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Medical and Surgical Applications for the Suprachoroidal Space
Open accessAbstract
In recent years, advances in ocular imaging, drug delivery, and ophthalmic surgery have allowed for better visualization and access to the suprachoroidal space. Although previously considered as only a potential space, the suprachoroidal space may serve as a route for drug delivery to the posterior pole, an egress for glaucoma drainage devices, a location for temporary buckling, and a site for prosthesis implantation. Drugs delivered to the suprachoroidal space may achieve higher concentrations in the retina while minimizing exposure to anterior segment tissues, potentially reducing risks of glaucoma or cataracts. Finally, advanced multimodal imaging now allows not only a better understanding of the physiology of the suprachoroid, but also in vivo monitoring of pathologies and drug delivery to the suprachoroidal space. Here, we discuss the newest developments in the medical and surgical applications of this space with potential.
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It was reported that suprachoroidal delivery of AAV in monkey might have a greater tendency to distribute circumferentially along the periphery rather than posteriorly toward the macula.
“Additionally, it was reported that suprachoroidal delivery of AAV in monkey might have a greater tendency to distribute circumferentially along the periphery rather than posteriorly toward the macula70,71.”
From An adeno-associated virus variant enabling efficient ocular-directed gene delivery across species (2024) · cites this paper as [70]
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Metadata
- Authors
- Emami-Naeini, P., & Yiu, G.
- Affiliations
- University of California, Davis (US)
- Venue
- International Ophthalmology Clinics
- Published
- 2019
- Volume
- 59
- Issue
- 1
- Pages
- 195-207
- ISSN
- 0020-8167 (ISSN-L)
- PMC
- PMC6310051
- OpenAlex
- W2906365035
- Cited by
- 41
- References
- 50
- Citations by year
- 2026: 9 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 1
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- International Ophthalmology Clinics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Eye Institute (K08EY026101)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal and Macular Surgery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Keywords
- suprachoroidal space, posterior pole, glaucoma drainage devices, multimodal ocular imaging, retinal drug delivery
- MeSH terms
- Catheterization, Choroid, Pharmaceutical Preparations, Humans, Retinal Diseases, Sclera, Drug Delivery Systems
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