The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.
Gutted! Unraveling the Role of the Microbiome in Major Depressive Disorder
Open accessAbstract
Microorganisms can be found in virtually any environment. In humans, the largest collection of microorganisms is found in the gut ecosystem. The adult gut microbiome consists of more genes than its human host and typically spans more than 60 genera from across the taxonomic tree. In addition, the gut contains the largest number of neurons in the body, after the brain. In recent years, it has become clear that the gut microbiome is in communication with the brain, through the gut–brain axis. A growing body of literature shows that the gut microbiome plays a shaping role in a variety of psychiatric disorders, including major depressive disorder (MDD). In this review, the interplay between the microbiome and MDD is discussed in three facets. First, we discuss factors that affect the onset/development of MDD that also greatly impinge on the composition of the gut microbiota—especially diet and stressful life events. We then examine the interplay between the microbiota and MDD. We examine evidence suggesting that the microbiota is altered in MDD, and we discuss why the microbiota should be considered during MDD treatment. Finally, we look toward the future and examine how the microbiota might become a therapeutic target for MDD. This review is intended to introduce those familiar with the neurological and psychiatric aspects of MDD to the microbiome and its potential role in the disorder. Although research is in its very early days, with much yet to be the understood, the microbiome is offering new avenues for developing potentially novel strategies for managing MDD.
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“Extensive evidence demonstrates that the brain-gut-microbiota axis plays a crucial role in the pathophysiology of MDD and other psychiatric disorders.423,424”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [423]
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Cites
2 retracted
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RetractedMohammadi, A. A., Jazayeri, S., Khosravi‐Darani, K., Solati, Z., Mohammadpour, N., Asemi, Z., Adab, Z., Djalali, M., Tehrani‐Doost, M., Hosseini, M., et al. (2015) · Nutritional Neuroscience · doi:10.1179/1476830515y.0000000023 · Cited by 241
RetractedA human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
A metagenome-wide association study of gut microbiota in type 2 diabetes
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Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors
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Revised Estimates for the Number of Human and Bacteria Cells in the Body
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Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
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The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders
Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857
Correia, A. S., & Vale, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158493 · Cited by 392
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246
“423,424 Hence, investigating the effects of the combination of the gut microbiome and epigenetic modi fi cation could potentially shed light on the underlying mechanisms of depression.”
BackgroundWhen Rhythms Meet the Blues: Circadian Interactions with the Microbiota-Gut-Brain Axis
Teichman, E. M., O’Riordan, K. J., Gahan, C. G. M., Dinan, T. G., & Cryan, J. F. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.008 · Cited by 199
Self-citationLeigh, S., Uhlig, F., Wilmes, L., Sánchez-Díaz, P., Gheorghe, C. E., Goodson, M. S., Kelley‐Loughnane, N., Hyland, N. P., Cryan, J. F., & Clarke, G. A. (2023) · The Journal of Physiology · doi:10.1113/jp281951 · Cited by 201
Self-citation
Metadata
- Authors
- Bastiaanssen, T. F. S., Cussotto, S., Claesson, M. J., Clarke, G., Dinan, T. G., & Cryan, J. F.
- Affiliations
- University College Cork (IE)
- Corresponding author
- Bastiaanssen, Thomaz F. S.
- Cussotto, Sofia
- ORCID
- Venue
- Harvard Review of Psychiatry
- Published
- 2020-01
- Volume
- 28
- Issue
- 1
- Pages
- 26-39
- ISSN
- 1067-3229 (ISSN-L)
- 1465-7309
- PMC
- PMC7012351
- OpenAlex
- W3000033244
- Cited by
- 159
- References
- 165
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 23 · 2023: 30 · 2022: 23 · 2021: 28 · 2020: 25
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Harvard Review of Psychiatry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science Foundation Ireland (SFI/12/RC/, 12/RC/2273, 12/RC/, SFI/12/RC/2273.)
- APC Microbiome Institute (SFI/12/RC/2273)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, major depressive disorder, gut-brain axis, diet, life events, microbiota alterations, depression treatment, microbiota-targeted therapy, mental illness
- MeSH terms
- Gastrointestinal Microbiome, Animals, Brain, Depressive Disorder, Major, Major Depressive Disorder, Humans, Probiotics, Gastrointestinal Tract
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