The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Trazodone and Cognitive Performance in Alzheimer Disease
Abstract
Camargos, Einstein Francisco MD, PhD; Quintas, Juliana Lima MsC (Psych); Louzada, Luciana Lilian MD, MsC; Naves, Janeth O.S. PhD (Pharm); Furioso, Audrey C.T. MsC (Biol); Nóbrega, Otávio Toledo PhD (Biol) Author Information
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There were no cognitive side effects or daytime somnolence after a 2-week intervention period with trazodone in patients with AD.
“Furthermore, there were no cognitive side effects or daytime somnolence after a 2-week intervention period, thus diminishing concerns for possible cholinergic, 𝛂 -adrenergic, or histaminergic antagonistic effects in sleep-promoting doses [12, 13].”
From Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers (2019) · cites this paper as [13]
Our findings partially contrast with previous results on AD, in which short-term trazodone use was not associated with cognitive benefits despite increased sleep duration.
“Our findings partially contrast with previous results on AD, in which short-term trazodone use was not associated with cognitive benefits despite increased sleep duration [13]”
From Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers (2019) · cites this paper as [13]
Trazodone increased total sleep time by 42.5 minutes on actigraphy in patients with AD.
“While melatonin, ramelteon, or mirtazapine use did not produce significant improvement on sleep measures, trazodone, previously shown to enhance SWS by 50-56% on polysomnography in younger and older adults [10, 11], increased total sleep time by 42.5 minutes on actigraphy in patients with AD [12, 13].”
From Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers (2019) · cites this paper as [13]
Citations
Cites
A Review of the Evidence for the Efficacy and Safety of Trazodone in Insomnia
Mendelson, W. B. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0409 · Cited by 308
In the Zzz Zone: The Effects of Z-Drugs on Human Performance and Driving
Gunja, N. (2013) · Journal of Medical Toxicology · doi:10.1007/s13181-013-0294-y · Cited by 177
Flagged first, then by citations
Research works printed but not linked: 12
- Vermeeren, 2011, Effects of the use of hypnotics on cognition., Prog Brain Res, 190, 89, 10.1016/B978-0-444-53817-8.00005-0 · DOI
- James, 2004, The use of trazodone as a hypnotic: a critical review., J Clin Psychiatry, 65, 752, 10.4088/JCP.v65n0605 · DOI
- Bossini, 2012, Off-label uses of trazodone: a review., Expert Opin Pharmacother, 13, 1707, 10.1517/14656566.2012.699523 · DOI
- Roth, 2011, Cognitive, psychomotor and polysomnographic effects of trazodone in primary insomniacs., J Sleep Res, 20, 552, 10.1111/j.1365-2869.2011.00928.x · DOI
- Rush, 1997, Trazodone and triazolam: acute subject-rated and performance-impairing effects in healthy volunteers., Psychopharmacology, 131, 9, 10.1007/s002130050259 · DOI
- Camargos, 2014, Trazodone improves sleep parameters in Alzheimer disease patients: a randomized, double-blind, and placebo-controlled study., Am J Geriatr Psychiatry, 22, 1565, 10.1016/j.jagp.2013.12.174 · DOI · Paper page
- Folstein, 1975, Mini-mental state. A practical method for grading the cognitive state of patients for the clinician., J Psychiatr Res, 12, 189, 10.1016/0022-3956(75)90026-6 · DOI · Paper page
- Greenblatt, 1987, Trazodone kinetics: effect of age, gender, and obesity., Clin Pharmacol Ther, 42, 193, 10.1038/clpt.1987.132 · DOI
- Burns, 1986, A comparison of the effects of trazodone and amitriptyline on skills performance by geriatric subjects., J Clin Psychiatry, 47, 252
- Sasada, 2013, Effects of repeated dosing with mirtazapine, trazodone, or placebo on driving performance and cognitive function in healthy volunteers., Hum Psychopharmacol, 28, 281, 10.1002/hup.2321 · DOI
- Obermann, 2013, Exploration of 100 commonly used drugs and supplements on cognition in older adults., Alzheimers Dement, 9, 724, 10.1016/j.jalz.2012.12.002 · DOI
- Riedel, 2006, Human cognition assessment in drug research., Curr Pharm Des, 12, 2525, 10.2174/138161206777698882 · DOI
Cited by
Sorted by citations
Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers
La, A. L., Walsh, C. M., Neylan, T. C., Vossel, K. A., Yaffe, K., Krystal, A. D., Miller, B. L., & Karageorgiou, E. (2019) · Journal of Alzheimer's Disease · doi:10.3233/jad-181145 · Cited by 83
Metadata
- Authors
- Camargos, E. F., Quintas, J. L., Louzada, L. L., Naves, J. O. S., Furioso, A. C. T., & Nóbrega, O. T.
- Affiliations
- Universidade de Brasília (BR)
- Venue
- Journal of Clinical Psychopharmacology
- Published
- 2015-02
- Volume
- 35
- Issue
- 1
- Pages
- 88-89
- ISSN
- 0271-0749 (ISSN-L)
- OpenAlex
- W2324408877
- Cited by
- 14
- References
- 2
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 3 · 2020: 2 · 2019: 2 · 2017: 2 · 2016: 1 · 2015: 1
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Keywords
- trazodone, Alzheimer's disease, cognitive performance, cognitive impairment, antidepressants
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cognition, Double-Blind Method, Female, Humans, Male, Prospective Studies, Trazodone, Selective Serotonin Reuptake Inhibitors, Cross-Over Studies, Sleep Disorders, Intrinsic
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