Axis I Psychopathology in Individuals with Traumatic Brain Injury
Abstract
Objectives To assess the incidence, comorbidity, and patterns of resolution of DSM-IV mood, anxiety, and substance use disorders in individuals with traumatic brain injury (TBI). Design The Structured Clinical Interview for DSM-IV Diagnoses (SCID) was utilized. Diagnoses were determined for three onset points relative to TBI onset: pre-TBI, post-TBI, and current diagnosis. Contrasts of prevalence rates with community-based samples, as well as chi-square analysis and analysis of variance were used. Demographics considered in analyses included gender, marital status, severity of injury, and years since TBI onset. Setting Urban, suburban, and rural New York state. Participants 100 adults with TBI who were between the ages of 18 and 65 years and who were, on average, 8 years post onset at time of interview. Main outcome measures SCID Axis I mood diagnoses of major depression, dysthymia, and bipolar disorder; anxiety diagnoses of panic disorder, obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), generalized anxiety disorder (GAD), and phobia; and substance use disorders. Results Prior to TBI, a significant percentage of individuals presented with substance use disorders. After TBI, the most frequent Axis I diagnoses were major depression and select anxiety disorders (ie, PTSD, OCD, and panic disorder). Comorbidity was high, with 44% of individuals presenting with two or more Axis I diagnoses post TBI. Individuals without a pre-TBI Axis I disorder were more…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Comorbid conditions with mTBI include substance use disorders, PTSD, and depression.
“Comorbid conditions include substance use disorders, PTSD, and depression [66-68].”
Cited by
Sorted by citations
Major Depression Following Traumatic Brain Injury
Jorge, R. E., Robinson, R. G., Moser, D., Tateno, A., Crespo-Facorro, B., & Arndt, S. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.1.42 · Cited by 737 · see citing works
Perry, D. C., Sturm, V. E., Peterson, M. J., Pieper, C. F., Bullock, T., Boeve, B. F., Miller, B. L., Guskiewicz, K. M., Berger, M. S., Kramer, J. H., et al. (2016) · Journal of Neurosurgery · doi:10.3171/2015.2.jns14503 · Cited by 440 · see citing works
Norden, D. M., Muccigrosso, M. M., & Godbout, J. P. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.028 · Cited by 413 · see citing works
Psychiatric Disorders Following Traumatic Brain Injury: Their Nature and Frequency
Whelan-Goodinson, R., Ponsford, J., Johnston, L., & Grant, F. (2009) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0b013e3181a712aa · Cited by 310 · see citing works
Scholten, A. C., Haagsma, J. A., Cnossen, M. C., Olff, M., van Beeck, E. F., & Polinder, S. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2015.4252 · Cited by 276 · see citing works
Whelan-Goodinson, R., Ponsford, J., & Schönberger, M. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.06.007 · Cited by 245 · see citing works
Findler, M., Cantor, J., Haddad, L., Gordon, W., & Ashman, T. (2001) · Brain Injury · doi:10.1080/02699050010013941 · Cited by 204 · see citing works
Ciurli, P., Formisano, R., Bivona, U., Cantagallo, A., & Angelelli, P. (2011) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0b013e3181dedd0e · Cited by 187 · see citing works
Brander, G., Pérez-Vigil, A., Larsson, H., & Mataix-Cols, D. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.011 · Cited by 172 · see citing works
Ponsford, J., Lee, N. K., Wong, D., McKay, A., Haines, K., Alway, Y., Downing, M., Furtado, C., & O'Donnell, M. L. (2016) · Psychological Medicine · doi:10.1017/s0033291715002640 · Cited by 173 · see citing works
Dahm, J., Wong, D., & Ponsford, J. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.011 · Cited by 155 · see citing works
Epidemiology and Natural History of Psychiatric Disorders After TBI
Ponsford, J., Alway, Y., & Gould, K. R. (2018) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.18040093 · Cited by 156 · see citing works
Alway, Y., Gould, K. R., Johnston, L., McKenzie, D., & Ponsford, J. (2016) · Psychological Medicine · doi:10.1017/s0033291715002986 · Cited by 153 · see citing works
Fann, J. R., Bombardier, C. H., Vannoy, S., Dyer, J., Ludman, E., Dikmen, S., Marshall, K., Barber, J., & Temkin, N. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2014.3423 · Cited by 147 · see citing works
Gender in obsessive–compulsive disorder: clinical and genetic findings
Lochner, C., Hemmings, S. M. J., Kinnear, C. J., Moolman-Smook, J. C., Corfield, V. A., Knowles, J. A., Niehaus, D. J. H., & Stein, D. J. (2004) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(03)00063-4 · Cited by 141 · see citing works
Gallagher, M., McLeod, H. J., & McMillan, T. M. (2019) · Neuropsychological Rehabilitation · doi:10.1080/09602011.2016.1258367 · Cited by 131 · see citing works
Juengst, S. B., Kumar, R. G., & Wagner, A. K. (2017) · Psychology Research and Behavior Management · doi:10.2147/prbm.s113264 · Cited by 102 · see citing works
Bombardier, C. H., Bell, K. R., Temkin, N. R., Fann, J. R., Hoffman, J., & Dikmen, S. (2009) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0b013e3181ad65f0 · Cited by 97 · see citing works
Depression trajectories during the first year after traumatic brain injury
Bombardier, C. H., Hoekstra, T., Dikmen, S., & Fann, J. R. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2015.4349 · Cited by 95 · see citing works
Waldron, B., Casserly, L. M., & O'Sullivan, C. (2013) · Neuropsychological Rehabilitation · doi:10.1080/09602011.2012.724196 · Cited by 93 · see citing works
Cooper-Evans, S., Alderman, N., Knight, C., & Oddy, M. (2008) · Neuropsychological Rehabilitation · doi:10.1080/09602010801948516 · Cited by 78 · see citing works
Ownsworth, T., Little, T., Turner, B., Hawkes, A., & Shum, D. (2008) · Brain Injury · doi:10.1080/02699050802446697 · Cited by 78 · see citing works
The Effect of Antidepressants on Depression After Traumatic Brain Injury: A Meta-analysis
Kreitzer, N., Ancona, R., McCullumsmith, C., Kurowski, B. G., Foreman, B., Ngwenya, L. B., & Adeoye, O. (2019) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000439 · Cited by 56 · see citing works
Soo, C., Tate, R. L., & Lane-Brown, A. (2011) · Brain Impairment · doi:10.1375/brim.12.1.54 · Cited by 42 · see citing works
Beedham, W., Belli, A., Ingaralingam, S., Haque, S., & Upthegrove, R. (2020) · Brain Injury · doi:10.1080/02699052.2020.1797169 · Cited by 41 · see citing works
Zhao, J., Huynh, J., Hylin, M. J., O'Malley, J. J., Perez, A., Moore, A. N., & Dash, P. K. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2016.4898 · Cited by 39 · see citing works
Little, A., Byrne, C., & Coetzer, R. (2021) · NeuroRehabilitation · doi:10.3233/nre-201544 · Cited by 29 · see citing works
Narapareddy, B. R., Narapareddy, L., Lin, A., Wigh, S., Nanavati, J., Dougherty, J., Nowrangi, M., & Roy, D. (2020) · Psychosomatics · doi:10.1016/j.psym.2020.04.012 · Cited by 23 · see citing works
Growth mixture modeling of depression symptoms following traumatic brain injury
Gomez, R., Skilbeck, C., Thomas, M., & Slatyer, M. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01320 · Cited by 21 · see citing works
Whiting, D. L., Simpson, G. K., McLeod, H. J., Deane, F. P., & Ciarrochi, J. (2012) · Brain Impairment · doi:10.1017/brimp.2012.28 · Cited by 19 · see citing works
Bernanke, A., Hasley, R., Sabetfakhri, N., de Wit, H., Smith, B. M., Wang, L., Brenner, L. A., Hanlon, C., Philip, N. S., Ajilore, O., et al. (2024) · JMIR Research Protocols · doi:10.2196/58206 · Cited by 2 · see citing works
- Authors
- Hibbard, M. R., Uysal, S., Kepler, K., Bogdany, J., & Silver, J.
- Affiliations
- Mount Sinai Hospital (US)
- Mount Sinai Health System (US)
- Lenox Hill Hospital (US)
- Corresponding author
- Hibbard, Mary R.
- ORCID
- Silver, Jonathan
- Venue
- Journal of Head Trauma Rehabilitation
- Published
- 1998-08
- Volume
- 13
- Issue
- 4
- Pages
- 24-39
- ISSN
- 0885-9701 (ISSN-L)
- OpenAlex
- W2053368004
- Cited by
- 491
- References
- 0
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 13 · 2021: 12 · 2020: 19 · 2019: 16 · 2018: 21 · 2017: 29 · 2016: 21 · 2015: 38 · 2014: 29 · 2013: 26 · 2012: 14
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Head Trauma Rehabilitation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- traumatic brain injury, mood disorders, major depressive disorder, substance use disorders, anxiety disorders, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, psychiatric comorbidity
- MeSH terms
- Adult, Aged, Anxiety Disorders, Brain Injuries, Female, Humans, Male, Middle Aged, Socioeconomic Factors, Mood Disorders, Substance-Related Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
