The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Neuropsychiatric Disorders in Persons With Severe Traumatic Brain Injury: Prevalence, Phenomenology, and Relationship With Demographic, Clinical, and Functional Features
Abstract
Objective To characterize neuropsychiatric symptoms in a large group of individuals with severe traumatic brain injury (TBI) and to correlate these symptoms with demographic, clinical, and functional features. Methods The Neuropsychiatric Inventory (NPI), a frequently used scale to assess behavioral, emotional, and motivational disorders in persons with neurological diseases, was administered to a sample of 120 persons with severe TBI. Controls were 77 healthy subjects. Results A wide range of neuropsychiatric symptoms was found in the population with severe TBI: apathy (42%), irritability (37%), dysphoria/depressed mood (29%), disinhibition (28%), eating disturbances (27%), and agitation (24%). A clear relationship was also found with other demographic and clinical variables. Conclusion Neuropsychiatric disorders constitute an important part of the comorbidity in populations with severe TBI. Our study emphasizes the importance of integrating an overall assessment of cognitive disturbances with a specific neuropsychiatric evaluation to improve clinical understanding and treatment of persons with TBI.
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“There are some reports that TBI can induce eating disruptions which can include both lack of interest in eating as well as hyperphagia.119,124–126”
From Effects of Traumatic Brain Injury on the Orexin/Hypocretin System (2025) · cites this paper as [119]
Citations
Cites
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The Neuropsychiatric Inventory: Development and Applications
Cummings, J. L. (2020) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988719882102 · Cited by 292
Foussias, G., Agid, O., Fervaha, G., & Remington, G. J. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.10.017 · Cited by 250
Livingston, G., Kelly, L., Lewis-Holmes, E., Baio, G., Stephen Morris, A., Patel, N. V., Omar, R., Katona, C., & Cooper, C. (2014) · Health Technology Assessment · doi:10.3310/hta18390 · Cited by 259
A Transdiagnostic Review of Negative Symptom Phenomenology and Etiology
Strauss, G. P., & Cohen, A. S. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx066 · Cited by 238
Neuropsychology of traumatic brain injury: An expert overview
Azouvi, P., Arnould, A., Dromer, E., & Vallat‐Azouvi, C. (2017) · Revue Neurologique · doi:10.1016/j.neurol.2017.07.006 · Cited by 237
Metadata
- Authors
- Ciurli, P., Formisano, R., Bivona, U., Cantagallo, A., & Angelelli, P.
- Affiliations
- Fondazione Santa Lucia (IT)
- University of Ferrara (IT)
- Venue
- Journal of Head Trauma Rehabilitation
- Published
- 2011-03
- Volume
- 26
- Issue
- 2
- Pages
- 116-126
- ISSN
- 0885-9701 (ISSN-L)
- OpenAlex
- W2094738658
- Cited by
- 187
- References
- 66
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 10 · 2023: 12 · 2022: 8 · 2021: 17 · 2020: 19 · 2019: 17 · 2018: 13 · 2017: 10 · 2016: 14 · 2015: 13 · 2014: 10 · 2013: 13 · 2012: 12
- FWCI
- 7.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Head Trauma Rehabilitation (publishedVersion)
- PubMed (publishedVersion)
- AIRUS (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- severe traumatic brain injury, neuropsychiatric symptoms, Neuropsychiatric Inventory, apathy, irritability, dysphoria, disinhibition, disordered eating, agitation, behavioral and emotional disorders, comorbidities
- MeSH terms
- Adolescent, Adult, Affective Symptoms, Mental Disorders, Brain Injuries, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Risk Factors, Cohort Studies, Glasgow Coma Scale, Prevalence, Case-Control Studies, Young Adult
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