Alcohol dependence as a chronic pain disorder

Egli, Mark; Koob, George F.; Edwards, Scott

doi:10.1016/j.neubiorev.2012.07.010

Cited by 347Pain Mechanisms and TreatmentsSubstance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

Alcohol dependence as a chronic pain disorder

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Egli, Mark, Koob, George F., Edwards, Scott·2012·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2012.07.010PMC PMC3612891

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Abstract

Dysregulation of pain neurocircuitry and neurochemistry has been increasingly recognized as playing a critical role in a diverse spectrum of diseases including migraine, fibromyalgia, depression, and PTSD. Evidence presented here supports the hypothesis that alcohol dependence is among the pathologies arising from aberrant neurobiological substrates of pain. In this review, we explore the possible influence of alcohol analgesia and hyperalgesia in promoting alcohol misuse and dependence. We examine evidence that neuroanatomical sites involved in the negative emotional states of alcohol dependence also play an important role in pain transmission and may be functionally altered under chronic pain conditions. We also consider possible genetic links between pain transmission and alcohol dependence. We propose an allostatic load model in which episodes of alcohol intoxication and withdrawal, traumatic stressors, and injury are each capable of dysregulating an overlapping set of neural substrates to engender sensory and affective pain states that are integral to alcohol dependence and comorbid conditions such as anxiety, depression, and chronic pain.

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Rodent models of alcohol withdrawal reliably show hyperalgesia in multiple pain assays.
“For example, rodent models of alcohol withdrawal have reliably observed hyperalgesia in multiple pain assays (Gatch et al., 1999;Gatch, 2009;Egli et al., 2012).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Egli et al., 2012
Abstinence from chronic alcohol consumption produces hyperalgesia in animal studies.
“As with opioids, although acute alcohol administration in animal studies may confer analgesic effects, abstinence from chronic alcohol consumption produces hyperalgesia (Gatch et al., 1999;Gatch, 2009;Egli et al., 2012).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Egli et al., 2012

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Intra-cerebral and intra-nasal melanocortin-4 receptor antagonist blocks withdrawal hyperalgesia in alcohol-dependent rats
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Alcohol Use Disorder and Chronic Pain: An Overlooked Epidemic
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At the intersection of alcohol use disorder and chronic pain.
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Authors: Egli, M., Koob, G. F., & Edwards, S.
Affiliations: National Institutes of Health (US)
Scripps Research Institute (US)
Corresponding author: Egli, Mark
ORCID: Egli, Mark
Koob, George F.
Edwards, Scott
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2012-11
Volume: 36
Issue: 10
Pages: 2179-2192
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2012.07.010
PMC: PMC3612891
OpenAlex: W1996880759
Cited by: 347
References: 233
Citations by year: 2026: 19 · 2025: 32 · 2024: 34 · 2023: 27 · 2022: 26 · 2021: 39 · 2020: 45 · 2019: 27 · 2018: 16 · 2017: 18 · 2016: 24 · 2015: 17 · 2014: 16 · 2013: 7
FWCI: 1.38
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (AA008459, AA012602, AA006420, AA007456, AA020608)
National Research Service Award (AA018250)
Topics: Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: alcoholism, chronic pain, hyperalgesia, neurochemistry, alcohol withdrawal, traumatic stress, anxiety comorbidity, comorbid depression, affective pain
MeSH terms: Alcoholism, Amygdala, Catechol O-Methyltransferase, Chronic Disease, Humans, Neural Pathways, Prefrontal Cortex, Receptors, Opioid, mu, Chronic Pain

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