Effect of Methylphenidate on Emotional Dysregulation in Children With Attention-Deficit/Hyperactivity Disorder + Oppositional Defiant Disorder/Conduct Disorder
Abstract
Background and aim Emotional dysregulation (ED) is a frequent feature of attention-deficit/hyperactivity disorder (ADHD). It can be observed as a dysregulation profile or a deficient emotional self-regulation (DESR) profile. Oppositional defiant disorder/conduct disorder (ODD/CD) comorbidity is prevalent in ADHD and known to be related with ED. The first-line treatment of ADHD includes psychostimulants, but their effects on ED are not well studied. This study aimed to evaluate the outcomes of methylphenidate (MPH) treatment on ED in ADHD + ODD/CD cases. Methods A total of 118 ADHD + ODD/CD patients with a mean age of 9.0 ± 1.9 years were treated with MPH for 1 year. Also, parents of cases were recruited for a parent-training program, which initiated after first month of MPH treatment. Symptom severity was assessed at baseline and 12th month by Turgay Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition-Based Child and Adolescent Behavior Disorders Screening and Rating Scale-Parent Form, Children Depression Inventory, Child Behavior Checklist 4-18 years, and Parental Acceptance and Rejection Questionnaire-Mother Form. Results Emotional dysregulation (DESR + DP) was present in 85.6% of cases. Conduct disorder was significantly higher in patients with DP, whereas ODD was significantly higher in the DESR and non-ED groups (P Conclusions Emotional dysregulation is highly prevalent in disruptive behavioral disorders as ODD and CD, which are comorbid with ADHD. The…
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Several studies indicate a positive impact of stimulant and non-stimulant treatment on emotional symptoms in children and adolescents.
“while the majority of these studies target adult ADHD populations, several studies also indicate a positive impact of stimulant and non-stimulant treatment on emotional symptoms in children and adolescents (Kutlu et al., 2017; López et al., 2017; Shih et al., 2019).”
From A Post-Hoc Analysis of Emotional Lability With Delayed-Release/Extended-Release Methylphenidate in Children Aged 6 to 12 Years of Age Participating in Two Phase 3 Clinical Trials (2024) · cites this paper as Kutlu et al., 2017
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Faraone, S. V., Rostain, A. L., Blader, J., Busch, B., Childress, A. C., Connor, D. F., & Newcorn, J. H. (2019) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12899 · Cited by 400 · see citing works
Arnold, V. K., López, F. A., Childress, A. C., Po, M. D., Uchida, C. L., Cuthbertson, L., Sallee, F. R., & Incledon, B. (2024) · Journal of Attention Disorders · doi:10.1177/10870547241243155 · Cited by 1 · see citing works
“…C. B. H. Surman & Walsh, 2022); while the majority of these studies target adult ADHD populations, several studies also indicate a positive impact of stimulant and non-stimulant treatment on emotional symptoms in children and adolescents (Kutlu et al., 2017; López et al., 2017; Shih et al., 2019).”
Background
- Authors
- Kutlu, A., Akyol Ardic, U., & Ercan, E. S.
- Affiliations
- From the *Department of Child and Adolescent Psychiatry, Behcet Uz Child Hospital, İzmir; †Department of Child and Adolescent Psychiatry, Denizli State Hospital, Denizli; ‡Department of Child and Adolescent Psychiatry, Ege University Faculty of Medicine, İzmir, Turkey.
- Venue
- Journal of Clinical Psychopharmacology
- Published
- 2017-04
- Volume
- 37
- Issue
- 2
- Pages
- 220-225
- ISSN
- 0271-0749 (ISSN-L)
- 1533-712X
- OpenAlex
- W2586832925
- Cited by
- 43
- References
- 8
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 8 · 2020: 4 · 2019: 5 · 2018: 2 · 2017: 1 · 2016: 1
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Keywords
- methylphenidate, emotional dysregulation, attention deficit hyperactivity disorder, oppositional defiant disorder, conduct disorder, psychostimulant treatment, parent training, disruptive behavior disorders, children, emotion regulation
- MeSH terms
- Self-Control, Adolescent, Affective Symptoms, Attention Deficit Disorder with Hyperactivity, Child, Female, Humans, Male, Methylphenidate, Comorbidity, Outcome Assessment, Health Care, Conduct Disorder
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