A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder
Open accessAbstract
OBJECTIVE: We conducted a randomized, double-blind, placebo-controlled efficacy and tolerability trial of Matricaria recutita (chamomile) extract therapy in patients with mild to moderate generalized anxiety disorder (GAD). We hypothesized that chamomile would be superior to placebo in reducing GAD symptoms with a comparable tolerability profile. MATERIALS AND METHODS: Sixty-one outpatients with mild to moderate GAD were enrolled, and 57 were randomized to either double-blind chamomile extract (n = 28) or placebo therapy (n = 29) for 8 weeks. The study was powered to detect a statistically significant and clinically meaningful group difference in change over time in total Hamilton Anxiety Rating (HAM-A) scores. Secondary outcomes included change in the Beck Anxiety Inventory, Psychological Well Being, and Clinical Global Impression Severity scores and the proportion of patients with 50% reduction or more in baseline HAM-A score. RESULTS: We observed a significantly greater reduction in mean total HAM-A score during chamomile versus placebo therapy (P = 0.047). Although the study was not powered to identify small to moderate differences in secondary outcomes, we observed a positive change in all secondary outcomes in the same direction as the primary outcome measure. One patient in each treatment group discontinued therapy for adverse events. The proportion of patients experiencing 0, 1, 2, or 3 adverse events or more was not significantly different between groups (P = 0.417). CONCLUSIONS: This is the first controlled clinical trial of chamomile extract for GAD. The results suggest that chamomile may have modest anxiolytic activity in patients with mild to moderate GAD. Future studies are needed to replicate these observations.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Chamomile was safe and efficacious in reducing anxiety symptoms in moderate GAD cases, but did not affect the rate of relapse.
“It was found that chamomile was safe and efficacious in reducing anxiety symptoms in moderate GAD cases, but did not affect the rate of relapse.”
From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Amsterdam et al., 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
An inventory for measuring clinical anxiety: Psychometric properties.
Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.56.6.893 · Cited by 14,407 · see citing works
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455 · see citing works
Trends in Alternative Medicine Use in the United States, 1990-1997
Eisenberg, D. M., Davis, R. B., Ettner, S. L., Appel, S., Wilkey, S. A., Rompay, M. I. V., & Kessler, R. C. (1998) · JAMA · doi:10.1001/jama.280.18.1569 · Cited by 6,693 · see citing works
The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines
Marty, A. T. (1999) · JAMA · doi:10.1001/jama.281.19.1852 · Cited by 847 · see citing works
Generalized anxiety disorder: prevalence, burden, and cost to society
Wittchen, H.-U. (2002) · Depression and Anxiety · doi:10.1002/da.10065 · Cited by 733 · see citing works
Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla
Avallone, R., Zanoli, P., Puia, G., Kleinschnitz, M., Schreier, P. H., & Baraldi, M. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00264-1 · Cited by 338 · see citing works
Ethnicity and Preferences for Depression Treatment
Givens, J. L., Houston, T. K., Van Voorhees, B. W., Ford, D. E., & Cooper, L. A. (2007) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2006.11.002 · Cited by 330 · see citing works
Grossi, E., Groth, N., Mosconi, P., Cerutti, R., Pace, F., Compare, A., & Apolone, G. (2006) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-4-88 · Cited by 291 · see citing works
Behavioral characterisation of the flavonoids apigenin and chrysin
Zanoli, P., Avallone, R., & Baraldi, M. (2000) · Fitoterapia · doi:10.1016/s0367-326x(00)00186-6 · Cited by 224 · see citing works
GABA-A-Receptor Ligands of Flavonoid Structure
Marder, M., & Paladini, A. C. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023393462 · Cited by 173 · see citing works
Nakazawa, T., Yasuda, T., UEDA, J., & Ohsawa, K. (2003) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.26.474 · Cited by 156 · see citing works
Stigma and the Acceptability of Depression Treatments Among African Americans and Whites
Givens, J. L., Katz, I. R., Bellamy, S. L., & Holmes, W. C. (2007) · Journal of General Internal Medicine · doi:10.1007/s11606-007-0276-3 · Cited by 154 · see citing works
Campbell, E., Chebib, M., & Johnston, G. A. R. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.07.022 · Cited by 146 · see citing works
Access To Conventional Medical Care And The Use Of Complementary And Alternative Medicine
Pagán, J. A., & Pauly, M. V. (2005) · Health Affairs · doi:10.1377/hlthaff.24.1.255 · Cited by 138 · see citing works
Mao, J. J. J., Farrar, J. T., Xie, S. X., Bowman, M. A., & Armstrong, K. (2006) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2006.07.006 · Cited by 129 · see citing works
Evidence-based pharmacotherapy of Generalized Anxiety Disorder
Baldwin, D. S., & Polkinghorn, C. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145704004870 · Cited by 126 · see citing works
Apigenin modulates GABAergic and glutamatergic transmission in cultured cortical neurons
Losi, G., Puia, G., Garzon, G., Vuono, M. C. D., & Baraldi, M. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.08.043 · Cited by 97 · see citing works
Breast enlargement during chronic antidepressant therapy
Amsterdam, J. D., García‐España, F., Goodman, D. B. P., Hooper, M. B., & Hornig, M. (1997) · Journal of Affective Disorders · doi:10.1016/s0165-0327(97)00086-4 · Cited by 84 · see citing works
Yamada, K., MIURA, T., Mimaki, Y., & Sashida, Y. (1996) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.19.1244 · Cited by 64 · see citing works
Improved Generalized Estimating Equation Analysis via xtqls for Quasi–Least Squares in Stata
Shults, J., Ratcliffe, S. J., & Leonard, M. B. (2007) · The Stata Journal Promoting communications on statistics and Stata · doi:10.1177/1536867x0700700201 · Cited by 53 · see citing works
Matricaria chamomillaCH12decreases handling stress in Nelore calves
Reis, L. S. L. D. S., Pardo, P. E., Oba, E., Kronka, S. D. N., & Frazatti-Gallina, N. M. (2006) · Journal of Veterinary Science · doi:10.4142/jvs.2006.7.2.189 · Cited by 40 · see citing works
Sussman, N., & Ginsberg, D. L. (1998) · Psychiatric Annals · doi:10.3928/0048-5713-19980201-10 · Cited by 37 · see citing works
Lorenzo, P. S., Rubio‐Terres, C., Medina, J. H., & Adler‐Graschinsky, E. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00486-4 · Cited by 30 · see citing works
Psychological Distress and Adaptational Problems Associated with Discontinuation of Benzodiazepines
O’Connor, K., Bélanger, L., Marchand, A., Dupuis, G., Elie, R., & Boyer, R. (1999) · Addictive Behaviors · doi:10.1016/s0306-4603(98)00107-5 · Cited by 29 · see citing works
New Advances in the Management of Anxiety Disorders
Pollack, M. H., & Frank, R. G. (2015) · Psychopharmacology Bulletin · doi:10.64719/pb.6887 · Cited by 15 · see citing works
Flagged first, then by citations
1 of the 26 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [16]First MB Spitzer RL Gibbon M Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition With Psychotic Screen (SCID-I/P W/PSY SCREEN) New York, NY Biometrics Research, New York State Psychiatric Institute 2002
Cited by
Sorted by citations
Baldwin, D. S., Anderson, I. M., Nutt, D. J., Allgulander, C., Bandelow, B., den Boer, J. A., Christmas, D. M., Davies, S., Fineberg, N., Lidbetter, N., et al. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114525674 · Cited by 676 · see citing works
Chamomile (Matricaria chamomilla L.): An overview
Singh, O., Khanam, Z., Misra, N., & Srivastava, M. (2011) · Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review · doi:10.4103/0973-7847.79103 · Cited by 665 · see citing works
Chamomile: A herbal medicine of the past with a bright future (Review)
Gupta, S. (2010) · Molecular Medicine Reports · doi:10.3892/mmr.2010.377 · Cited by 517 · see citing works
Sarris, J. J., Panossian, A. G., Schweitzer, I., Stough, C. K. K., & Scholey, A. B. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.04.002 · Cited by 479 · see citing works
Wang, M., Firrman, J., Liu, L., & Yam, K. L. (2019) · BioMed Research International · doi:10.1155/2019/7010467 · Cited by 330 · see citing works
Sartori, S. B., & Singewald, N. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107402 · Cited by 236 · see citing works
Yeung, K., Hernandez, M., Mao, J. J., Haviland, I., & Gubili, J. (2018) · Phytotherapy Research · doi:10.1002/ptr.6033 · Cited by 212 · see citing works
Sarris, J., Ravindran, A., Yatham, L., Marx, W., Rucklidge, J., McIntyre, R., Akhondzadeh, S., Benedetti, F., Caneo, C., Cramer, H., et al. (2022) · World Journal of Biological Psychiatry · doi:10.1080/15622975.2021.2013041 · Cited by 190 · see citing works
Diet and Anxiety: A Scoping Review
Aucoin, M., LaChance, L., Naidoo, U., Remy, D., Shekdar, T., Sayar, N., Cardozo, V., Rawana, T., Chan, I., & Cooley, K. (2021) · Nutrients · doi:10.3390/nu13124418 · Cited by 223 · see citing works
Herbal medicines in the treatment of psychiatric disorders: 10‐year updated review
Sarris, J. J. (2018) · Phytotherapy Research · doi:10.1002/ptr.6055 · Cited by 210 · see citing works
Mao, J. J., Xie, S. X., Keefe, J. R., Soeller, I., Li, Q. S., & Amsterdam, J. D. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.10.012 · Cited by 161 · see citing works
Self-citationSarris, J. J., McIntyre, E., & Camfield, D. (2013) · CNS Drugs · doi:10.1007/s40263-013-0059-9 · Cited by 154 · see citing works
Falzon, C. C., & Balabanova, A. (2017) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2017.02.001 · Cited by 152 · see citing works
Anesthetic Agents of Plant Origin: A Review of Phytochemicals with Anesthetic Activity
Tsuchiya, H. (2017) · Molecules · doi:10.3390/molecules22081369 · Cited by 140 · see citing works
A systematic review study of therapeutic effects of Matricaria recuitta chamomile (chamomile)
Miraj, S., & Alesaeidi, . (2016) · Electronic physician · doi:10.19082/3024 · Cited by 138 · see citing works
GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence
Savage, K., Firth, J., Stough, C., & Sarris, J. (2018) · Phytotherapy Research · doi:10.1002/ptr.5940 · Cited by 131 · see citing works
Saki, K., Bahmani, M., & Rafieian‐Kopaei, M. (2014) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(14)60201-7 · Cited by 129 · see citing works
Kava in the Treatment of Generalized Anxiety Disorder
Sarris, J. J., Stough, C. K. K., Bousman, C., Wahid, Z. T., Murray, G., Teschke, R., Savage, K. M., Dowell, A., Ng, C. H., & Schweitzer, I. (2013) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318291be67 · Cited by 126 · see citing works
Zick, S. M., Wright, B. D., Sen, A., & Arnedt, J. T. (2011) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-11-78 · Cited by 116 · see citing works
Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds
Feng, Y., & Bounda, G. (2015) · Pharmacognosy Research · doi:10.4103/0974-8490.157957 · Cited by 115 · see citing works
Chang, S., & Chen, C. (2015) · Journal of Advanced Nursing · doi:10.1111/jan.12836 · Cited by 115 · see citing works
PHARMACOLOGICAL POTENTIAL OF MATRICARIA RECUTITA-A REVIEW
Gupta, V. S., Mittal, P., Bansal, P., Khokra, S. L., & Kaushik, D. (2010) · International Journal of Pharmaceutical Sciences and Drug Research · doi:10.25004/ijpsdr.2010.020102 · Cited by 111 · see citing works
Keefe, J. R., Mao, J. J. J., Soeller, I., Li, Q. S., & Amsterdam, J. D. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.10.013 · Cited by 103 · see citing works
Guzmán‐Gutiérrez, S. L., Reyes‐Chilpa, R., & Jaime, H. B. (2014) · Revista Brasileira de Farmacognosia · doi:10.1016/j.bjp.2014.10.007 · Cited by 101 · see citing works
Faustino, T. T., de Almeida, R. B., & Andreatini, R. (2010) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462010005000026 · Cited by 96 · see citing works
Sarris, J. J., Moylan, S., Camfield, D., Pase, M. P., Mischoulon, D., Berk, M., Jacka, F. N., & Schweitzer, I. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/809653 · Cited by 97 · see citing works
Complementary Therapies for Mental Health Disorders
Asher, G. N., Gerkin, J., & Gaynes, B. N. (2017) · Medical Clinics of North America · doi:10.1016/j.mcna.2017.04.004 · Cited by 93 · see citing works
Amsterdam, J. D., Justine Shults, A., Soeller, I., Mao, J. J. J., Rockwell, K. A., & Newberg, A. B. (2012) · PubMed · Cited by 87 · see citing works
Zhao, K., & So, H. (2018) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2018.2856535 · Cited by 86 · see citing works
White, D., De Klerk, S., Woods, W., Gondalia, S., Noonan, C., & Scholey, A. (2016) · Nutrients · doi:10.3390/nu8010053 · Cited by 85 · see citing works
Alginate controls heartburn in patients with erosive and nonerosive reflux disease
Savarino, E. V. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i32.4371 · Cited by 79 · see citing works
Medicinal herbs for the treatment of anxiety: a systematic review and network meta-analysis
Zhang, W., Yan, Y., Wu, Y., Yang, H., Zhu, P., Yan, F., Zhao, R., Tian, P., Wang, T., Fan, Q., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106204 · Cited by 75 · see citing works
Shahrajabian, M. H., Sun, W., Soleymani, A., & Cheng, Q. (2020) · Phytotherapy Research · doi:10.1002/ptr.6888 · Cited by 73 · see citing works
Hieu, T. H., Dibas, M., Dila, K. A. S., Sherif, N. A., Hashmi, M. U., Mahmoud, M., Trang, N. T. T., Abdullah, L., Nghia, T. L. B., Mai Nhu, Y., et al. (2019) · Phytotherapy Research · doi:10.1002/ptr.6349 · Cited by 71 · see citing works
Medicinal Plants for Insomnia Related to Anxiety: An Updated Review
Borrás, S., Martínez‐Solís, I., & Rı́os, J. L. (2021) · Planta Medica · doi:10.1055/a-1510-9826 · Cited by 78 · see citing works
Chauhan, R., Singh, S., Kumar, V., Kumar, V., Kumar, A., Rathore, S., Kumar, R., & Singh, S. (2021) · Plants · doi:10.3390/plants11010029 · Cited by 70 · see citing works
Mexican medicinal plants with anxiolytic or antidepressant activity: Focus on preclinical research
López‐Rubalcava, C., & Estrada-Camarena, E. M. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.03.053 · Cited by 69 · see citing works
Amsterdam, J. D., Li, Q. S., Xie, S. X., & Mao, J. J. J. (2019) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2019.0252 · Cited by 74 · see citing works
GABAergic implications in anxiety and related disorders
Arora, I., Mal, P., Arora, P., Paul, A., & Kumar, M. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150218 · Cited by 68 · see citing works
Joumaa, M. M. E., & Borjac, J. (2022) · Phytochemistry Reviews · doi:10.1007/s11101-022-09817-0 · Cited by 65 · see citing works
Liu, G., Weinger, J. G., Lu, Z., Xue, F., & Sadeghpour, S. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150538 · Cited by 60 · see citing works
Chamomile tea: Source of a glucuronoxylan with antinociceptive, sedative and anxiolytic-like effects
Chaves, P. F. P., Hocayen, P. D. A. S., Dallazen, J. L., Werner, M. F. D. P., Iacomini, M., Andreatini, R., & Cordeiro, L. M. C. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.08.039 · Cited by 53 · see citing works
Neanderthal self-medication in context
Hardy, K., Buckley, S., & Huffman, M. (2013) · Antiquity · doi:10.1017/s0003598x00049528 · Cited by 40 · see citing works
Sharifi, F., Simbar, M., Mojab, F., & Majd, H. A. (2013) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2013.09.002 · Cited by 49 · see citing works
Plants and phytochemicals potentials in tackling anxiety: A systematic review
Phootha, N., Yongparnichkul, N., Fang, Z., Gan, R.-Y., & Zhang, P.-Z. (2022) · Phytomedicine Plus · doi:10.1016/j.phyplu.2022.100375 · Cited by 40 · see citing works
Motti, R., & de Falco, B. (2021) · Horticulturae · doi:10.3390/horticulturae7120523 · Cited by 48 · see citing works
Martinelli, M., Ummarino, D., Giugliano, F. P., Sciorio, E., Tortora, C., Bruzzese, D., Giovanni, D. D., Rutigliano, I., Valenti, S., Romano, C., et al. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13145 · Cited by 45 · see citing works
An Ethnobotanical Survey of Medicinal Plants Used in Papantla, Veracruz, Mexico
Lara-Reimers, E. A., Fernández-Cusimamani, E., Reimers, D. J. L., Chaloupková, P., del Valle, J. M. Z., Milella, L., & Russo, D. (2019) · Plants · doi:10.3390/plants8080246 · Cited by 45 · see citing works
Phytotherapy of Opioid Dependence and Withdrawal Syndrome: A Review
Tabatabai, S. M., Dashti, S., Doosti, F., & Hosseinzadeh, H. (2013) · Phytotherapy Research · doi:10.1002/ptr.5073 · Cited by 41 · see citing works
Eguchi, E., Funakubo, N., Tomooka, K., Ohira, T., Ogino, K., & Tanigawa, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151712 · Cited by 41 · see citing works
Chamomile as a potential remedy for obesity and metabolic syndrome
Bayliak, M. M., Dmytriv, T. R., Melnychuk, A. V., Strilets, N. V., Storey, K. B., & Lushchak, V. I. (2021) · EXCLI journal · doi:10.17179/excli2021-4013 · Cited by 40 · see citing works
Barić, H., Đorđević, V., Cerovečki, I., & Trkulja, V. (2018) · Advances in Therapy · doi:10.1007/s12325-018-0680-6 · Cited by 39 · see citing works
Baek, J. H., Nierenberg, A. A., & Kinrys, G. (2014) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867414539198 · Cited by 39 · see citing works
Efficacy of Chamomile in the Treatment of Premenstrual Syndrome: A Systematic Review
Khalesi, Z. B., Beiranvand, S. P., & Bokaie, M. (2019) · Journal of pharmacopuncture · doi:10.3831/kpi.2019.22.028 · Cited by 38 · see citing works
Mao, J. J. J., & Li, Q. S. (2015) · Journal of Clinical Trials · doi:10.4172/2167-0870.1000188 · Cited by 36 · see citing works
Coppola, C., Greco, M., Munir, A., Musarò, D., Quarta, S., Massaro, M., Lionetto, M. G., & Maffia, M. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46050251 · Cited by 43 · see citing works
Tabari, M. A., & Tehrani, M. A. B. (2017) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-017-1405-0 · Cited by 31 · see citing works
Anti-anxiety Properties of Selected Medicinal Plants
Khan, A., Akram, M., Thiruvengadam, M., Daniyal, M., Zakki, S. A., Munir, N., Zainab, R., Heydari, M., Mosavat, S. H., Ребезов, М. Б., et al. (2021) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201022666210122125131 · Cited by 35 · see citing works
Preoperative Management of Surgical Patients Using Dietary Supplements
Cummings, K. C., Keshock, M. C., Ganesh, R., Sigmund, A., Kashiwagi, D. T., Devarajan, J., Grant, P., Urman, R. D., & Mauck, K. F. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.08.016 · Cited by 30 · see citing works
Bhattacharya, A., Chakraborty, M., Chanda, A., Alqahtani, T., Kumer, A., Dhara, B., & Chattopadhyay, M. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18220 · Cited by 27 · see citing works
Ahmad, S., Azhar, A., Tikmani, P., Rafique, H., Khan, A., Mesiya, H., & Saeed, H. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e10774 · Cited by 28 · see citing works
Bioactive constituents and pharmacological importance of Matricaria chamomilla: A recent review
Al‐Snafi, A. E., & Hasham, L. F. (2023) · GSC Biological and Pharmaceutical Sciences · doi:10.30574/gscbps.2023.22.2.0477 · Cited by 25 · see citing works
Generalized Anxiety Disorder (GAD)
Ross, S. M. (2013) · Holistic Nursing Practice · doi:10.1097/hnp.0b013e3182a8eb62 · Cited by 24 · see citing works
Keefe, J. R., Amsterdam, J. D., Li, Q. S., Soeller, I., DeRubeis, R. J., & Mao, J. J. J. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.09.029 · Cited by 24 · see citing works
Keefe, J. R., Guo, W., Li, Q. S., Amsterdam, J. D., & Mao, J. J. J. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.10.011 · Cited by 26 · see citing works
Herbal remedies in depression – state of the art.
Szafrański, T. (2014) · Psychiatria Polska · doi:10.12740/pp/21865 · Cited by 23 · see citing works
Les plantes anxiolytiques au Maroc. Études ethnobotanique et ethno-pharmacologique
Doukkali, Z., Bouidida, E. H., Srifi, A., Taghzouti, K., Cherrah, Y., & Alaoui, K. (2015) · Phytothérapie · doi:10.1007/s10298-015-0921-z · Cited by 23 · see citing works
Jensen, M. G., Goode, M., & Heinrich, M. (2024) · PharmaNutrition · doi:10.1016/j.phanu.2024.100399 · Cited by 26 · see citing works
Abejuela, H. R., & Osser, D. N. (2016) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000098 · Cited by 22 · see citing works
Singh, H., Bajaj, P., Kalotra, S., Bhandari, A., Kaur, T., Singh, A. P., & Kaur, G. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104937 · Cited by 22 · see citing works
Dietary and botanical anxiolytics
Alramadhan, E., Hanna, M. S., Hanna, M. S., Goldstein, T. G., Avila, S. M., & Weeks, B. S. (2012) · Medical Science Monitor · doi:10.12659/msm.882608 · Cited by 23 · see citing works
Abdullahzadeh, M., Matourypour, P., & Naji, S. A. (2017) · Journal of Education and Health Promotion · doi:10.4103/jehp.jehp_109_15 · Cited by 21 · see citing works
‘Omic’ Genetic Technologies for Herbal Medicines in Psychiatry
Sarris, J. J., Ng, C. H., & Schweitzer, I. (2011) · Phytotherapy Research · doi:10.1002/ptr.3573 · Cited by 20 · see citing works
The Effect of Oral Chamomile on Anxiety: A Systematic Review of Clinical Trials
Saadatmand, S., Zohroudi, F., & Tangestani, H. (2024) · Clinical Nutrition Research · doi:10.7762/cnr.2024.13.2.139 · Cited by 19 · see citing works
Mahdavian, M., Najmabadi, K. M., Hosseinzadeh, H., Mirzaeian, S., Aval, S. B., & Esmaeeli, H. (2019) · Journal of Caring Sciences · doi:10.15171/jcs.2019.026 · Cited by 19 · see citing works
Bazzan, A. J., Zabrecky, G. P., Monti, D., & Newberg, A. B. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2014.892420 · Cited by 18 · see citing works
Medicinal plants for the "nerves": a review of ethnobotanical studies carried out in South Brazil
Gross, A. V., Stolz, E. D., Müller, L. G., Rates, S. M. K., & Ritter, M. R. (2019) · Acta Botanica Brasilica · doi:10.1590/0102-33062018abb0386 · Cited by 18 · see citing works
Cannabinoid type-2 receptors modulate terpene induced anxiety-reduction in zebrafish.
Johnson, A. L., Verbitsky, R., Hudson, J., Dean, R., & Hamilton, T. J. (2023) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2023.115760 · Cited by 16 · see citing works
Phytomedicines for Prevention and Treatment of Mental Health Disorders
Gerbarg, P. L., & Brown, R. P. (2013) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2012.12.004 · Cited by 18 · see citing works
An ethnobotanical study of medicinal plants used in Zacatecas state, Mexico
Lara-Reimers, E. A., Fernández-Cusimamani, E., Rodríguez, E. A. L., del Valle, J. M. Z., Polesný, Z., & Pawera, L. (2018) · Acta Societatis Botanicorum Poloniae · doi:10.5586/asbp.3581 · Cited by 17 · see citing works
Woodbury, A., Soong, S. N., Fishman, D., & García, P. S. (2015) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-015-0506-9 · Cited by 17 · see citing works
O uso de plantas medicinais e a qualidade de vida relacionada à saúde de pacientes com câncer
Pereira, A. R. A. (2022) · doi:10.11606/t.22.2022.tde-18082022-094229 · Cited by 17 · see citing works
Novel investigational therapeutics for generalized anxiety disorder (GAD)
Schanzer, B., Rivas-Grajales, A. M., Khan, A. Z., & Mathew, S. J. (2019) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2019.1680638 · Cited by 15 · see citing works
Kolanoś, R., & Stice, S. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821038-3.00044-6 · Cited by 15 · see citing works
Chamomile: A systematic review of adverse events
Ostovar, M., Rezaee, Z., Najibi, S. M., & Hashempur, M. H. (2025) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2025.103192 · Cited by 14 · see citing works
Amaghnouje, A., Slighoua, M., Es-safi, I., Jaoudi, R. E., Elyoubi, A., Bousta, D., & Grafov, A. (2020) · Phytothérapie · doi:10.3166/phyto-2020-0225 · Cited by 14 · see citing works
HELICHRYSUM CYMOSUM (L.) D.DON (ASTERACEAE): MEDICINAL USES, CHEMISTRY, AND BIOLOGICAL ACTIVITIES
Maroyi, A. (2019) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2019.v12i7.33771 · Cited by 14 · see citing works
Żełabowski, K., Pichowicz, W., Skowron, I., Szwach, J., Biedka, K., Wesołowski, M., Błaszczyk, K., Ziobro, O., Petrov, W., Kukula-Koch, W. A., et al. (2025) · Molecules · doi:10.3390/molecules30183814 · Cited by 15 · see citing works
Elmaghraby, D. A., Alsalman, G. A., Alawadh, L. H., Al-Abdulqader, S. A., Alaithan, M. M., & Alnuwaysir, B. I. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04197-0 · Cited by 13 · see citing works
Firoozabadi, A., Kolouri, S., Zarshenas, M. M., Salehi, A., Mosavat, S. H., & Dastgheib, S. A. (2017) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2017.08.003 · Cited by 13 · see citing works
Grosso, C. (2016) · Springer eBooks · doi:10.1007/978-3-319-14021-6 · Cited by 12 · see citing works
Shahrajabian, M. H. (2022) · Recent Patents on Biotechnology · doi:10.2174/1872208316666220321102216 · Cited by 12 · see citing works
The Effect of Chamomile on Pain and Menstrual Bleeding in Primary Dysmenorrhea: A Systematic Review.
Niazi, A., & Moradi, M. (2021) · PubMed Central · doi:10.30476/ijcbnm.2021.87219.1417 · Cited by 12 · see citing works
A narrative review on the potential therapeutic benefits of chamomile in the acute care setting
Kimura, R., Schwartz, J. A., & Bennett‐Guerrero, E. (2023) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2023.100714 · Cited by 13 · see citing works
Anxiety is associated with increased risk for atrial cardiopathy
Wang, Z., Qin, H., Chen, G., Dai, Y., Cai, Y., Cheng, X., Qian, Y., Chu, M., & Lu, X. (2020) · Acta Neurologica Belgica · doi:10.1007/s13760-020-01335-0 · Cited by 11 · see citing works
Non-Antidepressant Treatment of Generalized Anxiety Disorder
Zahreddine, N., & Richa, S. (2013) · Current Clinical Pharmacology · doi:10.2174/15748847113089990058 · Cited by 11 · see citing works
A naturalistic study of herbal medicine for self-reported depression and/or anxiety a protocol
Casteleijn, D., Steel, A., Bowman, D., Lauche, R., & Wardle, J. (2019) · Integrative Medicine Research · doi:10.1016/j.imr.2019.04.007 · Cited by 11 · see citing works
Panţuroiu, M., Gălățanu, M. L., Manea, C. E., Popescu, M., Sandulovici, R. C., & Pǎnuş, E. (2025) · Compounds · doi:10.3390/compounds5040050 · Cited by 10 · see citing works
Lekamge, S., Nakachi, M., Sato, S., Ito, K., & Nomura, S. (2017) · International Journal of Affective Engineering · doi:10.5057/ijae.ijae-d-17-00001 · Cited by 9 · see citing works
Faustino, T. T., de Almeida, R. B., & Andreatini, R. (2010) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.1590/s1516-44462010000400017 · Cited by 10 · see citing works
- Authors
- Amsterdam, J. D., Li, Y., Soeller, I., Rockwell, K., Mao, J. J., & Shults, J.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Amsterdam, Jay D.
- Soeller, Irene
- Venue
- Journal of Clinical Psychopharmacology
- Published
- 2009-08
- Volume
- 29
- Issue
- 4
- Pages
- 378-382
- ISSN
- 0271-0749 (ISSN-L)
- PMC
- PMC3600416
- OpenAlex
- W2091881469
- Cited by
- 218
- References
- 26
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 18 · 2023: 14 · 2022: 17 · 2021: 17 · 2020: 9 · 2019: 18 · 2018: 10 · 2017: 15 · 2016: 15 · 2015: 12 · 2014: 10 · 2013: 14 · 2012: 8
- FWCI
- 20.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH063818, R34MH070753, R01MH060713, R01MH060998, R01MH060353)
- National Cancer Institute (R01CA096885)
- National Center for Complementary and Integrative Health (R21AT001916, R21AT002289, AT001916)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- chamomile, chamomile extract, generalized anxiety disorder, anxiolytic effects, herbal medicine, tolerability, Hamilton Anxiety Rating Scale, Beck Anxiety Inventory, psychological well-being
- MeSH terms
- Administration, Oral, Adult, Aged, Anxiety Disorders, Capsules, Double-Blind Method, Female, Humans, Male, Middle Aged, Plant Extracts, Psychiatric Status Rating Scales, Severity of Illness Index, Time Factors, Anti-Anxiety Agents, Treatment Outcome, Chamomile
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
