Left ventricular remodelling in patients with moderate systolic dysfunction after myocardial infarction: favourable effects of exercise training and predictive role of N -terminal pro-brain natriuretic peptide
Abstract
AIMS: To investigate the effects of exercise training (ET) on left ventricular (LV) volumes, cardiopulmonary functional capacity and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in postinfarction patients with moderate LV dysfunction. METHODS: Sixty-one postinfarction patients were randomized into two groups: group T [n=30, LV ejection fraction (EF) 41.6+/-11.3%, mean+/-SD] entered a 6-month ET programme, whereas group C (n=31, EF 42.0+/-7.6%, P=NS) did not. NT-proBNP assay, Doppler-echocardiography and cardiopulmonary exercise test were performed upon enrolment and at sixth months. RESULTS: At sixth months, trained patients showed an improvement in workload (+26%, P<0.001), Vo2peak (+31%, P<0.001), LV end-diastolic volume index (LVEDVI; -9%, P<0.001), a reduction in NT-proBNP (-71%, P<0.001) and a significant correlation between changes in NT-proBNP and in LVEDVI (r=0.858, P<0.001). Baseline NT-proBNP correlated with changes in LVEDVI in both trained (r=0.673, P<0.001) and untrained (r=0.623, P<0.001) patients. Group C showed unfavourable LVEDVI dilation (+8%, P<0.001; T vs. C group, P<0.001) and a smaller reduction in NT-proBNP (-40%, P<0.001; T vs. C group, P<0.001). CONCLUSIONS: Six month ET induced a favourable LV remodelling and a marked fall in NT-proBNP that could predict LV remodelling in postinfarction patients with moderate LV dysfunction.
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Exercise intervention after MI remarkably reduces NT-proBNP in patients with moderate LV dysfunction.
“or induce a favourable LV remodelling (decreased LV end-diastolic volume) while remarkably reducing N-terminal pro-brain natriuretic peptide (NT-proBNP) -a hormone released from ventricles in response to myocyte stretch-after MI in patients with moderate LV dysfunction.161”
From Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation (2023) · cites this paper as [161]
Exercise intervention after MI can induce favourable LV remodelling (decreased LV end-diastolic volume) in patients with moderate LV dysfunction.
“or induce a favourable LV remodelling (decreased LV end-diastolic volume) while remarkably reducing N-terminal pro-brain natriuretic peptide (NT-proBNP) -a hormone released from ventricles in response to myocyte stretch-after MI in patients with moderate LV dysfunction.161”
From Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation (2023) · cites this paper as [161]
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- Authors
- Giallauria, F., Cirillo, P., Lucci, R., Pacileo, M., De Lorenzo, A., D'Agostino, M., Moschella, S., Psaroudaki, M., Del Forno, D., Orio, F., Vitale, D. F., Chiariello, M., & Vigorito, C.
- Affiliations
- Cardiac Rehabilitation Unit
- Division of Cardiology, Department of Clinical Medicine, Cardiovascular and Immunological Sciences
- University of Naples Federico II (IT)
- Fondazione Salvatore Maugeri (IT)
- Corresponding author
- Giallauria, Francesco
- ORCID
- Venue
- European Journal of Cardiovascular Prevention & Rehabilitation
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-02
- Volume
- 15
- Issue
- 1
- Pages
- 113-118
- ISSN
- 1741-8267 (ISSN-L)
- OpenAlex
- W2142794898
- Cited by
- 99
- References
- 31
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 10 · 2020: 7 · 2019: 5 · 2018: 8 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 23.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Cardiovascular Prevention & Rehabilitation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- left ventricular remodeling, exercise training, myocardial infarction, systolic dysfunction, NT-proBNP, left ventricular end-diastolic volume, cardiopulmonary exercise capacity, peak oxygen uptake, cardiac biomarkers
- MeSH terms
- Exercise Test, Exercise Therapy, Female, Humans, Male, Middle Aged, Myocardial Infarction, Peptide Fragments, Predictive Value of Tests, Prospective Studies, Surveys and Questionnaires, Systole, Echocardiography, Doppler, Linear Models, Treatment Outcome, Ventricular Dysfunction, Left, Natriuretic Peptide, Brain, Ventricular Remodeling
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