteria in health and disease of periodontal tissues
Feng, Z., & Weinberg, A. (2006) · Periodontology 2000 · doi:10.1111/j.1600-0757.2005.00148.x · Cited by 269
Katz, J., Flugelman, M. Y., Goldberg, A., & Heft, M. W. (2002) · Journal of Periodontology · doi:10.1902/jop.2002.73.5.494 · Cited by 264
Folsom, A. R., Aleksic, N., Catellier, D., Juneja, H. S., & Wu, K. K. (2002) · American Heart Journal · doi:10.1067/mhj.2002.124054 · Cited by 227
Periodontal infections and cardiovascular disease
Demmer, R. T., & Desvarieux, M. (2006) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2006.0402 · Cited by 213
Self-citationPERIODONTAL DISEASES: PATHOGENESIS AND MICROBIAL FACTORS
Genco, R. J., Kornman, K. S., Williams, R. C., Offenbacher, S., Zambon, J. J., Ishikawa, I., Listgarten, M. A., Michalowicz, B. S., Page, R. C., Schenkein, H. A., et al. (1998) · The Journal of the American Dental Association · doi:10.1016/s0002-8177(15)30088-x · Cited by 204
Gender Differences in the Relationship Between Periodontal Disease, Tooth Loss, and Atherosclerosis
Desvarieux, M., Schwahn, C., Völzke, H., Demmer, R. T., Lüdemann, J., Kessler, C., Jacobs, D. R., John, U., & Kocher, T. (2004) · Stroke · doi:10.1161/01.str.0000136767.71518.36 · Cited by 172
Self-citationElevated White Blood Cell Count and Carotid Plaque Thickness
Elkind, M. S. V., Cheng, J., Boden-Albala, B. M., Paik, M. C., & Sacco, R. L. (2001) · Stroke · doi:10.1161/01.str.32.4.842 · Cited by 144
Self-citationPapapanou, P. N., Madianos, P., Dahlén, G., & Sandros, J. (1997) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.1997.tb02135.x · Cited by 132
Self-citationBECK, J., Eke, P. I., LIN, D., Madianos, P. N., Couper, D. J., MOSS, K. L., Elter, J. R., HEISS, G. M., & Offenbacher, S. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.03.017 · Cited by 125
Tooth Loss Is Associated With an Increased Risk of Hypertension in Postmenopausal Women
Taguchi, A., Sanada, M., Suei, Y., Ohtsuka, M., Lee, K., Tanimoto, K., Tsuda, M., Ohama, K., Yoshizumi, M., & Higashi, Y. (2004) · Hypertension · doi:10.1161/01.hyp.0000128335.45571.ce · Cited by 115
Serum Antibodies to Periodontal Bacteria as Diagnostic Markers of Periodontitis
Dye, B. A., Herrera‐Abreu, M., Lerche‐Sehm, J., Vlachojannis, C., Pikdöken, L., Pretzl, B., Schwartz, A. B., & Papapanou, P. N. (2009) · Journal of Periodontology · doi:10.1902/jop.2009.080474 · Cited by 96
Self-citationPeriodontal microbiota and clinical periodontal status in a rural sample in southern Thailand
Papapanou, P. N., Teanpaisan, R., Obiechina, N. S., Pithpornchaiyakul, W., Pongpaisal, S., Pisuithanakan, S., Bælum, V., Fejerskov, O., & Dahlén, G. (2002) · European Journal Of Oral Sciences · doi:10.1034/j.1600-0722.2002.21361.x · Cited by 79
Self-citationGender differences in the relation between number of teeth and systolic blood pressure
Völzke, H., Schwahn, C., Dörr, M., Schwarz, S., Robinson, D. M., Dören, M., Rettig, R., Felix, S. B., John, U., & Kocher, T. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000234104.15992.df · Cited by 63
Refining exposure definitions for studies of periodontal disease and systemic disease associations
Demmer, R. T., Kocher, T., Schwahn, C., Völzke, H., Jacobs, D. R., & Desvarieux, M. (2008) · Community Dentistry And Oral Epidemiology · doi:10.1111/j.1600-0528.2008.00435.x · Cited by 59
Self-citationDemmer, R. T., Papapanou, P. N., Jacobs, D. R., & Desvarieux, M. (2008) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2008.01232.x · Cited by 56
Self-citation
Cited by
Sorted by citations
Kebschull, M., Demmer, R. T., & Papapanou, P. N. (2010) · Journal of Dental Research · doi:10.1177/0022034510375281 · Cited by 429
Self-citationValm, A. M. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.05.016 · Cited by 450
Periodontitis is associated with hypertension: a systematic review and meta-analysis
Muñoz Aguilera, E., Suvan, J., Buti, J., Czesnikiewicz-Guzik, M., Barbosa Ribeiro, A., Orlandi, M., Guzik, T. J., Hingorani, A. D., Nart, J., & D’Aiuto, F. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvz201 · Cited by 394
The Microbiota and Microbiome in Aging: Potential Implications in Health and Age‐Related Diseases
Zapata, H. J., & Quagliarello, V. J. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13310 · Cited by 279
Toll-like Receptors in the Vascular System: Sensing the Dangers Within
Goulopoulou, S., McCarthy, C. G., & Webb, R. C. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.010090 · Cited by 267
Metadata
- Authors
- Desvarieux, M., Demmer, R. T., Jacobs, D. R., Jr, Rundek, T., Boden-Albala, B., Sacco, R. L., & Papapanou, P. N.
- Affiliations
- Columbia University (US)
- University of Minnesota (US)
- University of Miami (US)
- Columbia University Irving Medical Center (US)
- Venue
- Journal of Hypertension
- Published
- 2010-07
- Volume
- 28
- Issue
- 7
- Pages
- 1413-1421
- ISSN
- 0263-6352 (ISSN-L)
- PMC
- PMC3403746
- OpenAlex
- W1966562186
- Cited by
- 206
- References
- 41
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 10 · 2023: 14 · 2022: 13 · 2021: 15 · 2020: 17 · 2019: 18 · 2018: 12 · 2017: 15 · 2016: 11 · 2015: 15 · 2014: 15 · 2013: 12 · 2012: 11
- FWCI
- 13.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS-29993, R56NS029993, R37NS029993, R01NS047655, R01NS029993)
- National Institute of Dental and Craniofacial Research (R01DE013094, K99DE018739, R00DE018739, R01 DE-13094)
- National Center for Research Resources (UL1RR024156)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Infective Endocarditis Diagnosis and Management
- Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
- Keywords
- periodontal pathogens, hypertension, subgingival plaque, periodontal disease, cardiovascular risk, blood pressure, chronic infection, cardiovascular disease, oral microbiota
- MeSH terms
- Aged, Antihypertensive Agents, Blood Pressure, Cardiovascular Diseases, Dental Plaque, Diabetes Mellitus, Female, Humans, Hypertension, Male, Periodontal Diseases, Prospective Studies, Risk, Cohort Studies, Prevalence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
