The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
A mouse model for chronic pain-induced increase in ethanol consumption
Open accessAbstract
Chronic pain conditions are often comorbid with alcohol abuse. “Self-medication” with alcohol introduces a host of problems associated with the abuse of alcohol which over time has the potential of exacerbating the painful condition. Despite the prevalence of chronic pain being associated with alcohol abuse, rodent models which mimic the comorbid conditions are lacking. In this study, we model osteoarthritis (OA) in C57BL/6J mice by surgically destabilizing the medial meniscus (DMM). Sham-operated mice served as controls. Thirteen weeks after surgery, DMM but not sham-operated mice exhibited pronounced incapacitance of the surgically manipulated hind limb compared with the nonsurgically manipulated hind limb. At this time, the mice were exposed to the 2-bottle ethanol choice, beginning with 2.5% with a gradual increasing to 20%. Compared with sham controls, DMM mice consumed more EtOH and preferred EtOH over water at the 20% EtOH concentration. Histological analysis verified that the DMM mice exhibited significant damage to the articular cartilage and osteophyte growth compared with sham controls and these measures of the severity of OA correlated with the amount of ethanol intake. Thus, the combination of the DMM model of OA with the enhanced two-bottle ethanol choice is a potential preclinical approach in mice by which the basis of the comorbid association of alcohol abuse and chronic pain conditions can be explored.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Glasson, S. S., Blanchet, T., & Morris, E. A. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.03.006 · Cited by 1,524
Little, C. B., Barai, A., Burkhardt, D., Smith, S. M., Fosang, A. J., Werb, Z., Shah, M., & Thompson, E. W. (2009) · Arthritis & Rheumatism · doi:10.1002/art.25002 · Cited by 642
Bove, S. E., Calcaterra, S., Brooker, R. M., Huber, C. M., Guzman, R. E., Juneau, P. L., Schrier, D. J., & Kilgore, K. S. (2003) · Osteoarthritis and Cartilage · doi:10.1016/s1063-4584(03)00163-8 · Cited by 508
Alcohol dependence as a chronic pain disorder
Egli, M., Koob, G. F., & Edwards, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.010 · Cited by 347
Voluntary ethanol consumption in 22 inbred mouse strains
Yoneyama, N., Crabbe, J. C., Ford, M. M., Murillo, A., & Finn, D. A. (2008) · Alcohol · doi:10.1016/j.alcohol.2007.12.006 · Cited by 316
Loeser, R. F., Olex, A. L., McNulty, M. A., Carlson, C. S., Callahan, M. F., Ferguson, C. M., Chou, J., Leng, X., & Fetrow, J. S. (2012) · Arthritis & Rheumatism · doi:10.1002/art.33388 · Cited by 222
Self-citationSelf-Report of Alcohol Use for Pain in a Multi-Ethnic Community Sample
Riley, J. L., & King, C. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.03.005 · Cited by 218
Ethanol Consumption and Taste Preferences in C57BL/6ByJ and 129/J Mice
Bachmanov, A. A., Tordoff, M. G., & Beauchamp, G. K. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01630.x · Cited by 168
Zarebska, J. M., Chanalaris, A., Driscoll, C. L., Burleigh, A., Miller, R. E., Malfait, A., Stott, B., & Vincent, T. L. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.10.008 · Cited by 136
Increased pain sensitivity in alcohol withdrawal syndrome
Jochum, T., Boettger, M. K., Burkhardt, C., Juckel, G., & Bär, K. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2009.11.008 · Cited by 128
Flagged first, then by citations
Cited by
Sorted by citations
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development
Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337
Edwards, S., Vendruscolo, L. F., Gilpin, N. W., Wojnar, M., & Witkiewitz, K. A. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14260 · Cited by 83
From Pleasure to Pain, and Back Again: The Intricate Relationship Between Alcohol and Nociception
Robins, M. T., Heinricher, M. M., & Ryabinin, A. E. (2019) · Alcohol and Alcoholism · doi:10.1093/alcalc/agz067 · Cited by 63
Neurobiological aspects of pain in the context of alcohol use disorder
Cucinello‐Ragland, J. A., & Edwards, S. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.09.001 · Cited by 27
McGinn, M. A., Edwards, K. N., & Edwards, S. (2020) · Neurobiology of Pain · doi:10.1016/j.ynpai.2020.100052 · Cited by 27
Metadata
- Authors
- Butler, R. K., Knapp, D. J., Ulici, V., Longobardi, L., Loeser, R. F., & Breese, G. R.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Breese, George R.
- Venue
- Pain
- Published
- 2016-11-30
- Volume
- 158
- Issue
- 3
- Pages
- 457-462
- ISSN
- 0304-3959 (ISSN-L)
- 1872-6623
- PMC
- PMC5303149
- OpenAlex
- W2557658390
- Cited by
- 20
- References
- 21
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 5
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA021275, R01AA022234, P60AA011605)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Keywords
- chronic pain, alcohol self-medication, ethanol consumption, osteoarthritis, destabilization of the medial meniscus, mouse model, articular cartilage damage, osteophytes
- MeSH terms
- Alcohol Drinking, Ethanol, Analysis of Variance, Animals, Choice Behavior, Disease Models, Animal, Male, Mice, Inbred C57BL, Disease Progression, Osteoarthritis, Knee, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
