Effects of live-online, group mindfulness training on opioid use and anxiety during buprenorphine treatment: A comparative effectiveness RCT
Open accessAbstract
Background Office-based opioid treatment with buprenorphine has emerged as a popular evidence-based treatment for opioid use disorder. Unfortunately, psychosocial stress, anxiety, pain, and co-morbid substance use increase patients' risk for relapse. We designed this study to compare the effects of complementing buprenorphine treatment with 24 weeks of a live-online Mindful Recovery Opioid Care Continuum (M-ROCC) group to a time and attention-matched, live-online Recovery Support Group (RSG) active control condition.Methods We plan to enroll a maximum of N = 280 and randomize at least N = 192 patients prescribed buprenorphine through referrals from office-based and telemedicine buprenorphine treatment providers and social media advertisements. Participants will be randomly assigned to M-ROCC or RSG and will be blinded to their treatment condition. The primary outcome for this study will be biochemically confirmed periods of abstinence from illicit opioids, as measured by self-reported use and randomly collected, video-observed oral fluid toxicology testing during the final 12 weeks of study participation. Secondary outcomes include changes in Patient-Reported Outcomes Measurement Information System (PROMIS) anxiety and pain interference scores between baseline and week 24.Results The trial was funded by the National Institutes of Health, HEAL Initiative through NCCIH (R33AT010125). Data collection is projected to end by September 2023, and we expect publication of results in 2024.Conclusion If the M-ROCC intervention is found to be effective in this format, it will demonstrate that live-online mindfulness groups can improve outcomes and address common co-morbidities like anxiety and pain during buprenorphine treatment.
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In addictions, mindfulness has shown a direct relationship between mindfulness and abstinence.
“Specifically, in the case of addictions, mindfulness has shown a direct relationship between mindfulness and abstinence [51].”
From Third-Generation Therapies for the Management of Psychoactive Substance Use in Young People: Scoping Review (2024) · cites this paper as [51]
The Introduction (page unavailable) reports that a mindfulness-based intervention reduced opioid cravings and use in one methadone-treated group. It also says mindfulness interventions did not consistently improve key substance-use outcomes. The paper therefore offers some support for a link between mindfulness-based treatment and reduced use, but not for an established direct relationship between mindfulness and abstinence. (LLM, conf=0.84)
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Schuman‐Olivier, Z., Goodman, H., Rosansky, J. A., Fredericksen, A. K., Barria, J., Parry, G. J., Sokol, R. G., Gardiner, P. M., Cook, B. L., & Weiss, R. D. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.54950 · Cited by 24 · see citing works
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- Authors
- Rosansky, J. A., Howard, L., Goodman, H., Okst, K., Fatkin, T., Fredericksen, A. K., Sokol, R., Gardiner, P., Parry, G., Cook, B. L., Weiss, R. D., & Schuman-Olivier, Z. D.
- Affiliations
- Cambridge Health Alliance (US)
- Tufts University (US)
- Harvard University (US)
- ORCID
- Venue
- Contemporary Clinical Trials
- Publisher
- Elsevier BV
- Published
- 2024-02
- Volume
- 137
- Pages
- 107417
- ISSN
- 1551-7144 (ISSN-L)
- PMC
- PMC11890101
- OpenAlex
- W4389990393
- Cited by
- 3
- References
- 72
- Citations by year
- 2025: 2 · 2024: 1
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Contemporary Clinical Trials (publishedVersion)
- SSRN Electronic Journal (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Center for Complementary and Integrative Health
- National Institutes of Health (T32AT000051, UG1 DA15831)
- National Institute on Drug Abuse
- National Institute of Neurological Disorders and Stroke
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Keywords
- mindfulness training, buprenorphine, opioid use disorder, opioid use disorder treatment, anxiety, pain interference, opioid abstinence, relapse prevention
- MeSH terms
- Analgesics, Opioid, Anxiety, Buprenorphine, Humans, Opioid-Related Disorders, Neoplasm Recurrence, Local, Pain, Mindfulness
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