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Cited by 498Treatment of Major DepressionMusculoskeletal pain and rehabilitationPain Mechanisms and Treatments

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Pain and Depression: A Systematic Review

IsHak, Waguih William, Wen, Raymond Y., Naghdechi, Lancer, Vanle, Brigitte, Dang, Jonathan, Knosp, Michelle, Dascal, Julieta, Marcia, Lobsang, Gohar, Yasmine, Eskander, Lidia, Yadegar, Justin, Hanna, Sophia, Sadek, Antonious, Aguilar-Hernandez, Leslie, Danovitch, Itai, Louy, Charles·2018·Harvard Review of Psychiatry
DOI 10.1097/hrp.0000000000000198
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Abstract

Background: Pain comorbid with depression is frequently encountered in clinical settings and often leads to significant impaired functioning. Given the complexity of comorbidities, it is important to address both pain and depressive symptoms when evaluating treatment options. Aim: To review studies addressing pain comorbid with depression, and to report the impact of current treatments. Method: A systematic search of the literature databases was conducted according to predefined criteria. Two authors independently conducted a focused analysis of the full-text articles and reached a consensus on 28 articles to be included in this review. Results: Overall, studies suggested that pain and depression are highly intertwined and may co-exacerbate physical and psychological symptoms. These symptoms could lead to poor physical functional outcomes and longer duration of symptoms. An important biochemical basis for pain and depression focuses on serotonergic and norepinephrine systems, which is evident in the pain-ameliorating properties of serotonergic and norepinephrine antidepressants. Alternative pharmacotherapies such as ketamine and cannabinoids appear to be safe and effective options for improving depressive symptoms and ameliorating pain. In addition, cognitive-behavioral therapy may be a promising tool in the management of chronic pain and depression. Conclusion: The majority of the literature indicates that patients with pain and depression experience reduced physical, mental, and social functioning as opposed to patients with only depression or only pain. In addition, ketamine, psychotropic, and cognitive-behavioral therapies present promising options for treating both pain and depression.

Overview

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Crossref · 10.1097/hrp.0000000000000198

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Citations

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Research works printed but not linked: 2

  1. 2013, Depression and chronic pain, Med J Aust, 199, S17
  2. 2010, The effectiveness of therapeutic touch on pain, depression and sleep in patients with chronic pain: clinical trial, Rev Esc Enferm USP, 44, 1100

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Related

Metadata

Authors
IsHak, W. W., Wen, R. Y., Naghdechi, L., Vanle, B., Dang, J., Knosp, M., Dascal, J., Marcia, L., Gohar, Y., Eskander, L., Yadegar, J., Hanna, S., Sadek, A., Aguilar-Hernandez, L., Danovitch, I., & Louy, C.
Affiliations
University of California, Riverside (US)
Corresponding author
IsHak, Waguih William
ORCID
Venue
Harvard Review of Psychiatry
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2018-11
Volume
26
Issue
6
Pages
352-363
ISSN
  • 1067-3229 (ISSN-L)
  • 1465-7309
DOI
10.1097/hrp.0000000000000198
OpenAlex
W2921028723
Cited by
498
References
54
Citations by year
2026: 38 · 2025: 76 · 2024: 82 · 2023: 79 · 2022: 80 · 2021: 62 · 2020: 76 · 2019: 4
FWCI
4.15
Type
journal article
Language
en
Open access
closed
Locations
  • Harvard Review of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Keywords
pain-depression comorbidity, chronic pain, depression, serotonergic antidepressants, norepinephrine reuptake inhibitors, ketamine, cannabinoids, cognitive behavioral therapy, functional disability
MeSH terms
Depressive Disorder, Humans, Comorbidity, Chronic Pain

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